James Cameron's "Avatar: The Way of Water" is scheduled to reach theaters in December.
The first "Avatar" movie focused on a battle for natural resources between human colonists and the blue Na'vi people on a moon called Pandora.
"We now have a family and to be honest, to me, the movie is about protecting your family."
It could be a communal family, the family that we choose," he added.
"He's a man that cares about the story he's telling and has dedicated a great portion of his life to telling, sharing this with the world," Worthington said.