American Kuss retained the red jersey and his one minute 37 seconds advantage over three-times Vuelta winner Roglic while Vingegaard is 1:44 adrift.
From the beginning of the stage he was in every attack and once the escape group became established it was clear he was the boss of it -- making a tough day look like a breeze.
"Yesterday was a very difficult day and also the evening with a lot of negative thoughts in my head," Evenepoel said.
"It was a super tough stage but really nice to take my second stage win.
Sunday's stage is a hilly route from Pamplona to Lekunberri.
Persons:
Remco Evenepoel, Romain Bardet, France's, masterclass, Sepp Kuss, Primoz Roglic, Jonas Vingegaard, Kuss, Roglic, Juan Ayuso, Evenepoel, Martyn Herman, Ed Osmond, Hugh Lawson
Organizations:
Belgian, Jumbo, UAE Team Emirates, Thomson
Locations:
Espana, Belgian, France, Spain, Vingegaard, Kuss, Pamplona, Lekunberri