The victory ends a 20-year Olympic drought in the event for the USA, when Justin Gatlin won the 100-meter race in Athens.
Thompson, who was the betting favorite in the race, took the silver medal and American Fred Kerley took home the bronze.
Lyles won the race - the first ever with a legal wind where every competitor ran sub-10 seconds - by five-thousandths of a second.
Cameron Spencer/Getty ImagesIt was a sterling version of the signature Olympic race.
When the time came, the lights went out in the Stade de France just as the sun had nearly set outside Paris.
Persons:
Denis, France CNN —, Noah Lyles, Kishane Thompson, Justin Gatlin, Thompson, Fred Kerley, Lyles, Cameron Spencer, didn’t, Yu
Organizations:
France CNN, Stade de France, USA, Paris Olympics
Locations:
France, Paris, Jamaica, Athens, American, Saint