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Search resuls for: "Jacob Hanna"


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Scientists create chimeric monkey with two sets of DNA
  + stars: | 2023-11-09 | by ( Katie Hunt | ) edition.cnn.com   time to read: +7 min
CNN —Scientists based in China have created a monkey chimera with two sets of DNA, experimental work they say could ultimately benefit medical research and the conservation of endangered species. It’s the world’s first live birth of a primate chimera created with stem cells, the researchers said. Scientists have created mouse embryos that are part human, and in 2021, scientists reported that they had grown human-monkey chimeric embryos. In September, researchers reported that they had grown kidneys containing mostly human cells inside pig embryos. Then they selected a subset of cells to inject into genetically distinct 4- to 5-day-old embryos from the same monkey species.
Persons: , , Miguel Esteban, chimeras, Zhen Liu, Liu, Jun Wu, hadn’t, Wu wasn’t, Jacob Hanna, ” Hanna, Penny Hawkins, Organizations: CNN —, Cell, Guangzhou Institute of Biomedicine, Chinese Academy of Sciences, Research, University of Texas Southwestern Medical Center, Weizmann Institute of Science, Royal Society for, National Academies of Sciences, Engineering, Medicine, Covid Locations: China, Health, Research Hangzhou, Israel, United States
Lab models of human embryos raise hopes and concerns
  + stars: | 2023-10-26 | by ( Katie Hunt | ) edition.cnn.com   time to read: +14 min
From the moment sperm fuses with an egg, human embryo development involves a string of complex and little understood processes. What happens during human embryo development, particularly in the crucial first month, remains largely unknown. However, 14 days is an important milestone because it is when permitted lab research on cultured human embryos routinely ends. He said, in the future, it might be possible to go as far as 40 days with human embryo models. Some in the field envision a “tipping point” wherein human embryo models might be afforded some protection like those surrounding human embryos, as scientific advances diminish the differences between the embryo models and their real-life counterparts.
Persons: CNN — It’s, , Jacob Hanna, demystify, they’ve, Hanna, “ It’s, ” Hanna, , Peter Rugg, Gunn, it’s, , Robin Lovell, Francis Crick, Naomi Moris, Francis Crick Institute’s, Moris, we’ve, ” Moris, It’s, Bobbie Farsides, ” Farsides Organizations: CNN, Weizmann Institute of Science, Weizmann Institute, Israel, Weizmann, Babraham Institute, International Society for Stem Cell Research, Stem Cell, Francis, Francis Crick Institute, Genetics, Development, , Sussex Medical School Locations: Israel, London, Brighton
REHOVOT, Israel (Reuters) - Scientists in Israel have created a model of a human embryo from stem cells in the laboratory, without using sperm, eggs or a womb, offering a unique glimpse into the early stages of embryonic development. "The question is, when does an embryo model become considered an embryo? At the moment we are really, really far off from that point," said team leader Jacob Hanna. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. The study raises some ethical questions over the possibility of potential future manipulation in human embryo development, Hanna and others noted.
Persons: Jacob Hanna, Hanna, Magdalena Żernicka, Goetz, Rami Amichay, Ari Rabinovitch, Mark Heinrich Organizations: Israel's Weizmann Institute of Science, International Society for Stem Cell Research, University of Cambridge Locations: REHOVOT, Israel, Boston
The Israeli team emphasised that they were a long way from being able to create an embryo from scratch. "The question is, when does an embryo model become considered an embryo? At the moment we are really, really far off from that point," said team leader Jacob Hanna. "None of these models fully recapitulate natural human development but each adds to ways in which many aspects of human development can now be studied experimentally," she said. The study raises some ethical questions over the possibility of potential future manipulation in human embryo development, Hanna and others noted.
Persons: Mehmet Yunus Comar, Jacob Hanna, Hanna, Magdalena Żernicka, Goetz, Rami Amichay, Ari Rabinovitch, Mark Heinrich Our Organizations: Weizmann Institute of Science, Israel's Weizmann Institute of Science, International Society for Stem Cell Research, University of Cambridge, Thomson Locations: Rehovot, Israel, Boston
Scientists used stem cells to create a model of an embryo in the lab without sperm or egg. Researchers brought us one step closer to understanding those early days by making a model of a human embryo in the lab, without using sperm or eggs. How scientists grew a model human embryo without a sperm or eggAn illustration of embryonic stem cells. Stem cells are cells that form other, more complex cell types depending on what messages the body sends them. Starting with stem cells, the researchers turned them into types of cells that make up a human embryo, from placenta to fetus.
Persons: Jacob Hanna, Hanna, aren't Organizations: Service, Weizmann Institute of Science, Mayo Clinic, BBC Locations: Wall, Silicon
Scientists Debut Lab Models of Human Embryos
  + stars: | 2023-06-24 | by ( Carl Zimmer | ) www.nytimes.com   time to read: +1 min
In its first week, a fertilized human egg develops into a hollow ball of 200 cells and then implants itself on the wall of the uterus. Over the next three weeks, it divides into the distinct tissues of a human body. And those crucial few weeks remain, for the most part, a black box. Dr. Hanna and a number of other biologists are trying to uncover those details by creating models of human embryos in the lab. They are coaxing stem cells to organize themselves into clumps that take on some of the crucial hallmarks of real embryos.
Persons: , Jacob Hanna, Hanna, Hanna’s Organizations: Weizmann Institute of Science Locations: Israel, Britain, United States, China
Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute. Hanna started a company called Renewal Bio to pursue the possibility of turning stem cells into organs for transplants.
Courtesy of Leilani GrahamIf pig organs turn out to be just as effective as human organs, she added, "That is more appealing to me than using marginal donors." While much of the shortage is driven by imperfect logistics and bureaucracy rather than supply, cutting-edge research could make organs — human, pig, or synthetic — more accessible in Graham's lifetime. If the technique works for human organs in the future, it could allow clinicians to preserve many more organs for donation after death. Changing organs' blood typeEnzymes are delivered to a lung inside a perfusion machine at Dr. Marcelo Cypel’s lab. Growing synthetic organs from stem cellsResearcher Stormy Chamberlain holds a tray of stem cells at the University of Connecticut's Stem Cell Institute.
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