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The Food and Drug Administration recently approved a heart stent made specifically for infants and young children, a device that could help kids born with certain congenital heart defects avoid a series of open heart operations over their childhoods. In some cases, those defects are treated with stents, which prop open blood vessels, ensuring that blood can properly flow through them. “You can imagine that is less than ideal — they’re too big.”This means that as the child grows older and their blood vessels get bigger, stents have to be replaced, often with open heart surgery, Zahn said. “It’s not unusual to have kids who are going into middle school who’ve had four or five or even six open heart surgeries,” he said. Patients are usually able to go home about a day later, compared with around seven days for open heart surgery, including some days in the ICU.

Persons: we’ve, ”, Evan Zahn, Guerin, Zahn, “, who’ve, Shabana Shahanavaz, she’s, Shahanavaz, Renata Organizations: Drug Administration, Centers for Disease Control, Guerin Congenital, Cedars Sinai Medical Center, Cincinnati Children’s Hospital Locations: U.S, Cedars, Los Angeles, California, Cincinnati

☆ How American malls survived the slow death of department stores
▼ + stars: | 2024-04-14 | by ( Delon Thornton | ) www.cnbc.com time to read: +2 min

Department stores — which were historically the most important real estate in the nation's malls — are a different story. Department stores are struggling to compete against new online direct-to-consumer competitors and smaller brick-and-mortar retailers that have been able to keep up with the ever-changing demand of consumers. Top-tier malls, known as Class A malls, are pivoting toward an experiential model, replacing department stores with grocery stores, casinos, gyms, ice skating rinks and, in some cases, even residential apartments. Lower-tier malls are feeling the effects of department store closures more acutely as inflation and economic pressures increasingly split consumers into two categories: luxury shoppers and discount shoppers. Watch the video above to find out more about how malls survived the death of the department store.

Persons: Michael Guerin, That's, America's, Haendel St, Juste Organizations: . Department, JCPenney, Sears, Macy's, Mizuho Securities Locations: Macerich

Ilya Sorokin made 30 saves in two periods for the Islanders, setting a career high by starting an 11th consecutive game. He let in a short-handed goal by Eriksson Ek and Foligno's flip-in in the final minute. The Islanders took six penalties, and Zuccarello and Eriksson Ek scored on the power play. The Islanders, who have lost four of their last five games, have also dropped six consecutive games to the Wild. Eriksson Ek had gone 10 straight games without scoring.

Persons: — Marc, Andre Fleury, Joel Eriksson Ek, Mats Zuccarello, Connor Dewar, Marcus Foligno, who'd, Fleury, Patrick Roy, Martin Brodeur, Flower, Ilya Sorokin, Kenneth Appleby, Semyon Varlamov, Appleby, Eriksson Ek, Zuccarello, Bill Guerin, Jonas Brodin, they've, —, Dewar, ___ Organizations: PAUL, 552nd, NHL, Minnesota Wild, New York Islanders, Islanders, Western Conference, Detroit, UP NEXT, Winnipeg, Tampa Locations: New Jersey, Arizona, UP

☆ 10 industry leaders transforming business in 2023
▼ + stars: | 2023-12-11 | by ( ) www.businessinsider.com time to read: +20 min

In 2023, Business Insider's annual list of People Transforming Business highlights key players across the advertising, ESG, finance, AI, and labor sectors. Increasingly, they're turning to more opaque private credit markets to borrow money. The world of private credit sits outside the traditional banking system. Analysts expect the private credit market to balloon in size — likely keeping lawyers like Breen very busy. Muthukrishnan is trying to make sense of how risky these private credit loans are by overseeing what is so far the most comprehensive look at vulnerabilities in the industry.

Persons: Mira Murati, who's, Vince Toye, Eileen Fisher, Eileen Fisher Fisher, Guerin Blask, Eileen Fisher Eileen Fisher, she's, Fisher, Janelle Jones, Jones, Lexey, —, She's, Justin Breen, Proskauer Breen, Proskauer Justin Breen, he's, Breen, Ares Capital, He's, McLaren, Julie Su, Labor Julie Su, Department of Labor Julie Su, Su, Marty Walsh, Murati, Jim Wilson, Neal Mohan, YouTube Mohan, Katie Thompson, YouTube It's, YouTube isn't, Mohan, Muthukrishnan, Satya Nadella, Microsoft Satya Nadella, Ben Kriemann, Nadella, Steve Ballmer, Mathias Döpfner, Axel Springer, Tim Cook, Apple Cook, Justin Sullivan, Cook, Steve Jobs, Jobs, JPMorgan Chase Toye, JPMorgan Chase, Toye, they'll, Vince Toye's, Bella Sayegh, Rebecca Ungarino, Lara O'Reilly, Juliana Kaplan, Alex Nicoll, Tim Paradis, Stephanie Hallett, Michelle Abrego, Josée Rose, Ryan Joe, Emily Canal, Kaja Whitehouse, Alyssa Powell, Davis, Jonann Brady Organizations: JPMorgan, Service Employees International, SEIU, New York, Ford, Service Employees International Union, United Auto Workers Union, Spelman College, US Department of Labor, Economic Policy Institute, Center for Economic, Research, Department of Labor, The New York Times, Ares, Churchill Asset Management, European, Atlético Madrid, Labor, Labor Department, MacArthur Foundation, New York Times, Dartmouth, OpenAI, Associated Press, YouTube, NFL, DirecTV, Federal, Microsoft, Manipal Institute of Technology, University of Wisconsin -, University of Chicago, Apple, Apple Watch, Google, Time, JPMorgan Chase, National Housing Trust, Trenton Almgren Locations: McDonald's, Lorain , Ohio, Atlanta, California, Los Angeles, Albania, Canada, Muthukrishnan, Hyderabad, India, University of Wisconsin - Milwaukee, OpenAI, Virginia, Wells Fargo, Trenton

But the way the Minnesota Wild have been playing, the general manager felt he had no choice but to switch head coaches to try to get them back on track. The Wild went 5-10-4 under Evason this season. The Wild are 22nd in the league in goals per game (2.95) and second-to-last in goals allowed per game (3.95). Dwyer had been serving as an assistant this season for the Iowa Wild in the AHL. “We were pretty optimistic when the season started and, you know, it’s not like from Game 1 it was bad.

Persons: Bill Guerin didn't, Dean Evason, ” Guerin, “, ’, Evason, John Hynes, Bruce Boudreau, Guerin, Louis, Hynes, ” Hynes, Matt Boldy, Kirill Kaprizov, There’s, Patrick Dwyer, Bob Woods, Dwyer, we’ve, We’ve, it’s, Marcus Foligno, It’s, ” Organizations: Minnesota, Evason, Nashville, Iowa, AHL, “, Blues Locations: New Jersey

ST. PAUL, Minn. (AP) — The Minnesota Wild fired coach Dean Evason and assistant Bob Woods on Monday after losing seven games and 14 of their first 19 to start to the NHL season. Evason, 59, was nearly a quarter of the way through his fourth full season as Minnesota’s coach. “Dean did an excellent job during his tenure with the Minnesota Wild, especially as head coach of our team,” Guerin said. I would also like to thank Bob for his hard work during his time as an assistant coach with the Wild. I wish Dean, Bob and their families all the best in the future.”Evason is the second NHL coach fired this season after the Edmonton Oilers dismissed Jay Woodcroft and replaced him with Kris Knoblauch.

Persons: Dean Evason, Bob Woods, Bill Guerin, Bruce Boudreau, “ Dean, ” Guerin, “, Bob, Dean, ” Evason, Jay Woodcroft, Kris Knoblauch, Matt Boldy, Kirill Kaprizov —, Louis, ___ Organizations: PAUL, Minnesota Wild, NHL, Minnesota, Edmonton Oilers, Oilers, San Jose Sharks, Louis Blues Locations: Minnesota

[1/5] English sparkling wine, brand Coates and Seely, is pictured at the Tate Modern art gallery in London, Britain, October 6, 2023. But with vineyards now dotted across hills in southern England and sustainability concerns growing, local fizz is emerging as the drink of choice. Quality has improved, and English wine is no longer mocked by continental neighbours who once joked it tasted of rain. English sparkling and still wine feeds into that narrative," he said. In the UK market for sparkling wine, English fizz accounts for 3% of volumes compared to Champagne's 12%.

Persons: Coates, Seely, Susannah Ireland, Winston Churchill, Josh Donaghay, Henkell Freixenet, Geneva Guerin, Seely Brut, Hectarage, Ned Awty, Awty, Hamish Anderson, Anderson, Champagne Martin, Sarah Young, Catherine Evans Organizations: Tate, REUTERS, UK, Seely, Seely Brut Reserve, Tate Enterprises, Searcys, Thomson Locations: London, Britain, England, Champagne, Boxley, Kent Downs, Bolney, Hampshire

☆ It's Time to Start Preparing Against Flu, RSV & COVID-19
▼ + stars: | 2023-09-15 | by ( Sept. | At A.M. | ) www.usnews.com time to read: +5 min

The flu vaccine is now available in some locations. And new respiratory syncytial virus (RSV) vaccines are recommended for some. "We should do what we can to protect ourselves — and others — with the best tool we have: the flu vaccine." Not only that, but COVID-19 and RSV could again spike at the same time as the flu, triggering a "tripledemic," Gandhi said. Women who are between 32 and 36 weeks pregnant can also protect their infants at birth by getting a new Pfizer RSV vaccine.

Persons: Cara Murez HealthDay, Soniya Gandhi, Gandhi, There's, Priya Soni, Sinai Guerin Children’s, Soni, Sonja Rosen, Rosen Organizations: Southern Hemisphere, U.S . Food, Drug Administration, Pfizer, GSK, U.S . Centers for Disease Control Locations: United States, Cedars, Sinai, Los Angeles, U.S, Guillain, Barre

☆ Drug shortages’ effects on cancer research may be felt for years to come
▼ + stars: | 2023-07-20 | by ( Jen Christensen | ) edition.cnn.com time to read: +8 min

But these shortages aren’t just bad for current patients, experts say; their effects on cancer research may be felt for years to come. The National Cancer Institute, the federal government’s main agency for cancer research and training, told CNN that at least 174 of its own trials may be affected by the shortages. Cisplatin and other platinum-based drugs are prescribed for 10% to 20% of all cancer patients, according to the National Cancer Institute. Crucial work on hold“With drug shortages, trials have become almost like an impossible task. “These drug shortages come and go, and there’s no real rhyme or reason, and there seems to be no rhyme or reason in terms of which institutions have shortages.

Persons: Joe Biden, it’s, ’ ”, Shadia Jalal, Indiana University Melvin, Jalal, She’s, they’ve, ” Jalal, “, ”, haven’t, “ We’ve, Mark Fleury, Fleury, you’re, ” Fleury, Dmitry Walker, Merck, We’ve, ” Walker, there’s, Biden, Lawrence Feldman, ” Feldman, Feldman, Dr, Sanjay Gupta, ‘ Organizations: CNN, National Cancer Institute, American Society of Health, Cancer, Indiana University, Bren Simon Comprehensive Cancer Center, Hematology, Oncology, IU School of Medicine, Hoosier Cancer Research Network, Veterans Administration, American Cancer Society Cancer Action Network, American Cancer Society, WVU Medicine, US Food, Pharmacists, National Comprehensive Cancer Network, University of Illinois Medical Center, CNN Health Locations: United States, China, Chicago

☆ A Century-Old Vaccine Fails to Protect Against Covid
▼ + stars: | 2023-04-26 | by ( Roni Caryn Rabin | ) www.nytimes.com time to read: +1 min

An old tuberculosis vaccine known to bolster the immune system did not prevent Covid infections among health care workers, scientists reported on Thursday. But the trial was shorter and smaller than originally designed, and the investigators said that the results did not rule out other potential benefits associated with the vaccine, known as B.C.G. The study, published in The New England Journal of Medicine, was the largest clinical trial of the vaccine’s potential to protect against Covid infections. The trial of health care workers began in March 2020, during the early days of the pandemic, when no effective treatments for Covid were available and a new vaccine against the highly infectious disease seemed to be a remote fantasy. The hope was that the old vaccine might be repurposed to save lives.

☆ NBA roundup: Knicks' Julius Randle scores 57, Wolves still prevail
▼ + stars: | 2023-03-21 | by ( ) www.reuters.com time to read: +5 min

Mike Conley (24 points, 11 assists) had a double-double for the Timberwolves, who snapped a three-game losing streak. Bulls 109, 76ers 105 (2OT)Zach LaVine scored 26 points, DeMar DeRozan added 25 and Chicago outlasted host Philadelphia 76ers. Joel Embiid had 37 points, 16 rebounds and three blocked shots for the Sixers. Hornets 115, Pacers 109Kelly Oubre Jr. scored 28 points and Charlotte wiped out a 21-point first-half deficit to defeat visiting Indiana. Curry finished with 30 points, seven rebounds and five assists while Thompson added 29 points and seven rebounds.

☆ This 31-year-old CEO says staying focused on one disease was the key to helping his company raise $120 million in a frozen biotech market
▼ + stars: | 2022-11-18 | by ( Yeji Jesse Lee | ) www.businessinsider.com time to read: +6 min

Arthur Kuan is the 31-year-old CEO of CG Oncology, a startup focused on treating bladder cancer. CG announced earlier this week that it has raised $120 million, despite a difficult biotech market. Since 2016, the year that Kuan became the CEO of CG Oncology, the Irvine, California-based cancer startup has raised big rounds from investors. "I think I've seen a lot of successful stories where you've stayed very focused on just one thing and you just see things that others don't by being very deep," Kuan told Insider. But when his father died that same year from pancreatic cancer, Kuan said he decided to focus on bladder cancer.

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