A season that began on the injured list could end the same way for star San Francisco 49ers running back Christian McCaffrey. After McCaffrey exited the 49ers’ 35-10 loss at Buffalo in Week 13 in the second quarter Sunday night and never returned, San Francisco coach Kyle Shanahan told reporters he had injured the posterior cruciate ligament in a knee. With five games left on the schedule, McCaffrey’s injury could be season-ending, Shanahan added. Losing McCaffrey to start the season and potentially to end it, as well, is a significant blow. Without McCaffrey for the majority of the season, the 49ers have stumbled to a 5-7 record.

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Persons: Christian McCaffrey, McCaffrey, Kyle Shanahan, Shanahan, Achilles, Ed, ”, ” Ed McCaffrey, Ross Tucker, Francisco standouts, Brandon Aiyuk, Deebo Samuel, George Kittle Organizations: San Francisco 49ers, 49ers, Buffalo Locations: San Francisco, Germany, Francisco