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☆ More people need transplants than there are organ donors. Pigs might offer a solution
▼ + stars: | 2024-01-30 | by ( Jen Christensen | ) edition.cnn.com time to read: +23 min

The need for more transplant organs is immense and growing. Researchers have transplanted genetically modified pig kidneys and hearts into people who were brain-dead to test whether they work in humans. Although Larry Faucette was too sick for a human heart transplant, University of Maryland doctors said he seemed physically strong enough for a genetically modified pig heart. It was more than a decade after the first heart transplant but long before such procedures became relatively routine. “We learned that the pig heart is an adequate substitute for a human heart.

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☆ Second person to receive experimental pig heart transplant dies nearly six weeks after procedure
▼ + stars: | 2023-10-31 | by ( Nadia Kounang | ) edition.cnn.com time to read: +3 min

CNN —Lawrence Faucette, the second living person to receive a genetically modified pig heart in a transplant, has died six weeks after the experimental procedure. Griffith had performed the experimental surgery. Faucette, 58, was first admitted to UMMC on September 14 after experiencing symptoms of heart failure and underwent the experimental transplant six days later. His heart disease and pre-existing conditions made him ineligible for a traditional human heart transplant. In January 2022, the University of Maryland also performed the first such experimental surgery on 57-year-old David Bennett, who died two months following the surgery.

Persons: CNN — Lawrence Faucette, “ Mr, Faucette’s, Dr, Bartley Griffith, Griffith, UMMC, “, ” Faucette, ”, Ann Faucette, “ We’ve, ” Griffith, Doctors, Ann, “ Larry, Sanjay Gupta, David Bennett, Bennett Organizations: CNN, University of Maryland Medical Center, University of Maryland School of Medicine, CNN Health, University of Maryland Locations: UMMC

WASHINGTON (AP) — The second person to receive a transplanted heart from a pig has died, nearly six weeks after the highly experimental surgery, his Maryland doctors announced Tuesday. Lawrence Faucette, 58, was dying from heart failure and ineligible for a traditional heart transplant when he received the genetically modified pig heart on Sept. 20. According to the University of Maryland School of Medicine, the heart had seemed healthy for the first month but began showing signs of rejection in recent days. The Maryland team last year performed the world’s first transplant of a heart from a genetically altered pig into another dying man. David Bennett survived two months before that heart failed, for reasons that aren’t completely clear although signs of a pig virus later were found inside the organ.

Persons: Lawrence Faucette, Faucette, Faucette’s, Ann, “, David Bennett, Faucette's, ” Dr, Bartley Griffith, — Organizations: WASHINGTON, University of Maryland School of Medicine, Maryland, Navy, Food and Drug Administration, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: Maryland, Frederick , Maryland

☆ Second Maryland Man to Receive an Altered Pig’s Heart Has Died
▼ + stars: | 2023-10-31 | by ( Roni Caryn Rabin | ) www.nytimes.com time to read: +1 min

A 58-year-old man with heart failure who received a new heart from a genetically modified pig died on Monday, nearly six weeks after receiving the pig organ, University of Maryland Medical Center officials announced on Tuesday. The first patient, 57-year-old David Bennett, died last year, two months after his transplant. He had developed multiple complications, and traces of a virus that infects pigs were found in his new heart. Both of the patients had terminal heart disease when they received the transplanted organs, and neither managed to recover sufficiently to leave the hospital. But while doctors said that Mr. Bennett did not show any signs of acute rejection of the new heart, which is the most significant risk in organ transplants, they said that Mr. Faucette’s transplanted heart had started to display some initial signs of rejection.

Persons: Lawrence Faucette, David Bennett, Mr, Bennett, Faucette’s Organizations: University of Maryland Medical Center Locations: Frederick, Md

Lawrence Faucette was dying from heart failure and ineligible for a traditional heart transplant when doctors at the University of Maryland School of Medicine offered the highly experimental surgery. In the first glimpse of Faucette provided since the Sept. 20 transplant, hospital video shows physical therapist Chris Wells urging him to push through a pedaling exercise to regain his strength. The Maryland team last year performed the world’s first transplant of a heart from a genetically altered pig into another dying man. David Bennett survived just two months before that heart failed, for reasons that aren’t completely clear although signs of a pig virus later were found inside the organ. In Friday’s hospital video, Faucette’s doctors said the pig heart has shown no sign of rejection.

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Two days later, the man was cracking jokes and able to sit in a chair, Maryland doctors said Friday. “You know, I just keep shaking my head – how am I talking to someone who has a pig heart?” Dr. Bartley Griffith, who performed the transplant, told The Associated Press. “It’s just an amazing feeling to see this pig heart work in a human,” said Dr. Muhammad Mohiuddin, the Maryland team’s xenotransplantation expert. That FDA allowed this second case “suggests that the agency is not ready to permit a pig heart clinical trial to start,” Mashke added. The pig heart, provided by Blacksburg, Virginia-based Revivicor, has 10 genetic modifications – knocking out some pig genes and adding some human ones to make it more acceptable to the human immune system.

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