SANTA CLARA, Calif. — All-Pro running back Christian McCaffrey has been ruled out of this weekend’s game for the San Francisco 49ers because of his lingering calf and Achilles’ injuries and could be headed to injured reserve. McCaffrey was held out of practice on Friday, a day after experiencing pain in practice. He was then ruled out of the game Sunday against Minnesota after expressing hope earlier in the week that he could play. Addison had seven catches for 123 yards and two TDs in a win against San Francisco last season. In other injury news for San Francisco, defensive end Yetur Gross-Matos is set to play after missing the opener with a knee injury.

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Persons: Christian McCaffrey, ’, McCaffrey, Kyle Shanahan, ” Shanahan, ” McCaffrey, “, John Lynch, it’s, It’s, Jordan Mason, Jordan Addison, Addison, Brian O’Neill, Harrison Smith, Ed Ingram, Yetur Gross, Matos, Dee Winters Organizations: San Francisco 49ers, Minnesota, Jets, NFL, Niners, New York Jets, Vikings, San Francisco, San Locations: SANTA CLARA, Calif, San Francisco’s, Minnesota, San Francisco