For many people, reaching their mid-40s may bring unpleasant signs the body isn’t working as well as it once did. Previous research showed that resting energy use, or metabolic rate, didn’t change from ages 20 to 60. The changes in metabolism affect how the body reacts to alcohol or caffeine, although the health consequences aren’t yet clear. For example, the changes in alcohol metabolism might be because people are drinking more in their mid-40s, Snyder said. “But it will take time to sort out what individual changes mean and how we can tailor medications to those changes.

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Persons: ”, Michael Snyder, It’s, Snyder, Josef Coresh, Coresh, Lori Zeltser, ” Zeltser Organizations: Stanford, Center for Genomics, Medicine, Stanford Medicine, NYU Grossman School of Medicine, Columbia University Vagelos College of Physicians and Surgeons Locations: midlife