The NFC South-leading Buccaneers (5-5), who entered last in the league with an average of 61 rushing yards per game, exceeded that by 100.
Chiefs 27, Jaguars 17Patrick Mahomes threw four touchdown passes to four different receivers as Kansas City captured a win over visiting Jacksonville.
Aaron Rodgers threw three touchdown passes to rookie Christian Watson, and the Packers rallied from a 14-point, fourth-quarter deficit to spoil Mike McCarthy's return to Lambeau Field.
Jimmy Garoppolo had 240 yards passing and a rushing TD for the 49ers (5-4).
After missing a game because of a hamstring issue, 49ers wideout Deebo Samuel had two receptions and 27 yards rushing.