By 0712 GMT, the blue-chip FTSE 100 (.FTSE) lost 0.6%, while the more domestically-focussed FTSE 250 midcap index (.FTMC) fell 0.3%.
Coca Cola HBC AG (CCH.L) jumped 3.6% after the bottler raised its 2023 profit expectation.
The pharmaceuticals and biotech (.FTNMX201030) and utilities (.FTUB6510) sectors were amongst the top losers, down 1.1% and 0.9%, respectively.
A key reading of U.S. jobs data due later in the day will be eyed to gauge the Federal Reserve's monetary tightening plans after the central bank kept rates steady in its previous decision.
Reporting by Shashwat Chauhan in Bengaluru; editing by Eileen SorengOur Standards: The Thomson Reuters Trust Principles.
Persons:
Jefferies, Shashwat Chauhan, Eileen Soreng
Organizations:
Federal Reserve, Coca Cola HBC, Coca Cola HBC AG, Federal, Thomson
Locations:
Bengaluru