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☆ Anxiety may increase risk of dementia, study finds
▼ + stars: | 2024-07-29 | by ( Kristen Rogers | ) edition.cnn.com time to read: +8 min

ingwervanille/Moment RF/Getty ImagesMore than 55 million people worldwide have dementia, a number expected to increase to 139 million by 2050. Previous studies exploring the relationship between anxiety and dementia have largely measured participants’ anxiety at one point in time, providing mixed conclusions — but how long someone’s anxiety lasts is an important aspect worth considering, the authors argued. Researchers measured participants’ anxiety at the first and second assessments. Someone’s anxiety was considered resolved if they had anxiety only at the time of the first wave. “This study agrees with earlier studies that therapy aimed at alleviating anxiety can help reduce risk for (Alzheimer’s disease).

Persons: ”, Kay Khaing, Glen R, Finney, ” Finney, wasn’t, “, Rudolph Tanzi, Dr, Joel Salinas, Isaac Health, Salinas wasn’t, Tanzi, Khaing, ” Khaing, ” Tanzi Organizations: CNN, American Geriatrics Society, Hunter New, Hunter New England Health, Getty, Australian Department of Health, American Academy of Neurology, McCance, Brain Health, Massachusetts General Hospital, NYU Langone Health, ”, National Alliance, Mental Locations: Hunter New England, Newcastle, Australia, Pennsylvania, Massachusetts, Boston, ” Salinas

☆ Brain Care Score may also predict depression, study finds
▼ + stars: | 2024-07-23 | by ( Kristen Rogers | ) edition.cnn.com time to read: +6 min

CNN —Scientists announced in December the successful creation of the Brain Care Score, a tool for assessing dementia or stroke risk without medical procedures. That score, which also helps patients and doctors identify beneficial lifestyle changes, may now also be able to predict the odds of developing depression later in life, according to a new study. The 21-point Brain Care Score, or BCS, refers to how a person fares on 12 health-related factors regarding physical, lifestyle and social-emotional components of health. “The Brain Care Score is a simple tool designed to help anyone in the world answer the question, ‘What can I do to take better care of my brain?’” said study author Dr. Jonathan Rosand, cofounder of the McCance Center for Brain Health at Massachusetts General Hospital and lead developer of the BCS, in a news release. The higher a participant’s score, the lower their risk of brain disease.

Persons: ”, ’ ”, Jonathan Rosand, Richard Isaacson, Isaacson, “, we’ve, ” Isaacson, Sanjula Singh, that’s Organizations: CNN —, Psychiatry, McCance, Brain Health, Massachusetts General Hospital, BCS, Harvard Medical School Locations: “, Massachusetts, Boston, United Kingdom, Florida

☆ Genes known to increase the risk of Alzheimer’s may actually be an inherited form of the disorder, researchers say
▼ + stars: | 2024-05-06 | by ( Brenda Goodman | ) edition.cnn.com time to read: +10 min

Among people diagnosed with Alzheimer’s, researchers recognize familial forms of the disease and sporadic cases. This shifting appreciation of inherited risk, researchers say, is due to a better understanding of the role of a fourth gene that carries the blueprints to make a lipid-carrying protein called apolipoprotein E, known as APOE. One known as APOE2 is thought to be protective against the development of Alzheimer’s disease. They also compared people with two copies of APOE4 to people with other inherited forms of the disease — early-onset autosomal dominant Alzheimer’s disease (ADAD) and Down syndrome-associated Alzheimer’s disease (DSAD). Gene testing isn’t currently recommendedIt is also likely to change how people who carry the APOE4 gene are diagnosed and treated.

Persons: APOE4, ”, Dr, Juan Fortea, Sant, Fortea, Charles Bernick, Bernick, Alzheimer’s wasn’t, isn’t, they’re, ” Fortea, Sanjay Gupta, Reisa Sperling, “, ” Sperling, ” Dr, Sterling Johnson, Johnson Organizations: CNN, Nature, National Alzheimer’s Coordinating, Neurology, Hospital de, Cleveland Clinic Lou, Brain Health, CNN Health, Alzheimer’s Research, Brigham, Women’s, Alzheimer’s, University of Wisconsin Locations: Alzheimer’s, Spain, United States, Santa, Barcelona, Wisconsin

☆ Behind Trump's campaign cash crunch: Small-dollar donor fatigue, major donor hesitation
▼ + stars: | 2024-03-18 | by ( Brian Schwartz | ) www.cnbc.com time to read: +12 min

The drop in Trump's small-dollar contributors could be significant obstacle as the former president faces the well-funded incumbent president, Democrat Joe Biden. Falling behind BidenEvidence from earlier in the 2024 election cycle already hinted at an erosion of Trump's small-dollar donor base, or support of $200 or less. In January of this year, Trump's campaign reported raising around $3 million from small-dollar donors, according to data from OpenSecrets. Elizabeth Frantz | ReutersMeanwhile, Trump's campaign told The New York Times that February was its strongest month so far in the 2024 campaign cycle for small-dollar donations. Between Jan. 1 and Dec. 31, 2020, Trump's campaign raised over $264 million from small-dollar supporters.

Persons: Donald Trump, Marco Bello, Reuters Donald Trump's, Joe Biden, Biden, Trump's, Elizabeth Frantz, Trump, Shannon Stapleton, John Paulson, Howard Lutnick, Letitia James, Steve Schwarzman, Miriam Adelson, Denise Truscello, Stephen Louro, Long, Louro, Greg Abbott, Elise Stefanik, Haley, Nikki Haley, MAGA, Adrienne Arsht, Mike Segar, Paul Singer, Singer, Paul Singer David A, Singer's, Lara Trump, Jonathan Drake Organizations: Reuters, White, Republican Party, Federal, Commission, U.S, Capitol, Washington , D.C, New York Times, CNBC, Trump, Republican National Committee, RNC, New York, Court, Trump Organization, AFP, Getty, PAC, Democrats, Blackstone, Cleveland Clinic Lou, Brain Health, MGM, Garden, Hamptons, Republican, New York Republican, Republican Texas Gov, South Carolina Gov, Former South Carolina, NBC News, Adrienne, Adrienne Arsht Center, Performing Arts, Republicans, Haley, Grogan, American Opportunity Alliance, Politico, North, North Carolina GOP Locations: Lago, Palm Beach , Florida, U.S, Washington ,, New York City, Las Vegas , Nevada, York, Former, Miami , Florida, Houston, New York, North Carolina, Greenville , North Carolina

☆ Rare cases of possible Alzheimer’s transmission uncovered in recipients of discontinued medical treatment
▼ + stars: | 2024-01-29 | by ( Jacqueline Howard | ) edition.cnn.com time to read: +9 min

All five adults had growth hormone deficiency as children and received pituitary growth hormones prepared in a specific way from cadavers. The treatment approach was discontinued after cases of a rare brain disorder called Creutzfeldt-Jakob disease were found to be associated with the administration of contaminated human growth hormone from cadavers. Although Alzheimer’s is not a prion disease, some separate research suggests that the two proteins that are hallmarks in Alzheimer’s disease — amyloid beta and tau — behave like prions. “This study suggests that in very rare circumstances Alzheimer’s disease may be transmitted between humans via human growth hormone from deceased donors. “I’m also intrigued by how these results may inform potential therapeutic targets and strategies in the future,” Isaacson said, regarding Alzheimer’s disease.

Persons: John Collinge, Jakob, Creutzfeldt – Jakob, Alzheimer’s, ” Collinge, ’, –, ” Dr, Susan Kohlhaas, ” Kohlhaas, “ It’s, Dr, Richard Isaacson, ”, Isaacson, “ I’m, ” Isaacson, “, Gargi Banerjee, ” Banerjee, James Galvin, Sanjay Gupta, ” Galvin, Lewy Organizations: CNN, Nature, University College London Institute, University College London, National Hospital for Neurology, Neurosurgery, Alzheimer’s Research, Science Media, Comprehensive, Brain Health, University of Miami Health, CNN Health Locations: United Kingdom, United States, United, Florida, UHealth, Creutzfeldt

☆ Address 12 health factors to prevent brain disease, research suggests
▼ + stars: | 2023-12-05 | by ( Kristen Rogers | ) edition.cnn.com time to read: +6 min

The 21-point Brain Care Score refers to how a person fares on 12 health-related factors concerning physical, lifestyle and social-emotional components of health, according to the study published December 1 in the journal Frontiers in Neurology. Those in their 50s had a 32% lower risk of dementia and a 52% lower chance of stroke. Participants older than 59 had the lowest estimates, with an 8% lower risk of dementia and a 33% lower risk of stroke. But in terms of explaining the overall findings, many past studies have affirmed the benefits of these health components for brain health. “But as scientists, we always want to see proof.”Participating in studies like this one can be a good way to manage your brain health, Isaacson said — especially if you have limited access to health care.

Persons: ”, Jonathan Rosand, Kistler, “, Richard Isaacson, Isaacson wasn’t, ” Isaacson, it’s, ‘, Isaacson, ” Rosand, — Organizations: CNN, BCS, McCance, Brain Health, Massachusetts General Hospital, Harvard Medical School, National Institutes of Health Locations: Massachusetts, United States, United Kingdom, Florida

☆ Alzheimer’s drug slows progression of cognitive decline in clinical trial, drugmakers say
▼ + stars: | 2022-09-27 | by ( Amanda Sealy | ) edition.cnn.com time to read: +4 min

CNN —A monoclonal antibody treatment for Alzheimer’s disease called lecanemab slows the progression of cognitive decline by 27% compared with a placebo, drugmakers Biogen and Eisai said Tuesday. Alzheimer’s is a very heterogeneous disease.”But he says that does not diminish the potential significance of the trial. “In the past, reducing amyloid in the brain has not always been tied to cognitive improvements or any meaningful clinical improvements. Biogen is also the company behind another Alzheimer’s drug, Aduhelm, which was controversially approved by the FDA in June 2021. Aduhelm was the first new Alzheimer’s drug approved in nearly 20 years, but there were questions about its efficacy and cost.

☆ How psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more
▼ + stars: | 2022-06-11 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +14 min

CNN —Shrooms, Alice, tweezes, mushies, hongos, pizza toppings, magic mushrooms — everyday lingo for psychedelic mushrooms seems to grow with each generation. Yet leading mycologist Paul Stamets believes it’s time for fans of psilocybin mushrooms to leave such childish slang behind. “The SSRI did not increase brain connectivity, and it actually did not improve well-being as much as psilocybin,” Nutt said. A typical microdose is 0.1 to 0.3 grams of dried psilocybin mushrooms, as compared with the 25-milligram pill of psilocybin that creates the full-blown psychedelic experience. “Our hope is that we can use this information to ultimately make drugs that mimic the benefits of psychedelic drugs without the psychedelic experience,” Roth said.

Persons: CNN — Shrooms, Alice, tweezes, Paul Stamets, “, ” Stamets, ”, Richard Isaacson, ” Isaacson, Pamela Kryskow, pharmacologist Brian Roth, Matthew Johnson, ” Johnson, David Nutt, Nutt, ” Nutt, you’ve, Johnson, they’ve, microdosing, microdosers, “ I’m, Harriet de Wit, Wit, Frederick Barrett, ” Barnes, Roth, ” Roth Organizations: CNN, US Food and Drug Administration, Prevention, Center for Brain Health, Florida Atlantic University, University of North, Johns Hopkins Medicine, Neuropsychopharmacology Unit, Brain Sciences, Imperial College London, ”, microdosing, University of Chicago, National Institute on Drug, Center, Research, Johns Hopkins Locations: University of North Carolina, “

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