Launching a small business is a challenge, especially these days. The top four cities on the ranking are all Floridian, largely due to criteria like low unemployment and relatively low corporate tax rates. Florida ranked 11th on CNBC's own list of the top U.S. states for businesses in 2022, for similar reasons. For those who don't want to move to Florida, cities like Durham and Boise offer bona fide alternatives. Join CNBC's Small Business Playbook virtually on May 4th, where entrepreneurs will share advice and tips on how to handle economic uncertainty, inflation and more so your business can succeed for the short-term and the long-term.

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