The third seed opens her defence against 49th-ranked American Shelby Rogers and will be looking to match Serena Williams - who won her sixth and seventh Wimbledon titles in 2015 and 2016.
Rybakina holds a 3-2 head-to-head advantage over Rogers, but with the defending champion having won both prior meetings on grass courts, she will take an edge into the encounter.
An action-packed women's singles schedule on Tuesday also features Australian Open champion Aryna Sabalenka taking on Hungary's Panna Udvardy, while last year's losing finalist Ons Jabeur is up against Poland's Magdalena Frech.
Greek eighth seed Maria Sakkari will face Ukraine's Marta Kostyuk, with two-time Wimbledon winner Petra Kvitova of the Czech Republic also in action.
The confidence grew a lot," U.S. Open winner Alcaraz told reporters.
Persons:
Elena Rybakina, Shelby Rogers, Serena Williams, Rybakina, It's, Rogers, Aryna Sabalenka, Panna Udvardy, Poland's Magdalena Frech, Maria Sakkari, Ukraine's Marta Kostyuk, Petra Kvitova, Carlos Alcaraz, Alcaraz, Novak, Djokovic, Daniil Medvedev, Briton Arthur Fery, Tsitsipas, Dominic Thiem, Andy Murray, Ryan Peniston, Aadi Nair, Toby Davis
Organizations:
Wimbledon, All England Club, Kazakh, U.S, Court, Thomson
Locations:
Eastbourne, Czech Republic, U.S, Belarusian, Bengaluru