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Read previewGenes that may have once helped ancient herders fight infectious parasites could contribute to autoimmune diseases today, like multiple sclerosis. For example, rates of MS are twice as high in the northwest of Europe, including in Scandinavia, compared to southern Europe. AdvertisementThey analyzed teeth and bones from Europe and Western Asia, adding to an ancient DNA database of about 1,600 genomes. Northern Europeans are also more susceptible to MS than in southern Europe, where Yamnayan ancestry is less common. AdvertisementFor some people, this inflammatory response can go overboard and start attacking the body's own cells, as with MS, Iversen said.
Persons: , it's, Rasmus Nielsen, Nielsen, Matthew Dunham NMB, immunologist Dr, Astrid Iversen, haven't, Iversen Organizations: Service, Business, University of Copenhagen, University of Cambridge, University of California, BBC Locations: Europe, Scandinavia, Western Asia, Berkeley, Northern
These genetic variants may have subsequently proved beneficial to European populations in making the shift from hunting and gathering to farming. “DNA from hunter-gatherers is present at higher levels in Northeastern Europe, which means the region has an elevated genetic risk of developing Alzheimer’s disease,” Barrie said. Similarly, the ancient genetic information shed light on the evolutionary history of traits such as height and lactose tolerance. And for most traits, MS included, the genetic effects are the result of multiple genetic variants,” he said. “Ultimately, we can’t say that MS came from Bronze Age populations, but these populations’ movements and environments contribute to differences in MS risk today.”
Persons: , , Rasmus Nielsen, It’s, William Barrie, Astrid Iversen, ” Iversen, ε4, ” Barrie, Samira, Asgari, Tony Capra, Capra, wasn’t Organizations: CNN —, University of California, Danish National, University of Cambridge’s, University of Oxford, Icahn School of Medicine, Bakar Computational Health Sciences Institute Locations: Western Europe, Central Asia, Europe, Berkeley, Kazakhstan, Northeastern Europe, Mount Sinai, New York, Bakar, San Francisco
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