The MSCI All-World index (.MIWD00000PUS) fell 0.2%, thanks to a broad-based decline in equities around the world.
S&P 500 and Nasdaq 100 futures , fell between 0.3-0.5%, suggesting a touch of weakness at the opening bell.
The Fed's "beige book" of economic conditions is published on Wednesday and appearances are due from Chicago Fed President Austan Goolsbee and New York Fed President John Williams.
In an interview with Reuters on Tuesday, St Louis Fed President James Bullard said that, far from pausing, the central bank should keep raising interest rates, based on how persistent inflation has proven to be.
UK inflation fell to 10.1% in March, from February's 10.4% - above expectations for a decline to 9.8% and the highest in western Europe, according to data on Wednesday.