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Paul Brodeur, whose deeply reported articles in The New Yorker brought national attention to subjects like the toxic hazards of asbestos and the destructive impact of chlorofluorocarbons on the ozone layer, died on Aug. 2 in Hyannis, Mass. His death, in a hospital, was caused by complications of pneumonia and hip replacement surgery, said his daughter, the novelist and memoirist Adrienne Brodeur. Mr. Brodeur’s first long-form article for The New Yorker, “The Magic Mineral,” published in 1968, described at great length the history of asbestos, a heat-resistant fiber with a history of being used in thousands of products — including building and insulation materials, rugs, potholders, roofing, military helmets and gas masks — and its connection to cancer, particularly mesothelioma, among workers who had been exposed to it. “There is not an automobile, airplane, train, ship, missile or engine of any sort that does not contain asbestos in some form or other, and it has found its way into literally every building, factory, home and farm across the land,” he wrote. “And, because its minuscule fibers are eminently respirable, asbestos has also found its way into the lungs of man, where, by remaining as indestructible as it does in nature, it can wreak terrible havoc.”
Persons: Paul Brodeur, memoirist Adrienne Brodeur, Mr, Brodeur’s, Organizations: Yorker Locations: Hyannis, Mass
Rumors of a curse have persisted since Howard Carter and others found Tutankhamun's tomb in 1922. But because he'd been present at the opening of Tutankhamun's tomb a few months prior, rumors of a curse started to swirl. But dozens of Egyptian laborers contributed physical and skilled labor to excavate Tutankhamun's tomb. As the decades passed, some scientists wondered if there was something deadly lurking in Tutankhamun's tomb: fungi. Egyptian carpenters prepare to reseal Tutankhamun's tomb with Howard Carter circa 1923.
Persons: Howard Carter, Lord Carnarvon, he'd, King, Carter, Carter's, Tutankhamun, George Herbert , 5th Earl of Carnarvon, LiveScience, Lord Carnarvon's, Susie, Carnarvon, Evelyn Herbert, Harry Burton, Sherlock Holmes, Sir Arthur Conan Doyle, Carnarvon's, Sir Ernest A, Wallis Budge, George Jay Gould, Philip Livingston Poe, Edgar Allen Poe, Richard Bethell, Howard, King Tutankhamun, Apic, Ali Kamel Fahmy Bey, Frank McClanahan Organizations: Service, New York Times, British Museum, Savoy, Harvard University, Hulton, Safety Locations: Wall, Silicon, British, Luxor, Egypt, Cairo, Hampshire, England, London, Aspergillosis
[1/3] Director William Friedkin attends a walking tour around Georgetown that focused on some of the film locations from the original Exorcist in Washington D.C., U.S. April 17, 2018. "The French Connection" won five Academy Awards, including best picture, best director for Friedkin and best actor for Gene Hackman, who Friedkin initially did not want in the memorable role of New York narcotics detective Popeye Doyle. "The Exorcist" was nominated for 10 Academy Awards, including best picture and best director for Friedkin. In "The French Connection," cops played by Hackman and Roy Scheider in the decaying New York City of the early 1970s track a French heroin smuggler. William David Friedkin was born on Aug. 29, 1935, and grew up in Chicago, the son of poor Ukrainian immigrants.
Persons: William Friedkin, Carlos Barria, ", Friedkin, Sonny, Cher, Gene Hackman, Popeye Doyle, Linda Blair, Tom Huddleston, they're, William Petersen, Willem Dafoe, Ashley Judd, Joe, Matthew McConaughey, Billy, Hackman, Roy Scheider, William Peter Blatty's, Blair, Oscar, levitates, Mercedes McCambridge, Al Pacino, Gay, William David Friedkin, Sherry Lansing, Jeanne Moreau, Lesley, Anne Down, Kelly Lange, Will Dunham, Danielle Broadway, Bill Trott, Rosalba O'Brien Organizations: Washington D.C, REUTERS, Creative Artists Agency, Chicago TV, Thomson Locations: Georgetown, Washington, York, L.A, New York City, Chicago, Hollywood, Los Angeles
[1/7] Freddie Mercury's signature crown and cape are displayed during Sotheby's 'Freddie Mercury: A World of His Own' press preview in London, Britain August 3, 2023. "We've conceived our gallery spaces to give it a sense of what it was like living with Freddie at home," said David MacDonald, head of single owner sales at Sotheby's London said. At the heart of the auction is Mercury's treasured, black Yamaha piano, estimated at 2-3 million pounds ($2.5-$3.8 million), on which he composed the 1975 Queen epic "Bohemian Rhapsody". "It was an extension of himself, his vehicle of creativity," Austin said of the baby grand piano. "He would never smoke at the piano or rest a glass on top of it and would ensure nobody else did either.
Persons: Freddie Mercury's, Sotheby's, Freddie Mercury, Susannah Ireland, Queen, Mary Austin, We've, Freddie, David MacDonald, he'd, MacDonald, Austin, Sachin Ravikumar, David Gregorio Our Organizations: REUTERS, Susannah, Tiffany, Thomson Locations: London, Britain
GSK reckons the spin-off has allowed the company to sharpen its focus on vaccines and infectious diseases and with $7 billion generated by the Haleon spin-off, it can fund deals to bolster a lacklustre drug pipeline. The company also reported an adjusted profit of 38.8 pence per share for the quarter, on sales of about 7.18 billion pounds ($9.26 billion). Analysts were expecting a profit of 34.7 pence per share on sales of about 6.77 billion pounds, according to company-compiled consensus estimates. Sales of Shingrix, the company's top-selling drug, generated 880 million pounds, beating analyst estimates of 872 million pounds. Sales of HIV treatments generated 1.58 billion in the quarter, ahead of the company-compiled consensus of about 1.5 billion pounds in the quarter.
Persons: Zantac, Emma Walmsley, Walmsley, Markus Manns, Dani Saurymper, Maggie Fick, Radhika Anilkumar, Janane Venkatraman, Savio D'Souza, Josephine Mason Organizations: GSK, British, Analysts, U.S, Union Investment, Pacific Asset Management, Thomson Locations: London, Bengaluru
Emily Wright, 38, a teacher in Toronto, started taking Ozempic in 2018. The diabetes drug Ozempic, and its sister drug for weight loss, Wegovy, utilize the same medication, semaglutide. Gastroparesis can have many causes, including diabetes, which is a reason many people are on these drugs in the first place. In more than half of cases of gastroparesis, doctors are unable to find a cause. Until more is known, George said, people need to be open with all their doctors about taking any drugs.
Persons: Joanie Knight, , I’d, , Knight, ” Brenda Allen, I’m, ” Allen, Emily Wright, she’s, Wright, “ I’ve, ” Wright, Ozempic, Emily Wright Allen doesn’t, they’ve, Gastroparesis, Michael Camilleri, Camilleri, liraglutide, ” Camilleri, ’ Joanie Knight, it’s, , I’ve, let’s, ’ ” Wright, gastroparesis, ” Knight, we’re, there’s, gastroparesis weren’t, “ Gastroparesis, Linda Nguyen, Nguyen, Renuka George, George, ” George, Dr, Michael Champeau, ” Champeau, Sanjay Gupta Organizations: CNN, US Food and Drug Administration, American Society of Anesthesiologists, Novo Nordisk, Mayo Clinic, National Institutes of Health, Diabetes, , FDA, Stanford University, American Gastroenterological Association, Medical University of South, CNN Health, Stanford Locations: Angie , Louisiana, Dallas, Toronto, Medical University of South Carolina, Louisiana
Man tests positive for MERS in Abu Dhabi near Oman border - WHO
  + stars: | 2023-07-24 | by ( ) www.reuters.com   time to read: +1 min
GENEVA, July 24 (Reuters) - A 28-year-old man has tested positive for the potentially fatal Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in a city in Abu Dhabi on the border with Oman, the World Health Organization said on Monday. The man in the city of Al Ain was admitted to hospital last month, the WHO said in a statement. The WHO said there were no signs the man had come into contact with dromedary camels, which spread the disease that is separate from COVID-19. The United Arab Emirates' health ministry did not immediately respond to a request for comment about the case. The UAE, a hub for international events, will host the United Nations Climate Change Conference in November and December.
Persons: Al Ain, Gabrielle Tétrault, Farber Organizations: World Health Organization, WHO, Health, United Arab, United Nations, Thomson Locations: GENEVA, Abu Dhabi, Oman, Al, United Arab Emirates, UAE
Nearly 800,000 Americans suffer permanently or die each year when doctors make diagnostic errors. The top five most misdiagnosed diseases — represented 38.7% of all misdiagnosed cases — were stroke, sepsis, pneumonia, venous thromboembolism (blood clots in veins), and lung cancer. According to the research, these diagnostic errors often occur when patients exhibit symptoms other than those most commonly associated with the disease. While adverse outcomes are still rare, according to Gupta, there are some simple questions patients can ask their doctor to lower their risk even further:What could be causing my problem? The good news, according to the research authors, is that only 15 account for more than 50% of the misdiagnoses.
Persons: there's, David Newman, Johns Hopkins, Jake Tapper, Sanjay Gupta, Gupta Organizations: Service, Johns Hopkins School of Medicine, American Cancer Society Locations: Wall, Silicon
New York CNN —ESPN’s Stephen A. Smith is wondering if he too might soon be out of a job. ESPN’s cuts are only the latest layoffs across several media companies, including The Athletic, National Geographic and CNN. But a person familiar with the staff reductions at the sports network told CNN that ESPN’s layoffs were unconnected with Disney (DIS)’s larger layoff plans. Aside from those mentioned by Smith, cuts included “College GameDay” analyst LaPhonso Ellis and NFL sideline reporter Suzy Kolber. Smith also briefly touched on the issue of race in his discussion about feeling uncomfortable about his job security.
Persons: New York CNN — ESPN’s Stephen A, Smith, , , Jalen Rose, Jeff Van Gundy, Keyshawn Johnson —, ” Smith, , ESPN’s, LaPhonso Ellis, Suzy Kolber, “ Don’t, “ I’ve Organizations: New, New York CNN, The Athletic, National Geographic, CNN, ESPN, Disney, , GameDay, NFL Locations: New York
GSK's RSV vaccine shows long-term efficacy in late-stage trial
  + stars: | 2023-06-21 | by ( ) www.reuters.com   time to read: +1 min
June 21 (Reuters) - GSK (GSK.L) on Wednesday said its vaccine for the respiratory syncytial virus (RSV), which recently won EU approval, showed strong long-term protection in older adults in a late-stage trial. The British drugmaker said a 'Phase III' trial showed vaccine efficacy against RSV-lower respiratory tract disease and severe disease over two full RSV seasons, including in participants with underlying medical conditions. GSK's shot, called Arexvy is designed to protect people aged 60 and over from RSV, which typically causes cold-like symptoms, but is a leading cause of pneumonia in toddlers and the elderly. European regulators approved the shot earlier this month for the disease which causes thousands of hospitalisations and deaths annually. Reporting by Eva Mathews in Bengaluru; Editing by Janane VenkatramanOur Standards: The Thomson Reuters Trust Principles.
Persons: British drugmaker, Eva Mathews, Janane Organizations: GSK, Thomson Locations: British, Bengaluru
A review of the past 10 years of ministry data shows the annual figure of cremations was consistently included in the fourth quarter data report – until now. China has faced criticism of its data transparency throughout the pandemic, including how it counts Covid-19 deaths. In January, a top WHO official accused China of “under-representing” the severity of its Covid outbreak, and repeated the agency’s critique of Beijing’s “narrow” definition of what constitutes a Covid death. At that time, Chinese health officials only listed those Covid patients who succumbed with respiratory failure and pneumonia as having died of Covid. It’s not clear if China plans to release the national data on cremations at a later date.
Persons: cremations, Yanzhong Huang, Covid, ” Huang, Hector Retamal, China’s, , bode, It’s Organizations: Hong Kong CNN, China’s Ministry of Civil Affairs, Council, Foreign Relations, Ministry, Civil Affairs, CNN, Getty, WHO, Covid, World Health Organization Locations: Hong Kong, China, New York, Shanghai, AFP, Wuhan, Communist,
REUTERS/Evan GarciaCORPUS CHRISTI, Texas, June 8 (Reuters) - Endangered sea turtles and other marine wildlife have found refuge in a new coastal rescue center in Corpus Christi, Texas. Like other reptiles, sea turtles are limited in how much they can regulate and control their core body temperatures. The Kemp's ridley sea turtle is the smallest species of sea turtle and most critically endangered in the world, according to the National Park Service. Ullmer explained how cold-stunning events cause sea turtles' heart and respiratory rates to drop dangerously low, along with a dramatic slowdown of their metabolisms. Ullmer readied one of the rescue turtles to check for recurrence of abnormalities on the CT scan.
Persons: Carrie Ullmer, Evan Garcia CORPUS, ridley, Ullmer, they're, Ulmer, Giovanna Pena, Evan Garcia, Diane Craft, Rosalba O'Brien Organizations: Texas State, Corpus Christi Center, Wildlife, REUTERS, Evan Garcia CORPUS CHRISTI, Corpus Christi, National Park Service, Thomson Locations: Texas State Aquarium’s, Corpus Christi , Texas, Evan Garcia CORPUS CHRISTI , Texas, Texas State Aquarium's, United States, New England, South Texas, Gulf, Mexico, Laguna Madre
Rome CNN —Pope Francis was recovering well in a Rome hospital on Thursday, the day after the 86-year-old had abdominal surgery that renewed health fears. “This wasn’t an urgent surgery,” Dr. Sergio Alfieri, the surgeon who operated on Pope Francis, said at a press conference. Pope Francis, seated in a wheelchair, attended a weekly general audience at the Vatican on June 7. Pope’s fragile healthThis operation is the latest in a series of health scares surrounding Pope Francis. Medical sources say that the intervention was likely related to the surgery Francis underwent in 2021, which removed half of his colon.
Persons: Rome, Rome CNN — Pope Francis, , , Matteo Bruni, Francis, ” Dr, Sergio Alfieri, Pope Francis, ” Alfieri, Andreas Solaro, Alfieri, he’s “, , Cardinal Pietro Parolin, Bruni, Francis ’, Pope Francis now, Annatuli, Carina, State Cardinal Tarcisio Bertone, Tarcisio Bertone, ’ ”, Pope Benedict XVI, Gregory XII, Volodymyr Zelensky Organizations: Rome CNN, Vatican, Gemelli, Reuters, Catholic, Papal, Getty, CNN, Spanish, ABC, State, Catholic Church Locations: Rome, AFP, The Prefecture, Mexico, Myanmar, Iraq, Ukraine
June 7 (Reuters) - European regulators have approved the region's first vaccine for respiratory syncytial virus (RSV), which causes thousands of hospitalisations and deaths annually. The shot, called Arexvy, is made by British drugmaker GSK (GSK.L) and is designed to protect people aged 60 and over. The complex molecular structure of the virus and safety concerns with previous vaccine attempts had stymied efforts to successfully develop a shot since the virus was first discovered in 1956. Given the different definitions of the trial endpoints across the GSK and Pfizer trials, a direct comparison of efficacy is difficult. In Europe, RSV leads to over 270,000 hospitalisations and about 20,000 in-hospital deaths in adults over 60 each year.
Persons: Luke Miels, Peter Welford, TD Cowen, Steve Scala, Natalie Grover, Eva Mathews, Maggie Fick, Savio D'Souza, Mark Potter Organizations: GSK, European Commission, European Medicines Agency, Reuters, U.S . Food, Drug Administration, Pfizer, Jefferies, Thomson Locations: British, Europe, U.S, London, Bengaluru
Rome CNN —Pope Francis will have surgery on his abdomen and remain in a Rome hospital for several days, the Vatican said Wednesday, sparking renewed fears over the 86-year-old’s fragile health. The pope was forced to cancel several work commitments in late May after he was debilitated by a fever. According to medical sources, the intervention is likely related to the surgery Francis experienced in 2021 to remove half of his colon. Should Francis be incapacitated for any length of time, the Vatican could find itself facing something of a constitutional crisis. Francis said he wrote the letter several years ago and gave it to then-Vatican Secretary of State Cardinal Tarcisio Bertone, who resigned in 2013.
Persons: Rome, Rome CNN — Pope Francis, Francis, he’s “, Vatican, Matteo Bruni, ” Francis, Pius XI, , Cardinal Pietro Parolin, State Cardinal Tarcisio Bertone, Tarcisio Bertone, ’ ”, Francis ’, Pope Benedict XVI, , Gregory XII Organizations: Rome CNN, Vatican, Rome’s Clinic, Catholic, Spanish, ABC, State Locations: Rome, St
Prince Harry’s expected testimony on Tuesday in a phone-hacking case will be the first time in over 130 years that a prominent member of Britain’s royal family is cross-examined in court. The last time it happened was in 1891, and it didn’t go well for the royal family. It was unusual then, too, for such a prominent member of the royal family — the future king, no less — to appear in court. Richard Fitzwilliams, a royal commentator, said: “You can see from reading this why it was subsequently decided that this is not something the royal family want. Furthermore, while Harry is a high-profile member of the royal family, he is no longer a working royal.
Persons: Prince Albert Edward, Queen Victoria, Prince Harry’s, didn’t, Prince Albert Edward — Queen Victoria’s, King Edward VII, , baccarat, Sir William Gordon, Cumming, Gordon, Richard Fitzwilliams, Edward, , ” Edward, Prince Harry, Belinda Jiao, Harriet Mordaunt, Fitzwilliams, Edward —, Bertie ”, Harry’s, Harry, Harry up, won’t, he’s, ” Mr, “ faultlessly, George V Organizations: Guardian, ., New York Times Locations: London
REUTERS/Johanna Geron/File PhotoJune 1 (Reuters) - Pfizer Inc (PFE.N) said on Thursday data from late-stage trials showed its experimental combination of antibiotics was effective in treating deadly infections caused by drug-resistant bacteria. Deaths from antibiotic-resistant bacteria, also known as superbugs, have been on the rise globally, and health regulators have called for the development of newer treatments as resistance to older antibiotics grows. The late-stage studies compared the experimental combination of the antibiotics aztreonam-avibactam (ATM-AVI) and existing generic drug metronidazole with a combination of two older antibiotics - meropenem and colistin - to treat complicated intra-abdominal infections and types of hospital-acquired pneumonia. Pfizer said the data from the studies shows the antibiotic combination of ATM-AVI is effective and well-tolerated in treating infections caused by gram-negative bacteria. For patients with types of hospital-acquired pneumonia and ventilator‐associated pneumonia, the cure rate was 45.9% for Pfizer's antibiotic combination with metronidazole, versus 41.7% for other, older treatments.
Persons: Johanna Geron, Leroy Leo, Sriparna Roy, Pooja Desai Organizations: Pfizer, REUTERS, Pfizer Inc, Disease Control, Thomson Locations: Puurs, Belgium, United States, Bengaluru
A new Navy report highlights safety issues with elite SEAL training like drug use and recruit deaths. A total of 11 SEAL candidates have died during training over the years, according to Navy reportThe training to become a Navy SEAL includes 24-week program known as Basic Underwater Demolition/SEAL or BUD/S. Navy SEAL candidates reportedly use PEDs like testosterone, growth hormone, and Viagra to get through trainingAfter Mullen's death, a subsequent Navy investigation found performance-enhancing drugs (PEDs) in his car, including testosterone and human growth hormone. Several other SEAL candidates were removed from the program for drug use following the investigation. Bradley Geary "believed the primary reason for attrition issue was the current generation had less mental toughness," according to the report.
Cases of human metapneumovirus, or HMPV, spiked this spring, according to US Centers for Disease Control and Prevention’s respiratory virus surveillance systems. An underestimated threatStudies show that HMPV causes as much misery in the US each year as the flu and a closely related virus, RSV. Like those infections, HMPV can lead to intensive care and fatal cases of pneumonia in older adults. Leigh Davidson caught human metapneumovirus during a family celebration in early April. The new virus was dubbed human metapneumovirus.
TDAP TRIALSThe Tdap vaccine can help prevent three diseases: tetanus, diphtheria, and pertussis, which is also known as whooping cough (here). Whooping cough can be “extremely serious especially in babies and young children, causing pneumonia, convulsions, brain damage, or death,” according to the CDC (here). FDA-approved vaccine package-insert documentation for Adacel (here) and Boostrix (here) shows that neither manufacturer states the vaccine has not been tested in clinical trials. In 2017, about 49% of all pregnant women in the U.S. received a Tdap vaccine during their pregnancy (here). Clinical trials and population data have shown the Tdap vaccine to be safe and effective in pregnancy.
When will an RSV vaccine be available?
  + stars: | 2023-05-18 | by ( Katia Hetter | ) edition.cnn.com   time to read: +6 min
CNN —The US Food and Drug Administration has approved a vaccine against the respiratory syncytial virus, or RSV, for adults 60 and older. Could the vaccine be available this winter, and how can people access it? The RSV vaccine specifically targets RSV. However, there is an RSV vaccine being developed by the drug company Pfizer that is being tested in pregnant women for the purpose of conveying protection to the infant. However, the FDA may not make a decision on when to make the vaccine available for pregnant people until this summer.
CNN —It’s time to add to your list of reasons to work out: Getting active could help prevent risk of death from the flu and pneumonia, according to new research. Meeting both recommendations for aerobic and muscle-strengthening activity cut the risk associated with flu or pneumonia death nearly in half, but meeting just the aerobic activity target was associated with a 36% lower risk, according to the study. This study might encourage them that physical activity may be another powerful tool for protecting themselves against influenza and pneumonia death,” he said. Even a little bit of exercise showed benefit in protecting against flu and pneumonia death, the study found. Getting 10 to 149 minutes a week of aerobic physical activity was associated with a 21% decreased risk of flu and pneumonia death, the study showed.
He seems to have been protected by a rare gene change that enhanced the function of a protein that helps nerve cells communicate. Scientists say that understanding how this gene change defended his brain may help prevent Alzheimer’s in other people. “Another big insight from this case is, it seems like maybe you don’t need this everywhere in the brain,” Arboleda-Velasquez said. This is the pathway that is important for extreme protection against Alzheimer’s,’ ” Arboleda-Velasquez said. The sister of the man in the new study also shared the rare protective gene change, and it helped her, but not as much.
Chelsea Clinton did not say that it is time to “force-jab” every unvaccinated child in the U.S., contrary to claims being shared online. The posts misrepresent Clinton’s comments about the “Big Catch-Up,” an authentic initiative to increase childhood vaccinations that were reduced during the COVID-19 pandemic. Clinton did speak at the conference on April 25, 2023 in a session about the initiative and importance of childhood vaccines (here). In the video, she does not say vaccines should be forced on children, with or without parental consent. Chelsea Clinton did not call for forced vaccines on children.
Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO), speaks during a news conference in Geneva, Switzerland, December 20, 2021. The spread of Covid-19 is no longer a global public health emergency, the World Health Organization declared Friday. "This trend has allowed most countries to return to life as we knew it before Covid-19," Tedros said. "It's therefore with great hope that I declared Covid-19 over as a global health emergency." The WHO's decision comes as the U.S. is set to end its national public health emergency on May 11.
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