The report - a collaboration between the Minnesota Indian Affairs Council and the university - found that the school developed and taught revisionist narratives intended to conceal the systemic harm perpetuated against Indigenous people.
The University of Minnesota extracted vast amounts of wealth from tribes in the region, the project's research team said on Tuesday.
The report urged the university to enact policies that benefit Indigenous people, including a combination of "reparations, truth-telling, policy change, and transformative justice processes."
Robert Larsen, president of the Minnesota Indian Affairs Council, said the report only scratched the surface of local history, which was mostly ignored in schools or not known to the general public.
The University of Minnesota has over 50,000 students and 20,000 faculty and staff, according to its website.