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The Food and Drug Administration has decided to delay action on a closely watched Alzheimer’s drug, donanemab, which the agency was widely expected to approve this month. will instead require donanemab to undergo the scrutiny of a panel of independent experts, the drug’s maker, Eli Lilly and Company, said Friday. The decision is likely to surprise many Alzheimer’s experts, doctors and patients who had expected the medication would soon be on the market. The F.D.A.’s move was startling to the company, which had been planning for the agency to greenlight the drug during the first quarter of this year. “We were not expecting this,” Anne White, an executive vice president of Lilly and president of its neuroscience division, said in an interview.
Persons: Eli Lilly, , Lilly, ” Anne White, Organizations: Drug Administration Locations: donanemab
CNN —There is still much researchers don’t know about popular weight loss medications — and those lack of studies could have consequences for eating disorders, according to experts. As the medication become more available, experts said they worry about the impact of these weight loss products on eating disorders. “The eating disorder field is hard because we’re just ignored.”Can these drugs treat binge eating disorder? Binge eating disorder is the most common eating disorder. “A lot of eating disorders do begin with restricted food intake and weight loss,” she said.
Persons: , Aaron Keshen, Jennifer Gaudiani, Susan McElroy, Linda, Harry Fath, McElroy, , ” McElroy, ” Keshen, it’s, Keshen, Gaudiani, ” Gaudiani, “ it’s, , haven’t Organizations: CNN, Nova, Disorder, National Association, Disorders, Gaudiani Clinic, Lindner, of HOPE, University of Cincinnati College of Medicine, International Locations: Nova Scotia, Dalhousie University’s, Halifax , Nova Scotia, United States, Denver, Minnesota
Read previewAxel Bouchon cofounded Matter Neuroscience in 2019 after leading the venture arms of pharma giants Moderna and Bayer. AdvertisementMatter has emerged from stealth with $26 million from ARCH Venture Partners, Polaris Partners, Exor Ventures, and Collaborative Fund, Business Insider has learned exclusively. That $26 million includes an initial seed round led by Polaris Partners and a Series A round led by ARCH Venture Partners. The startup views itself now as a consumer biotech startup, Bouchon said. Here's the 17-slide pitch deck Matter used to raise $26 million.
Persons: , Axel Bouchon, Bouchon Organizations: Service, pharma, Moderna, Bayer, Business, Venture Partners, Polaris Partners, Exor Ventures, Fund, Brain Imaging, Icahn School of Medicine Locations: Maastricht, Netherlands, Mount Sinai, Seoul, South Korea
For years, the Duke professor Dan Ariely was at the top of his game. Three professors behind the blog Data Colada reported evidence of fake data in a 2012 paper Ariely coauthored on honesty pledges. "When people do take a risk and they succeed, everybody enjoys it," Ariely told BI. In 2010, Ariely told NPR that two dentists examining the same teeth for cavities would agree only 50% of the time, citing research from Delta Dental. While the board originally said it would "unanimously stand in support of President Gay," Gay stepped down in early January in response to the backlash.
Persons: Dan Ariely, Dan Ariely's, Jesse L, Martin, Ariely, Duke, sniffed, they'd, James B, , they're, Francesca Gino, Ariely's, Marc Tessier Lavigne, Claudine Gay, Prince Andrew ., he's, Brad Swain, He's, Gordon Pennycook, Sean Gallup, Nick Brown, who's, Michael Sanders, who'd, Sanders, Gino, Aimee Drolet Rossi, Rossi, she'd, Amir, wasn't, hasn't, I've, haven't, isn't, would've, Claudine Gay's, Andrew Lichtenstein, Bill Ackman, Gay, Harvard, doesn't, Gay should've, Brown, Cornell Watson, who've, wouldn't Organizations: Google, NBC, UCLA, Duke, Business, Harvard Business, TED, Irrational, Cornell, Getty, Burda, King's College London, New York Times, NPR, Delta Dental, Higher Education, Hartford, Ariely, Harvard, University, Universities, BI, Colorado's, King's College Locations: Buckingham Palace, British, Hartford, Gaza, Montana
Test tubes are seen in front of a displayed AbbVie logo in this illustration taken on May 21, 2021. AbbVie on Tuesday said longtime executive Robert Michael will become the company's new CEO, replacing Richard Gonzalez. Michael, who is AbbVie's president and chief operating officer, will become the company's second-ever CEO on July 1. Gonzalez, who has led the company since it spun out from Abbott Laboratories in 2013, will retire and become AbbVie's executive chairman. Now is the opportune time to hand the CEO role over to Rob," Gonzalez said in a release.
Persons: AbbVie, Robert Michael, Richard Gonzalez, Michael, Gonzalez, Rob Organizations: Abbott Laboratories, AbbVie, CNBC PRO Locations: Humira
There's been a lot of chatter about the mental health crisis since the Covid-19 pandemic. Attention to a long-time crisis The mental health crisis is nothing new. However, there has also been a growing awareness and acceptance of mental health illnesses over the past decade, said Canaccord Genuity analyst Richard Close. "There's been recognition that mental health has a significant impact on a person's overall health," he said. "This is the mental health moment," said Dr. Ken Duckworth, NAMI's chief medical officer and author of "You Are Not Alone: The NAMI Guide to Mental Health."
Persons: There's, Covid, Peter Micca, AbbVie, Emraclidine, Myers Squibb, Karuna, Marc Goodman, Canaccord, Richard Close, MacKenzie Scott, Ken Duckworth, NAMI, Deloitte's Micca, William Blair, Myles Minter, Minter, Auvelity, Leerink's Goodman, Ashwani Verma, Verma, Goodman, BioHaven, Cerevel, Neumora, tardive, David Song, BetterHelp, psychedelics Johnson, Johnson, Spravato, Blair's Minter, Axsome, Micca, Michael Bloom Organizations: Institute for Health Metrics, Deloitte, Cerevel Therapeutics, Karuna Therapeutics, Bristol Myers, Leerink Partners, Centers for Disease Control, National Alliance, Mental, Mental Health, Wall Street, Therapeutics, Neumora Therapeutics, UBS, Karuna, Cellular Therapies, Xenon Pharmaceuticals, Neurocrine Biosciences, Acadia Pharmaceuticals, Tema Neuroscience, Axsome Therapeutics, Acadia Healthcare, BetterHelp, CNBC, pharma, Cellular Locations: Covid, Bristol, XEN1101, Acadia, Tema
My family sometimes thinks we're spoiling our children, but that doesn't change how I parent. I’m a mom of three girls aged seven and under, and I feel confident in the way my husband and I parent. I don’t think I’m spoiling my children — I think I’m setting them up for long-term mental and emotional well-being. AdvertisementI have grace for the way my family has judged my parentingIt's common in our culture to prioritize productivity over well-being. I might not be parenting perfectly, but I’m parenting on purpose.
Persons: I've, I’m, I’ve, There’s, Janet Lansbury, RIE, I’d Organizations: Infant Educators
Shanker also raised his price target to $80 from $75, suggesting nearly 34% downside from Friday's close. — Spencer Kimball 8:16 a.m.: Loop Capital upgrades Corteva, touts growth acceleration in 2025 Corteva's stronger-than-expected 2024 full-year guidance will jumpstart a period of strong growth, according to Loop Capital. The firm upgraded the agricultural chemicals company to buy from hold and increased its price target to $65 from $57. Analyst Jay Sole upgraded Urban to neutral from sell and upped his 12-month price target by $20 to $41. Kaufman's $183 price target indicates roughly 6.3% downside for shares, which have fallen more than 18% over the past year.
Persons: headwinds, Morgan Stanley downgrades XPO, Morgan Stanley, Ravi, Shanker, — Michelle Fox, Julien Dumoulin, Smith, Duke's, — Spencer Kimball, Chris Kapsch, Kapsch, Brian Evans, Cassie Chan, they'll, Chan, , Jay Sole, URBN, Sole, Urban's, — Pia Singh, Filippo Falorni, Falorni, Hershey, Stanley, Pamela Kaufman, Kaufman's, Hershey's, Kaufman, Graham Doyle, Doyle, Piper Sandler, David Amsellem, Amsellem, Amsellam, Christopher Horvers, Jan, Horvers, Fred Imbert, Dan Levy, Levy Organizations: CNBC, Barclays, Automotive, JPMorgan, Corp, Bank of America, Bank of America downgrades Duke Energy, Duke Energy, Duke, Wall, America, UBS, Urban Outfitters, Free People, Urban, Citi, PepsiCo, Citi Research, Pepsi, Hershey, GE Healthcare Technologies, UBS GE Healthcare Technologies, Pharmaceutical, Teva Pharmaceutical, Federal, Barclays downgrades Rivian, Rivian Automotive, North American EV Locations: Bank of America downgrades, GEHC, David Amsellem U.S
Here are five expert tips for keeping your mind sharp into your 80s and beyond. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . With the President's cognitive capabilities making headlines again, here are five top tips from experts to keep your brain sharp for when you get to be Biden's age. A 2019 study concluded that tea drinkers have higher cognitive functions and better-organized brain regions when compared to non-tea drinkers. "But learning new things helps with brain plasticity, and if you are able to keep using your brain in new ways, you can have better mental outcomes as you age."
Persons: , Joe Biden's, Biden, you've, Talia Lerner, Jason Shepherd Organizations: Service, Business, Blue Zone, Northwestern University, University of Utah Locations: Ikaria
Mamadi Doumbouya for The New York Times Talk A Leading Memory Researcher Explains How to Make Precious Moments LastOur memories form the bedrock of who we are. Tell me more about what you mean when you say “illusion.” I probably overstated it with the word “illusion,” but there is an illusionary component. But if you think about it from an evolutionary perspective, memory, often, is educated guesses by the brain about what’s important. You know, the training environment I was in was very down on psychoanalysis, but it always comes back to memory. We have these little compartments that are rooted somewhat in memory that we can access at different moments.
Persons: Mamadi Doumbouya, , Charan Ranganath, Davis, Ranganath, ” Ranganath, You’re, , shoplifted, there’s, We’re, Charan, UC Davis, you’re, you’ve, Sasha Bakhter, It’s, hadn’t Organizations: The New York Times, University of California, UC, Smiths, UC Davis Locations: Davis
Dry January “was the perfect eye-opener.”Now sober, Montejano has adopted several tactics to keep herself on track: talking to a therapist, journaling and drinking nonalcoholic beverages like mocktails. By comparison, a 12-ounce glass of beer contains about 5% alcohol, according to the CDC. “The nonalcoholic beverages have a lot of the cues that are associated with real alcoholic beverages,” she said. “Are you reaching those goals with nonalcoholic beverages?” she said. Ultimately, going sober can have social ramifications, so it’s important to surround yourself with people who can support you.
Persons: Corrina Montejano, Montejano, , , Ginger Hultin, nonalcoholic, Hilary Sheinbaum, Molson Coors, ” Sheinbaum, Hultin, Dr, Lara Ray, Dana Ellis Hunnes, you’re, Hunnes, Ray, they’re, Sanjay Gupta, I’ve, ’ ”, “ You’ve, Journaling, ” Montejano Organizations: CNN, US Centers for Disease Control, Heineken, Molson, US Department of, Tobacco Tax, Trade Bureau, UCLA, World Health Organization, ” WHO, UCLA Medical Center, US Food and Drug Administration, mocktails, CNN Health Locations: San Francisco, Seattle
In 2020, Neuralink showed off one of its chips embedded in a pig named Gertrude. The Neuralink device in Gertrude's brain transmitted live data during the demo as she snuffled around. Musk said the pig had been living with the chip embedded in her skull for two months. "This is solid engineering, but mediocre neuroscience," he said. Jackson told Insider following the 2020 presentation that the wireless relay from the Neuralink chip could potentially have a big impact on the welfare of animal test subjects in science, as most neural interfaces currently in use on test animals involve wires poking out through the skin.
Persons: Neuralink, Gertrude, Musk, Andrew Jackson, Jackson Organizations: Newcastle University
NEW LOOK Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. After Senate Majority Leader Chuck Schumer called for a federal probe into "Zyn" nicotine pouches last week, the GOP backlash was swift. "Unfortunately Chuck Schumer is more focused on Zyn Pouches than he is about Fentanyl pouring over our border," wrote Rep. Tim Burchett of Tennessee. A 'pro-society' drugA variety of factors drive the proliferation of nicotine among the younger right-wing crowd. Containers of "Zyn" nicotine pouches.
Persons: Tucker Carlson, , Chuck Schumer, Marjorie Taylor Greene, Schumer, Sen, Thom Tillis, Tim Burchett, Peter Thiel, JD Vance, Ohio, Vance, It's, Michael M, Carlson, Tucker Carlson's, that's, Saagar Enjeti, Greg Price, Andrew Huberman, Peter Attia, they're, There's, Enjeti, Tillis, Gregory Conley, Conley Organizations: Service, GOP, Rep, Fox News, Atlantic, Senate, Republican, State Freedom Caucus Network, Stanford University, Republicans, American Vapor Manufacturers Association, Capitol, Democrats Locations: North Carolina, Tennessee, mainstreaming Zyn, Swedish
Only one digital health startup went public in the US in 2022 — digital therapeutics company Akili Interactive, whose shares have since crashed a whopping 97%, per MarketWatch. Not a single healthcare startup went public last year. ArriVent Biopharma went public a few days later, bringing in $175 million. AdvertisementIndustry experts remain skeptical about whether the public markets will be ready for a successful healthcare IPO this year. Business Insider has identified seven startups that could be considering an IPO as the markets reopen, based on conversations with top VCs and bankers and public filings.
Persons: , Metagenomi, ArriVent Biopharma Organizations: Service, Business, Akili Interactive, Alto Neuroscience, Oncology, BrightSpring Health Services, KKR, Walgreens, Industry
The company is developing a brain implant that aims to help patients with severe paralysis control external technologies using only neural signals. The in-human clinical trial marks just one step on Neuralink's path toward commercialization. Neuralink did not disclose how many human patients will participate in its initial in-human trial. Paradromics is aiming to launch its first trial with human patients in the first half of this year. Precision Neuroscience carried out its first in-human clinical study last year.
Persons: Elon, Neuralink, Musk, Stephen Hawking, Blackrock Neurotech, Tom Oxley's Organizations: U.S . Food, Drug Administration, FDA, SpaceX, BCI, Neuroscience, Paradromics, Blackrock Locations: U.S
CNN —Treating loneliness and social isolation may put people classified as obese at a lower risk for health complications, according to a new study. Social isolation was found to be a greater risk factor for all causes of mortality, including cancer and cardiovascular disease, than depression, anxiety and lifestyle risk factors — which included alcohol, exercise and diet, according to the study. But the findings do point to improving “social isolation as a potential remedy for the reduction of mortality,” he said. “Think of maintaining a social network like any other health-promoting activity: exercising regularly, eating well, looking after yourself,” Canli said. And fatphobia can lead communities to make it harder for people with obesity to feel understood and accepted, she said.
Persons: , , Lu Qi, Qi, ” Qi, Philipp Scherer, Gifford O, Touchstone Jr, Randolph G, Dallas . Scherer wasn’t, Turhan Canli, Canli, ” Canli, Rachael Benjamin, Benjamin, Benjamin said, ” Benjamin Organizations: CNN, Tulane University School of Public Health, Tropical Medicine, University of Texas Southwestern Medical School, Diabetes Research, Touchstone Diabetes, Stony Brook University Locations: New Orleans, Dallas, New York City
Beyond fear of pain and temporary disfigurement from missing teeth, I had another major concern: I was addicted to heroin in my 20s. As an expert on addiction, I knew that a return to compulsive drug use wasn’t inevitable with medical opioid exposure. As a result, some languish in extreme pain because they believe that drug exposure will cause them to lose control and immediately return to active addiction. There is much misinformation about how opioid pain treatment affects people in recovery and those at high risk of addiction. Understanding how psychoactive drugs and addictions really work is crucial for better managing medical opioid use — and ending policies that interfere with both prevention and recovery.
Persons: I’d, , Sarah Wakeman, Dennis Bohlin Organizations: Neuroscience, Harvard Medical School
Dario Amodei, Daniela Amodei, Tom Brown, Jack Clark, Jared Kaplan, and Sam McCandlish, cofounders of AnthropicAnthropic's Dario Amodei, Jack Clark, and Daniela Amodei. Since then, the company has received billions in funding from both Google and Amazon in what some have termed an "AI arms race." CEO Dario Amodei, a former Google Brain researcher with a Ph.D. in computational neuroscience, has been writing about the cataclysmic potential of AI since 2016. Constitutional AI is partly the brainchild of two other OpenAI alums and Anthropic cofounders, Tom Brown and Jared Kaplan. Both Kaplan and Brown have worked on Anthropic's efforts to "red team" the company's flagship language model, Claude, probing for misuse possibilities.
Persons: Dario Amodei, Daniela Amodei, Tom Brown, Jack Clark, Jared Kaplan, Sam McCandlish, Anthropic Anthropic's Dario Amodei, Menlo Ventures Anthropic, Amodei's, Anthropic, , Anthropic cofounders, Brown, Kaplan, Johns Hopkins, Claude, AGI, I'm Organizations: Google, Menlo Ventures, Bloomberg, Johns, OpenAI Locations: OpenAI, GPT
"I wanted to give it a try," Isla, who uses a pseudonym to protect her privacy, told Business Insider. This story is available exclusively to Business Insider subscribers. At the time, the Canadian creator was in her last year of undergrad studies in psychology and neuroscience, and was working as a lab tech and lab coordinator at her college. In 2023, Isla made almost $5 million across two profiles on the platform, before OnlyFans took its 20% cut. On her main account, direct messages accounted for almost $2 million of the $4.7 million Isla earned in revenue in 2023.
Persons: , Isla Moon, I'm, Isla, OnlyFans, TikTok, She's, she's Organizations: Service, Business, YouTube Locations: OnlyFans, Canadian
Many biotech stocks struggled in 2023 despite a robust year for U.S. drug approvals. "We expect this environment to continue but look forward to the prospect of lower interest rates in 2024." When that happens, Canaccord Genuity said to expect a "strong rally across the biotech sector rewarding innovative, but riskier assets." Analysts have said the rich price reflects the opportunity for ImmunoGen's Elahere cancer treatment , which has quickly established itself as the standard of care for types of ovarian cancer. 'Oversold and cheap' In a research note Friday, Jefferies analyst Michael Yee said "a significant short squeeze" was helping biotech stocks in the fourth quarter.
Persons: Dan Lyons, Janus Henderson, John Newman, Canaccord Genuity, Janus, Lyons, Bristol Myers Squibb, Karuna, AstraZeneca, Eli Lilly, AbbVie, Jonathan Miller, Miller, bode, Jonathan Krinsky, Krinsky, BTIG's, Jefferies, Michael Yee, Yee, NASH, Madrigal, we're, David Risinger, — CNBC's Michael Bloom Organizations: Drug, Federal, Bristol Myers, Karuna Therapeutics, CART, Bristol Myers Squibb, Cerevel Therapeutics, Securities and Exchange Commission, pharma, P Biotech, Nasdaq Biotech, Apogee Therapeutics, Madrigal Pharmaceuticals, Madrigal, resmetirom, Vertex Pharmaceuticals, Leerink Partners Locations: ImmunoGen
Despite an overall slump in startup funding, 2023 saw a scramble among investors to pour money into AI and machine learning startups. And the company's star still appears to be rising, despite a messy leadership struggle that recently spilled into public view. Meanwhile OpenAI's perennial rival Anthropic attracted multi-billion dollar investments from both Google and Amazon to fund a competing AI model known as Claude. At the same time legacy companies from John Deere to accounting firm PwC played up their AI bona fides to capitalize on the hype. The list doesn't include startups who have not publicly released the amount of their funding rounds.
Persons: OpenAI, Anthropic, Claude, Databricks, John Deere, PwC, Fresh Organizations: Microsoft, Google, Alpha, Technology, Monogram, Sigma, Lambda, Helsing, Metals, Eagle Eye, Amelia, Asimov, Farmers Business, Harbinger, Prins, Silo, Mistral, Alto, AMP, Management Software, Universal, Coro, Kodiak Robotics, Aerospace, Defense, Sana, Corti, Kyte, Mitra, Tech, Boss Digital Technology, Halcyon, & $ Locations: PitchBook
Chinstrap penguins take catnaps instead sleeping for a long period of time, researchers found. Chinstrap penguins in Antarctica need to guard their eggs and chicks around-the-clock in crowded, noisy colonies. Chinstrap penguins, named for the thin line of black facial feathers resembling a chinstrap, usually lay their eggs in pebble nests in November. For the first time, the scientists tracked the sleeping behavior of chinstrap penguins in an Antarctic breeding colony by attaching sensors that measure brain waves. "For these penguins, microsleeps have some restorative functions — if not, they could not endure," he said.
Persons: , Niels Rattenborg, Max Planck, Chinstrap, King, King George Island, Won Young Lee, Paul, Antoine Libourel, Daniel Paranhos Zitterbart Organizations: Service, WASHINGTON, Max, Max Planck Institute for Biological Intelligence, Korean Polar Research, Neuroscience Research, of Lyon, Penguins, Oceanographic, Associated Press Health, Science Department, Howard Hughes Medical Institute's Science, Educational Media Group, AP Locations: Germany, King George, Antarctica, France, Massachusetts
She says it's difficult to pivot mid career but wishes more people her age were studying AI. AdvertisementThis as-told-to essay is based on a transcribed conversation with Evrim Kanbur, a 40-year-old former university teacher who is learning to code to work in AI. To pay bills, I get passive income from online classes I pre-record for the e-learning platform Udemy, which I've been doing since 2017. Kabur's home studio where she recorded online classes Evrim KanburRetraining has been quite hardRetraining is not something that's easy to do. But I want to do this now and I'm happy I'm sticking with it.
Persons: Evrim Kanbur, , I've, I'm, it's Organizations: Service, Deloitte, Riot Games, Harvard University, MIT Locations: Shanghai, China
CNN —The art of nodding off appears to have been mastered by breeding chinstrap penguins, who take more than 10,000 naps a day, with each nap lasting an average of four seconds, according to a new study. They observed that the penguins in the colony engaged in more than 600 bouts of microsleep an hour. A 1986 study found captive, nonbreeding emperor penguins to have fragmented sleep called “drowsiness,” which also resembles the microsleep pattern of the breeding chinstrap penguins. He added that through these short bursts of sleep the penguins could “sleep and remain vigilant” while incubating. “I think that’s why it’s important to study sleep.
Persons: King George Island, ecophysiologist Paul, Antoine Libourel, ” Libourel, Federico Anfitti, Libourel, , they’d, , Christian Harding, Vladyslav Organizations: CNN, Neuroscience Research, of Lyon, University of California, University of Oxford Locations: France, South Korea, Germany, Antarctica, , microsleeps, San Diego
Decades of treatment of military veterans and sexual assault survivors have left little doubt that traumatic memories function differently from other memories. The team conducted brain scans of 28 people with PTSD while they listened to recorded narrations of their own memories. Some of the recorded memories were neutral, some were simply “sad,” and some were traumatic. The brain scans found clear differences, the researchers reported in a paper published on Thursday in the journal Nature Neuroscience. The people listening to the sad memories, which often involved the death of a family member, showed consistently high engagement of the hippocampus, part of the brain that organizes and contextualizes memories.
Organizations: Yale University, Icahn School of Medicine, Mount, Neuroscience
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