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New RSV vaccines may soon put an end to rough seasons
  + stars: | 2022-10-31 | by ( Brenda Goodman | ) edition.cnn.com   time to read: +15 min
The monoclonal antibody, Synagis, is given monthly during RSV season to protect preemies and other high-risk babies. In the failed RSV vaccine trial, the chemical the researchers used to deactivate the virus denatured its proteins – essentially flattening them. Four companies have RSV vaccines for adults in the final phases of human trials: Pfizer and GSK are testing vaccines for pregnant women as well as seniors. Janssen, Pfizer and GSK each appear effective at preventing infections in adults for the first RSV season after the vaccine. The vaccines for pregnant women are meant to get newborns through their first RSV season.
The recently authorized booster vaccine protects against the original SARS-CoV-2 virus and the more recent omicron variants, BA.4 and BA.5. The Food and Drug Administration said two studies this week showing that the new omicron boosters weren't that much better than the old shots were too small to come to any real conclusions. The antibody responses were slightly higher with the omicron boosters, though the studies concluded the difference wasn't significant. The studies are of public interest because there's very limited human data on how the omicron BA.5 boosters perform right now. The FDA also looked at data directly on the BA.5 shots that came from animal studies.
CNN —The Omicron BA.5 subvariant is no longer the dominant cause of Covid-19 infections in the United States, according to estimates released Friday by the US Centers for Disease Control and Prevention. The gaggle of new variants have been gaining ground against BA.5, which has dominated Covid-19 infections in the United States since July. Together, they now account for more than 1 in 4 new Covid-19 infections nationwide, according to CDC data. BQ.1.1 is now causing about 1 in 5 new Covid-19 infections in the Northeast, where cases and hospitalizations are rising. But that strain is causing just 3% of new Covid-19 infections in the Pacific Northwest.
The new COVID-19 booster which includes protection for Omicron at AltaMed Health Services in South Gate on Thursday, October 6, 2022. Two studies are raising doubts about whether the new omicron BA.5 booster really will offer better protection against Covid than the first generation shot. Scientists at Columbia University in New York City found the new boosters did not produce a better antibody response in humans against BA.5 than the first-generation vaccines. Hotez said there should also be investigations into how the boosters perform against emerging omicron subvariants such as XBB and BQ.1., as the currently dominant BA.5 declines in circulation. It could be the case that the new boosters perform better against these emerging variants than the first generation shots do, Hotez said.
Though BA.5 still accounts for most U.S. Covid-19 cases, percentages are rising for the other omicron variants circulating throughout the country, per the CDC. "The ones that are particularly concerning are BQ.1 and another related one called BQ.1.1. Internationally, another concerning variant, XBB, which first emerged in Singapore and hasn't been detected in the U.S., is being closely watched worldwide as it spreads quickly in other countries. The new variants were coined the "Scrabble" variants by Peter Hotez, co-director of the Center for Vaccine Development at Texas Children's Hospital, during an interview with the Houston Chronicle. The nickname refers to the letters that are used to define the variants like B, X and Q, which would rack up many points in a game of Scrabble.
Pediatric cases of the flu and RSV, or respiratory syncytial virus, are on the rise. Here are the signs and symptoms to look out for if your child has a respiratory virus. Does my child have RSV, Covid or the flu? Early symptoms of Covid, RSV and the flu can look similar for many children, including:CongestionCoughRunny noseMuscle achesFeverHeadacheA sore throat, Moffitt said, could be a sign of Covid, as doctors have noticed that infections with omicron subvariants often begin with sore throats. Hotez also urged parents to get their children vaccinated against Covid and the flu.
CNN —A flurry of new Covid-19 variants appears to be gaining traction globally, raising fears of a winter surge. As the US moves into the fall, Covid-19 cases are dropping. But virus experts fear that the downward trend may soon reverse itself, thanks to this gaggle of new variants. Lumped together, the variants accounted for almost 1 in 3 new Covid-19 infections nationwide last week, according to the latest estimates from the US Centers for Disease Control and Prevention. The updated bivalent booster vaccines and antiviral drugs like Paxlovid are expected to continue to be protective against severe outcomes from Covid-19 infections caused by the new variants.
CNN —There are signs that the United Kingdom could be heading into a fall Covid-19 wave, and experts say the United States may not be far behind. A recent increase in Covid-19 cases in England doesn’t seem to be driven by a new coronavirus variant, at least for now, although several are gaining strength in the US and across the pond. Spector runs the Zoe Health Study, which uses an app to let people in the UK and US report their daily symptoms. After seeing a downward trend for the past few weeks, the Zoe study saw a 30% increase in reported Covid-19 cases within the past week. In the US, some models have predicted that Covid-19 cases will begin to rise again in October and continue to increase into the winter.
The following is a preview of one Insider Intelligence Health report, The Digital Health Ecosystem . Key digital trends in the health ecosystemWhat is digital health? While the healthcare industry was slow-moving when it came to digital solutions, COVID-19 upended the entire health ecosystem, including insurance, healthcare delivery, and pharmaceutical spaces. Telemedicine is a growing part of the digital health ecosystem. Health ecosystem forecast for 2021While some aspects of the healthcare ecosystem are tough to predict moving forward, one thing is certain: digital healthcare is here to stay.
Vaccine Development Has Changed Forever
  + stars: | 2021-05-13 | by ( ) www.wsj.com   time to read: 1 min
Inside the Company Minting the Next Generation of Child StarsPocket.watch, a digital-media company in Culver City, Calif., wants to be ‘the Nickelodeon of the future,’ its CEO says. WSJ’s Chavie Lieber explains how the company identifies and then signs YouTube’s biggest kid creators and then works to create new shows and distribution deals with streaming giants. Zoe Thomas hosts. Photo: Pat Martin for WSJ Magazine
Persons: WSJ’s Chavie Lieber, Zoe Thomas, Pat Martin Organizations: Nickelodeon, WSJ Magazine Locations: Culver City, Calif
23 Black leaders who are shaping history today
  + stars: | 2021-02-01 | by ( Courtney Connley | ) www.cnbc.com   time to read: +39 min
Following the lead of trailblazers throughout American history, today's Black history-makers are shaping not only today but tomorrow. —Cory StiegRosalind Brewer, 58, Walgreens' next CEO and only Black woman to currently lead a Fortune 500 firmWalgreens' next CEO Rosalind Brewer. When she steps into this new role, she will be the only Black woman currently leading a Fortune 500 firm, and just the third Black woman in history to serve as a Fortune 500 CEO. "When you're a Black woman, you get mistaken a lot," she said during a 2018 speech at her alma mater, Spelman College. —Tom Huddleston Jr.Jason Wright, 38, first Black president of a National Football League teamWashington Football Team president Jason Wright.
Persons: Shirley Chisholm, John Lewis, Maya Angelou, Mary Ellen Pleasant, Kamala Harris, Gene Kim, Harris, Shyamala Gopalan Harris, Shyamala, , — Cory Stieg Rosalind Brewer, Rosalind Brewer, Ursula Burns, Mary Winston, Brewer, Kimberly, Clark, she's, — Courtney Connley, Kizzmekia, Corbett, Kizzmekia Corbett, Anthony Fauci, Fauci, Dr, — Cory Stieg Victor J, Glover , Jr, Victor Glover, Amanda Gorman, Joe Biden, Gorman, Abraham Lincoln, Martin Luther King Jr, Lady Jill Biden, Robert Frost, Oprah, Angelou, — Jennifer Liu, Amanda Gorman's, Raphael Warnock, Georgia's, Kelly Loeffler, Warnock, Ebenezer Baptist Church —, — Abigail Johnson Hess Rashida Jones, Rashida Jones, Jones, Kristen Welker, Carole Simpson, Nicolle Wallace's, Dorothy Tucker, Brown, — Taylor Locke Sandra Lindsay, Sandra Lindsay, Lindsay, She's, I'm, Jade Scipioni Nicholas Johnson, Princeton's, Nicholas Johnson, Princeton University's, Johnson, William Massey, — Abigail Johnson Hess Cynthia, Cynt, Marshall, Cynthia Marshall, Cynt Marshall, George Floyd, Marshall —, Mark Cuban, Scipioni, Cynthia Marshall's, Dallas Mavericks Cori Bush, Missouri's, Missouri, Cori Bush, Michael Brown, Ferguson, William Lacy Clay Jr, Bush, Essence.com, I've, he's, Louis, Clay, — Jennifer Liu Alicia Boler Davis, Amazon's, Jeff Bezos Alicia Boler Davis, Alicia Boler Davis, Boler Davis, Jeff Bezos, alums, Jennifer Liu, Noah Harris, Harvard Noah Harris, Harvard's, It's, we've, Fentrice Driskell, Du Bois, — Abigail Johnson Hess, Harvard Mellody Hobson, Mellody Hobson, Ariel Investments, Hobson, — Courtney Connley Sydney Barber, Sydney Barber, Barber, Ms, Janie Mines, wasn't, Mines, Jesse Collins, Collins, Indiewire, " Collins, Jennifer Liu Nia DaCosta, Nia DaCosta, Marvel, DaCosta, Nora Ephron, Jordan Peele, Peele, — Tom Huddleston Jr, Aicha Evans, Zoox, Evans, Jason Wright, Wright, He's, Dan Snyder, — Emmie Martin Dana Canedy, Dana Canedy, Simon, Simon & Schuster, Dana Canedy's, Canedy, Denzel Washington, Alicia Adamczyk, Schuster Bozoma Saint John, Saint John, Beyonce, Kanye West, Nicki Minaj, Michael Jackson, — Courtney Connley Cheick Camara, Ermias Tadesse, Cornell University's, Cheick Camara, Ermias Organizations: CNBC, White, South, Latina, Howard University, Alpha Kappa Alpha Sorority, Inc, Democrat, United States Senate, U.S, Walgreens, Fortune, Starbucks, Walgreens Boots Alliance, Xerox, Bed, Sam's, Walmart, Nonwovens, Spelman College, Moderna, National Institute of Allergy, National Urban League, FDA, Vaccine Research, University of North, Space Station, NASA, Capitol, LA, Poet, Harvard, Georgia, Black, Morehouse College cum, Ebenezer Baptist Church, United, MSNBC, University of Missouri's School of Journalism, NBC, ABC News, National Association of Black Journalists, Jewish Medical Center, Northwell, Long, Pfizer, Pew Research Center, Princeton, Massachusetts Institute of Technology, NBA Dallas Mavericks, Dallas Mavericks, NBA, Mavericks, Congress, Senate, Democratic, Green New Deal, General Motors Institute, GM, Amazon, Employees, Amazon's, Ariel Investments, Ariel, Financial Planning's Diversity, Princeton University, JPMorgan, Lucas Family Foundation, Hobson College, Naval, U.S . Naval Academy, U.S . Naval, Naval Academy, Academy, Super, Super Bowl, Jesse Collins Entertainment, ViacomCBS Cable Networks, BET, CMT, Comedy Central, MTV, Paramount Network, VH1, Marvel, Marvel Studios, Marvel Universe, Tribeca, Wall Street, George Washington University, Intel, Financial, Automotive News, National Football League, Washington Football, Washington Football Team, National Football, NFL, Atlanta Falcons, Cleveland Browns, Arizona Cardinals, University of Chicago, McKinsey & Company, Washington, Morning, Simon &, New York Times, Jordan, Crown Publishers, New Yorker, Netflix, Saint, Longtime, Endeavor, Uber, Apple, PepsiCo, BlackGen Capital, Cornell, BlackGen Locations: United States, Oakland , California, India, America, White, California, University of North Carolina, Chapel, Los Angeles, Georgia's, Savannah , Georgia, Ebenezer, Long, New York, Queens , New York, Jamaica, Princeton, Montreal, Canada, Spring, Missouri, Louis, St, Detroit, Hattiesburg , Mississippi, Florida, Chicago, U.S, Lake Forest , Illinois, Sydney, mull, Senegal, Zoox, Charlottesville , VA
The COVID-19 pandemic has infected nearly millions of people, and scientists raced to develop a vaccine at record speed. But vaccines often take years, and sometimes even decades, to develop, test, and approve for public use. Here's how long it took to develop vaccines for infectious diseases throughout history, including COVID-19. Amid the COVID-19 pandemic, scientists were about to develop and distribute shots to prevent those infected from severe illness. To gain some perspective on the complexities of vaccine development, here's how long it took to develop vaccines for other infectious diseases throughout history.
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