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Major Study Confirms Salt's Deadly Effect on Blood Pressure
  + stars: | 2023-11-13 | by ( Nov. | At A.M. | ) www.usnews.com   time to read: +4 min
Investigators said theirs is one of the largest studies ever to include people taking high blood pressure meds in a look at the effect of reducing dietary intake of sodium. She said researchers previously didn't know if people already on blood pressure meds could lower their blood pressure even more by reducing their sodium intake. High blood pressure is a leading cause of illness and death worldwide. Before each study visit, participants wore blood pressure monitors and collected their urine for 24 hours. "The effect of reduction in dietary sodium on blood pressure-lowering was consistent across nearly all individuals, including those with normal blood pressure, high blood pressure, treated blood pressure and untreated blood pressure," Gupta said in a Northwestern news release.
Persons: Carole Tanzer Miller, , Norrina Allen, Deepak Gupta, Allen, Gupta, Dr, Cora Lewis, Johns Organizations: Northwestern University Feinberg School of Medicine, Vanderbilt University Medical Center, University of Alabama, American Medical Association, American Heart Association, Johns Hopkins Medicine, Northwestern University Locations: Chicago, Nashville, Tenn, Northwestern, Birmingham, Philadelphia
The handful of patients had severe heart disease that had caused chest pain and heart attacks. After trying available cholesterol-lowering medications, they could not get their cholesterol as low as cardiologists recommended. So they volunteered for an experimental cholesterol-lowering treatment using gene editing that was unlike anything tried in patients before. Each had a genetic abnormality, familial hypercholesterolemia, that affects around one million people in the United States. In the United States alone, more than 800,000 people have heart attacks each year.
Organizations: Verve Therapeutics, American Heart Association Locations: Boston, United States
Still life of Wegovy an injectable prescription weight loss medicine that has helped people with obesity. Novo Nordisk's Wegovy cut the risk of serious cardiovascular complications in people with obesity and heart disease in a closely watched trial, demonstrating a particularly large effect on heart attacks, a promising new frontier for the drug. The roughly 17,500-person Select study tested Wegovy in people with obesity and heart disease but who did not have diabetes. The new data could also help the Danish pharmaceutical company maintain its lead over Eli Lilly, whose competing weight-loss drug Zepbound was approved in the U.S. earlier this week. Zepbound has been shown to help people lose more weight, but it hasn't yet demonstrated an effect on cardiovascular outcomes.
Persons: Robert Kushner, Eli Lilly, Zepbound, Howard Weintraub Organizations: Wegovy, American Heart Association Scientific Sessions, New England, of Medicine, Novo Nordisk, Northwestern University Feinberg School of Medicine, Center for, NYU Langone Locations: Danish, U.S
CNN —Cutting 1 teaspoon of salt from your diet each day can lower your top blood pressure reading just as much as a typical hypertension medication, even if you don’t have high blood pressure, a new study found. Wirestock/iStockphoto/Getty ImagesNearly half of all Americans live with high blood pressure, according to the American Heart Association. Compared to the high-sodium diet, blood pressure on the extremely low-salt diet dropped 8 millimeters of mercury. “Compared to their normal diet, people reduced their blood pressure by about 6 millimeters of mercury, about the same effect you’d see for a first-line blood pressure medication,” Allen said. “Taste bud adjustment takes a little bit longer, but the blood pressure improvements are pretty quick,” she added.
Persons: , Norrina Allen, ” Allen, Andrew Freeman, Freeman, bouillon, , Allen, ” Freeman, Dietitians Organizations: CNN, American Heart Association, Northwestern University’s Feinberg School of Medicine, World Health Organization, Jewish Health, National Library of Medicine Locations: Denver
A 0.25 mg injection pen of Novo Nordisk's weight-loss drug Wegovy is shown in this photo illustration in Oslo, Norway, September 1, 2023. REUTERS/Victoria Klesty/Illustration/File Photo Acquire Licensing RightsPHILADELPHIA, Nov 11 (Reuters) - Novo Nordisk (NOVOb.CO) on Saturday said the heart protective benefits of its wildly popular Wegovy obesity treatment are due to more than weight loss alone, according to new data presented at a major medical meeting on Saturday. Given that patients had not started losing weight when the cardiovascular benefits first appeared suggests the heart protection was not purely the result of weight loss, Novo said. Though the trial was not conducted to test weight loss, participants lost an average of nearly 10% of their total body weight. Novo said patients in the heart study were not required to track diet and exercise as they are in obesity trials.
Persons: Victoria Klesty, Wegovy, Novo, Martin Lange, Lange, Eli Lilly's, Patrick Wingrove, Bill Berkrot Organizations: REUTERS, Rights, Novo Nordisk, American Heart Association, New England, of Medicine, Novo Nordisk's, U.S . Food, Drug Administration, Thomson Locations: Oslo, Norway, Victoria, Philadelphia, U.S, EU
To cardiologist Dr. Steven Nissen of the Cleveland Clinic, who wasn’t involved in the trial but is leading a similar one of tirzepatide, those effects are all evidence of the benefits of weight loss. Tirzepatide has shown greater levels of weight loss than semaglutide in clinical trials, leading many, including Nissen, to hope it will show even stronger cardiovascular benefits. Importantly, participants didn’t have a history of diabetes; a previous trial had shown that treating people with diabetes with a GLP-1 drug, Ozempic, reduced their cardiovascular risk. The Wegovy trial showed that 569 of 8,803 people taking the drug had a heart attack or stroke or died from heart-related causes, or 6.5%. The amount of weight loss seen in the trial, 9.4%, was less than in other studies of Wegovy, which showed average weight loss closer to 15%.
Persons: Ania Jastreboff, Wegovy, Dr, Amit Khera, National Institutes of Health’s Dr, Tiffany M, Powell, Wiley, Eli Lilly, Steven Nissen, wasn’t, ” Nissen, , Tirzepatide, Nissen, Michael Lincoff, Lincoff, , Jastreboff, Sanjay Gupta, hadn’t, “ semaglutide Organizations: CNN, Nordisk’s Wegovy, American Heart Association, Yale Obesity Research Center, University of Texas Southwestern Medical Center Dallas, National Institutes of Health’s, New England, of Medicine, US Food and Drug, Cleveland Clinic, Novo Nordisk, Cleveland, CNN Health Locations: Philadelphia, Powell
A pivotal new study suggests that the weight loss drug Wegovy cut the risk of heart attack, stroke or death from cardiovascular issues by 20 percent among overweight or obese people with heart disease — a striking benefit that could change the standard of care for these patients. “We’ve just identified a new best practice,” said Dr. Clyde Yancy, chief of the division of cardiology at Northwestern Medicine, who was not involved with the study. Drug companies see potential for the medicines that extends far beyond obesity. Outside of statins, she said, no medication has so dramatically reduced cardiovascular risk among people with heart disease. “The uptake of this drug is going to be skyrocketing in the next couple of years,” she said.
Persons: “ We’ve, , Clyde Yancy, Yuan Lu Organizations: Northwestern Medicine, American Heart Association, Yale School of Medicine Locations: Philadelphia, statins
CNBC's Jim Cramer on Friday laid out what to look for going into next week, highlighting earnings reports from several retail outfits as well as the latest consumer price index. Tuesday brings the latest consumer price index, and Cramer expressed optimism the figures would be "surprisingly cool." Wednesday will see an aggregate retail sales report, which Cramer expects to be weak. Cramer also highlighted Target , which reports Wednesday before the market opens, calling the stock one of the current worst of the retail bunch. He'll be watching more retail reports on Thursday, namely Walmart and Macy's .
Persons: CNBC's Jim Cramer, it's, Cramer, Eli Lilly Organizations: American Heart Association, Novo Nordisk, Accenture, Walmart, Macy's Locations: Novo
Does Eli Lilly deserve to trade at a premium to Novo Nordisk shares? LLY YTD mountain Eli Lilly shares since the start of the year. According to Shin, Lilly deserves a premium to Novo Nordisk because its portfolio is more diverse and it has less exposure to insulin. NVO YTD mountain Novo Nordisk shares year to date In the coming weeks, Lilly will start rolling out Zepbound to patients. Novo Nordisk is scheduled to release the full results of its Select cardiovascular trial at the American Heart Association conference.
Persons: Eli Lilly, James Shin, Shin, Lilly, We're, Lilly's, Zepbound, Wegovy, Chris Schott, Karsten Munk Knudsen, Novo, Schott, AstraZeneca, Eccogene, David Ricks, — CNBC's Michael Bloom Organizations: Novo Nordisk, Deutsche Bank, Biotech, Pharma, Centers for Disease Control, Novo, CNBC, American Heart Association Locations: U.S, GLP, Novo, Denmarkt
Eli Lilly (LLY) remains our favorite way to play the weight-loss drug market, despite a new entry this week from AstraZeneca (AZN). Eli Lilly shares had their worst day of the year Thursday, falling 4.5% in the session to close at $591.32. AstraZeneca's encroachment on turf currently dominated by Eli Lilly and Danish rival Novo Nordisk (NVO) may have contributed to Thursday's declines. That approval, despite being widely expected, pushed Eli Lilly to an all-time closing high Wednesday, at $619.13 per share. Our desire to own Eli Lilly over Novo Nordisk hinges, in part, on our confidence in Eli Lilly's other treatment opportunities, such as in Alzheimer's.
Persons: Eli Lilly, Jim Cramer, Jim, Lilly's, Eli Lilly's tirzepatide, Zepbound, Novo's, Eli Lilly's, Eli Lilly's GLP, Dave Ricks, Lilly, Ricks, AstraZeneca's, ECC5004, retatrutide, Jim Cramer's, David Ricks, Eli Lilly Scott Mlyn Organizations: AstraZeneca, Novo Nordisk, American Heart Association, Novo Nordisk's semaglutide, CNBC, Reuters, Citigroup Locations: Danish, GLP, North Carolina, Novo, Denmark, Zepbound, Alzheimer's
Shares of Eli Lilly (LLY) jumped Wednesday after the U.S. government gave the green light for the company's blockbuster GLP-1 drug to be used as an obesity treatment. In a widely expected move, the U.S. Food and Drug Administration on Wednesday approved Eli Lilly's GLP-1 drug for weight loss. Eli Lilly said it will market the drug as an obesity treatment under the name Zepbound. Shares of Eli Lilly — which have climbed more than 67% year-to-date — soared nearly 2% Wednesday afternoon, to $611.36 apiece. Eli Lilly and Company, Pharmaceutical company headquarters in Alcobendas, Madrid, Spain.
Persons: Eli Lilly, LLY, Eli Lilly's GLP, Eli Lilly —, Eli Lilly's, Jim Cramer, Jim, Jim Cramer's, Cristina Arias Organizations: U.S, U.S . Food, Drug Administration, American Heart Association, Novo Nordisk, Novo, GLP, Nordisk's GLP, FDA, Nordisk, CNBC, Company, Pharmaceutical Locations: U.S, Danish, Alcobendas, Madrid, Spain
CNN —Older adults who don’t smoke tobacco but do use marijuana were at higher risk of both heart attack and stroke when hospitalized, while people who use marijuana daily were 34% more likely to develop heart failure, according to two new non-published studies presented Monday at the American Heart Association Scientific Sessions in Philadelphia. “You need to treat this just like you would any other risk factor (for heart disease and stroke), and honestly understand the risks that you were taking,” he said. Heart failure doesn’t mean the heart has stopped working, but that the heart isn’t pumping oxygenated blood as well as it should, according to the AHA. At the end of the study, researchers found people who reported daily marijuana use had a 34% increased risk of developing heart failure, compared to those who reported never using marijuana. Also called atherosclerosis, CAD is the most common type of heart disease, according to the US Centers for Disease Control and Prevention.
Persons: ” Robert Page II, , Westend61, Avilash, ” Page, it’s, Yakubu Bene, Alhasan Organizations: CNN, American Heart Association Scientific Sessions, Heart, Cannabis, Cardiovascular Health, University of Colorado Skaggs School of Pharmacy, Pharmaceutical Sciences, National Institute on Drug Abuse, Nazareth Hospital, AHA, US Centers for Disease Control, Health Locations: Philadelphia, Aurora , Colorado, Baltimore
For years, medical professionals widely recommended regular aspirin to prevent heart problems, since aspirin can reduce blood clotting to prevent complications like heart attacks or strokes. Still, many health care professionals still consider aspirin to be beneficial for many patients who have heart problems or have a stent. Dropping aspirin also reduced the risk of severe bleeding by nearly 50% compared with patients on the combination therapy, said Mehran — without increasing the risk of cardiac complications. Given the results of her clinical trial and a growing amount of evidence suggesting that long-term aspirin may not be beneficial for acute coronary syndrome, Mehran prescribes a treatment plan without long-term aspirin for her own patients. Aspirin remains ‘an essential therapy’However, experts agree that aspirin remains a beneficial medication for heart conditions.
Persons: ’ ”, Roxana Mehran, Mehran, ” Mehran, Aspirin, Dr, Harlan Krumholz, ticagrelor, Sanjay Gupta, Organizations: CNN, Icahn School of Medicine, World Health Organization, American College of Cardiology, American Heart Association, United States Preventive Services Task Force, Yale School of Medicine, CNN Health Locations: Mount Sinai, United States, South Korea
On Sept. 10, 2022, Katz purchased a charged lemonade from a Panera Bread in Philadelphia, according to the suit. It's an energy drink that has lemon flavor," said Elizabeth Crawford, a partner at Philadelphia-based law firm Kline & Specter, PC. The lawsuit alleges the charged lemonade is "defective in design because it is a dangerous energy drink." Conroy said Katz had bought at least one other charged lemonade in the days prior to her cardiac arrest. Katz's parents, who declined to speak about the lawsuit, are desperate for people to understand exactly what is in Panera's charged lemonade before they buy it, Crawford said.
Persons: Panera, Sarah Katz, Katz, Victoria Rose Conroy, Conroy, Sarah, Red Bull, Elizabeth Crawford, Kline, Specter, I've, Crawford, Charles Berul, Berul Organizations: Ivy League, NBC News, of Pennsylvania, American Heart Association, National Hospital, Panera, Emergency, Food and Drug Administration Locations: Philadelphia, Washington
While BE-FAST helps with finding the most common symptoms of stroke, it may not reflect the stroke experience of all people. Stroke symptoms in men vs. womenScientists have come up with several theories for why men and women experience stroke differently. If women are outliving men, they also have more time and opportunity to have a stroke, Miller added. There are treatments available to improve the survival outcomes for stroke, Kamdar said, but they are all time sensitive. Even if you’re unsure whether someone is having a stroke, Miller advised calling 911 anyway.
Persons: , Eliza Miller, Dr, Hera Kamdar, Kamdar, ” Kamdar, “ It’s, ” Miller, Miller, , , neurologists, Jocelyn Solis, Moreira Organizations: CNN, NewYork, Presbyterian, Columbia University Irving Medical Center, American Heart Association, BE, The Ohio University Wexner Medical, US Centers for Disease Control, Research Locations: United States, New York
The crayon maker, a subsidiary of Hallmark Cards, on Tuesday announced the launch of Crayola Flowers, an online flower shop selling bright bouquets and boxed flowers. Crayola is getting into the flower business with the launch of Crayola Flowers, an online marketplace for fresh flowers. Crayola announced it has launched Crayola Flowers, a retail and fundraising platform. Crayola Flowers partnered with Mrs. Bloom's, an importer and distributor of fresh cut flowers. Schorr said Crayola Flowers’ launch was three years in the making.
Persons: Crayola, Bloom’s, ” Warren Schorr, , Schorr, Bloom's Organizations: New, New York CNN, Hallmark Cards, Tuesday, Crayola, Nonprofit, Footwear, CNN, American Heart Association, Autism, Brothers, Sisters, America, Humane Society, St, Research Locations: New York
Fernandez sees a total addressable market of $140 billion to support patients with obesity. He expects there is a potential for GLP-1 drugs to become as common and widely used, much like statins are used to lower cholesterol. Morgan Stanley's Flynn estimates a 30% share of the diabetes market would generate $109 billion on a worldwide basis for GLP-1 drugs. Layer in a 15% to 30% share of the obesity market and that equates to worldwide sales of $97.4 billion to $194.8 billion. Guggenheim's estimates also assume that oral GLP-1 drugs that are currently in development are able to come to market a few years from now.
Persons: Seamus Fernandez, Fernandez, Lilly, Eli Lilly, Morgan Stanley, Terence Flynn, Eli Lilly's Mounjaro, Insulet, Canaccord, William Plovanic, Plovanic, It's, Morgan Stanley's Flynn, Flynn, Novo, Michael Bloom Organizations: Wall, Novo, American Heart Association, Food and Drug Administration, Novo Nordisk, Iqvia, Disease Control Locations: GLP
Many people might describe certain foods like chocolate, cheese or potato chips as "guilty pleasures." If you want a single serving of potato chips, for example, it's going to be one to two ounces. Single-serving bags of chipsWhen I open a full-sized bag of chips, I can lose all sense of what a single serving is. That's why I've switched to one-ounce mini bags of chips, as they're usually perfectly portioned out to be a single serving. My fiancé and I love going out to dinner for date nights, and we often share entrees or desserts.
Persons: I've, that's, Lauren Armstrong, Lauren Organizations: American Heart Association, Children, Western Michigan University Locations: cheddar, dietetics, Western
Documented marijuana-related traffic accidents that required treatment in an emergency room rose 475% between 2010 and 2021, the study found. Just after Canadian legalization in 2018, when marijuana stores and products were limited, researchers found a 94% increase in emergency room visits, Myran said. Car crashes involving weed were serious. Another issue is the rising potency of cannabis, Myran said. Canada’s lower-risk cannabis guidelines recommend not driving for at least 6 hours after using cannabis and avoiding cannabis and alcohol together.
Persons: , Daniel Myran, Myran, Marco Solmi, ” Myran, , Solmi, , ” Solmi, Robert Page II, Page, I’m, ” Page Organizations: CNN, University of Ottawa, Ottawa Hospital Research Institute, JAMA, Traffic, NHTSA, Research, Highway, Transportation Safety Administration Locations: Canada, United States, Colorado
CNN —Are you using — or considering using — marijuana to help with anxiety, pain, muscle spasms, nausea during pregnancy, poor sleep and more? It can also be triggered by “sleep deprivation, certain prescription medications, and the misuse of alcohol or drugs,” according to the National Institute of Mental Health. Where marijuana can helpAreas in which marijuana has been shown to help include seizures disorders, muscle spasms, chronic pain and sleep — but only for certain people, the study found. “Overall, cannabis was effective in improving pain across multiple measures of pain across different populations, he said. However, there is “no evidence cannabis improves sleep in the general population.”And no one suffering from any of these conditions should self-medicate with cannabis, Solmi stressed.
Persons: , Marco Solmi, ” Solmi, Carol Boyd, Robert Page II, Page, Solmi, ” Page, , ” Young, Cinnamon Bidwell Organizations: CNN, University of Ottawa, Ottawa Hospital Research Institute, Center, Drugs, University of Michigan, US Food and Drug Administration, National Institute of Mental Health, University of Colorado Locations: Canada, Ann Arbor, University of Colorado Boulder
Today, it is one of the most popular plant-based foods and an easy substitute for animal products like chicken and eggs. According to the American Heart Association, tofu also contains essential vitamins and minerals like:CalciumManganeseIronVitamin AThe plant-based food also has isoflavones, a type of plant estrogen, says Mok. Soy products and isoflavones aren't looked at favorably in the U.S. due to a complicated history, according to the AHA. This has caused many to raise an eyebrow at tofu as a healthy alternative. Here's what Mok says — and research shows — about whether or not tofu qualifies as a healthy food.
Persons: Jamie Mok, aren't, Mok Organizations: Academy of Nutrition, American Heart Association, AHA Locations: Asia, U.S
CNN —When it comes to developing high blood pressure, Covid-19 might play an outsized role, a new study says. Of the hospitalized Covid-19 patients, more than 1 in 5 developed hypertension during their time in the hospital, while actively infected with Covid-19, despite having no history of high blood pressure. However, in comparison with patients who were infected with the flu, Covid-19 patients had worse blood pressure outcomes. Covid-19 patients who had been hospitalized were 2.23 times as likely to develop high blood pressure as hospitalized influenza patients. But scientists are unsure how the Covid-19 virus might trigger new-onset high blood pressure.
Persons: Covid, Dr, Tim Duong, Sanjay Gupta, ” Duong Organizations: CNN, US Centers for Disease Control, CDC, American Heart Association, American College of Cardiology, Albert Einstein College of Medicine, CNN Health Locations: United States, Bronx, New York City, Covid
Someone in the US has a heart attack about every 40 seconds, according to the US Centers for Disease Control and Prevention. Heart disease including heart attack is the leading cause of death in the US, but most people survive their first heart attack and go on to lead a normal life, according to the American Heart Association. Additionally, pain could be a deterrent to lifestyle changes that might lower someone’s risk of another heart attack, such as exercise. Dangas said the new study could remind doctors to pay particular attention to their heart attack patients who talk about pain. Cardiac rehabilitation cuts the risk of death in the five years after a heart attack by about 35%, according to a 2016 study.
Persons: CNN —, George Dangas, , Dangas, , Dr, Sanjay Gupta, they’ll, They’ll, Linda Vixner Organizations: CNN, US Centers for Disease Control, American Heart Association, Sinai Hospital, CNN Health, School of Health, Welfare, Dalarna University, Falun Locations: Sweden, Mount Sinai Queens, New York City, Dalarna
Companies Novo Nordisk A/S FollowCOPENHAGEN, Aug 10 (Reuters) - Novo Nordisk's (NOVOb.CO) limits on U.S. supplies of starter doses of its hugely popular Wegovy weight-loss drug will last into next year even as the Danish drugmaker spends billions boosting output, its CEO told Reuters on Thursday. Earlier on Thursday, the company said it would continue to restrict U.S. supplies of starter doses of Wegovy as the company struggles to keep up with soaring demand. Novo has denied this, but when asked about this on Thursday Jorgensen said there may be shortages. The company expects to apply for regulatory approval for an expanded label indication in the U.S. and European Union later this year. "It'll take some time before we get it on label," Jorgensen said.
Persons: Lars Fruergaard Jorgensen, Thursday Jorgensen, Jim Vondruska, Jorgensen, " Jorgensen, Martin Lange, Nikolaj Skydsgaard, Jacob Gronholt, Josephine Mason, Jason Neely, Mark Potter Organizations: Novo Nordisk, COPENHAGEN, Reuters, REUTERS, Wegovy, Union, American Heart Association, Pedersen, Thomson Locations: Danish, Chicago , Illinois, U.S, Philadelphia, Copenhagen, London
“All cigars, including premium cigars, can cause death and disease, and no tobacco product should be without regulation of any kind,” he said. began a process to regulate cigars. The agency did ask for public comment over whether premium cigars could be regulated less rigorously. opted to require premium cigar makers to conduct extensive studies of their products, list ingredients and register them annually. The agency concluded that regulating all cigars equally “more completely protects the public health.”Groups supporting the cigar industry, in turn, sued.
Persons: Thomas Carr, Mr, Carr, Michael Edney, Hunton Andrews Kurth, , , ’ ” Organizations: Public, American Lung Association, American Heart Association, American Academy of Pediatrics, American Cancer Society, Tobacco Control, Rights, America, Congress
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