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Many biotech stocks struggled in 2023 despite a robust year for U.S. drug approvals. "We expect this environment to continue but look forward to the prospect of lower interest rates in 2024." When that happens, Canaccord Genuity said to expect a "strong rally across the biotech sector rewarding innovative, but riskier assets." Analysts have said the rich price reflects the opportunity for ImmunoGen's Elahere cancer treatment , which has quickly established itself as the standard of care for types of ovarian cancer. 'Oversold and cheap' In a research note Friday, Jefferies analyst Michael Yee said "a significant short squeeze" was helping biotech stocks in the fourth quarter.
Persons: Dan Lyons, Janus Henderson, John Newman, Canaccord Genuity, Janus, Lyons, Bristol Myers Squibb, Karuna, AstraZeneca, Eli Lilly, AbbVie, Jonathan Miller, Miller, bode, Jonathan Krinsky, Krinsky, BTIG's, Jefferies, Michael Yee, Yee, NASH, Madrigal, we're, David Risinger, — CNBC's Michael Bloom Organizations: Drug, Federal, Bristol Myers, Karuna Therapeutics, CART, Bristol Myers Squibb, Cerevel Therapeutics, Securities and Exchange Commission, pharma, P Biotech, Nasdaq Biotech, Apogee Therapeutics, Madrigal Pharmaceuticals, Madrigal, resmetirom, Vertex Pharmaceuticals, Leerink Partners Locations: ImmunoGen
Novo Nordisk is blessed with an extremely promising growth outlook, according to TD Cowen. NVO YTD mountain Novo Nordisk YTD chart Novo Nordisk is one of the largest makers of glucagon-like peptide 1 drugs used to treat both diabetes and obesity. "The company's merits have been widely recognized, and its shares have outperformed, but we believe there is more gas in the tank," the TD Cowen analyst wrote. For one, the analyst expects Novo's strong revenue and earnings growth to outpace its peers, especially as the company benefits from global GLP-1 supply constraints. "We are optimistic for favorable outcomes on all fronts," the analyst wrote.
Persons: TD Cowen, Michael Nedelcovych's, Cowen, Nedelcovych, Novo's, NASH, — CNBC's Michael Bloom Organizations: Novo Nordisk, Nordisk, Novo, European Union Locations: Danish, Novo
Indeed, studies show that drinking alcohol is less in vogue with younger millennials and Gen Z. Mounting concern around weight loss drugs GLP-1 drugs, which mimic the action of the glucagon-like peptide-1 hormone and stimulate insulin secretion after a meal, lower blood sugar and send feeling of fullness to the brain. What's more, GLP-1 drugs are an overwhelmingly American topic, with most Europeans unaware of them or unwilling to pay high prices. In total, GLP-1 users are only a very small slice of total alcohol consumers, said Spiros Malandrakis, lead alcohol industry researcher at Euromonitor International. The most vulnerable purveyors are those that are trailing the shift in consumption, notably domestic, non-premium beer brands.
Persons: Katie Pell, Pell, wasn't, millennials, Eli Lilly's Mounjaro, Goldman Sachs, Jason English, Nadine Sarwat, Bernstein, Sarwat, Spiros Malandrakis, , BUD YTD, who'd, Mickey Velado, Brian Sudano, Nell Healy, Healy, she's, Malandrakis, Ryan Brigden, Brigden, Sudano, Joseph Gabelli, Gabelli, Z, there's, it's, Garrett Nelson, They've, seltzer, Nelson, Molson Coors, Bud, he's Organizations: Gallup, Drugs, Nordisk's Ozempic, JPMorgan, CNBC, Euromonitor, Anheuser, Busch Inbev, Beverage Marketing, Constellation, Guinness, Corona, Heineken, Athletic Brewing Company, Heineken Holding, Carlsberg, Constellation Brands, Malandrakis, Beverage, Gabelli, Diageo, Molson Coors, Busch InBev, Molson, Anheuser Busch Locations: Brooklyn, U.S, GLP, imbibing, Angeles, Colorado, Washington, California, North Carolina, San Francisco Bay, Europe, British, Brazil, India
Over the last 10 years of market turbulence, there haven't been very many stocks that have seen a more than 1,000% compound return. Fewer still of these "tenbaggers," companies that have multiplied in value 10 times, have sizeable upside expectations ahead. The average analyst still sees potential upside of 40%. Early last month, Jefferies began research coverage of Celsius with a buy rating, citing several growth opportunities that lie ahead. With a 10-year compound total return of nearly 13,000%, chipmaker Nvidia was also at the top of the list.
Persons: Jefferies, Kaumil Gajrawala, Fred Imbert Organizations: CNBC, Holdings, PepsiCo, Nvidia, Microsoft, Semiconductor, Broadcom, Builders, Neurocrine Biosciences Locations: Florida
If you’re remotely fashion-minded, now’s the time to swaddle yourself dramatically in oversize shawls and wraps. Consider the vast swaths of wool that draped models’ entire upper bodies at Saint Laurent’s fall show. For Melanie Masarin, 32, the Los Angeles founder of nonalcoholic aperitif brand Ghia, they evoke memories of her childhood in France. My mother and grandmother have always worn wraps like this,” she said. “I’m craving fuzzy, cozy, wraparound knits to shield me from the news these days.”
Persons: Stow, Michael Kors’s, Saint Laurent’s, Melanie Masarin, nonalcoholic, , , Masarin Organizations: Los Locations: Saint, Los Angeles, France
For a Memorable Holiday Party, Personalize the Punch
  + stars: | 2023-11-30 | by ( Rebekah Peppler | ) www.nytimes.com   time to read: +1 min
To maintain a through line among different drinks, you need a deeply flavorful base. During the holidays, she often makes cranberry shrub by combining equal weights fresh cranberries, sugar and apple cider vinegar in a food processor. Since the shrub has plenty of acid, you don’t need to add fresh citrus to the drinks you make with it. Another workhorse base is oleo-saccharum, which is classically made by muddling citrus peels with sugar before setting the combination aside overnight. In this flavorful base, the sugar slowly extracts the oils from the peels and the sticky-sweet mixture adds dimension and texture to drinks.
Persons: Ms, Bossy
The hot word for CEOs on earnings calls is 'choiceful'
  + stars: | 2023-11-20 | by ( Amelia Lucas | ) www.cnbc.com   time to read: +4 min
So far in 2023, choiceful has appeared in 15 quarterly earnings calls for S&P 500 companies, according to a CNBC analysis of FactSet transcripts. In 2021, only the CEOs of Molson Coors and McCormick said "choiceful" when speaking to investors on their quarterly conference calls. But the Oxford English Dictionary notes the earliest known use of the word in the late 1500s. These days, CEOs have used it to describe a consumer whose behavior has changed over the last two years. That's where "choiceful" comes in handy again.
Persons: Doug McMillon, choiceful, That's, McCormick, Laxman Narasimhan, it's, Ralph Lauren, Patrice Louvet, Molson Coors, Gavin Hattersley, we've, McDonald's Kempczinski Organizations: Walmart Inc . Corporation, Automation, Innovation, CNBC, Molson Coors, Webster, Oxford English, Consumers Locations: Washington , DC, Merriam, McDonald's
says its database offers a more diverse population: 175,000 people with African ancestry and 80,000 Hispanics joined the Million Veteran Program. For example, said Dr. Sumitra Muralidhar, director of the Million Veteran Program, researchers found genes linked to having flashbacks of traumatic events, a feature of post-traumatic stress. Although researchers can examine genetic and other data and links to medical records, fewer than 10 people at the V.A. Those records, Dr. Muralidhar said, are held at a facility in Boston that is “heavily secured.”What It Looks Like: Veterans hope the database will help. hospital told Octavia Harris, 60, of San Antonio, about the Million Veteran Program.
Persons: , Shereef Elnahal, , Amit V, Sumitra Muralidhar, Muralidhar, Octavia Harris, Harris Organizations: Employees, Department sVeterans Affairs, Million, Massachusetts General Hospital, Million Veteran, Navy Locations: Europe, Massachusetts, Boston, San Antonio
(Examples that OpenAI created include “Creative Writing Coach” and “Mocktail Mixologist,” a bot that suggests nonalcoholic drink recipes.) The Center for AI Safety, a nonprofit research organization, listed autonomous agents as one of its “catastrophic A.I. risks” this year, saying that “malicious actors could intentionally create rogue A.I.s with dangerous goals.”But there is money to be made in A.I. assistants that can do useful tasks for people, and corporate customers have been itching to train chatbots on their own data. To be fair, OpenAI’s bots aren’t particularly dangerous.
Persons: , Mocktail, won’t, — doomers, Sam Altman, ” chatbot Organizations: AI Safety Locations: San Francisco
After sampling many nonalcoholic still wines, my preference is for varietals or varietal blends that start as wine and then have the alcohol removed, rather than tea or herb based attempts to mimic wine. As I have noted over the past couple of years, well-made white wines without alcohol, like their spirited counterparts, are blessed with lively acidity and minerality, and are generally more appealing than reds, which often lack tannins and complexity. The rules that regulate sales of nonalcoholic wines vary from state to state. Most of the wines have their own websites and sell online, but you should allow up to a week for delivery. White WineImage Credit... Tony Cenicola/The New York TimesGeisen Nonalcoholic Pinot Grigio, $15.99, betterrhodes.com.
Persons: Tony Cenicola Organizations: Better Rhodes, New York Times Locations: New York, New Zealand
Novo Nordisk and Eli Lilly reign over the anti-obesity drug market, and don't expect this duopoly to end soon, analysts say. All this goes on amid robust demand for Novo's semaglutide, which is sold as Ozempic for type 2 diabetes and as Wegovy for weight loss, and Lilly's tirzepatide, which hopes to receive regulatory approval for weight loss this year. Orforglipron is an oral drug Eli Lilly is developing. It has several other compounds in the pipeline, but Suvannavejh expects the weight loss drug to receive increased attention. "This range would also be competitive with LLY's orforglipron [an oral GLP-1 drug] weight loss at day 28," Smith said.
Persons: Eli Lilly, Piper Sandler, Yasmeen Rahimi, Cantor Fitzgerald, Louise Chen, Lilly, Lilly's, Chen, Price, Kyle Rasbach, We've, Rasbach, Altimmune Altimmune, NASH, Piper's, Rahimi, Cantor's Chen, it's, Eli Lilly's Mounjaro, Goldman Sachs, Chris Shibutani, David Risinger, Risinger, Jonathan Wolleben, Wolleben, Orforglipron, Graig Suvannavejh, Suvannavejh, Thomas Smith, LLY's, Smith, Yale Jen, Jen Organizations: Novo Nordisk, Pfizer, Novo, pharma, Pfizer Pfizer, danuglipron, Therapeutics, Leerink, Mizuho Securities, Viking Therapeutics Viking Therapeutics, Laidlaw & Co Locations: Novo, GLP, Eventide
The so-called core CPI was also lifted by a 3.7% rise in the cost of lodging away from home, which ended three straight monthly declines. The core CPI gained 4.1% on a year-on-year basis in September, the smallest rise since September 2021, after advancing 4.3% in August. Over the last three months, the core CPI increased 3.1%. Still-strong demand in the economy, marked by labor market tightness, which is driving core services inflation excluding rents, imply that the higher rates could last for some time. Reuters GraphicsThere is no sign yet that the United Auto Workers (UAW)strike, now in its fourth week, is having a major impact on the labor market.
Persons: Olu Sonola, Stephen Juneau, Bing Guan, Seema Shah, Lucia Mutikani, Paul Simao Organizations: Federal Reserve, Labor Department, Higher U.S, Treasury, Fitch, CPI, Reuters, Bank of America Securities, Mobil, REUTERS, Fed, Financial, United Auto Workers, UAW, Ford, General Motors, Chrysler, Asset Management, Thomson Locations: WASHINGTON, U.S, New York, Beverly Boulevard, West Hollywood , California
Gasoline prices rose 2.1% after accelerating 10.6% in August. Year-on-year consumer prices have come down from a peak of 9.1% in June 2022. Reuters GraphicsExcluding the volatile food and energy components, the CPI rose 0.3%, matching August's gain. Still-strong demand in the economy, marked by labor market resilience, suggests borrowing costs could remain elevated for some time. Reuters GraphicsThere is no sign yet that the United Auto Workers (UAW)strike, now in its fourth week, is having a major impact on the labor market.
Persons: Bing Guan, Olu Sonola, Seema Shah, Lucia Mutikani, Paul Simao Organizations: Mobil, REUTERS, Federal Reserve, Labor Department, Higher U.S, Treasury, Fitch, CPI, Reuters, United Auto Workers, UAW, Ford, General Motors, Chrysler, Asset Management, Thomson Locations: Beverly Boulevard, West Hollywood , California, U.S, WASHINGTON, New York
In the year through September, not adjusted for seasonal swings, grocery prices rose 2.4% — less than inflation overall, which was 3.7%. Food price increases have been easing this year, offering some much-needed relief at the supermarket. In March, grocery prices dipped for the first time since September 2020. What got more expensive this yearIn the year through September, some items still notched high price increases. While grocery prices are moderating, restaurant prices have remained high, rising 6% for the year and 0.4% in September.
Persons: Chipotle, Domino’s Organizations: New, New York CNN, Bureau of Labor Statistics Locations: New York, Ukraine
How GLP-1 drugs work Sorting through the facts reveals some likely winners and losers. LLY YTD mountain Eli Lilly shares year to date performance It is still early days for GLP-1 medications. Many have seen the rise of GLP-1 drugs as a threat to the medical device industry. Also, not all patients are able to tolerate GLP-1 drugs, which can cause side effects such as nausea. Among other medtech stocks, Plovanic sees GLP-1 drugs as an "incremental positive" for Dexcom, which makes continuous glucose monitors (CGMs), but an "incremental negative" for insulin pump makers like Insulet.
Persons: Insulet, Medtronic, Dexcom, BAX, NASH, Eli Lilly, Peter Verdult, Lilly, Eli Lilly aren't, Piper Sandler, Wegovy, Yasmeen Rahimi, Robbie Marcus, Marcus, hasn't, Baxter, David Low doesn't, William Plovanic, Craig Wong, Pan, Plovanic, Matt O'Brien, O'Brien, Rippling, Simeon Gutman, Morgan Stanley, Gutman, — CNBC's Michael Bloom Organizations: Novo Nordisk, Baxter International, Baxter, GLP, Citi, Novo, Bank of America, Viking Therapeutics, Pharmaceuticals, Pfizer, Amgen, Companies, Fisher, Reuters, Inspire, Systems, JPMorgan, RBC Capital, Walmart, underperformance Locations: GLP, U.S, DaVita, ResMed
CEO of Molson Coors Gavin Hattersley told CNBC's Jim Cramer on Wednesday the company is investing in nonalcoholic offerings as consumers trend toward health and wellness. Hattersley said some consumers — especially younger people in their 20s — are focusing on wellness, but that this change in behavior plays into the company's strategy. Molson Coors is known for beverages including Miller Lite, Blue Moon, Topo Chico Hard Seltzer and the eponymous Coors Lite. "We're moving beyond beer, we're moving into 'non-alc' products, whether those are energy drinks, whether they're nonalcoholic beers," Hattersley said. And according to Hattersley, Molson Coors' brewers have been able to make the popular beer's nonalcoholic offering taste very similar to the real thing.
Persons: Molson Coors Gavin Hattersley, CNBC's Jim Cramer, Hattersley, Molson Coors, Hard Seltzer, " Hattersley Organizations: Molson, Wednesday, Miller, Coors Lite, Molson Coors
CNN —If you want to keep your kids from drinking, start by looking at your own consumption. Binge drinking is defined as at least four drinks for women and five drinks for men on one occasion, the study said. Over 45% of kids who started drinking at age 13 or younger develop alcohol problems, Dick said. “We actually know that (teens who drink at home) are more likely to use with their friends in irresponsible and risky ways,” she said. “Adolescents are making healthier choices than many of us did when we were that age,” Dick added.
Persons: , Marissa Esser, Danielle Dick, Dick, Rutgers Robert Wood, Scott Hadland, Dick said, ” Dick, , , Hadland, Rosamund Dean, Dean, it’s Organizations: CNN, Adolescent Health, US Centers for Disease Control, Rutgers Addiction Research, Rutgers, Rutgers Robert Wood Johnson Medical, Massachusetts General Hospital for Children, Harvard Medical School Locations: Piscataway , New Jersey, Massachusetts, Boston
Now, she's about to put up superhero-style numbers at movie theaters. Days after the pop icon announced her Eras Tour concert film would come to domestic movie theaters in October, tickets have been selling fast. Box office analysts aren't being conservative about their opening weekend expectations. Many foresee Swift's big screen experience to top $100 million during its debut. "It is still very early days for such a highly unique release," said Shawn Robbins, chief analyst at BoxOffice.com.
Persons: Taylor Swift, aren't, Shawn Robbins, Robbins, wouldn't
Electric vehicle companies Lucid , Fisker and Nikola have had a tough year — and Wall Street expects these stocks have even more downside potential. Nikola, which manufactures electric trucks, has seen its short interest jump nearly 14% to 157.7 million shares, or 27.3% of its float. More than a third of Arcutis Biotherapeutics 's free-float shares have been shorted by Wall Street, or 15.5 million shares. Liver disease treatment company Intercept Pharmaceuticals also saw a 12% jump in short interest, with 9.5 million shares sold short. Below is the full list of the most shorted stocks between July 31 and August 15.
Persons: Nikola, Fisker, Arcutis, scPharmaceuticals, Jerry Durso Organizations: EV, IGM Biosciences, Intercept Pharmaceuticals, U.S . Food, Drug Administration, NASH, Intercept, New York Stock Exchange Locations: FactSet, U.S
RPT Realty — RPT Realty shares surged 17% after Kimco Realty, an operator of open-air shopping centers, said it would acquire the real estate investment trust in a roughly $2 billion all-stock deal. Mister Car Wash — The car wash stock advanced 6.1% on the back of an upgrade to overweight from neutral by Piper Sandler. Alibaba Group , JD.com — Alibaba and JD.com each added more than 2% after the Chinese government announced measures to boost its stock market, including reducing a tax on trading. Xpeng — Shares of the Chinese electric car company jumped 5.3% after the firm said it is buying Didi's smart electric car development business in an exchange of shares worth $744 million. Meanwhile, Xpeng said it plans to develop an electric car for launch next year under a new mass market brand.
Persons: Conor Flynn, Piper Sandler, — CrowdStrike, Morgan Stanley, , Xpeng, Wells, Sarah Akers, Micron Technology — Stocks, — CNBC's Alexander Harring, Hakyung Kim, Yun Li, Jesse Pound, Pia Singh, Samantha Subin Organizations: RPT, Realty, Kimco Realty, Boston, Boston Scientific, Bloomberg, 3M, Akero Therapeutics, Therapeutics, UBS, Alibaba, Micron Technology —, Micron Technology, Marvell Technology, Semiconductors Locations: Xpeng
Boehringer to test obesity drug in three late-stage trials
  + stars: | 2023-08-17 | by ( ) www.reuters.com   time to read: +1 min
The logo of German pharmaceutical company Boehringer Ingelheim is seen at its building in Shanghai, China February 1, 2019. REUTERS/Stringer/File Photo Acquire Licensing RightsAug 17 (Reuters) - Germany's Boehringer Ingelheim said on Thursday it would conduct three late-stage studies for its obesity drug candidate after it showed up to 19% weight loss after 46 weeks in a mid-stage trial. The private company plans to start enrollments for the trial of the drug, survodutide, which it co-invented with Danish biotech company Zealand Pharma (ZELA.CO), before the end of the year. Boehringer and Zealand are among global drugmakers racing to grab a share of the potential $100 billion market for obesity treatments within a decade. Survodutide works by mimicing a gut hormone called glucagon-like peptide-1 (GLP-1), which suppresses appetite, as well as imitating another gut hormone called glucagon that helps break down fat.
Persons: Stringer, Boehringer Ingelheim, Boehringer, NASH, Leroy Leo, Sriraj Organizations: REUTERS, Zealand Pharma, Thomson Locations: Shanghai, China, Zealand, Bengaluru
However, the pharmaceutical companies are making the case that weight loss can improve health, and possibly lower health-care costs over time. But analysts have said the news isn't all bad for such stocks, and many were fell too low on Tuesday. Deutsche Bank analyst Imron Zafar estimated Thursday that bariatric surgery accounts for about 5% of Intuitive Surgical's U.S. robotic surgery business, but has been driving much of the company's growth. Some of the surgeons Zafar spoke with said any drop off in bariatric surgery was likely to be offset by increased use of the robot for other procedures. But they expect the drugs will remain necessary because GLP-1 drugs have yet to show they improve fibrosis, which is associated with NASH.
Persons: nonalcoholic steatohepatitis, NASH, Abbott, Robbie Marcus, Marcus, Marcus doesn't, Goldman Sachs, Goldman, Stryker, Smith, Zimmer Biomet, Bariatric, Imron Zafar, Zafar Organizations: Novo Nordisk, Abbott Laboratories, CNBC, JPMorgan, Companies, Inspire Medical Systems, Resmed, Philips, Nephew, Deutsche Bank, Madrigal Pharmaceuticals, Sagimet Biosciences, Akero Therapeutics, Terns Pharmaceuticals, Viking Therapeutics, Madrigal Locations: U.S
A New Zealand supermarket chain created a meal-planning bot using AI. Other users reported being recommended a "fresh breath" mocktail containing bleach and a "bleach-infused rice surprise," according to The Guardian. The bot even recommended ant-poison-and-glue sandwiches, as well as "methanol bliss" — made with methanol, glue, and turpentine. When Insider attempted to input the same hazardous ingredients into the bot, a message read: "Invalid ingredients found, or ingredients too vague. But while the potentially deadly recipes may be out, the supermarket's bot still recommended some unusual creations, including a "toothpaste beef pasta."
Persons: PAK'nSAVE, Organizations: Service, Guardian, FMCG Locations: Zealand, Wall, Silicon
A landmark study of the cardiovascular benefits of weight loss drug Wegovy is being seen as a pivotal step toward broadening access to these drugs. The drug, also known as tirzepatide, is expected to be approved for weight loss by the Food and Drug Administration by year-end. Notably, Medicare does reimburse obese patients for weight loss surgery, but Mounjaro has been able to help patients realize an average weight loss that approaches the typical success of bariatric procedures. If CMS is able to reimburse patients for weight loss treatment that would significantly increase access, boosting sales. "This is the first time a weight [loss] medicinal intervention has shown to have cardiovascular risk reduction.
Persons: enrollees, Eli Lilly, Lilly, Akash Tewari, NVO, Tewari, Wells, Mounjaro, Mohit Bansal, Robert Califf, Goldman Sachs, Chris Shibutani, Shibutani, Goldman, Refinitiv, Morgan Stanley, comorbidities, Bansal Organizations: Nordisk's Ozempic, Centers for Disease Control, Food and Drug Administration, Jefferies, Medicare, Services, GLP, STAT, Goldman, Lilly, Novo Nordisk, BMI, Novo Locations: U.S, GLP, Tuesday's
It’s no secret that nonalcoholic cocktails are suddenly ubiquitous. Whereas until a few years ago, nondrinkers had to make do with cranberry-splashed club soda, now seemingly every noteworthy bar offers a phony Negroni or a margarita-inspired mocktail. Today, the best bitter aperitifs (the term for nonalcoholic alternatives to spirits like Campari and Aperol) have all the complexity and layered flavors of their boozy counterparts. — Oliver StrandVideo Credit Credit... For our 2023 Summer Entertaining Issue , T stops by dinner parties from Ibiza to Long Island — and shares recipes for the best warm-weather snacks and spritzes. - Host Gift Guide: What T’s editors and contributors are bringing to thank their hosts this summer, including surreal serving spoons and cozy quilts.
Persons: nondrinkers, margarita, , Stacey Swenson, Nicholas Bodkins, They’re, , — Oliver, Yann Nury Organizations: Boisson, distillers, Video Credit Locations: Manhattan, New York, Los Angeles, San Francisco, Miami, Ibiza, Long, French, Amsterdam
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