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☆ Eli Lilly says U.S. FDA rejects accelerated approval for Alzheimer's drug
▼ + stars: | 2023-01-19 | by ( Deena Beasley | ) www.reuters.com time to read: +3 min

REUTERS/Mike SegarJan 19 (Reuters) - Eli Lilly and Co on Thursday said the U.S. Food and Drug Administration had rejected accelerated approval of its experimental Alzheimer's drug because it had not submitted enough trial data from patients who were treated for at least a year. That study, Lilly said, would form the basis of donanemab's application for traditional FDA approval shortly thereafter. The FDA can grant "accelerated" approval to drugs based on their impact on a measurement, in this case amyloid brain plaques, likely to correlate with patient response. Donanemab is in the same class as aducanumab and lecanemab, the latter being a treatment for early Alzheimer's that was given accelerated approval by the FDA earlier this month. Sales of amyloid-lowering Alzheimer's drugs, which need to be given by infusion, are expected to be minimal until they receive standard FDA approval.

☆ 39 more Regal theaters are closing in the US amid bankruptcy. See the full list.
▼ + stars: | 2023-01-19 | by ( Travis Clark | Sindhu Sundar | ) www.businessinsider.com time to read: +4 min

Over three dozen Regal Cinemas locations in the US are expected to close. Cineworld detailed the plan to reject the leases starting February 15 in a new bankruptcy filing on Tuesday. Regal is the second-largest cinema chain in the US, behind AMC, with over 500 theaters. The company's plan to close locations during its bankruptcy is fairly routine. Cineworld filed for bankruptcy at a time when the larger theatrical industry is struggling to fully rebound from the pandemic.

A newly approved Alzheimer's drug will be available to patients in the coming days, according to its maker, the Japanese pharmaceutical company Eisai. While Leqembi offers hope to patients and their families, experts say that there are still some key unanswered questions about the drug, including about its safety and effectiveness. Besides questions about who will benefit the most, there are also questions about how long the drug will benefit patients. About 17% of the Leqembi group experienced brain bleeds, compared with 9% in the placebo group. The reports of brain bleeding and brain swelling "may only be the tip of the iceberg," he said.

Shortness of breath, loss of taste and smell, and other lingering Covid symptoms tend to ease over time and may be gone within a year, according to new research. The study did not include patients who developed long Covid from omicron or its subvariants, but doctors in the U.S. say they do see new patients with long Covid symptoms following an omicron infection. Most common long Covid symptomsThree years into the pandemic, it remains unclear exactly how many people have long Covid. The findings are consistent with what long Covid experts in the U.S. have found. While the study found that many long Covid symptoms abate within a year, it remains clear that some patients continue to suffer long afterward.

☆ These 4 lucrative side hustles dominated 2022—and they require less than 20 hours of work per week
▼ + stars: | 2023-01-11 | by ( Megan Sauer | ) www.cnbc.com time to read: +4 min

The couple now only spends about an hour per week managing bookings, they say. She works 10-15 hours per week managing, cleaning and checking in on the bookings. Vending machinesYou might be surprised to learn how lucrative vending machines are for their owners. Now, he spends six hours per week managing 57 vending machines, which bring in an average of $30,000 per month, as his full-time job. In 2018, he moved from Rochester, New York, to Philadelphia and bought two vending machines.

☆ Bang Bang Chicken: A gun-stuffed bird was among the weirdest items found by airport security teams in 2022. See the full list.
▼ + stars: | 2023-01-06 | by ( Beatrice Nolan | ) www.businessinsider.com time to read: +3 min

The TSA released its "top 10 catches" list, consisting of unusual items found at airports in 2022. Cash stashed in crutchesSoiled money hidden inside a pair of crutches was discovered by agents at El Paso International Airport in Texas. An inert grenadeA grenade was found after a passenger attempted to get it through airport security in a carry-on at General Mitchell International Airport in Wisconsin. A gun hidden in an arm slingAgents discovered a gun concealed in a man's arm sling at Greater Rochester International Airport. A gun stuffed in a raw chickenA handgun was discovered stuffed inside a raw chicken at Fort Lauderdale–Hollywood International Airport.

☆ Special Report: Boy Scouts, Catholic dioceses find haven from sex abuse suits in bankruptcy
▼ + stars: | 2022-12-30 | by ( Kristina Cooke Mike Spector Benjamin Lesser Dan Levine Disha Raychaudhuri | Kristina Cooke | Mike Spector | ) www.reuters.com time to read: +19 min

The Boy Scouts, for instance, said on a website the group set up for restructuring that it launched a “comprehensive noticing campaign” in the media. He sought compensation in the Boy Scouts bankruptcy in June, long after a deadline of November 16, 2020 for filing claims. The Boy Scouts bankruptcy reorganization plan, approved by a judge in September, halts all lawsuits against the Boy Scouts, local councils, churches and other organizations that chartered scouting activities. His case was halted by the Boy Scouts bankruptcy. Later that year, in August, he filed his lawsuit against defendants including a Boy Scouts local council and DeSandre.

How much does insulin cost? People with Type 1 diabetes need, on average, one to three vials of insulin per month, according to the American Diabetes Association. Patients with Type 2 diabetes don't always need to take insulin, but those who do can sometimes require more than people with Type 1 diabetes. Even people with what's considered good health insurance coverage can face steep costs in certain situations. In addition to insulin and insurance premiums, Gibson also must spend $550 every three months for glucose monitors and $1,100 for insulin pumps.

The Buffalo Airport, which has been closed since Dec. 23, was expected to reopen on Wednesday morning, according to a tweet. A little more than 1,400 energy customers in New York state were without power Wednesday morning — amounting to only 0.02% of the state — according to PowerOutage.us. Storms to batter the West CoastMeanwhile, a total of five separate storm systems will impact the West through next Monday. Oregon State Parks announced emergency closures for Ecola and Cape Meares because of high winds and the potential for falling trees. Colusa and Mendocino counties had 650 and just over 700 power outages as of Wednesday morning, respectively, according to PowerOutage.us.

☆ 'Never flying Southwest again': Stranded and frustrated customers scramble to find flights and alternative travel
▼ + stars: | 2022-12-27 | by ( Antonio Planas | Antonio Planas Is A Breaking News Reporter For Nbc News Digital. | ) www.nbcnews.com time to read: +6 min

Most Southwest Airlines flights aren't going anywhere, but frustration levels for scores of travelers across the country are soaring. In the post-Christmas rush and severe winter storm chaos, the Dallas-based airline canceled nearly two-thirds of its flights Tuesday and said that the disruptions likely won't be over for several days. More than 3,500 flights scheduled to leave Wednesday have already been canceled, with Southwest constituting about 70% of those cancellations, according to FlightAware. He said he couldn't find another seat on a Southwest flight to Dallas until Monday. But unlike some Southwest customers, she has loved ones she can lean on for accommodations.

☆ Rep. Zoe Lofgren crashed Proud Boy Enrique Tarrio's January 6 deposition to ask why he called her the C-word on Telegram
▼ + stars: | 2022-12-24 | by ( Laura Italiano | ) www.businessinsider.com time to read: +9 min

Rep. Zoe Lofgren interrupted the Proud Boys' Enrique Tarrio's Capitol-riot deposition. "I see that Ms. Lofgren has come onto video," a committee lawyer whose name is redacted is recorded as saying. "I just don't understand why that's just such a big deal," Tarrio's lawyer said, dismissing Telegram as "just kind of a really nasty Irish bar scene." Tarrio told committee members: "I took it to be, like, 'Hey, the election's coming up. The Proud Boys seditious-conspiracy trial follows the November seditious-conspiracy conviction of the Oath Keepers founder Stewart Rhodes and is expected to last about six weeks.

☆ 'Bomb cyclone' forces DoorDash to pause food deliveries in multiple US cities. The company says more shutdowns are coming and New York City could be next.
▼ + stars: | 2022-12-23 | by ( Nancy Luna | ) www.businessinsider.com time to read: +3 min

Winter Storm Elliot is intensifying into a "bomb cyclone," according to The Weather Channel. DoorDash said it is pausing food deliveries in Minnesota, Iowa, Michigan, and Indiana. 1 delivery operator, is suspending operations in multiple cities in Minnesota, Iowa, Michigan, and Indiana. "We have activated our Severe Weather Protocol in response to Winter Storm Elliot," the company said. According to The Weather Channel, Winter Storm Elliot is intensifying in the Plains, Midwest, and Great Lakes.

Share this -Link copied'It's too much for me': Zelenskyy begins speech by thanking U.S. Zelenskyy began his remarks before a joint meeting of Congress at 7:40 p.m. "I think we share the exact same vision, that of a free, independent and prosperous Ukraine," Biden said. The Ukrainian president added that the soldier told him that "many (of) his brothers, this system saved." President Joe Biden holds a medal presented to him by Ukrainian President Volodymyr Zelenskyy in the Oval Office. Share this -Link copiedPhoto: Zelenskyy shakes hands with Biden as he arrives President Joe Biden welcomes Ukrainian President Volodymyr Zelenskyy to the White House.

The Mark Cuban Cost Plus Drug Company negotiates directly with drugmakers. So far, that's been the strategy for the Mark Cuban Cost Plus Drug Company. In October, Cost Plus Drug Company announced a partnership with Capital Blue Cross. Cuban said he wanted Cost Plus Drug Company to be as transparent as possible on pricing. Cost Plus Drug Company is considering a test program for insulin that would offer a 90-day supply of insulin, or a total of 12 vials, for $170.

Hector Carvajal, 26, is the founder of Don Carvajal Cafe, a Dominican-sourced coffee roaster, and lives on $25,000 a year just outside New York City. Today, the 26-year-old runs Don Carvajal Cafe, a coffee roasting company out of the South Bronx that sources its beans from the Dominican Republic. "In the countryside of the Dominican Republic, we farm, we harvest, we roast coffee," he says. For the first three years of running his business, Carvajal lived rent-free with his mom in the Bronx in her rent-stabilized apartment. It's also why it's so important to him to source his coffee from farmers in the Dominican Republic.

☆ American college student who went missing in France reunited with family
▼ + stars: | 2022-12-17 | by ( Leila Sackur | ) www.nbcnews.com time to read: +2 min

An American college student who was reported missing during a study abroad trip in France has been reunited with his mother and is heading back to the United States, authorities said Saturday. DeLand had gone missing last month but made contact with his parents on Friday morning from Spain. They said at the time that they had last heard from DeLand on Nov. 27 via WhatsApp, a text message and calling app. The 22-year-old went to class on Nov. 28, his family had said. The following day, he left his host family’s home and boarded a train for Valence, France, packing a small bag that held his cellphone, food, wallet and a change of clothes.

An American college student who was reported missing during a study abroad trip in France is alive in Spain, his family and officials said Friday. A spokesperson for the Grenoble public prosecutor’s office said prosecutor Eric Vaillant told French media that Ken DeLand Jr. had been able to speak with his parents. The family said on a website dedicated to finding DeLand that he called them early Friday morning. On the website, the family thanked news outlets, saying: "Without the media’s help, Kenny would not have seen himself in the news." DeLand was reported missing last month while studying at the University Grenoble Alpes in France, his family said in an older post on the website.

☆ American college student reported missing while studying abroad in France
▼ + stars: | 2022-12-12 | by ( Marie Brockling | Gabrielle Nolin | ) www.nbcnews.com time to read: +3 min

An American college student has been reported missing by his family while studying abroad in France. The parents of 22-year-old Ken DeLand Jr. have set up a website in an effort to share information about their son, who they say has been missing since last month. The family says they “fear the worst and want him to be located.”DeLand Jr. was studying at the University Grenoble Alpes in France through a study abroad program. DeLand Jr. was last seen making a purchase at 9 a.m. on Dec. 3, 2022. A surveillance camera captured DeLand Jr. entering a sports store in Montelimar in southeast France on Dec. 3, where he made a purchase for $8.40, according to the parents.

☆ Poor sleep can make you prickly. Here’s what to do
▼ + stars: | 2022-12-01 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

Develop a sleep debt from those worries, and you’ll pay a price in your ability to think, plan and manage your emotions. “Sleep debt, also called a sleep deficit, is the difference between the amount of sleep someone needs and the amount they actually get,” said sleep specialist Dr. Raj Dasgupta, an associate professor of clinical medicine at the University of Southern California’s Keck School of Medicine. Research has found many people have little idea how much poor sleep has affected their mood and coping skills, said Dr. Bhanu Prakash Kolla, a sleep medicine specialist in the Center for Sleep Medicine at the Mayo Clinic in Rochester, Minnesota. Loss of sleep can directly affect your ability to control emotions and manage expectations, said Dr. Bhanu Prakash Kolla of the Mayo Clinic. “Sleep medications are seldom the solution for chronically poor sleep and impaired daytime functioning,” he said.

☆ Eisai, Biogen Alzheimer's drug slows cognitive decline, safety for some becomes focus
▼ + stars: | 2022-11-30 | by ( Deena Beasley | ) www.reuters.com time to read: +5 min

The drug, lecanemab, was associated with a type of brain swelling in 12.6% of trial patients, a side effect previously seen with similar drugs. He suggested that could be because homozygous study patients who were given a placebo fared better than expected. Overall, lecanemab patients benefited by 23% to 26% compared with a placebo on these secondary trial goals. Detailed data from the study were presented at the Clinical Trials on Alzheimer's Disease meeting in San Francisco and published in the New England Journal of Medicine. Dr. Howard Fillit, chief science officer at the Alzheimer’s Drug Discovery Foundation, said doctors always balance the benefits and risks of therapies.

In the early 2010s, Mr. Mellow set out for still more distant shores, traveling to many famous surf breaks in the South Pacific. Mr. Abdul-Rashed and Mr. Danian traveled to Hawaii to connect with Mr. Mellow, their spiritual guide and Pacific expedition leader. Mr. Mellow posted an ad on Facebook and Craigslist offering $10,000 for passage to the South Pacific. Mr. Schmidt was in sync with the young seekers when it came to fear of Big Brother and vaccines, but dreading port officials brandishing nasal swabs struck even Mr. Schmidt as a little unhinged. When asked if he was at all responsible for what had happened to Mr. Danian and Mr. Abdul-Rashed, Mr. Mellow looked genuinely confused.

☆ The mall where Black Friday refuses to die
▼ + stars: | 2022-11-25 | by ( Alicia Wallace | ) edition.cnn.com time to read: +10 min

Black Friday serves as the kickoff of the holiday shopping season here, ever since mall officials decided seven years ago to close on Thanksgiving Day. Jamie Kelter Davis for CNNShoppers walk through the mall during the day. “This particular year is going to be a real test of the traditional Black Friday shopping mall experience,” he said. Jamie Kelter Davis for CNNThe 30th Black Friday at the ‘megamall’The Mall of America was America’s brand-new “megamall,” hosting its first-ever Black Friday on November 27, 1992. Jamie Kelter Davis for CNN

☆ Inside a $2.5 million Michigan castle that harkens back to medieval Europe with its secret passageways, wooden drawbridge, and wine cellar
▼ + stars: | 2022-11-24 | by ( Robert Davis | ) www.businessinsider.com time to read: +4 min

The LeBlanc Castle is a custom 10,000-square-foot property about 30 minutes north of Detroit. The castle, set on more than 6 acres, has been on the market for three months asking $2.5 million. To this day, he has not spent a single night at the five-bedroom, seven-bathroom mansion a 30-minute drive north of Detroit known to locals as The LeBlanc Castle. It harkens back to the 15th-century Scottish medieval era with its secret passageways, wooden drawbridge, and other classical features like a moat. Since taking possession of the castle, Gatecliff said he has updated several pieces of the home's infrastructure.

☆ The dream of plant-based meat in fast food may already be dead
▼ + stars: | 2022-11-23 | by ( Mary Meisenzahl | ) www.businessinsider.com time to read: +3 min

Fast food chains have experimented with plant-based proteins for years with limited success. Plant-based meat is too expensive and adds too much complexity for widespread fast food adoption, an analyst said. Despite some exceptions like Burger King's Impossible Whopper, plant-based fast food menu items have largely been featured as limited-time offerings. It's "very hard" to convert meat eaters to plant-based meat, he said. Plant-based meat isn't likely to disappear from fast food menus, but it's also not going to replace beef.

☆ New York Approves First Batch of Recreational Marijuana Retailers
▼ + stars: | 2022-11-22 | by ( Jimmy Vielkind | ) www.wsj.com time to read: 1 min

New York state regulators Monday approved roughly three dozen dispensaries for the recreational sale of marijuana, despite a recent court ruling that limited the potential locations for stores. The first permits eventually will allow for the legal sale of marijuana in Manhattan, the Bronx, Queens and Staten Island—but not Brooklyn, the state’s most populous county. A federal judge in Albany earlier this month blocked the state’s Office of Cannabis Management from approving applications for stores in the borough as well as upstate regions including Syracuse, Rochester and Buffalo following a lawsuit by a company owned by a person convicted of a marijuana crime in Michigan who argued that the program’s requirements discriminate against out-of-state residents.

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