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☆ Levoit LVAC-200 cordless vacuum review: A powerful stick vac with value that exceeds its budget-friendly price
▼ + stars: | 2024-07-29 | by ( Pauline Lacsamana | Jaclyn Turner | ) www.businessinsider.com time to read: +16 min

Levoit LVAC-200 Cordless Stick Vacuum Levoit's cordless stick vacuum offers great performance for the price. AdvertisementOur review of the Levoit LVAC-200 Cordless VacuumThe Levoit LVAC-200 is lightweight and easy to use, plus it can stand on its own, without a dock. This rings true for the Levoit LVAC-200 Cordless Vacuum. The LVAC-200 Cordless Vacuum is compact but packs a major punch with performance almost on par with the high-end vacuums I've tried. Some purchase-worthy alternatives are our best overall and budget-friendly picks, the Shark Stratos Cordless Vacuum and Hoover OnePWR Evolve Pet Elite Cordless Vacuum, respectively.

Persons: I'm, Levoit, Pauline Lacsamana, isn't, it's, Dyson, vacuums I've, scratchers, Cheerios, It's, I've, Sophia Carlisle, we've, Stratos, Hoover OnePWR, Hoover, Ken Doty Organizations: Business, Eco, micron, Shark, Hoover

☆ Alzheimer’s blood test catches 90% of early dementia cases, study finds
▼ + stars: | 2024-07-28 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +10 min

CNN —A combined blood test for cognitive decline has a 90% accuracy rate in determining whether memory loss is due to Alzheimer’s disease, a new study found. “The p-tau217 blood test is turning out to be the most specific for Alzheimer’s and the one with the most validity. “These are absolutely transformational times.”How does a p-tau217 blood test work? The results of the blood tests were then measured against patient diagnoses provided by Swedish primary care doctors and specialists. “There’s no one more bullish on these tests than I am, but Alzheimer’s blood tests aren’t fully definitive yet,” he said.

Persons: CNN —, Sebastian Palmqvist, ” Palmqvist, ”, Maria Carrillo, Carrillo, “ You’re, that’s, ” Carrillo, “, ” Tau tangles, Richard Isaacson, Oskar Hansson, ” Hansson, Hansson, Isaacson, ” Isaacson Organizations: CNN, Lund University, “, Alzheimer’s Association, International Conference Locations: Sweden, Alzheimer’s, Florida, United States, Philadelphia

☆ In new criteria for Alzheimer’s, some see much-needed progress while others fear profit may be driving ‘diagnostic creep’
▼ + stars: | 2024-07-01 | by ( Brenda Goodman | ) edition.cnn.com time to read: +12 min

CNN —With another pricey Alzheimer’s disease treatment expected to receive an approval decision soon, the nonprofit Alzheimer’s Association has published the final version of its new diagnostic criteria for the disease. Together with another protein, tau, which makes fibrous tangles that block the communication of nerve cells, they are considered a hallmark of Alzheimer’s disease. “There’s no evidence for it,” said Dr. George Perry, a neurobiologist and editor of the Journal of Alzheimer’s Disease. Two members of the panel were employees of the Alzheimer’s Association, which also takes funding from pharmaceutical companies. Widera says he hopes that in the next round of guidelines, the Alzheimer’s Association will consider the risks involved.

Persons: There’s, –, donanemab, “, ”, George Perry, Adriane Fugh, Berman, haven’t, Maria C, Carrillo, Alzheimer’s, It’s, Eric Widera, Widera, it’s, Aduhelm, Karl Herrup, Clifford Jack, ” Jack, “ It’s, Niles Franz, ” Franz, Dr, Sanjay Gupta, Franz, ” Widera Organizations: CNN, Alzheimer’s Association, Food and Drug Administration, FDA, Georgetown University, University of California San, American Geriatrics Society, Abbott Labs, University of Pittsburgh School of Medicine, Mayo Clinic, Nature Medicine, federal National Institute, Aging, Alzheimer’s Association International, National Institute, National Institutes of Health, NIA, Alzheimer’s, National Academy of Medicine, CNN Health, Association Locations: University of California San Francisco

☆ Nigel Farage: The US-style migration debate taking over Britain’s election
▼ + stars: | 2024-06-16 | by ( Rob Picheta | ) edition.cnn.com time to read: +14 min

“It’s a bit like God’s waiting room.”But Clacton is the front line of Britain’s migration debate. The Reform leader uses divisive language on migration, warning supporters of what he calls an "invasion" of asylum seekers. Despite years of tough rhetoric and policies aimed at deterring the arrival of asylum seekers – devised largely to placate Farage’s supporters – Britain’s asylum system is creaking. Laws prevent most asylum seekers from working, so while taxpayers fund their accommodation, they cannot contribute formally to the economy. That could widen even further the chasm in understanding between his voters and Britain’s asylum seekers, experts fear.

Persons: ” Danny Botterell, Nigel Farage, BEN STANSALL, Donald Trump, Nigel, ” Botterell, “, Farage, ” Farage, –, Rob Picheta, CNN Britain’s, Rishi Sunak’s, ” Zoe Gardner, “ Farage, “ They’ll, ”, Louise Brockwell, Danny Botterell, David Cameron –, Europe –, Sunak, Cameron, Farage’s, ted Britain’s, France –, ” Gardner, Masood, they’re, ” Masood, Brexit, Douglas Carswell, ” Carswell, ” “ There’s, Carswell, Bob Brace, Farage's, hasn’t, Jack, can’t, you’re, Bridget Tyril, Roy Whitehead, Keir Starmer, “ It’s, they’ve, Karen French, “ I’ve, He’s, James Johnson, Theresa May’s, pollster, Queen Elizabeth II, restauranter Dean Coles, Jehosh, Gardner Organizations: England CNN —, Seagulls, CNN, Getty, Clacton, Labour, Brexit Party, Tories, Jays, Sky News, Times, Home Office, Conservative, UKIP, EU, Brexit, Mississippi Center for Public, John, People, Trump, Downing, Partners, “, Conservatives Locations: Clacton, England, Clacton Pier, Europe, ”, London, “, AFP, United States, Britain, Westminster, India, France, Bibby Stockholm, Kent, Afghanistan, UAE, Essex, Jaywick, It’s France, Netherlands, Germany

☆ The scary secret behind the boom in data centers
▼ + stars: | 2024-06-04 | by ( Adam Rogers | ) www.businessinsider.com time to read: +10 min

Last year all the data centers in the world had room for 10.1 zettabytes of information — roughly 456 billion Wikipedias. And with the rise of artificial intelligence, which requires vast quantities of data and power, the global capacity of data centers is expected to double by 2027. Data centers are more than just vast digital warehouses. The more data centers those companies have, the more of those services they can offer, and the more storage and number-crunching capacity they can provide. Over time, economists warn, AI startups will inevitably lose out to the tech giants that control the data centers.

Persons: they're, Cecilia Rikap, Matthew Wansley, Jonas Jacobi, Jacobi, It's, Rikap, Bengt, Åke, There's, Lina Khan, Today's, Adam Rogers Organizations: Google, Microsoft, Amazon Web Services, Big Tech, Corporate, Regulators, Yeshiva University, Amazon, Venture, Aalborg University, Tech, Google Cloud, Federal Trade Commission, Business Locations: OpenAI, Hotel California, Denmark, Europe, lockstep

☆ Nerd world's most famous faces are out to conquer the gothic horror gaming space — and their heartbreak prince is here to get the job done
▼ + stars: | 2024-04-08 | by ( Cheryl Teh | ) www.businessinsider.com time to read: +10 min

Critical Role recently released "Candela Obscura," a gothic horror roleplaying game. These qualities make O'Brien ideal for stepping into the game master role for "Candela Obscura," Critical Role's new gothic horror game, and he's leaning hard into the tragedy. AdvertisementIt's also one of the more punishing gaming systems he's played in, O'Brien told during our video call. Mercer, the team's designated game master, is the one who crafts the narrative and controls how the story develops. "I always prefer complicated narratively satisfying endings to a neat little happy ending," O'Brien told me.

Persons: Liam O'Brien, —, Matthew Mercer, O'Brien, I've, It's, he's, Twitch, Mercer, — O'Brien, — Taliesin Jaffe, Imari Williams, Aimee Carrero, Alexander Ward —, Taliesin Jaffe, Alexander Ward, Julius Caesar, Irish, Martin McDonagh, Spenser Starke, Rowan Hall, Aabria Iyengar, Starke, Mary Shelley, it's, Amazon, Marisha Ray, Travis Willingham, Ashley Johnson, Sam Riegel, Laura Bailey, Matthew Mercer Robyn von Swank Organizations: Service, Wembley, Darrington Press, Hasbro's, Hasbro, CR Locations: Europe, Ireland, New York, Mercer, Starke

☆ Critical Role's heartbreak prince helped make 'Dungeons & Dragons' cool. Now he's coming for the gothic horror gaming scene.
▼ + stars: | 2024-04-08 | by ( Cheryl Teh | ) www.businessinsider.com time to read: +10 min

Critical Role recently released "Candela Obscura," a gothic horror roleplaying game. AdvertisementIn October, Critical Role, a crew of eight self-professed "nerdy-ass voice actors," played their long-running "Dungeons & Dragons" game at a sold-out Wembley Arena. These qualities make O'Brien ideal for stepping into the game master role for "Candela Obscura," Critical Role's new gothic horror game, and he's leaning hard into the tragedy. AdvertisementIt's also one of the more punishing gaming systems he's played in, O'Brien told me during our video call. Mercer, the team's designated game master, is the one who crafts the narrative and controls how the story develops.

☆ A Great Lakes Pipeline Tangles Politics in Two Battleground States
▼ + stars: | 2024-03-27 | by ( Rebecca Halleck | Dionne Searcey | ) www.nytimes.com time to read: +1 min

An icy crust on the Straits of Mackinac is melting into slush atop a shimmering, narrow waterway prized for its beauty and its role in supporting the local economy. The fight over Line 5 in both Michigan and Wisconsin, where another section of the pipeline crosses the Bad River Reservation, could have sweeping implications for the power of states to regulate fossil fuels, for tribal sovereignty and for U.S.-Canada relations. Some or all of these issues are bound to surface in the upcoming presidential election. Both Wisconsin and Michigan are battleground states. And in either place the debate over Line 5 could complicate election-year politics, particularly as candidates compete to eke out any advantage with voters they can find, whether on environmental issues, fossil fuel reliance or jobs.

Organizations: U.S Locations: Mackinac, Lake Huron, Lake Michigan, Michigan, Wisconsin, Canada

☆ Apparently Healthy, but Diagnosed With Alzheimer’s?
▼ + stars: | 2024-03-04 | by ( Paula Span | ) www.nytimes.com time to read: 1 min

Determining whether someone has Alzheimer’s disease usually requires an extended diagnostic process. A doctor takes a patient’s medical history, discusses symptoms, administers verbal and visual cognitive tests. or a spinal tap — tests that detect the presence of two proteins in the brain, amyloid plaques and tau tangles, both associated with Alzheimer’s. All of that could change dramatically if new criteria proposed by an Alzheimer’s Association working group are widely adopted. Its final recommendations, expected later this year, will accelerate a shift that is already underway: from defining the disease by symptoms and behavior to defining it purely biologically — with biomarkers, substances in the body that indicate disease.

Organizations: Alzheimer’s Association

☆ Healthy living may battle cognitive decline even with signs of dementia in the brain, study suggests
▼ + stars: | 2024-02-05 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +6 min

CNN —Living a healthy lifestyle with a focus on a nutritious diet, regular exercise, minimum alcohol consumption and other healthy habits can help keep your brain sharp into old age, doctors say. But what if your brain already has signs of beta amyloid or tau — two of the hallmark signs of Alzheimer’s and other brain pathologies? Will a healthy lifestyle still protect you from cognitive decline? Not everyone who has signs of Alzheimer’s or vascular dementia goes on to develop cognitive issues, but many do. In fact, “a higher healthy lifestyle score was associated with better cognition even after accounting for the combined burden of brain pathologies,” according to Yaffe and Leng.

Persons: ”, Dr, Klodian, Richard Isaacson, “, Isaacson, wasn’t, —, Kobus, Lewy, Yue Leng, Kristine Yaffe, Yaffe, San Francisco Weill Institute for Neurosciences . Leng, Leng, it’s Organizations: CNN, Rush Institute, Healthy Aging, Rush University, “, University of California, San Francisco Weill Institute for Neurosciences . Locations: Chicago, Florida, San

☆ ‘I.S.S.’ Review: Ariana DeBose’s Turn as a Space Warrior
▼ + stars: | 2024-01-18 | by ( Manohla Dargis | ) www.nytimes.com time to read: +1 min

Three Americans, three Russians and one exceedingly cramped office hovering 250 miles above Earth — what could possibly go wrong? Given the typical genre coordinates, the 95 minute running time and historic hostilities between Russia and the United States, the more relevant questions here are when and how quickly and entertainingly things will go kablooey in “I.S.S.,” an enjoyable, low-wattage thriller set on the International Space Station. There are nothing but bilateral hugs and smiles when the space newbie Kira Foster (Ariana DeBose) arrives on the station, having been shot into the story on a Russian Soyuz rocket. The movie — written by Nick Shafir and directed by Gabriela Cowperthwaite — flashes its wailing red alarms early and often. The space station itself — a cluttered warren with tangles of wires, claustrophobic chambers and eerily weightless bodies — makes a convincing pressure cooker.

Persons: Kira Foster, Ariana DeBose, John Gallagher Jr, —, Nick Shafir, Gabriela Cowperthwaite —, who’s, Alexey, Pilou, gruffly, Kira Organizations: Space, Russian Soyuz Locations: Russia, United States, “ I.S.S, Russian

☆ Bigger belly in 40s and 50s linked to early signs of Alzheimer’s disease
▼ + stars: | 2023-11-20 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +8 min

CNN —Inflammation from belly fat may be linked to the early stages of Alzheimer’s disease decades before symptoms begin, new research has found. “That’s important because brain atrophy is another biomarker of Alzheimer’s disease,” Raji said. “These are people who, if they do develop Alzheimer’s disease, it won’t happen for another 20 or 25 more years. “Regardless of weight, people should find out if they have hidden visceral fat,” Raji said. Visceral fat ‘easier to lose’There’s good news: Visceral fat responds well to diet and exercise, Raji said.

Persons: “, ”, Richard Isaacson, Isaacson, Cyrus Raji, St . Louis, ” Raji, Dr, Mahsa, Raji, ” Isaacson, It’s Organizations: CNN, Washington University School of Medicine, Radiology Society, Cleveland Clinic, Mayo Clinic Locations: Florida, St .

☆ Between Israelis and Palestinians, a Lethal Psychological Chasm Grows
▼ + stars: | 2023-11-20 | by ( Roger Cohen | More About Roger Cohen | ) www.nytimes.com time to read: +2 min

But in general the decades since the collapse of the Oslo Accords in 1993 have accentuated the psychological gulf. Day-to-day interaction between Israelis and Palestinians in the West Bank and Gaza has been drastically reduced by walls and fences in a push for physical separation. In the intervening decades, Hamas and the ultranationalist religious Israeli right have each extended their influence. “On the Palestinian side, the ideal solution has become that Israel disappear,” Professor Shany said. “On the Israeli side, there is a desire for Gaza to go away, even if that means bombing it away.

Persons: Yitzhak Rabin’s, “, God, Jordan, Peace, ”, Yuval Shany, Mahmoud al, Shany Organizations: Oslo Accords, West Bank, Hebrew University of Jerusalem Locations: Oslo, Gaza, Palestine, France, Germany, Alsace, Lorraine, Ireland, Israel, “ Israel, Ethiopia, Poland, America

Former U.S. President Donald Trump attends the Trump Organization civil fraud trial, in New York State Supreme Court in the Manhattan borough of New York City, U.S., November 6, 2023. Trump's testimony wrapped up in midafternoon. Over roughly four hours on the witness stand, Trump often avoided direct answers, instead bragging about his properties and his wealth. New York state lawyers said in their lawsuit that the estimates misled lenders and insurers, earning him more than $100 million and exaggerating his wealth by $2 billion. At one point when Trump was on the stand, Engoron asked Kise to take Trump to the back of the courtroom and "explain the rules."

Persons: Donald Trump, Eduardo Munoz, Arthur Engoron, Trump, Engoron, Christopher Kise, Ivanka, Letitia James, Alina Habba, I've, James, Kise, Eric, Donald Jr, Michael Cohen, Trump's, Jack Queen, Luc Cohen, Andy Sullivan, Scott Malone, Lisa Shumaker, Grant McCool Organizations: U.S, Trump Organization, Court, REUTERS Acquire, Companies Trump Organization, Trump, Republican, New, Deutsche Bank, Mar, Thomson Locations: New York, Manhattan, New York City, U.S, midafternoon, Doral, Florida, Springs, United States

☆ Trump tangles with judge at NY fraud trial
▼ + stars: | 2023-11-06 | by ( Reuters Editorial | ) www.reuters.com time to read: 1 min

PoliticsTrump tangles with judge at NY fraud trialPostedDonald Trump complained of unfair treatment in a defiant and rambling performance on the witness stand on Monday, prompting the judge overseeing his New York civil business-fraud trialto threaten to cut his testimony short. This report produced by Jillian Kitchener.

Persons: Donald Trump, Jillian Kitchener Organizations: Trump, New Locations: New York

[1/5] Actor Nadjma Abshir, 29 year old, performs a scene from the play ‘Desperate Times’, a sell-out comedy presentation by the Somali women's theatre company ‘Side eYe Productions’, at the Rich Mix arts centre in London, Britain, October 25, 2023. Artistic director Hannah Abdule, a civil servant, co-founded Side eYe Productions in 2019 to create opportunities she felt were denied to people like her. As part of its inclusive mission, Side eYe aims to give opportunities to Somali women with little theatrical experience. "Our parents had more of a mentality of survival and that is getting traditional jobs in sciences, teaching," Abshir said. "We've done what we've needed to do and are looking at the things that truly interest us."

Persons: Nadjma Abshir, Hannah McKay, Hannah Abdule, Sabrina Ali, tangles, Amal Abdi, Abshir, Barbara Lewis, Emelia Sithole Organizations: Somali women's, Rich Mix, REUTERS, Edinburgh Fringe, Somali, Somali Arts and Culture, Thomson Locations: Somali, London, Britain, England, Sheffield, Bristol

☆ Sweet spot for HRT may reduce dementia risk by nearly a third, study says
▼ + stars: | 2023-11-02 | by ( Sandee Lamotte | ) edition.cnn.com time to read: +8 min

Just how harmful or helpful hormone replacement therapy may be also depends on the type of hormones that are prescribed, especially at older ages. Estrogen-only hormone therapy can be prescribed if the uterus has been removed via hysterectomy. Scientists are developing a new generation of hormone replacement called selective estrogen receptor modulator, or SERM. Scientists are working on new forms of hormone replacement therapy that go directly to the brain, thus making them safer for menopausal women. In addition, some women are not candidates for hormone replacement therapy, perhaps due to family history, heart conditions or clotting disorders.

Persons: hasn’t, “, ”, Lisa Mosconi, Mosconi, Richard Isaacson, ” Isaacson, gynecologists, midlife, ” Mosconi Organizations: CNN, Weill Cornell Medicine, “ Locations: New York City, midlife, Florida

☆ ‘George Harrison’ Review: Why His Guitar Gently Wept
▼ + stars: | 2023-10-21 | by ( D.J. Taylor | Philip Norman | ) www.wsj.com time to read: +2 min

George Harrison (with Eric Clapton at left) performing at the Concert for Bangladesh in August 1971. Photo: Henry Diltz/Getty ImagesThe paradoxes of George Harrison’s career can perplex even the most casual Beatles fans. Grab a Copy George Harrison: The Reluctant Beatle By Philip Norman Scribner 512 pages We may earn a commission when you buy products through the links on our site. One of the most ominous subtexts of “George Harrison: The Reluctant Beatle,” it turns out, is the sense of a man grown old before his time. Hospitalized for six weeks at the age of 13 with nephritis, a martyr to swollen tonsils and on-tour exhaustion, he spent much of his early life being ill.

Persons: George Harrison, Eric Clapton, Henry Diltz, George Harrison’s, John Lennon’s solipsism, Paul, ”, Harrison, Philip Norman, Philip Norman Scribner, Barnes, Norman, “ George Harrison, Ed Sullivan, Monty Python’s Eric Idle Organizations: Concert, Bangladesh, Noble

☆ Doubts abound about a new Alzheimer’s blood test
▼ + stars: | 2023-10-18 | by ( Judith Graham | ) edition.cnn.com time to read: +10 min

The Quest Diagnostics blood test, AD-Detect, measures elevated levels of amyloid-beta proteins, a signature characteristic of Alzheimer’s. But Alzheimer’s researchers and clinicians aren’t convinced the Quest test is backed by sound scientific research. Though blood tests for Alzheimer’s are likely to become common in the years ahead, the Alzheimer’s Association said it’s premature to offer a test of this kind directly to consumers. Because the science behind blood tests for Alzheimer’s is still developing and because “patients may not really understand the uncertainty of test results,” Edelmayer said, the Alzheimer’s Association “does not endorse the use of the AD-Detect test by consumers.”Quest’s blood test is one of several developments altering the landscape of Alzheimer’s care in the United States. The bottom line: Before taking a test, “older adults need to ask themselves, ‘Why do I want to know this?

Persons: aren’t, Alzheimer’s, Michael Racke, ”, there’s, Suzanne Schindler, St . Louis, That’s, ” Schindler, Racke, Meera Sheffrin, —, Rebecca Edelmayer, ” Edelmayer, Eric Widera, Dr, Sanjay Gupta, Emily Largent, ’ ”, Munro Cullum Organizations: Health, Diagnostics, Alzheimer’s Association, Quest, University of Michigan, International Conference, Washington University School of Medicine, Senior, Stanford Healthcare, The University of Michigan, FDA, National Institute, Aging, University of California, Get CNN, CNN Health, University, Pennsylvania’s Perelman, of Medicine, HIPAA, University of Texas Southwestern Medical Center, Kaiser Health, KFF Locations: U.S, San Diego, St ., United States, San Francisco

☆ Blood tests needed for widespread Alzheimer's diagnosis on the way
▼ + stars: | 2023-10-11 | by ( Deena Beasley | ) www.reuters.com time to read: +6 min

Several Alzheimer's blood tests are in the works – and one is already being sold to consumers – but none have been established as accurate, formally approved by regulators or reimbursed by insurers. Researchers have been working for years on blood tests for Alzheimer's that can replicate these diagnostic tools. The need for blood tests has become more pressing since the FDA approved Leqembi in July. Accurate blood tests are expected to help identify which dementia patients actually have Alzheimer’s, the most common but not the only cause of dementia. "When there are widely available, scalable, sensitive and specific blood tests it will be an absolute game changer for Alzheimer's patients."

Persons: Denis Balibouse, Eli Lilly, Dr, Sarah Kremen, Eliezer Masliah, Eisai, Michael Irizarry, Roche, Bruce Jordan, Russ Paulsen, Deena Beasley, Caroline Humer, Bill Berkrot Organizations: Memory Centre, of Readaptation, University Hospital, REUTERS, FDA, Sinai Medical Center, Wednesday, Quest Diagnostics, National Institute, Aging, U.S . National Institutes of Health, C2N Diagnostics, Roche Diagnostics, Alzheimer's Association, RAND, Thomson Locations: Geneva, Switzerland, Leqembi, Eisai, Los Angeles, U.S

Defendants have been filing a slew of motions for separate trials, faster trials, trial in a different jurisdiction or – in Trump's case – no trial at all. But the flurry of paperwork could delay the trials, aiding Trump's efforts to push off any resolution until after the 2024 elections. "The RICO conspiracy charge ensures any trial would share the same evidence and witnesses,” Willis wrote. Prosecutors in all of the cases against Trump have apparently anticipated the efforts to draw out the cases. Putting all 19 defendants on trial next month, however, is a bigger legal and logistical task – and one the judge appears skeptical could happen.

Persons: Donald Trump, Racketeer, Fani Willis, Willis, ” Willis, Trump, Mark Meadows, Steve Jones, Trump –, Meadows, Jack Smith, Kenneth Chesebro, Sidney Powell, Scott McAfee, Joe Biden, ” McAfee, –, Chesebro, Powell Organizations: Fulton, Circuit, Appeals, Prosecutors, Trump, District of Columbia Locations: Georgia, Fulton County, Fulton, Meadows, U.S, Florida, Atlanta

☆ DeSantis sharpens critique of Trump but faces huge odds
▼ + stars: | 2023-08-01 | by ( Stephen Collinson | ) edition.cnn.com time to read: +14 min

While he faces classic signs of a campaign in free fall, including staffer layoffs and donor concern, DeSantis’ problems are not all self-inflicted. Keith Davis, who has served as Sheriff of Wayne County since 1997, is a Trump voter who is now backing DeSantis. Scott Olson/Getty ImagesIn his first post-reset swing through Iowa, DeSantis had mixed results. While he was in Iowa, DeSantis also repeatedly paid tribute to Reynolds after Trump alienated some caucus-goers by badmouthing the state’s popular Republican governor. But what DeSantis is trying to do, by running a classic Iowa campaign, is a ultimately a conventional move.

Persons: Donald Trump –, Ron DeSantis, DeSantis, ”, Angus, Rudy Giuliani, Scott Walker, Jeb Bush, Trump, he’s, “ There’s, ” DeSantis, Fox’s Bret Baier, Bill Clinton, “, who’s, He’s, Charlie Neibergall, –, Keith Davis, Kim Reynolds, Davis, ” Davis, mouthing Trump, Dee Snodgrass, Scott Olson, Donald J, Ralph Alshouse, Reynolds, Terry Branstad, it’s, Dr, Anthony Fauci, Kamala Harris, won’t, Reba Saldanha, Reuters DeSantis, Jimmy Carter, Barack Obama, Clinton, John McCain Organizations: Iowa CNN, Florida Gov, Wayne County, Hawkeye State, Trump, Republican Party, New York Times, Siena, Republican, GOP, Republican Party of, Iraq, Yale, Harvard, Reagan, “, Republican Party of Iowa, DeSantis, Jimmy Centers, PAC, Gov, Reuters, Fox News Locations: Chariton, Iowa, Wayne, The Florida, Florida, Granite State, New Hampshire, Wayne County, American, Arkansas, Des Moines, DeSantis, Knoxville , Iowa, Washington, Rye , New Hampshire

☆ Volkswagen Seeks to Regain Edge in China as It Cuts Delivery Forecast
▼ + stars: | 2023-07-27 | by ( Melissa Eddy | More About Melissa Eddy | ) www.nytimes.com time to read: +3 min

But overall revenue increased 18.2 percent as the company stemmed some of its losses in China, where deliveries were down 1.2 percent. Western Europe provided the company with its strongest business, with 1.65 million vehicles ordered in the first half of the year, and 200,000 of them — or 12 percent — were electric vehicles, the company said. Volkswagen hopes that its investment in XPeng will help advance the German automaker’s electric vehicle software to the standards produced by Chinese manufacturers. Some analysts interpreted the move as a concession that Volkswagen was unable to compete with Chinese companies on the latest technology. But Oliver Blume, Volkswagen’s chief executive, expressed confidence that VW customers, including those in China, want more variety in their vehicles.

Persons: ”, Ferdinand Dudenhöffer, Oliver Blume, Mr, Blume, “ Organizations: Volkswagen, Volkswagen Group Rus, China, BYD, Audi, SAIC, British, Center for Automotive Research, “, Tesla, Volkswagen Group, Porsche, Lamborghini, VW Locations: China, Western Europe, Russia, Avilon, Moscow, XPeng, Duisburg, Germany

☆ Treating Alzheimer’s Very Early Offers Better Hope of Slowing Decline, Study Finds
▼ + stars: | 2023-07-17 | by ( Pam Belluck | More About Pam Belluck | ) www.nytimes.com time to read: +1 min

Treating Alzheimer’s patients as early as possible — when symptoms and brain pathology are mildest — provides a better chance of slowing cognitive decline, a large study of an experimental Alzheimer’s drug presented Monday suggests. The study of 1,736 patients reported that the drug, donanemab, made by Eli Lilly, can modestly slow the progression of memory and thinking problems in early stages of Alzheimer’s, and that the slowing was greatest for early-stage patients when they had less of a protein that creates tangles in the brain. For people at that earlier stage, donanemab appeared to slow decline in memory and thinking by about four and a half to seven and a half months over an 18-month period compared with those taking a placebo, according to the study, published in the journal JAMA. Among people with less of the protein, called tau, slowing was most pronounced in those younger than 75 and those who did not yet have Alzheimer’s but had a pre-Alzheimer’s condition called mild cognitive impairment, according to data presented Monday at the Alzheimer’s Association International Conference in Amsterdam. “The earlier you can get in there, the more you can impact it before they’ve already declined and they’re on this fast slope,” Dr. Daniel Skovronsky, Eli Lilly’s chief medical and scientific officer, said in an interview.

Persons: Eli Lilly, donanemab, “, they’ve, Dr, Daniel Skovronsky, Eli Lilly’s Organizations: Alzheimer’s Association International Locations: Amsterdam

☆ Alzheimer's diagnosis revamp embraces rating scale similar to cancer
▼ + stars: | 2023-07-16 | by ( Julie Steenhuysen | ) www.reuters.com time to read: +4 min

July 16 (Reuters) - Alzheimer's disease experts are revamping the way doctors diagnose patients with the progressive brain disorder - the most common type of dementia - adopting a seven-point rating scale based on cognitive and biological changes in the patient. "Stage 1a is really the beginning of evidence that someone has the disease," Jack said. The new scale also includes a Stage 0 for people who carry genes that guarantee they will develop Alzheimer's. Noting the new system's similarity to cancer stages, Jack said, "There's no such thing as mild breast cancer. Jack also noted that many other conditions can cause dementia but not all dementia is Alzheimer's disease.

Persons: Clifford Jack, Eli Lilly's, Maria Carrillo, Jack, Julie Steenhuysen, Will Dunham Organizations: Alzheimer's Association, Mayo Clinic, National Institute of Aging, government's National Institutes of Health, Drug Administration, FDA, Down, Thomson Locations: Amsterdam, Rochester , Minnesota, Chicago

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