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☆ CNBC Daily Open: S&P 500 briefly crosses 5,500, closes lower
▼ + stars: | 2024-06-21 | by ( Abid Ali | ) www.cnbc.com time to read: +3 min

This report is from today's CNBC Daily Open, our international markets newsletter. CNBC Daily Open brings investors up to speed on everything they need to know, no matter where they are. S&P 500 slips from record highThe S&P 500 briefly passed the 5,500 mark for the first time before ending the session lower. Open AI challengerAnthropic, a leading AI competitor to OpenAI, unveiled Claude 3.5 Sonnet, its most advanced AI model to date. [PRO] AI real estateCiti analysts pinpoint a "compelling emerging" real estate trend fueled by AI and nearshoring.

Persons: Gilead, Anthropic, Claude, Donald Trump's, Trump, Masato Kanda Organizations: New York Stock Exchange, CNBC, Nasdaq, Nvidia, Dow Jones, Gilead Sciences, Google, Trump Media, New, Nikkei, Bank of, Reuters, United, CSI, Citi Locations: New York City, U.S, New York, Japan, United States, Asia, Pacific

☆ Gilead’s twice-yearly shot to prevent HIV succeeds in late-stage trial
▼ + stars: | 2024-06-20 | by ( Angelica Peebles | In Angelicapeebles | ) www.cnbc.com time to read: +3 min

Gilead 's experimental twice-yearly medicine to prevent HIV was 100% effective in a late-stage trial, the company said Thursday. The results bring Gilead one step closer to introducing a new form of pre-exposure prophylaxis, or PrEP, and broadening its HIV business. If those results are positive, the company could bring lenacapavir for PrEP to market as soon as late 2025. RBC Capital Markets analyst Brian Abrahams expects Gilead's shot will significantly increase the number of people interested in preventive HIV medicine. In its statement disclosing the lenacapavir trial results Thursday, Gilead said it plans to share an update on how it plans to address access in such countries where people suffer high incidence rates of HIV.

Persons: Gilead, Jared Baeten, Gilead's Truvada, Bruce Richman, Tim Oliver, they'd, Brian Abrahams, Gilead's, — CNBC's Leanne Miller Organizations: Food and Drug Administration, PrEP, Centers for Disease Control, Prevention, Health, FDA, RBC Capital Locations: U.S, New York

☆ Australian sheep, cattle prices slump as El Nino scorches pastures
▼ + stars: | 2023-11-29 | by ( Peter Hobson | ) www.reuters.com time to read: +6 min

After three years of plentiful rain and rising livestock numbers, dry weather has withered pastures across Australia. The extreme change in conditions has helped trigger the fastest plunge in cattle and sheep prices in decades, threatening livelihoods in Australia's A$75 billion ($50 billion) red meat and livestock industry. While farmers suffer, falling livestock prices have brought some relief to Australian households hurting from high inflation. Falling U.S. beef production means demand for Australian beef should rise, helping support livestock prices, said Angus Gidley-Baird, an analyst at Rabobank in Sydney. Agricultural consultants Episode 3 estimate that Australian beef processors are reaping their best profits in at least two decades thanks to low local cattle prices and high sale prices in export markets.

Persons: Angus Hobson, Peter Hobson, Angus, Hobson, Stuart Austin, Wilmot, Angus Gidley, Baird, Teys, Mat Larkings, gaunt, haven't, they'll, Sonali Paul Organizations: Livestock, New, REUTERS, Beef, Livestock Australia, Woolworths, Data Monitor, Rabobank, Meat packers, Teys Australia, Farmers, Thomson Locations: Delegate, New South Wales, Australia, Angus Hobson's, Australia's, United States, El Nino, Japan, China, Sydney, Walcha

☆ Bayer Cancels Asundexian Phase III Study Program
▼ + stars: | 2023-11-19 | by ( Nov. | At P.M. | ) www.usnews.com time to read: +1 min

(Reuters) - Germany's Bayer AG said on Sunday it is cancelling a phase III study program to investigate the efficacy and safety of asundexian, an oral Factor XIa (FXIa) inhibitor. The decision to stop the study is based on the recommendation by the Independent Data Monitoring Committee (IDMC). IDMC monitoring showed an inferior efficacy of asundexian compared to the control arm of the study. "A phase III study investigating asundexian compared to Apixaban in patients with atrial fibrillation at risk for stroke is being stopped early," the company said in a statement. Bayer, which initiated the study in August 2022, said it will further analyze the data to understand the outcome and will take appropriate measures.

Persons: Bayer, Jose Joseph, Chris Reese Organizations: Reuters, Germany's Bayer AG, Independent Data Monitoring, Bayer Locations: Bengaluru

☆ Shares of dialysis providers drop after Ozempic's early kidney trial success
▼ + stars: | 2023-10-11 | by ( ) www.reuters.com time to read: +2 min

The outdoor sign seen at the DaVita Dialysis clinic in Denver February 16, 2016. U.S.-listed shares of Fresenius fell 16.4%, to $17.5, and Davita fell about 16%, to $76.7, in premarket hours. Shares of U.S.-based Baxter International (BAX.N), which makes products used by dialysis therapy providers, also fell about 9%, to $33.99 premarket. Davita and U.S.-listed shares of Fresenius Medical are among the top percentage losers on the New York Stock Exchange. As of Tuesday's close, U.S.-listed shares of Fresenius were up about 28.2%, Davita's shares were up 22.2%, while Baxter's shares were down about 27% so far this year.

Persons: Rick Wilking, Ozempic, Danish drugmaker, Veronika Dubajova, Davita, Eli Lilly's, Akash Tewari, Fresenius, Mariam Sunny, Janane Venkatraman, Pooja Desai Organizations: REUTERS, Novo Nordisk's, Citi, Baxter, Jefferies, Fresenius, New York Stock Exchange ., Thomson Locations: Denver, Danish, Fresenius, New York Stock Exchange . Frankfurt, U.S, Bengaluru

☆ Novo Nordisk stops Ozempic kidney trial after early signs of success
▼ + stars: | 2023-10-10 | by ( Patrick Wingrove | ) www.reuters.com time to read: +2 min

Pens for the diabetes drug Ozempic sit on a production line to be packaged at Danish drugmaker Novo Nordisk's site in Hillerod, Denmark, September 26, 2023. Novo said the trial would be halted almost a year early based on a recommendation from the independent data monitoring board overseeing the study. Independent monitors can recommend stopping a trial early if there is clear evidence that a drug was going to succeed or fail based on interim analyses. Semaglutide is also the active ingredient in Novo Nordisk's powerful weight-loss drug Wegovy. Novo's success has also created an economic boom for Denmark, according to Danish economists, analysts, and executives at the Novo Nordisk Foundation.

Persons: Tom Little, Novo, Danish drugmaker, Wegovy, Emily Field, Patrick Wingrove, Sriparna Roy, Bill Berkrot Organizations: REUTERS, Novo Nordisk, Barclays, Novo Nordisk Foundation, Thomson Locations: Hillerod, Denmark, Danish, New York, Bengaluru

☆ As Apple launches new phone, key facts on titanium
▼ + stars: | 2023-09-13 | by ( ) www.reuters.com time to read: +2 min

A man check his phone near an Apple logo outside its store in Shanghai, China September 13, 2023. China's titanium producers said they expect stronger demand after the launch of the new Apple models. Titanium minerals are used to make titanium sponge which can be turned into metal for industrial applications. China was the second largest importer of titanium sponge with more than 13,000 tons last year, followed by South Korea with 9,000 tons, according to TDM. WHAT IS TITANIUM USED FOR?

Persons: Aly, Pratima Desai, Emelia Sithole Organizations: Apple, REUTERS, United States Geological Survey, WHO, Trade Data Monitor, Titans, Thomson Locations: Shanghai, China, Japan, Russia, Kazakhstan, Ukraine, United States, South Korea, Saudi Arabia, vaping

☆ Japan PM Kishida spoke about Fukushima water release with G20 leaders
▼ + stars: | 2023-09-09 | by ( Katya Golubkova | ) www.reuters.com time to read: +3 min

Japanese Prime Minister Fumio Kishida attends Partnership for Global Infrastructure and Investment event on the day of the G20 summit in New Delhi, India, September 9, 2023. Japan started releasing treated radioactive water from the wrecked Fukushima nuclear power plant into the Pacific Ocean last month, and faced harsh criticism from China which immediately banned all seafood imports from Japan. Japan says the water release is safe, noting that the International Atomic Energy Agency (IAEA) has also concluded that the impact it would have on people and the environment was "negligible." "Prime Minister Kishida explained that the data monitored since last month's (water) discharge has been made public in a prompt and highly transparent manner. The Fukushima water release was among topics at Kishida's meetings with Turkish President Tayyip Erdogan, Dutch Prime Minister Mark Rutte, Australian Prime Minister Anthony Albanese and Indian Prime Minister Narendra Modi on the sidelines of the G20 summit, Japan foreign ministry said in separate statements.

Persons: Fumio Kishida, Evelyn Hockstein, Kishida, Joe Biden, Rishi Sunak, Emmanuel Macron, Saudi Arabia's Mohammed bin Salman, Hikariko Ono, Ono, Li Qiang, Tayyip Erdogan, Mark Rutte, Anthony Albanese, Narendra Modi, Katya Golubkova, Chizu Organizations: Global Infrastructure, REUTERS, International Atomic Energy Agency, British, World Trade Organization, IAEA, Dutch, Australian, Indian, Thomson Locations: New Delhi, India, DELHI, Japan, China, Saudi, Indonesia

☆ How private equity giants like Apollo and EQT are using the cloud to improve dealmaking, boost portfolio companies, and tap into AI
▼ + stars: | 2023-09-05 | by ( Bianca Chan | ) www.businessinsider.com time to read: +5 min

Here's how Apollo and EQT use Google Cloud to improve themselves and their portfolio companies. The cloud represents big cost savings and efficiency gains among portfolio companies; for example, buyout firm THL migrated one of its portfolio companies to the cloud to save 50% on annual IT infrastructure costs. PE firms benefit from having their data — and their portfolio companies' data — in one place to gain better business insights and check out opportunities. Using cloud to improve portfolio companies and investment firms themselvesBoosting employee productivity with the cloud and AI is top of mind for Apollo's Mahidhar. Google Cloud's tech talent has also helped Swedish PE giant EQT speed up cloud projects among portfolio companies.

Persons: Vikram Mahidhar, THL, Mahidhar, Carl, Magnus Hallberg, execs, Adaire Fox, Martin, Hallberg, Apollo's Mahidhar, it's, —, Zac Maufe, Maufe, it'll, Fox Organizations: Apollo Global Management, Apollo, Google, KKR Locations: EQT, Swedish

☆ PrEPVacc: HIV vaccine trial that could be ‘the last roll of the dice’ this decade is underway
▼ + stars: | 2023-08-28 | by ( Tom Page | Thomas Page | ) edition.cnn.com time to read: +24 min

CNN —A novel trial that has been described as “the last roll of the dice” for a generation of HIV vaccines has entered its latter stages. Nearly 40 years since HIV was identified as the cause of AIDS, and 36 years since the first HIV vaccine trial, the medical community still does not have a working vaccine. But that is not necessarily why they were chosen to participate, said Eugene Ruzagira, PrEPVacc trial director. Evaluating the combination of a trial HIV vaccine and PrEP is a first, say organizers. “I did my very first HIV vaccine trial in 1991,” recalled Weber.

Persons: PrEPVacc, ”, Jonathan Weber, Frank, Helena Herholdt, Eugene Ruzagira, Ruzagira, “, Weber, ” Ruzagira, “ We’ve, Mark Runnacles, Edward Jenner, Louis Pasteur, Galileo, Win McNamee, Humphry Davy, JEAN, SEBASTIEN EVRARD, Haydn West, Joe Raedle, ANNE, CHRISTINE POUJOULAT, Alexander Fleming, Fleming, wasn't, Louise Joy Brown, Sandy Huffaker, Daniel Acker, James Watson, Francis Crick, Rosalind Franklin, Watson, Crick, Raphael GAILLARDE, Sean Gallup, Wilhelm Conrad Röntgen, Thomas Edison's, INDRANIL MUKHERJEE, Descovy, Luwano Geofrey, Dr, Luke Dray, Geofrey, Nishanta Singh, Sharon Lewin, Lewin, “ it’s, it’s, ” Lewin, ” Geofrey Organizations: CNN, Imperial College Academic Health Science Centre, PrEPVacc, Medical Research, Uganda Virus Research Institute, European Union, Smithsonian National Museum of, Cleveland Clinic, Volvo, Bayer, U.S . Food, Drug Administration, Getty, Keystone, — Farmers, Food and Drug Administration, FDA, Bloomberg, PANTHAKY, PrEP, US Centers for Disease Control, Independent, The University of Melbourne, International AIDS Society, Muhimbili University of Health, Allied Sciences, Dar Locations: Entebbe, Uganda, Thailand, London, Mbeya, Tanzania, South Africa, Ugandan, Durban, Masaka, Salam, African, Africa, China, FPG, AFP, United States, America, U.S, Peoria , Illinois, Europe, “, Dar es Salaam, Rwanda

☆ Merck's Keytruda meets main goal in late-stage breast cancer study
▼ + stars: | 2023-07-28 | by ( ) www.reuters.com time to read: +1 min

July 28 (Reuters) - Merck (MRK.N) said on Friday its blockbuster drug Keytruda, in combination with chemotherapy, met one of the main goals in a late-stage trial testing it in some breast cancer patients. The study showed that the therapy was able to help clear all signs of tumor in patients compared to neo-adjuvant placebo plus chemotherapy. Breast cancer is one of the leading causes of cancer-related deaths in women. The therapy addresses the patients who are diagnosed with a sub-type of breast cancer, which has an increased risk of spread to lymph nodes and recurrence. Reporting by Khushi Mandowara in Bengaluru; Editing by Shilpi MajumdarOur Standards: The Thomson Reuters Trust Principles.

Persons: Khushi, Shilpi Majumdar Organizations: Merck, Thomson Locations: Bengaluru

☆ Russia's crude oil exports show little sign of slowing, but energy revenue is tumbling
▼ + stars: | 2023-07-05 | by ( Filip De Mott | ) www.businessinsider.com time to read: +2 min

Russian crude exports rebounded sharply last week to the highest in nearly two months. But the Kremlin's revenue from oil and gas taxes sank 26% in June from a year ago. Meanwhile, Russia's gas exports to Europe have tumbled and were the biggest drag on revenue from that energy source. The Kremlin has tried to prop up oil prices, and recently joined Saudi Arabia in extending voluntary crude production cuts into the summer. However, Russia's previous pledges to trim output were followed by increases in oil exports, suggesting Moscow wasn't actually pulling back on production.

Persons: —, Russia's Organizations: Service, Bloomberg Locations: Ukraine, China, Europe, Saudi Arabia, Moscow

☆ US Senate leaders unveil $107 bln aviation policy bill
▼ + stars: | 2023-06-12 | by ( David Shepardson | ) www.reuters.com time to read: +3 min

WASHINGTON, June 12 (Reuters) - Leaders of the Senate Commerce Committee on Monday introduced a bipartisan aviation policy bill that would boost runway safety, track high-altitude balloons and prohibit airlines from charging fees for families to sit together. Senate Commerce Committee Chair Maria Cantwell, a Democrat, top Republican Ted Cruz and the aviation subcommittee leaders -- Senators Tammy Duckworth and Jerry Moran -- proposed a $107 billion five-year Federal Aviation Administration (FAA) reauthorization bill. The Senate bill "requires the FAA to increase runway safety by deploying the latest airport surface detection equipment and technologies." The Senate bill would ban family seating fees as does the House bill. The Senate bill would require refund request buttons at the top of their websites and double USDOT statutory civil penalties for aviation consumer violations from $25,000 to $50,000 per violation.

Persons: Maria Cantwell, Ted Cruz, Tammy Duckworth, Jerry Moran, Cantwell, Joe Biden's, Mark Kelly, David Shepardsond, Jonathan Oatis, David Gregorio Our Organizations: Senate, Democrat, Aviation Administration, FAA, Washington National Airport, National Transportation Safety Board, Transportation Department, airline, Airlines for, American Airlines, Delta Air Lines, United Airlines, U.S, Thomson Locations: Airlines for America

☆ Analysis: In Turkey, an election reckoning for the rise and fall of Erdogan's economy
▼ + stars: | 2023-05-08 | by ( Jonathan Spicer | ) www.reuters.com time to read: +8 min

The May 14 vote, which lands during the Turkish Republic's centenary year, is Erdogan's biggest test yet. At the same time, a global reversal in market liquidity left Turkey and other emerging markets starved for funding. But the economic crisis was damaging. This trend accelerated in 2013, wiping out big gains made in 2006-2010 during Erdogan's first decade in charge. "If Erdogan wins the election and continues his economic policy it will come to a complete crash at one point.

☆ Pfizer RSV vaccine for older adults should be monitored for nervous system condition Guillain-Barre, scientists say
▼ + stars: | 2023-04-06 | by ( Spencer Kimball | ) www.cnbc.com time to read: +2 min

A health worker prepares a flu vaccine shot before administering it to a local resident in Los Angeles, the United States, on Dec. 17, 2022. People who receive Pfizer 's RSV vaccine for older adults should be monitored for Guillain-Barre syndrome, after two people developed the nervous system disorder after they received the shot, scientists said in clinical trial results published in the New England Journal of Medicine. The scientists concluded the vaccine was effective in preventing lower respiratory tract illness in adults ages 60 and older without any evident safety concerns. But they flagged the Guillain-Barre cases as a potential cause for concern moving forward. Guillain-Barre syndrome is a rare disorder in which the body's immune system mistakenly attacks the nerves.

☆ Real-Time Data Was Used to Regulate Water Use. It May Have Worked Too Well.
▼ + stars: | 2023-02-24 | by ( Sam Ori | ) www.wsj.com time to read: 1 min

Researchers see promise—but also shortcomings—in using real-time data monitoring to encourage people to conserve scarce resources. Sam Ori is the executive director of the Energy Policy Institute at the University of Chicago. Real-time data and monitoring technology informs and improves so many aspects of our daily lives—from sensors that avoid a collision before drivers can respond, to smartwatches that can detect when we’ve been in an accident and call for help.

☆ Roomba says leaked pictures including one of a woman on the toilet were taken by test vacuums, not purchased ones
▼ + stars: | 2022-12-20 | by ( Aaron Mok | ) www.businessinsider.com time to read: +4 min

Robot vacuum maker iRobot confirmed that sensitive images leaked online were taken by its devices. Roomba said the images, including one of a woman on the toilet, were taken only by test units. The images were leaked by Venezuelan contractors who worked with iRobot, MIT Tech Review reported. But images from that data got leaked to Facebook, Discord and other social sites, MIT Tech Review reported and iRobot confirmed to Insider. Experts who have spoken to labelers told MIT Tech Review that they found the work "really uncomfortable."

☆ U.S. FDA grants priority review to Pfizer's RSV vaccine
▼ + stars: | 2022-12-07 | by ( ) www.reuters.com time to read: +1 min

Dec 7 (Reuters) - Pfizer Inc (PFE.N) said on Wednesday the U.S. Food and Drug Administration will review its respiratory syncytial virus (RSV) vaccine candidate on priority. It could become the first approved RSV vaccine in the U.S. for older adults who are at risk of the lung disease. Pfizer's application to the FDA is supported by data from a late-stage study in which the vaccine was found safe and effective. There are no U.S. approved vaccines for RSV, a common virus that typically causes mild cold-like symptoms but can be fatal for young kids and older adults. RSV is estimated to cause about 14,000 annual deaths among older adults in the United States.

☆ RSV vaccine trial shows promising results, Pfizer says; company will seek FDA approval this year
▼ + stars: | 2022-11-01 | by ( Brenda Goodman | ) edition.cnn.com time to read: +5 min

Pfizer’s vaccine candidate is administered to pregnant women who then make antibodies that cross the placenta and protect the baby after birth. In March, the FDA designated Pfizer’s RSV vaccine a breakthrough therapy, a status that speeds its review. Pfizer’s vaccine contains the virus’ F-protein, the site that it uses to attach to human cells. Pfizer’s RSV vaccine is bivalent, containing F-proteins from both the A and B subgroups of the RSV virus, which are the two most commonly circulating strains. “Further analysis to better understand safety data from these trials is ongoing,” spokesperson Alison Hunt said in a statement to CNN.

LONDON, Oct 14 (Reuters) - European copper buyers are going to be paying a lot more to get their metal next year. Aurubis (NAFG.DE) cited a combination of high freight and power costs and low visible copper stocks. European annual copper premiumsSANCTIONS CREEPThere were no official sanctions on Russian copper until earlier this month, when the British government announced an asset freeze on Iskander Makhmudov. ASIAN DISCOUNTWhat will happen to all the Russian copper if Europe stages a collective boycott? The sharp hike in next year's European premiums says much about the cost of refusing Russian metal.

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