October 15 - Dustin Hopkins kicked a go-ahead, 29-yard field goal with 1:40 left in the game and the host Cleveland Browns spoiled the San Francisco 49ers' chance at a perfect season with a 19-17 victory on Sunday afternoon.
Jordan Mason had put the 49ers ahead 17-13 when he rushed for an 8-yard touchdown with 10:58 remaining.
The 49ers also lost wide receiver Deebo Samuel, who exited the contest in the first quarter due to a shoulder injury.
Brandon Aiyuk had four catches for 76 yards for San Francisco, which was held to 215 yards of total offense.
San Francisco moved 84 yards in just five plays on the game's opening drive, taking a 7-0 lead when Purdy found McCaffrey for a 13-yard touchdown.
Dustin Hopkins, Jake Moody, Jordan Mason, Hopkins, Mason, Christian McCaffrey, Deebo Samuel, Brock Purdy, Brandon Aiyuk, P.J . Walker, Deshaun Watson, Amari Cooper, Jerome Ford, Moody, Kareem Hunt, San, Purdy, McCaffrey
Cleveland Browns, San Francisco 49ers, 49ers, Cleveland, Browns, San, Niners, Thomson
San Francisco, Cleveland