The renewed interest in Alzheimer's vaccines follows a promising first attempt more than 20 years ago that was abandoned after 6% of study volunteers developed life-threatening brain inflammation known as meningoencephalitis.
Dr. Reisa Sperling, an Alzheimer's researcher at Mass General Brigham in Boston, said she believes vaccines will play an important role as researchers look to prevent Alzheimer's.
She is considering vaccines for her next study in asymptomatic people with Alzheimer's proteins in their blood, but not enough to register on brain scans.
Alzheimer's vaccines are still in the early stages and will require large, years-long trials to show they work.
Generating a strong immune response is critical for such vaccines, which would typically be given to older individuals with weaker immune systems, he said.
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