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Among people diagnosed with Alzheimer’s, researchers recognize familial forms of the disease and sporadic cases. This shifting appreciation of inherited risk, researchers say, is due to a better understanding of the role of a fourth gene that carries the blueprints to make a lipid-carrying protein called apolipoprotein E, known as APOE. One known as APOE2 is thought to be protective against the development of Alzheimer’s disease. They also compared people with two copies of APOE4 to people with other inherited forms of the disease — early-onset autosomal dominant Alzheimer’s disease (ADAD) and Down syndrome-associated Alzheimer’s disease (DSAD). Gene testing isn’t currently recommendedIt is also likely to change how people who carry the APOE4 gene are diagnosed and treated.
Persons: APOE4, , Dr, Juan Fortea, Sant, Fortea, Charles Bernick, Bernick, Alzheimer’s wasn’t, isn’t, they’re, ” Fortea, Sanjay Gupta, Reisa Sperling, , ” Sperling, ” Dr, Sterling Johnson, Johnson Organizations: CNN, Nature, National Alzheimer’s Coordinating, Neurology, Hospital de, Cleveland Clinic Lou, Brain Health, CNN Health, Alzheimer’s Research, Brigham, Women’s, Alzheimer’s, University of Wisconsin Locations: Alzheimer’s, Spain, United States, Santa, Barcelona, Wisconsin
CNN —In a historic first, scientists have used gene editing to induce virgin birth in fruit flies, a major step in unlocking the mysteries of the intriguing phenomenon known as parthenogenesis. The researchers used fruit flies because they’re considered “model organisms,” meaning the flies are among a list of organisms that scientists have long studied in depth to gain a better fundamental understanding of biology. Fruit flies’ short life spans of about 80 days have made it easy to observe changes throughout generations relatively quickly. And prior research into fruit flies is so extensive it’s possible to order genetic mutations for some flies online. “There’s just so many tools,” Sperling said, “and the tools are easily, cheaply available to all researchers” when it comes to fruit flies.
Persons: Alexis Sperling, Sperling, ” Sperling, , we’d, they’re, “ There’s, , aren’t, Dr, Warren Booth, Booth, ” Booth, parthenogenesis Organizations: CNN, UK’s University of Cambridge, Pesticides, Virginia Polytechnic Institute, State University Locations: United Kingdom
Eisai and Biogen are scheduled to present full data from their lecanemab study on Tuesday at the Clinical Trials on Alzheimer's Disease conference in San Francisco. Lecanemab’s success rests on years of research into the causes of Alzheimer’s as well as advances in measuring amyloid deposits through brain scans and spinal fluids. At least 16 treatments are being tested in clinical trials, with results expected over the next three years, according to a Reuters review of the clinicaltrials.gov registry. The drugmaker has been largely absent from the Alzheimer's space after the high-profile failure of its drug verubecestat five years ago. But several antibody therapies from Lilly, Biogen and AbbVie(ABBV.N) that were designed to slow the rate of tau accumulations failed outright last year.
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