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☆ Biden to nominate cancer surgeon Monica Bertagnolli to lead National Institutes of Health
  + stars: | 2023-05-15 | by ( Spencer Kimball | ) www.cnbc.com   time to read: +1 min
Dr. Monica Bertagnolli speaks during a visit from first lady Jill Biden to the University of California San Francisco Helen Diller Family Comprehensive Cancer Center in San Francisco, Oct. 7, 2022. President Joe Biden will nominate Dr. Monica Bertagnolli, a cancer surgeon, to lead the National Institutes of Health, the White House announced Monday. Bertagnolli is currently the director of the National Cancer Institute and is the first woman to lead the organization. The NIH, which has a budget of about $45 billion, funds medical research across the U.S. and around the world. The agency played a pivotal role in developing the messenger RNA technology that underlies the Covid-19 vaccine made by Moderna.
☆ Researchers found a surefire predictor of success — and what separates those who find it from those who keep failing
  + stars: | 2023-05-12 | by ( Susie Allen | Kellogg Insight | ) www.businessinsider.com   time to read: +12 min
Using this insight, the researchers are able to successfully predict an individual's long-term success with just a small amount of information about that person's initial attempts. Indeed, in another recent study, Wang himself found that an early career setback often set up scientists for later success. In all three datasets, an individual's second-to-last attempt did tend have a higher probability of success than their very first effort. Rather, there's a singular learning threshold that separates eventual successes from the rest. "Thomas Edison said, 'people give up because they don't know how close they are to success,'" Wang explains.
☆ Opinion | We Could Easily Make Risky Virological Research Safer
  + stars: | 2023-05-10 | by ( David Wallace-Wells | ) www.nytimes.com   time to read: +2 min
The 2007 outbreak of foot-and-mouth disease in Britain was traced to a faulty drainage pipe at a research facility. In 2015 the Department of Defense discovered that a germ-warfare program in Utah had mistakenly mailed almost 200 samples of live anthrax over 12 years. Lab accidents happen, and they aren’t especially rare. In January the National Science Advisory Board for Biosecurity issued a series of draft recommendations for tightening regulation and oversight. And many of those who see the Covid pandemic as merely the sort of pathogenic disaster that lab accidents might cause agree that greater safety is needed.
☆ At Musk’s brain-chip startup, animal-testing panel is rife with potential conflicts
  + stars: | 2023-05-04 | by ( Rachael Levy Marisa Taylor | Rachael Levy | Marisa Taylor | ) www.reuters.com   time to read: +13 min
The membership of the panel at Musk’s company, Neuralink, raises questions about potential violations of conflict-of-interest regulations aimed at protecting research integrity, a dozen animal-research and bioethics experts told Reuters. Autumn Sorrells has chaired an oversight board approving animal experiments by Elon Musk’s brain-chip startup, Neuralink, and also run the company’s animal care program. Reuters couldn’t determine the compensation terms of the Neuralink IACUC members who are also company employees. The independence of such boards, Nicolelis said, is critical to protecting the integrity of animal research that could impact humans in future clinical trials. These institutions generally prohibit people with direct financial interests from serving on IACUCs or voting on animal experiments.
☆ 2 Wisconsin Republicans want 14-year-olds to be allowed to serve alcohol in restaurants
  + stars: | 2023-05-02 | by ( Erin Snodgrass | ) www.businessinsider.com   time to read: +4 min
New proposed legislation would make it legal for kids as young as 14 to serve alcohol in Wisconsin. The move comes amid a seeming broader push by Republicans nationwide to roll back child labor laws. In the memo this week, Stafsholt and Green cited "workforce issues" stemming from underage employees only being allowed to do "part of their job," if they aren't allowed to serve alcohol, according to the outlet. A wide-reaching Iowa bill would allow 16 and 17-year-olds to serve alcohol in restaurants as long as their parent signs off on it. Only two other states in the country — Maine and West Virginia — allow teenagers that age to to serve alcohol, according to The National Institutes of Health.
☆ Alzheimer’s patients may wait years to get treated with new drugs, putting them at risk of more severe disease
  + stars: | 2023-04-30 | by ( Spencer Kimball | ) www.cnbc.com   time to read: +17 min
But time spent waiting robs early patients of their memory and ability to live independently. This condition is often, though not always, a sign of early Alzheimer's disease. PET scans cumbersomeTwo types of tests can diagnosis Alzheimer's disease: PET scans and spinal taps. Early Alzheimer's disease can also be diagnosed with a spinal tap, in which fluid around the spinal cord is extracted with a catheter and tested. He believes big players like CVS will provide infusions for Alzheimer's disease on a major scale if they see there's a large and stable market.
☆ Moderna's billionaire CEO draws criticism for earning nearly $400 million in stock options last year, and then getting a raise on top of it
  + stars: | 2023-04-29 | by ( Jordan Hart | ) www.businessinsider.com   time to read: +3 min
French businessman Stéphane Bancel made $393 million in stock options in 2022, according to securities filings. Bancel, 50, also owns stocks valued around at least $2.8 billion, and received a 50% raise from 2021 to 2022. Moderna's chief executive officer Stéphane Bancel raked in about $393 million in 2022 thanks to stock options, and then received a raise on top of it — compensation that's giving some analysts pause. In addition to exercising his stock options in 2022, 50-year-old Bancel earned a $1.5 million salary — a 50% jump from 2021, according to securities filings from March. Meanwhile, Amazon CEO Andy Jassy's pay dropped from $212 million in 2021 to $1.3 million in 2022 due to receiving any stock awards.
☆ 10 ‘spring-cleaning’ tips to help you feel better in your body
  + stars: | 2023-04-28 | by ( Dana Santas | ) edition.cnn.com   time to read: +8 min
Imagine how great you would feel if you took that same spring-cleaning approach to your body — your living, breathing home. But what about taking a closer look at how you fuel and move your body — and making healthy changes to clean up those areas? That’s why I enlisted the help of two nutrition and human movement experts to provide 10 “spring-cleaning” tips to avoid injury, move pain-free, reduce inflammation, maintain a healthy weight and generally feel better in your body. Breathe better to move better and feel betterBreathing plays a vital role in how you think, feel and move. Just like the physical and mental benefits of traditional spring-cleaning within your home, these 10 tips will refresh and revitalize your body and mind in noticeably positive ways.
☆ A drug company abandoned a treatment for ‘bubble boy disease.’ After a 5-year fight, this little girl is about to get it
  + stars: | 2023-04-27 | by ( Elizabeth Cohen Lauren Mascarenhas | Elizabeth Cohen | Lauren Mascarenhas | ) edition.cnn.com   time to read: +29 min
The Sulacks weighed their options: Have a transplant with a match that was less than ideal – far less – or wait for gene therapy to become available. The news release didn’t say anything else about the SCID gene therapy. Or was the company abandoning its plans for SCID gene therapy altogether? In February, 2021, the parents of more than 20 children who were waiting for the gene therapy treatment, including the Sulacks, wrote a letter to Gaspar. Insurance companies have sometimes balked at paying for gene therapy, which is typically given in one treatment.
☆ Ex-Harvard Professor Sentenced in China Ties Case
  + stars: | 2023-04-26 | by ( Gina Kolata | ) www.nytimes.com   time to read: +3 min
For his work on nanotechnology, he had been seen by some as a contender for the Nobel Prize. But he also secretly accepted money from China, which had established a government initiative, the Thousand Talents program, to gain access to scientific knowledge and expertise, often paying scientists lavishly. When questioned about his involvement with Thousand Talents in 2018 by federal investigators, he denied it. Why It MattersDr. Lieber’s conviction in December 2021 resulted from the China Initiative, an effort launched in 2018, under the Trump administration, to identify scientists suspected of sharing sensitive information with China. But critics said that the China Initiative had unfairly targeted academic researchers of Asian descent.
☆ Ex-Harvard professor sentenced to 6 months house arrest for lying about China ties
  + stars: | 2023-04-26 | by ( Kanishka Singh Nate Raymond | Kanishka Singh | Nate Raymond | ) www.reuters.com   time to read: +3 min
REUTERS/Katherine Taylor/File PhotoWASHINGTON, April 26 (Reuters) - A former Harvard University professor was sentenced on Wednesday to six months' house arrest for lying about his ties to a China-run recruitment program, prosecutors said, in one of the highest-profile cases resulting from a crackdown on Chinese influence on U.S. research. Lieber was sentenced to two days in prison - time that he had already served following his arrest - and half a year of house arrest with a fine of $50,000, prosecutors said. He was also sentenced to two years of supervised release and a restitution to the Internal Revenue Service of $33,600, according to prosecutors. The failed cases included another one in Boston in which prosecutors in January 2022 dropped charges against Massachusetts Institute of Technology professor Gang Chen for concealing his ties to China when seeking grant money. Prosecutors said Lieber failed to report his salary on his 2013 and 2014 income tax returns and for two years failed to report the bank account.
☆ Sleep gummies: Possibly harmful doses of melatonin, CBD found
  + stars: | 2023-04-25 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +7 min
CNN —Testing of over two dozen melatonin “gummies” sold as sleep aids found some had potentially dangerous amounts of the hormone that helps regulate sleep, according to a new study. “Four of the tested products contained levels of CBD that were between 4% and 18% higher than on the label,” Cohen said. “We choose gummies over other products because we thought parents would chose edibles to give to their children,” Cohen said. Gummies sold as sleep aids had much higher levels of melatonin than stated on the label, as well as CBD, according to the study. “However, that doesn’t mean melatonin products are going to work or they’re a good idea to take.
☆ 'It totally backfired': The pitfalls of Alzheimer's genetic testing
  + stars: | 2023-04-21 | by ( Julie Steenhuysen | ) www.reuters.com   time to read: +8 min
CHICAGO, April 21 (Reuters) - Wendy Nelson watched her mother slowly die of Alzheimer's disease, unable to move or swallow at the end. When her father's memory began to fail a year later, one of her two sisters doubted it could be Alzheimer's, Nelson said. THE TESTING REVOLUTIONUntil recently, most doctors tended not to order genetic tests to determine Alzheimer's risk, because there were no effective treatments to slow or prevent the disease. US regulators recommend genetic testing before starting treatment with Leqembi. Some members of families with increased genetic risk of Alzheimer's say it might be better not to know at all.
☆ Factbox: What is APOE4 and how does it relate to Alzheimer's disease?
  + stars: | 2023-04-21 | by ( Julie Steenhuysen | ) www.reuters.com   time to read: +1 min
Three decades ago, scientists discovered that the gene also plays a role in Alzheimer's risk, though exactly how is still not clear. APOE3 is the most common, and does not raise Alzheimer's risk. APOE4 increases Alzheimer's risk and is linked with an earlier onset of the disease. Some 25% of people have one copy of APOE4 and 2-5% have two copies. Children of a parent with two copies of the APOE4 variant are presumed to have at least one copy, increasing their own risk.
☆ White House Close to Nominating Monica Bertagnolli for Top NIH Job
  + stars: | 2023-04-19 | by ( Liz Essley Whyte | ) www.wsj.com   time to read: 1 min
The NIH’s $47 billion budget gives it a powerful role in investigating diseases and exploring new treatments. Photo: Eric Lee for The Wall Street JournalThe White House is nearing a decision to nominate Monica Bertagnolli to run the federal government’s National Institutes of Health life-sciences research agency, people familiar with the matter said. Since October, Dr. Bertagnolli has been running the National Cancer Institute, the largest of the 27 research institutes that make up the NIH.
☆ Uganda: Leading scientists urge President Museveni to veto anti-LGBT bill
  + stars: | 2023-04-19 | by ( Catherine Nicholls | ) edition.cnn.com   time to read: +3 min
CNN —A group of leading global scientists and academics have signed an open letter urging Ugandan President Yoweri Museveni to veto a hardline bill criminalizing homosexuality in the country. The Anti Homosexuality Bill 2023, which was passed by Ugandan lawmakers in March, is set to be either signed into law or vetoed by the president on Thursday. Before the bill was passed almost unanimously last month, President Museveni called on scientists to establish whether homosexuality was natural or learned. The letter has been signed by 15 leading scientists around the world, from countries including South Africa, the United States, Canada, the UK, Kenya, and Australia. Under the Anti Homosexuality Bill 2023, it would be a crime to even identify as lesbian, gay, bisexual, transgender, or queer.
☆ What is autism? An expert explains
  + stars: | 2023-04-12 | by ( Matt Villano | ) edition.cnn.com   time to read: +10 min
To mark Autism Awareness Month, CNN talked with him about what autism is and what causes it. Geschwind: About a decade ago, the term “autism spectrum disorder” was adopted to encompass everything that we called autism into one rubric. When I started researching autism 25 years ago, the autism rate was 1 in 1,000 or 1 in 2,000. You can calculate a risk score for having autism based on genetics, (but) right now, the risk score for autism is not that predictive because we haven’t done enough research. The problem is that for many autistic individuals, current therapies are not that effective.
☆ Alzheimer’s patients retain the benefits of Leqembi even when they stop the drug, Eisai says
  + stars: | 2023-04-06 | by ( Annika Kim Constantino | ) www.cnbc.com   time to read: +4 min
Alzheimer's patients who take Leqembi retain the benefits of the treatment even when they stop taking it, new research by Eisai shows. The findings also come as Eisai and Biogen try to regain their footing after the polarizing approval and disastrous rollout of its other Alzheimer's disease therapy, aduhelm, last year. In the analysis, Alzheimer's patients stopped taking Leqembi after 18 months in a phase two clinical trial and later resumed the treatment in an extension trial. Amyloid is a protein that builds up on the brain in Alzheimer's patients and disrupts cell function. That means Alzheimer's disease progressed at a slower rate in patients who received Leqembi compared to those who took the placebo during the clinical trial.
☆ Pfizer RSV vaccine for older adults should be monitored for nervous system condition Guillain-Barre, scientists say
  + stars: | 2023-04-06 | by ( Spencer Kimball | ) www.cnbc.com   time to read: +2 min
A health worker prepares a flu vaccine shot before administering it to a local resident in Los Angeles, the United States, on Dec. 17, 2022. People who receive Pfizer 's RSV vaccine for older adults should be monitored for Guillain-Barre syndrome, after two people developed the nervous system disorder after they received the shot, scientists said in clinical trial results published in the New England Journal of Medicine. The scientists concluded the vaccine was effective in preventing lower respiratory tract illness in adults ages 60 and older without any evident safety concerns. But they flagged the Guillain-Barre cases as a potential cause for concern moving forward. Guillain-Barre syndrome is a rare disorder in which the body's immune system mistakenly attacks the nerves.
☆ Exclusive: US to build $300 mln database to fuel Alzheimer's research
  + stars: | 2023-04-03 | by ( Julie Steenhuysen | ) www.reuters.com   time to read: +4 min
The platform will draw on data from medical records, insurance claims, pharmacies, mobile devices, sensors and various government agencies, they said. The database could help identify healthy people at risk for Alzheimer's, which affects about 6 million Americans, for future drug trials. The U.S. Medicare health plan for older adults will likely require such tracking in a registry as a condition of reimbursement for Leqembi. Silverberg said the data platform could also help researchers working in other disease areas understand which patients are most at risk and the impact of medications. The system would be built in a secure computing environment with a number of restrictions to ensure the privacy of people's health data, Silverberg said.
☆ FDA advisors reject Biogen's ALS drug for rare and aggressive form of the disease
  + stars: | 2023-03-22 | by ( Annika Kim Constantino | ) www.cnbc.com   time to read: +3 min
The Food and Drug Administration's independent panel of advisors on Wednesday declined to endorse accelerated approval of Biogen's investigational ALS drug for a rare and aggressive form of the disease. The drug tofersen was developed to treat a rare genetic form of amyotrophic lateral sclerosis, or ALS. That number is even smaller in the U.S., with roughly 330 people affected by the SOD1 mutation. The median survival time from diagnosis with the rare form of ALS to death is 2.7 years, according to the company. The SOD1 mutation is associated with 20% of cases that occur within families.
☆ FDA advisors vote against effectiveness of Biogen's ALS drug for rare and aggressive form of the disease
  + stars: | 2023-03-22 | by ( Annika Kim Constantino | ) www.cnbc.com   time to read: +3 min
The Food and Drug Administration's independent panel of advisors on Wednesday voted against the effectiveness of Biogen's investigational ALS drug for a rare and aggressive form of the disease. The drug tofersen was developed to treat a rare genetic form of amyotrophic lateral sclerosis, or ALS. That number is even smaller in the U.S., with roughly 330 people affected by the SOD1 mutation. The median survival time from diagnosis with the rare form of ALS to death is 2.7 years, according to the company. The SOD1 mutation is associated with 20% of cases that occur within families.
☆ Moderna CEO Stephane Bancel defends fivefold price hike of Covid vaccine during Senate grilling
  + stars: | 2023-03-22 | by ( Spencer Kimball | ) www.cnbc.com   time to read: +4 min
Moderna plans to raise the list price of its vaccine 400% to $130 when the shots are sold on the private market as early as this fall. Moderna CEO Stephane Bancel on Wednesday defended the company's plans to hike the price of its Covid shots fivefold, deflecting pressure at a Senate hearing to abandon the increase while taking barbs over his compensation. Chairman Bernie Sanders, I-Vt., questions Stephane Bancel, CEO of Moderna, during the Senate Health, Education, Labor and Pensions Committee hearing titled Taxpayers Paid Billions For It: So Why Would Moderna Consider Quadrupling the Price of the COVID Vaccine? He told the committee that the Covid vaccine market is changing substantially as the U.S. government stops buying and distributing the shots for the entire country. The Covid vaccine remains Moderna's only product on the market at the moment.
☆ US declines to force lower price on cancer drug Xtandi
  + stars: | 2023-03-21 | by ( ) www.reuters.com   time to read: +2 min
WASHINGTON, March 21 (Reuters) - The U.S. government will not force Pfizer Inc (PFE.N) and Astellas Pharma Inc (4503.T) to lower the price of their prostate cancer drug Xtandi using its emergency "march-in" authority, the National Institutes of Health (NIH) said on Tuesday. Patient group the Union for Affordable Cancer Treatment first filed a petition calling on the NIH to use its authority to lower the drug's price in March 2016. The NIH said in a letter made public on Tuesday that its analyses in response to the petition found the prostate cancer treatment was widely available. "NIH does not believe that use of the march-in authority would be an effective means of lowering the price of the drug," the letter said. Progressive lawmakers in the Democratic Party have been calling on President Joe Biden's administration to use its march-in authority to lower drug prices.
☆ If you had Covid before you were vaccinated, you might have less immunity than you think, study says
  + stars: | 2023-03-21 | by ( Annika Kim Constantino | ) www.cnbc.com   time to read: +4 min
Co-funded by the National Institutes of Health, the study released Monday challenges older research that suggested a prior Covid infection enhanced a vaccinated individual's immune response — a phenomenon known as hybrid immunity, which some scientists believe provides the best protection against reinfection. In the study, researchers from Stanford University analyzed how immune cells found in the blood called CD4+ T cells and CD8+ T cells respond to Covid infection and vaccination. The study found that vaccinating people who had never been infected with Covid before produced "robust" CD4+ and CD8+ T cell responses to the virus. Vaccination in those people also generated cell-signaling molecules that recruit other immune cells to help fight Covid, they said. Ray said the study, while interesting, needs to factor in long-term knowledge about how Covid immunity works: "It's probably not the last chapter in this story."
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