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But the nation’s successive elected governments were at least willing to cooperate with Washington, allowing the U.S. military to conduct regional counterterrorism activities. Washington has stopped short of calling the crisis a coup — a move that would require the United States to halt security and economic assistance. Wagner will be ready. Their operations have frequently resulted in the deaths of civilians, with credible accusations of sexual violence, torture and extrajudicial killings. Within days of Wagner’s aborted advance on Moscow, Russia’s foreign minister, Sergei Lavrov, said that Wagner’s African footprint would remain.
Persons: Jama’at Nusrat al, Barkhane, jihadists, Wagner, , Al Qaeda, Bazoum, Prigozhin’s, Wagner’s, Sergei Lavrov, Prigozhin, Putin Organizations: U.S, United, Nigerien, Islamic, West, Central African, Kremlin Locations: Sahel, Africa, Islamic State, Greater Sahara, Haram, Islam, Niger, Washington, United States, America, Mali, Libya, Central African Republic, Sudan, Moscow, St . Petersburg
"Our drone base in Niger is extremely important in countering terrorism in the region," one of the U.S. officials said. FOREIGN ASSISTANCEThe Biden administration has not formally labeled the military takeover in Niger a coup, a designation that would limit what security assistance Washington can provide the country. The U.S. drone base has grown in importance due to a lack of Western security partners in the region. The drone base, known as airbase 201, was built near Agadez in central Niger at a cost of more than $100 million. Wagner's chief, Yevgeny Prigozhin, has welcomed the coup in Niger and said his forces were available to restore order.
Persons: Abdourahmane Tiani, Balima, Mohamed Bazoum, Russia's Wagner, Biden, Antony Blinken, Nusrat al, Cameron Hudson, Hudson, Terence McCulley, WAGNER, Yevgeny Prigozhin, Wagner, Idrees Ali, Daphne Psaledakis, Simon Lewis, Michelle Nichols, Don Durfee, Deepa Babington Organizations: REUTERS, Nigerien, Islamic State, Al, West African, Center for Strategic, International Studies, United States Institute of Peace, Wagner Group, ., U.S, Thomson Locations: Niger, Niamey, United States, Sahel, Al Qaeda, France, Africa, insurgencies, Russia, China, Washington, U.S, Mali, Burkina Faso, Agadez, State, Nigeria, Ivory Coast, Niger's, Nigerien
Though it is still unclear which 10 drugs Medicare will select, several pharmaceutical companies have already revealed in court filings that they expect four of their blockbuster medications to be targeted. Bristol-Myers Squibb and Johnson & Johnson , in separate filings, said their blood thinners Eliquis and Xarelto will be subject to the negotiations this year. The list price of Januvia has surged 275% since 2006, according to the AARP. Johnson & Johnson reported $2.47 billion in revenue from Xarelto. "More and more people face cost-sharing that is directly affected by drug price increases," Leigh Purvis, who analyzes health-care costs for AARP, told reporters on a call Thursday.
Persons: Daniel Acker, Merck, Johnson, Abbvie, Imbruvica, Jardiance, Boehringer Ingelheim, Amgen Symbicort, Pfizer Xtandi, Breo, Biden, Januvia, Eliquis, Xarelto, Leigh Purvis Organizations: Merck, Co, Inc, Bloomberg, Getty, Medicare, Services, Myers Squibb, Johnson, Pharmacy, AstraZeneca Ibrance, Pfizer, Astellas Pharma, GSK, AARP, Bristol Myers Squibb, Jama Network, Industry Locations: Bristol, U.S, Januvia, Xarelto
But after a second check from the blood pressure machine, and taking his own blood pressure at home, it had returned to much more acceptable levels. At the hospital, his first blood pressure cuff had been too small, and it was changed only at his request. Now, a new clinical trial highlights how much an improperly sized blood pressure cuff can distort blood pressure readings taken by automated blood pressure devices. But frequently, only regular-sized cuffs are used to take someone’s blood pressure, even though clinical guidelines recommend using cuffs suited for a person’s arm circumference. Either way, experts say, a one-size-fits-all approach can skew blood pressure readings, interfering with core metrics that doctors use to monitor and treat heart conditions.
Persons: Georges Benjamin, Benjamin, , , Benjamin said, Tammy Brady, ” Brady, Brady, Dr, Sanjay Gupta Organizations: CNN, American Public Health Association, Johns Hopkins University, Get CNN, CNN Health Locations: Baltimore
CNN —American women have a problem with booze. The messaging around women and drinking has reflected women’s shift toward the dysfunctional, which may then create a vicious cycle as more women see problem drinking cast as cheeky, fun or normal. And more women may now be paying the price for this normalization of alcohol abuse. I suspect many of them are turning to alcohol as one way to dull the painful reality of isolation. None of that will end alcohol abuse, which has been a centuries-long problem.
Persons: Jill Filipovic, , White, , they’re, we’re Organizations: Twitter, CNN, American Medical Association, White Locations: New York, prurient, America, Europe
CNN —As little as one or two minutes of vigorous exercise a day could lower your cancer risk, according to a new study. Participants reported not regularly exercising in their leisure time, and they wore accelerometers to track their VILPA, or vigorous intermittent lifestyle physical activity, the study said. Adults who incorporated about 4½ minutes of vigorous activity in short one- or two-minute bouts had more than 30% lower incidence rates of cancer, the study found. “The large majority of middle aged and older adults, more than 70-80% in most countries, are not regular exercisers in leisure time, or simply never do any exercise,” Stamatakis said via email. “Previous early-stage trials (showed) that VILPA leads to rapid improvements in cardiorespiratory fitness,” Stamatakis said in an email.
Persons: Emmanuel Stamatakis, , , Stamatakis, Charles Perkins, Dana Santas, ” Stamatakis, Glenn Gaesser, Gaesser, Keith Diaz, Diaz, ” Gaesser, Santas, It’s, ’ ” Organizations: CNN’s, CNN, Charles, Charles Perkins Centre, University of Sydney, College of Health Solutions, Arizona State University, Columbia University Irving Medical Locations: Australia, New York City
CNN —Compulsive nail-biting, skin-picking, hairpulling, and lip- and cheek-biting are among a range of body-focused repetitive behaviors, or BFRBs, that can become a source of distress, but new research may offer hope for relief. Gently tapping the middle and index fingers against the thumb is one of the habit replacement techniques suggested by research. In the study, Moritz recruited 268 people with BFRBs — include participants exhibiting skin-picking, trichotillomania, nail-biting, and lip- and cheek-biting behaviors — who were between ages 18 and 80. After six weeks, 54% of people in the group using the habit replacement techniques reported improvement on a scale devised to measure the severity of body-focused repetitive behavior compared with 20% in the control group. However, she said she thinks habit replacement techniques are just part of a bigger BFRB treatment puzzle.
Persons: Steffen Moritz, , Moritz, , They’re, I’ve, BFRBs, , ” Moritz, Stacy Nakell, haven’t, Nakell, ” Nakell Organizations: CNN, University Medical Center Locations: Eppendorf, Germany
Somalia says Russia grants relief on debt worth $684 million
  + stars: | 2023-07-27 | by ( ) www.reuters.com   time to read: +2 min
MOGADISHU, July 27 (Reuters) - Russia has granted debt relief on over $684 million owed by Somalia in a deal finalised on the sidelines of a Russia-Africa summit in St Petersburg, officials from the Horn of Africa nation said. Emerging from decades of civil war, Somalia is seeking to secure sweeping external debt relief under the International Monetary Fund (IMF) and World Bank's Heavily Indebted Poor Countries (HIPC) Initiative. The agreement signed on Wednesday between Egeh and Russian deputy finance minister Timur Maksimov concerned Paris Club loans, Somali Deputy Prime Minister Salah Ahmed Jama told Russian state news agency RIA Novosti. Somalia owed Moscow nearly $695 million in 2019, according to the IMF. Reporting by Hereward Holland, Abdi Sheikh and Rachel Savage; editing by Joe Bavier and Mark HeinrichOur Standards: The Thomson Reuters Trust Principles.
Persons: Bihi Egeh, Timur Maksimov, Salah Ahmed Jama, Jama, Vladimir Putin, Putin, pare, Hereward Holland, Abdi Sheikh, Rachel Savage, Joe Bavier, Mark Heinrich Our Organizations: International Monetary Fund, Somali Finance, Moscow, Paris Club, RIA Novosti, African, IMF, Thomson Locations: MOGADISHU, Russia, Somalia, Africa, St Petersburg, Horn of Africa, Egeh, Paris, Russian, Moscow, Ukraine
A diagnosis of depression in adulthood could more than double your risk of developing dementia in older age, according to a new study. But the latest study shows a connection between dementia risk and depression diagnoses in early and mid-life as well. “Our results therefore provide strong evidence that depression is not only an early symptom of dementia, but also that depression increases dementia risk,” she said. “For example, there may be shared common risk factors for depression and dementia that occur earlier in the lifecourse, depression may increase dementia risk through alterations in levels of key neurotransmitters, or depression may lead to changes in health behaviors that in turn increase risk for dementia,” she added in an email. Regardless of dementia risk, treating depression should be a priority, Elser agreed.
Persons: Holly Elser, Natalie Marchant, Marchant, Elser, , ” Elser, ” Marchant Organizations: CNN, University of Pennsylvania, University College London
Right now, the program for seniors will only cover one PET scan per lifetime for patients participating in clinical trials. The Medicare proposal would allow regional organizations, called Medicare Administrative Contractors, to decide whether to cover the diagnostic tool. It is still unclear when the decision on PET scans will be finalized. PET scans are a crucial diagnostic tool that detect an amyloid protein on the brain that is associated with Alzheimer's disease. People on Medicare generally pay 20% of the cost of a PET scan after meeting their deductible.
Persons: Jay Reinstein, Chiquita Brooks, LaSure Organizations: Georgetown University Hospital, Contractors, Centers, Medicare, Services Locations: Washington , DC, U.S
A cohort of more than 100,000 people used accelerometers to capture their movement over the course of a week, the study said. Adults need at least 150 minutes of moderate-intensity physical activity per week, according to the Physical Activity Guidelines for Americans. “Even for me, if I have a crazy something or other going on, I might concentrate more on a weekend,” Freeman said. One study from 2021 found that as little as 11 minutes a day can increase your life span. On the days you miss a workout, Freeman encourages making sure to make up the time later in the week to get the 150 minutes.
Persons: , , Shaan Khurshid, ” Khurshid, Andrew Freeman, Freeman, ” Freeman, Khurshid, Oleg Breslavtsev, , Dana Santas Organizations: CNN’s, CNN, JAMA, Massachusetts General Hospital, Harvard Medical School, Jewish Health, Denver's National Jewish Health Locations: Massachusetts, Boston, Denver
Overall, an FDA spokesperson says that “trial participants should reflect the population that is likely to use the product if FDA-approved. Across a group of 10 novel cancer therapies approved by the FDA in 2022, data shows the share of Black participants in key clinical trials ranged from zero to 8%. “Access to clinical trials at the sites where patients are living is an important factor to changing the landscape,” Perez says. “There’s been some novel ways to recruit patients, like using the church and using barbershops to recruit Black patients,” Cho says. Haddad says a number of Mayo patients were receiving experimental therapies through clinical trials when the pandemic began.
Persons: , Leslie Cho, Robert, Suzanne Tomsich, it’s, Edith Perez, Bolt Biotherapeutics, ” Perez, Eli Lilly, , Lilly “, they’ll, Craig Lipset, ” Lipset, ” Cho, “ There’s, Dr, Tufia Haddad, Haddad, Mayo, Jennifer Dahne, Larry Hawk, Hawk Organizations: Women’s Cardiovascular, Cleveland Clinic, of Cardiovascular Medicine, U.S . Food, Drug Administration, FDA, , Health, Committee, Cancer, Janssen Pharmaceuticals, Centers for Disease Control, Research Alliance, Mayo Clinic Comprehensive Cancer Center, Care, Mayo’s Center for Digital Health, College of Medicine, Medical University of South, of Psychology, University, Buffalo, SUNY, JAMA Locations: U.S, Chicago, Dallas, Los Angeles, Philadelphia, Los Angeles County, Alaska, , Medical University of South Carolina
Lilly expects the U.S. Food and Drug Administration to decide by the end of this year whether to approve donanemab. The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. The deaths of three trial patients were linked to the treatment, researchers reported. For high tau patients, donanemab was shown to slow disease progression by about 17%, while the benefit was 35% for those with low-to-intermediate tau levels. Both medications are also being studied in large trials to see if they have an impact on delaying onset of Alzheimer's disease symptoms.
Persons: Seth Gale, Brian Snyder, Eli Lilly, Anne White, Lilly, Susan Kohlhaas, Liana Apostolova, White, Liz Coulthard, donanemab, Deena Beasley, Ludwig Burger, Will Dunham, Bill Berkrot, Caroline Humer Organizations: Alzheimer Research, Brigham, Women’s, REUTERS, Alzheimer's Association International, U.S . Food, Drug Administration, Alzheimer’s Research, Indiana University School of Medicine, Doctors, University of Bristol, JAMA, FDA, Alzheimer's Association, Health Organization, New York Stock Exchange, Thomson Locations: Boston , Massachusetts, U.S, Amsterdam, Eisai
It was shown in May and in fuller Phase 3 clinical trial results released at the Alzheimer’s Association International Conference on Monday to delay the disease’s progression. More than 6 million Americans are estimated to have Alzheimer’s disease, with about 1 million estimated to be in the early symptomatic stages where these drugs have shown benefit. Both Leqembi and donanemab work by clearing buildups of a protein in the brain called amyloid, a hallmark of Alzheimer’s. It’s been a hypothesis that treating Alzheimer’s earlier with amyloid-clearing drugs would yield better results; Skovronsky said the donanemab trial bore that out. “We could look at people who had mild cognitive impairment, MCI, which is the earliest stage, versus mild Alzheimer’s versus moderate Alzheimer’s,” Skovronsky explained.
Persons: Leqembi, Eli Lilly’s donanemab, Lilly, “ Donanemab, Jennifer Manly, Kacie, , Dr, Gil Rabinovici, Renaud La Joie, Daniel Skovronsky, , Skovronsky, ” Skovronsky, It’s, Eric Widera, Sharon Brangman, University of Wisconsin’s Dr, Nathaniel Chin, Donanemab, Lilly hasn’t, Lawrence Honig, Honig, White, Sanjay Gupta, Deters, ” Lilly, it’s “, it’s, there’s, Joe Montminy Organizations: CNN, Alzheimer’s Association, Food and Drug Administration, American Medical Association, Columbia University Irving Medical Center, University of California, MCI, SUNY, University of Wisconsin’s, Leqembi, FDA, donanemab, CNN Health, ” Manly Locations: Los Angeles,
The FDA approval of nirsevimab, sold under the brand name Beyfortus, comes ahead of RSV season this fall. This is a major advantage over palivizumab, which is administered monthly throughout RSV season. Nirsevimab is administered either before or during an infant's first RSV season. Toddlers up to two years old who remain vulnerable can also receive the shot during their second RSV season. Pfizer has developed a vaccine that protects infants by administering the shot to the mother while she is pregnant.
Persons: Biden, Nirsevimab Organizations: Drug Administration, AstraZeneca, Sanofi, FDA, Disease Control, Children, CDC, Pfizer Locations: U.S, Nirsevimab
Treating Alzheimer’s patients as early as possible — when symptoms and brain pathology are mildest — provides a better chance of slowing cognitive decline, a large study of an experimental Alzheimer’s drug presented Monday suggests. The study of 1,736 patients reported that the drug, donanemab, made by Eli Lilly, can modestly slow the progression of memory and thinking problems in early stages of Alzheimer’s, and that the slowing was greatest for early-stage patients when they had less of a protein that creates tangles in the brain. For people at that earlier stage, donanemab appeared to slow decline in memory and thinking by about four and a half to seven and a half months over an 18-month period compared with those taking a placebo, according to the study, published in the journal JAMA. Among people with less of the protein, called tau, slowing was most pronounced in those younger than 75 and those who did not yet have Alzheimer’s but had a pre-Alzheimer’s condition called mild cognitive impairment, according to data presented Monday at the Alzheimer’s Association International Conference in Amsterdam. “The earlier you can get in there, the more you can impact it before they’ve already declined and they’re on this fast slope,” Dr. Daniel Skovronsky, Eli Lilly’s chief medical and scientific officer, said in an interview.
Persons: Eli Lilly, donanemab, , they’ve, Dr, Daniel Skovronsky, Eli Lilly’s Organizations: Alzheimer’s Association International Locations: Amsterdam
The participants, who were all older than 71, were then screened for dementia using the Dementia Screening Interview, the study said. In people with distance visual impartment, that jumped to 19.5%; 21.5% for near visual impairment; and 32.9% for people who had moderate to severe visual impairment or were blind, according to the study. Another factor that might lead to the correlation is a possible decrease in opportunities and community participation that could come with vision loss, Silverman said. “When it comes to vision impairment and blindness, an estimated 80 plus percent is either preventable or even reversible,” he added. “If you notice that you have vision that is starting to be impaired, get it checked out.”But not every case of vision loss is treatable.
Persons: Joshua Ehrlich, Ehrlich, , , Arielle Silverman, Silverman, Thomas Holland, Chicago . Holland, Holland, ” Holland, ” Silverman Organizations: CNN, Ophthalmology, University of Michigan, American Foundation for, Rush Institute, Healthy Aging, Rush Medical College Locations: United States, Ann Arbor, Chicago ., Holland
As the coronavirus pandemic dragged through its second year, an increasing number of American families were so desperate to get help for depressed or suicidal children that they brought them to emergency rooms. A large-scale analysis of private insurance claims shows that this surge in acute mental health crises was driven largely by a single group — girls aged 13 to 17. During the second year of the pandemic, there was a 22 percent increase in teenage girls who visited emergency rooms with a mental health emergency compared with a prepandemic baseline, with rises in patients with suicidal behavior and eating disorders, according to the study of 4.1 million patients published on Wednesday in JAMA Psychiatry. During the same period, March 2021 to March 2022, the records showed a 9 percent drop in teenage boys who made emergency room visits for mental health problems.
Organizations: Psychiatry
As old cables degrade, lead can leach into the soil at high levels, the report found. A 2021 pediatric study found that half the kids in the US have high levels of lead in their blood. According to the EPA, the safety standard for lead levels in the soil where children play is 400 parts per million. The Journal's investigation found that more than 100 schools have lead cables running overhead, and more than 1,000 schools and childcare centers are within half a mile of underwater lead cables. "We have not seen, nor have regulators identified, evidence that legacy lead-sheathed telecom cables are a leading cause of lead exposure or the cause of a public health issue."
Persons: Linda Birnbaum, USTelecom Organizations: Service, Street Journal, Verizon, EPA, JAMA Pediatrics, American Medical Association, Centers for Disease Control, Wall Locations: Wall, Silicon, Passaic, New Jersey, Detroit, Michigan, Willamette, Oregon, Mississippi, Louisiana
Leqembi is the first Alzheimer's antibody treatment to receive full FDA approval. The antibody, administered twice monthly through intravenous infusion, targets a protein called amyloid that is associated with Alzheimer's disease. Medicare coverage is a crucial step to help older Americans with early Alzheimer's disease pay for the treatment. Costs may vary depending on whether the patient has supplemental Medicare coverage or other secondary insurance, according to the agency. Philipson and his colleagues at the University of Chicago estimated that delaying Medicare coverage of Alzheimer's antibody treatments by one year would result in $6.8 billion in increased spending.
Persons: Joanna Pike, Leqembi, Pike, David Knopman, Knopman, Anna Eshoo of, Nanette Barragan, There's, Tomas Philipson, Bush, Philipson, Sen, Bernie Sanders, Xavier Becerra, Sanders, Eisai Organizations: Drug Administration, Medicare, FDA, Alzheimer's Association, Mayo Clinic, Services, Health, University of Chicago, Senate Health, Human Services, Clinical Locations: U.S, Minnesota, Anna Eshoo of California
CNN —Clinical overuse of marijuana is linked to a variety of complications after major elective surgery, including blood clots, stroke, breathing difficulties, kidney issues and even death, a new study found. Compared with people who were not overly dependent or addicted to marijuana, those with cannabis use disorder were more likely to suffer complications from those surgeries. The most significant associations were for blockages of coronary arteries, stroke, injury to the kidneys, blood clots, breathing complications, infection and in-hospital death, the study found. People with cannabis use disorder also stayed in the hospital longer and had higher hospital bills than people without the disorder. “In the context of increasing cannabis use rates, our findings support preoperative screening for cannabis use disorder,” the authors wrote.
Persons: Hannes P, Albert Organizations: CNN, McGovern Medical School, University of Texas Health Science Center, National Institute on Drug Abuse Locations: Houston
July 3 (Reuters) - The number of U.S. women who died within a year after pregnancy more than doubled between 1999 and 2019, with the highest deaths among Black women, researchers said on Monday. There were an estimated 1,210 maternal deaths in 2019, compared with 505 in 1999, according to a study published in the medical journal JAMA. Unlike previous U.S. studies of maternal mortality, which focused on national trends, the current study analyzed data state-by-state. To the researchers' surprise, Black women had the highest maternal mortality rates in some Northeast states. "Our findings provide important insights on maternal mortality rates leading up to the pandemic, and it's likely that we'll see a continued increase in the risk of maternal mortality across all populations if we analyze data from subsequent years," Bryant said.
Persons: Dr, Allison Bryant, Brigham, Bryant, Nancy Lapid, Michael Erman Organizations: American Indians, Alaska Natives, Blacks, Pacific Islanders, U.S . Centers for Disease Control, Thomson Locations: Alaska, California, Massachusetts, Boston, Midwest, Great
CNN —You may know someone who has taken melatonin to help them sleep. Sometimes, they mention a friend who recommended a specific brand that’s supposed to be “really strong.” Then I ask them if taking melatonin has worked for them. Finally, people can become psychologically dependent on taking the supplement and become afraid of what will happen to their sleep if they stop taking melatonin. To understand how melatonin supplements work (and why they often don’t), it’s important to look at how the hormone naturally functions in the human body. This makes consulting a sleep specialist before taking melatonin all the more important.
Persons: Jennifer Martin, Australia — Organizations: David Geffen School of Medicine, University of California, American Academy of Sleep, CNN, JAMA, European Union, Twitter, Facebook Locations: Los Angeles, cannabidiol, Canada, United Kingdom, Japan, Australia
For the new company's first hire, GymBird is choosing one lucky person to walk 10,000 steps in one day for $10,000, according to its site. Accepting the offer requires the CSO to train for a month until they feel comfortable walking 10,000 steps in a single day. "By the last day of the month, they must walk the full 10,000 steps within a 24-hour period," GymBird wrote in its job offering. Just under 10,000 steps each day (9,800) can lower risk of dementia by 50%, according to two studies published in JAMA Neurology and JAMA Internal Medicine last year. For every 2,000 steps you walk daily, you can reduce your risk of cancer, heart disease and premature death by 10%, peaking at 10,000 steps, the research shows.
Persons: GymBird, they're, Warren Buffett Organizations: CSO, Nutrition Solutions, Newsweek, CNBC Locations: U.S
Birds flying over the corridor of the Jama Masjid at sunrise in New Delhi on October 27, 2016. India's growth is looking like a "bright spot" as the country's outsourcing sector remains robust on top of an increasing trend of tech companies moving their manufacturing lines to the country, according to the CEO of Destination Wealth Management. The International Monetary Fund recently released its forecast for India's economy to expand by 5.9% in 2023. A large part of this is driven by India's outsourcing sector being on pace to keep its momentum, said the CEO. Many companies are opting to outsource software development projects to India for quality at reasonable costs, according to Krina Mehta, a co-founder of U.S.-based offshore software development company Fortune Infosys.
Persons: Michael Yoshikami, he's, Krina Mehta, Yoshikami Organizations: Destination Wealth Management, Monetary Fund, U.S, Fortune Infosys Locations: Jama, New Delhi, India
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