The Japanese currency is particularly sensitive to the gap between U.S. and Japanese long-term bond yields.
Japanese officials staged their first yen-buying intervention since 1998 on Sept. 22, when the yen tumbled to as low as 145.90 per dollar.
Sterling slipped 0.13% to $1.0947, and earlier touched $1.09385, marking a fresh low since Sept. 29, following the comments by the BoE governor.
Gilt yields soared on Tuesday, lifting yields in the U.S. and elsewhere.
The New Zealand dollar was 0.21% lower at $0.5570, approaching the previous day's low of $0.5536, a level not visited since March 2020.