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Mitch Daniels would have been an ideal GOP Senate candidate. Daniels' decision offers a look at the obstacles that the party continues to face headed in 2024. Mitch Daniels would have been seen by most traditional conservatives as an ideal candidate to run for the Senate. Eric Holcomb is a potential candidate in the 2024 Indiana Republican Senate primary. AP Photo/Manuel Balce CenetaIndiana could drive the GOP Senate roadmapAhead of the 2022 midterm elections, Republicans anticipated making major gains in Congress, which eventually didn't come to pass.
The pharmaceutical industry, whose members gathered in the thousands this week in San Francisco for the annual JP Morgan Healthcare conference, opposed the legislation and has begun implementing strategies to mitigate its impact. "In 10 years, we'll have far fewer small molecules being developed than we do today." He questioned the benefit of "rules that really just disincentivize investment in what ends up being convenient drugs, drugs for tough conditions like cancer and drugs that get really cheap when they go generic." Most medicines on the market today are small molecules, which can be taken by mouth, absorbed into the bloodstream and easily penetrate cell membranes. He noted it is not unusual for pharmaceutical companies to choose not to pursue a drug they once thought promising.
Larson to attempt Indy 500 and NASCAR 600 double in 2024
  + stars: | 2023-01-12 | by ( ) www.reuters.com   time to read: +2 min
Jan 12 (Reuters) - Kyle Larson will attempt the Indianapolis 500 and NASCAR Coca-Cola 600 double next year after announcing on Thursday he would join Arrow McLaren Racing for a one-off run at the famed Brickyard. Larson, the 2021 NASCAR Cup Series champion, will become the first driver to attempt the double since Kurt Busch raced in both events in 2014. Only four drivers have attempted the double of racing in Indy 500 in Indianapolis and flying to Charlotte, North Carolina to jump in a car and run the Coca-Cola 600 later that same day. While Rick Hendrick's stock car teams have won a record 291 Cup Series races, the Indy 500 will mark Hendrick Motorsports first IndyCar series event. McLaren have routinely added notable names to their driver lineup for the Indy 500, including twice Formula One world champion Fernando Alonso.
Eli Lilly (LLY) has spent decades researching Alzheimer's disease without successfully bringing to market a treatment that slows the memory-destroying condition. For Eli Lilly as a company, an Alzheimer's drug is an important pursuit. Lilly's Alzheimer's history Eli Lilly's "first real foray" into Alzheimer's came in the 1990s, according to Dr. John Sims, Eli Lilly's head of medical development for donanemab. Financial implications for Lilly LLY mountain 2021-10-08 The Club started a new position in Eli Lilly (LLY) in October 2021. The Eli Lilly logo is shown on one of the company's offices in San Diego, California, September 17, 2020.
It was the team's first game since the Bills' safety, Damar Hamlin, collapsed and suffered cardiac arrest in the midst of a Monday night game against the Bengals in Cincinnati — and the team said its stunning success from the very start of the game was in Hamlin's honor. After Hines' second kickoff return for a touchdown occurred in the third quarter of the game, fans and teammates went wild. Trainers surrounded Hamlin and he received CPR for several minutes as the Bills knelt to pray on the field. "Thankful for everyone who has reached out and prayed," Hamlin tweeted. The NFL said Hamlin will receive his full $825,000 for 2022 despite landing on the injured reserve list.
Vanessa Hughes recently moved to West Lafayette, Indiana, a city of 45,000 and a major university. In West Lafayette, she's paying half the amount for a significantly bigger space with a yard for their two dogs. In 2023, the search for affordable housing could pull more homebuyers towards Midwestern spots like West Lafayette. Michael Hickey/Getty ImagesBy the end of November, they had made the move to West Lafayette. West Lafayette is just one place that offers people incentives to move there.
Ms. O'Grady joined the paper in August 1995 and became a senior editorial page writer in December 1999. She was appointed an editorial board member in November 2005. In 2012 Ms. O’Grady won the Walter Judd Freedom Award from The Fund for American Studies. In 2009 Ms. O'Grady received the Thomas Jefferson Award from The Association of Private Enterprise Education. Ms. O'Grady received a bachelor's degree in English from Assumption College and an M.B.A. in financial management from Pace University.
ENGLEWOOD, Colo. — The Denver Broncos fired first-year head coach Nathaniel Hackett on Monday with two games left in the season. Firing Hackett with two games left in a lost season allows Penner to begin his search for a replacement immediately. The Broncos scheduled a news conference for Tuesday, when they’re expected to name their interim head coach for games at Kansas City next weekend and at home against the Chargers in Week 18. Hackett is the third NFL head coach fired during the 2022 season. The Carolina Panthers replaced Matt Rhule with interim head coach Steve Wilks and the Indianapolis Colts fired Frank Reich and replaced him with coaching novice Jeff Saturday.
Republican Sen. Mike Braun is running for governor of Indiana in 2024. He filed the paperwork to create the new Mike Braun for Indiana, Inc., campaign committee in late November and has since rolled out a promotional website. "I'm very confident Indiana will stay in Republican hands," Daines told Insider between votes at the US Capitol. And fortunately for the Hoosier State, we have a lot of talented people who might run for that seat," Young told Insider at the US Capitol. The Banks and Spartz campaigns did not immediately respond to requests for comment about prospective Senate runs in 2024.
The global electric commercial vehicle market is expected to top $370 billion in annual revenue by 2030. With a flood of new battery-powered autos set to transform the business of building passenger vehicles, it was natural that commercial vehicles would be next. The global electric commercial vehicles market is expected to surpass $370 billion in annual revenue by 2030, according to Guidehouse Insights. It also has its toes deep into electric mobility, building batteries not only for EVs but also electric buses, boats, and trucks. Now, through internal changes and acquisitions, BorgWarner is positioning itself for the electrified future, especially as that future comes to commercial vehicles.
Messi, Mbappé, and a World Cup Masterpiece
  + stars: | 2022-12-18 | by ( Jason Gay | ) www.wsj.com   time to read: 1 min
Alright, I did not think anything could top the Minnesota Vikings roaring back from 33-0 to stun the Indianapolis Colts Saturday in yet another absurdist “Minneapolis Miracle.” And yet…If you watched Sunday’s World Cup final between Argentina and France, I don’t need to explain.
[1/3] Dec 17, 2022; Minneapolis, Minnesota, USA; Minnesota Vikings place kicker Greg Joseph (1) celebrates his game winning field goal against the Indianapolis Colts after the game at U.S. Bank Stadium. With the win, the Minnesota Vikings clinched the NFC North. Minnesota trailed 33-0 at halftime before orchestrating the largest comeback victory in NFL history. Kirk Cousins was 34-of-54 passing for 460 yards and four touchdowns for Minnesota, with two interceptions. Matt Ryan was 19-of-33 passing for 182 yards and a touchdown in defeat for the Colts (4-9-1).
“(It’s) not a season-ending type of knee,” Harbaugh said after the game, according NFL.com “We’ll see if he can go back this week. Katie Stratman/USA TODAY Sports/ReutersThe Bengals were down by seven going into the final quarter but turned it around. Only the Detroit Lions have scored more in the final quarter when they scored 34 against the Bears in 2007. With the win the Cowboys (9-3) maintain their winning form and remain two games behind the Philadelphia Eagles (11-1) in the NFC East. All three of Prescott's thrown touchdowns came in the third quarter before the Cowboys' final quarter onslaught.
Biden’s Dirty Oil Deal With Venezuela
  + stars: | 2022-11-28 | by ( Mary Anastasia O Grady | ) www.wsj.com   time to read: +1 min
Ms. O'Grady joined the paper in August 1995 and became a senior editorial page writer in December 1999. She was appointed an editorial board member in November 2005. In 2012 Ms. O’Grady won the Walter Judd Freedom Award from The Fund for American Studies. In 2009 Ms. O'Grady received the Thomas Jefferson Award from The Association of Private Enterprise Education. Ms. O'Grady received a bachelor's degree in English from Assumption College and an M.B.A. in financial management from Pace University.
Indiana's Republican-controlled legislature passed the law in May, overriding the veto of the state's Republican governor, Eric Holcomb, who had said it was unnecessary. Proponents of the law say that allowing transgender girls to play on girls' teams is unfair because they have a biological advantage. The mother of a 10-year-old transgender girl attending public school in Indianapolis then sued the school district in Indianapolis federal court, seeking to stop it from enforcing the law against her. The Indianapolis school district itself did not oppose the injunction, but the state of Indiana intervened to defend its law. A group of 19 Republican-led states filed their own brief supporting Indiana in September.
How a Coach Named Saturday Moved From Fridays to Sundays
  + stars: | 2022-11-10 | by ( Andrew Beaton | ) www.wsj.com   time to read: 1 min
University of South Carolina quarterback Colten Gauthier was scrolling Twitter on Monday when he saw news he couldn’t believe: Jeff Saturday, who coached him at a tiny Christian high school just a couple of years earlier, had been named interim coach of the Indianapolis Colts. “I thought it was one of those parody accounts,” Gauthier says.
CNN —The Indianapolis Colts have parted ways with head coach Frank Reich, the NFL team announced Monday. Former Colts Pro Bowl center and Super Bowl winner Jeff Saturday has been named interim head coach. You have to be able to work with people.”His interim coach “knows this game inside and out,” he assured reporters. Reich, who was in his fifth season with the Colts, compiled a 40-33-1 record in the regular season and 1-2 in the playoffs. Frank Reich walks off the field after losing 17-16 to the Washington Commanders at Lucas Oil Stadium on October 30 in Indianapolis.
Ledecky breaks 800m freestyle short-course world record
  + stars: | 2022-11-05 | by ( ) www.reuters.com   time to read: +1 min
[1/2] Nov 4, 2022; Indianapolis, IN, USA; United States Katie Ledecky walks off the poo deck after competing in the 200 meter freestyle swim during the FINA Swimming World Cup finals on Friday, Nov 4, 2022; Indianapolis, IN, USA; at Indiana University Natatorium. Mandatory Credit: Grace Hollars-USA TODAY SportsNov 5 (Reuters) - Ten-times Olympic medallist Katie Ledecky broke her second world record in just over a week on Saturday, beating the all-time women's short-course time in the 800 metres freestyle at the Indianapolis FINA World Cup meeting on Saturday. The American led from the start and finished in 7:57.42, shaving nearly two seconds off the previous mark set by Spain’s Mireia Belmonte in 2013. Ledecky, who earned her third straight Olympic gold in the 800m freestyle in Tokyo last year, the short-course world record in the 1,500 metres freestyle by nearly 10 seconds the previous Saturday. Reporting by Amy Tennery in New York; Editing by Ken FerrisOur Standards: The Thomson Reuters Trust Principles.
INDIANAPOLIS — An Indianapolis doctor who performed an abortion on a 10-year-old rape victim from Ohio is suing Indiana’s attorney general, seeking to block him from using allegedly “frivolous” consumer complaints to issue subpoenas seeking patients’ confidential medical records. The lawsuit targeting Attorney General Todd Rokita was filed Thursday in Marion County on behalf of Dr. Caitlin Bernard, an Indianapolis obstetrician-gynecologist, her medical partner, Dr. Amy Caldwell, and their patients. After the news of the 10-year-old’s abortion broke, Rokita told Fox News he would investigate whether Bernard violated child abuse notification or abortion reporting laws. He also said his office would look into whether anything Bernard said to The Indianapolis Star about the girl’s case violated federal medical privacy laws. Bernard’s attorney, Kathleen DeLaney, signaled in a July court filing that she planned to sue Rokita.
Eli Lilly (LLY) reported a noisy third-quarter before the opening bell Thursday, but the numbers did not change our thesis in what we think is the best long-term growth story in large cap pharma. On the bottom line, Eli Lilly grew its adjusted earnings-per-share by 12% to $1.98, beating the consensus forecast of $1.92, according to Refinitiv. Bottom line Another messy quarter for Eli Lilly but one that has little impact on what we believe is still a compelling story. Verzenio revenue of $618 million beat estimates of $615 million Jardiance revenue of $573 million beat estimates of $495 million Taltz revenue of $679 million missed estimates of $682 million Retevmo revenue of $40.5 million missed estimates of $52 million. This Tuesday, July 17, 2012, photo shows the Eli Lilly corporate headquarters in Indianapolis.
Eli Lilly — which generates about 40% of its sales overseas — largely attributed the guidance cut to the strong U.S. dollar. With three quarters already reported, Eli Lilly now expects full-year sales to range between $28.5 billion to $29 billion and adjusted per-share earnings between $7.70 to $7.85. New diabetes drug off to great start One of our biggest reasons for liking Eli Lilly is the company's new type 2 diabetes drug that's also shown promise as an obesity treatment . The drug is similar to one that Eli Lilly is working to treat the most common form of dementia. David Ricks, CEO, Eli Lilly Scott Mlyn | CNBC
INDIANAPOLIS — An Indianapolis police officer accused of kicking a handcuffed man in the face during an arrest last year was indicted Tuesday by a federal grand jury for alleged use of excessive force. The police body camera video of a forceful arrest on Sept. 24, 2021, appears to show an officer, Sgt. Police Chief Randal Taylor recommended last year that Huxley, then a 14-year veteran of the Indianapolis Metropolitan Police Department, be dismissed. Court records detailing those charges said Huxley and two officers approached a man near the city’s Monument Circle after hearing him shouting. Officers asked the man to stop shouting, but after he refused he was handcuffed.
Starbucks is closing a store in downtown Indianapolis, Indiana over safety concerns. Starbucks has closed more than a dozen other locations since July, citing safety concerns. But local police and business owners are puzzled by the announcement, telling Fox 59 that the area is safe. "We were not made aware of any type of safety concerns," Phil Burton, commander of the Indianapolis Metropolitan Police Department's Downtown District, told the outlet. Starbucks said that employees at the Indianapolis store will be able to transfer to other stores nearby.
An Indiana woman who poisoned the oatmeal of her child's father and strangled him with his favorite tie has been sentenced to more than 100 years in prison. They found Kelley unresponsive at his home, and Littlefield '"grabbed Fran’s 'favorite tie'" and strangled him, the affidavit states. When Littlefield was convicted of murder and conspiracy to commit murder, her daughter provided some of the most damaging witness testimony The Indianapolis Star reported in August. Littlefield's daughter pleaded guilty in March to conspiracy to commit murder and was sentenced to 26 years in prison. Her boyfriend pleaded guilty in May to conspiracy to commit murder.
Law enforcement in Ohio was aware of the case, Trick added, and they had to go to Indianapolis to retrieve tissue to be tested as part of a sexual assault investigation. In a prior statement regarding the initial lawsuit, Yost disagreed that the right to an abortion is protected under state law. “Aside from filing the wrong action in the wrong court, they are wrong as well on Ohio law. Abortion is not in the Ohio Constitution.”In the wake of the overturning of Roe, 13 states have put laws in place restricting most abortions. “Many patients broke down in tears in our office,” Sharon Liner, the medical director of Planned Parenthood Southwest Ohio, said in the affidavit.
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