DIRS.INFO The most relevant business & tech news

☆ Analysis: Bank of Japan gives an inch, investors ready to claim a mile
▼ + stars: | 2022-12-21 | by ( Tom Westbrook | ) www.reuters.com time to read: +5 min

But rather than providing breathing room, investors say it is likely to encourage more of the sort of pressure that has bent the bond market out of shape. "Fifty basis points becomes the new 25 basis points. When trading resumed in Japan, 10-year JGB yields shot towards their new ceiling and futures fell so fast it triggered a circuit breaker suspending trade. By the end of the session, 10-year bond yields sat 14.5 basis points higher at 0.395%, the sharpest one-day rise for Japanese 10-year yields in more than 14 years. Mandatory credit Kyodo/via REUTERSThose swaps - another market measure of interest rate expectations - tracked bond yields until early this year.

☆ Surprising Fatty Liver Results Could Put Madrigal in Big Pharma’s Sights
▼ + stars: | 2022-12-19 | by ( David Wainer | ) www.wsj.com time to read: 1 min

There have been so many disappointing trial results targeting the liver disease known as NASH, or nonalcoholic steatohepatitis, that investors were understandably cautious going into one small biotech’s late-stage results. Yet the topline results released by Madrigal Pharmaceuticals on Monday looked better than most analysts had expected, sending the stock soaring 220%. Ahead of the results, most analysts expected the study to achieve one of the two primary endpoints—a reduction in inflammation—but weren’t as confident it could also deliver on the reduction of liver scarring. The latter is an important measure because it can lead to complications such as cirrhosis.

☆ A tiny biotech's experimental treatment for a silent disease that strikes millions just cleared a key hurdle and the stock is up more than 200%
▼ + stars: | 2022-12-19 | by ( Sarah Braner | ) www.businessinsider.com time to read: +2 min

Madrigal Pharmaceuticals reported positive results in its phase 3 trial for a drug to treat NASH. NASH is a serious liver condition that does not have an FDA-approved treatment. Many people don't even know they have it, which is why some people call it a "silent" disease. In a trial of more than 950 patients, 26% of patients taking 80mg and 30% of patients taking 100mg of the drug showed that NASH activity like swelling had been reduced. Pharma hasn't found a way to treat NASH yetThe pharma industry has been watching NASH for a while.

☆ Madrigal NASH drug meets goals in much-awaited trial, shares surge
▼ + stars: | 2022-12-19 | by ( ) www.reuters.com time to read: +1 min

Dec 19 (Reuters) - Madrigal Pharmaceuticals' (MDGL.O) experimental drug for fatty liver disease met both of the main goals in a highly anticipated late-stage study, it said on Monday, sending the company's shares soaring over 200%. The positive data sets the stage for the drug, resmetirom, to become the first approved treatment for NASH, or nonalcoholic steatohepatitis, a disease that affects about 5% of adults in the United States. Data from the trial shows a lower 80 milligram dose helped 26% of patients reach NASH resolution, compared to 30% for a higher 100 milligram dose, and 10% for placebo. NASH is a form of nonalcoholic fatty liver disease, characterized by the organ developing fibrosis or scarring, which can progress to cirrhosis and liver failure. The company plans to file a marketing application seeking accelerated approval for the drug in the first half of 2023.

☆ Third Point could see big returns from small changes at Bath & Body Works
▼ + stars: | 2022-12-17 | by ( Kenneth Squire | ) www.cnbc.com time to read: +6 min

Business: Bath & Body Works is a specialty retailer of home fragrance, body care, soaps and sanitizer products. In August 2021, Bath & Body Works (formerly known as L Brands) completed the separation of its Victoria's Secret business. Loeb is one of the true pioneers in the field of shareholder activism and definitely one of a handful of activists who shaped what has become modern day shareholder activism. He invented the poison pen letter in a time when a poison pen was often necessary, and as times have changed, he has transitioned from the poison pen to the power of the argument. Third Point expressed its concern with Bath & Body Works' executive compensation structure , noting that excessive awards have been made that are disconnected to important performance metrics.

☆ Golden Globe Awards 2023: See the full list of nominees
▼ + stars: | 2022-12-12 | by ( Lisa Respers France | ) edition.cnn.com time to read: +7 min

CNN —The nominees for the 80th Golden Globe Awards were announced on Monday. Mayan Lopez and Selenis Leyva, two of the stars from “Lopez vs. Lopez,” announced the range of film and television nominees as selected by members of the Hollywood Foreign Press Association (HFPA). Favored Oscars contender “The Banshees of Inisherin” led the film categories, with nominations including best musical or comedy film. It stars Colin Farrell and Brendan Gleeson. The ceremony, which was not broadcast last January over controversy surrounding the HFPA, will return to NBC on Jan. 10.

☆ LeBron James passes Magic Johnson on NBA’s career assists list
▼ + stars: | 2022-12-03 | by ( Amy Woodyatt | ) edition.cnn.com time to read: +1 min

CNN —LeBron James moved past Magic Johnson for sixth place on the NBA’s all-time assists list as the Los Angeles Lakers took a hard earned 133-129 win over the Milwaukee Bucks. James added 28 points in a match where the lakers managed to hold off the Milwaukee Bucks, winning 133-129. James finished the match with 11 assists in total, taking his tally to 10,144. “It means a lot, obviously,” James said, of surpassing Johnson’s assists, according to NBA.com. James is now creeping closer to the title of NBA all-time leading scorer, and is currently 936 career points behind Kareem Abdul-Jabbar.

☆ 3 Ski Vacation Ideas That Suit Both Devotees and Dabblers
▼ + stars: | 2022-12-01 | by ( Donna Bulseco | ) www.wsj.com time to read: +2 min

“A NEW YEAR, a new slope” could be the mantra of Lisa Parilla, whose Bay Area family of four like to try out new ski runs during winter breaks. While dad and the couple’s 11-year-old son ski all day, she and their 13-year-old daughter like to squeeze in shopping, sightseeing and leisurely lunch breaks. Given high travel costs, booking flights, food and comfortable digs for a five-day spree at $10,000 demands creativity and flexibility. Its iconic Corbet’s Couloir run, however, with a terrifying 45-degree pitch, is not for the faint of heart. For this family trip, Ms. Nash suggests Hotel Terra in Teton Village, or a 1-2 bedroom with full kitchen at Teton Mountain Lodge, a ski-in, ski-out option in Mountain Village.

☆ Goldman Sachs says this little-known biotech stock can double on potentially ‘blockbuster’ revenue
▼ + stars: | 2022-12-01 | by ( Sarah Min | ) www.cnbc.com time to read: +2 min

Investors should buy biopharma stock Altimmune as it can double from here depending on the success of a new obesity drug, according to Goldman Sachs. However, the analyst expects that the growing obesity market is not a "zero-sum game" and has niches for new players. "We believe that cardiovascular and lipid benefits conferred by pemvidutide will allow ALT to earn meaningful market share and blockbuster revenues," Jenkins wrote. The analyst expects further studies on the pemvidutide's treatment on other diseases could also help differentiate the drug. Shares of Altimmune are up 8% this year, but the analyst expects they'll advance further.

Some 83 percent of babies in the United States start out on breast milk, but by 6 months, just 56 percent are breastfed — and at that stage, only a quarter drink breast milk exclusively, as the American Academy of Pediatrics recommends. To find out what it takes to breastfeed a baby, The New York Times followed four mothers for a day as they nursed, pumped and supplemented their milk with formula. Dr. Ma returned to work four weeks after her oldest daughter’s birth and two weeks after her second arrived. While performing long operations, she leaked breast milk under her surgical gown. Now her hours are more reasonable, and she has an office with a door that locks — but Dr. Ma still feels relentless pressure to keep up.

☆ American Music Awards 2022: How to watch and more
▼ + stars: | 2022-11-20 | by ( Sandra Gonzalez | ) edition.cnn.com time to read: +1 min

CNN —The 50th American Music Awards will take place Sunday night. The event celebrates some of the year’s best music and performances, and the winners are voted on by fans. The hostActor, producer and musician Wayne Brady will bring his talents to the stage to helm the event. PerformersViewers can tune into to watch performances by Pink, Dove Cameron, Lil Baby, Bebe Rexha, Carrie Underwood, Imagine Dragons and more. Meanwhile, Lionel Richie, a 17-time AMA winner, will be honored with the Icon Award, marking his career contributions to the music industry.

☆ How Much House Can I Afford?
▼ + stars: | 2022-11-19 | by ( ) www.wsj.com time to read: +6 min

By Sheryl Nance-NashYou’ve decided you’re going to pursue the American dream and get that house, be it your first one or to trade up. One of the first—and most important—things you’ll need to do is figure out how much house you can afford. Read on to get started building a budget for your house. Plug in factors like income, estimated down payment, loan term, how much you spend a month on debt, and your credit score and you’ll get a sense of what you can and cannot afford. Costs to include in your housing DTIprincipalinterestreal estate taxesmortgage interestAdditional costs to include in your broader DTIcredit card debtcar loansstudent loansOther installment loansHow much house can I afford without putting 20% down?

☆ Stocks making the biggest moves premarket: Macy's, BJ's Wholesale, Kohl's and others
▼ + stars: | 2022-11-17 | by ( Peter Schacknow | ) www.cnbc.com time to read: +2 min

Check out the companies making headlines before the bell:Macy's (M) – Macy's stock leaped 9.6% in the premarket after the retailer reported better-than-expected profit and revenue. BJ's Wholesale (BJ) – BJ's added 2.4% in premarket trading after beating analyst forecasts on both the top and bottom lines for its latest quarter. The warehouse retailer also reported better-than-expected comparable store sales and raised its full-year forecast. Alibaba (BABA) – The China-based e-commerce giant reported better-than-expected earnings but revenue fell short of analyst forecasts. Norwegian Cruise Line (NCLH) – The cruise line operator's stock slid 5% in premarket trading after a double-downgrade from Credit Suisse to underperform from outperform, with the firm citing a number of factors including valuation.

☆ David Dobrik's L.A. pizza restaurant opening draws massive weekend crowds despite influencer’s controversial past
▼ + stars: | 2022-11-14 | by ( Morgan Sung | Morgan Sung Is A Trends Reporter For Nbc News Digital. | ) www.nbcnews.com time to read: +7 min

YouTuber David Dobrik’s restaurant, Doughbrik’s, would open its doors at 1 p.m. Saturday. The family knew its early arrival would guarantee them a prime spot in line, a slice of pizza and most important: a Dobrik sighting. The lull in content follows a string of controversies entangling Dobrik since he filed for the Doughbrik’s trademark in 2020. Dozens of people flocked around the entrance to the restaurant on Saturday, where Dobrik was posing for photos with fans who braved the line. The restaurant, he wrote, "sold out of pizza" its opening day.

☆ Finance influencers who promoted FTX are saying 'sorry' to fans and promising to do better — and it shows the risks of giving investment advice to your followers
▼ + stars: | 2022-11-11 | by ( Amanda Perelli | ) www.businessinsider.com time to read: +5 min

Crypto-exchange platform FTX has filed for Chapter 11 bankruptcy. Finance influencers who promoted FTX are doing some soul searching in the wake of its implosion. FTX had several high-profile deals with celebrities, athletes, and influencers, including a 19-year sponsorship of the Miami Heat for $135 million. Among the celebrities and influencers FTX paid to talk about the platform was the personal finance YouTuber Graham Stephan, who published a video on Thursday titled, "Let's talk about FTX." "As much as I trusted the information that I was given, I was wrong and I'm sorry," Stephan said to his 4.1 million subscribers.

CNN —Suspended Brooklyn Nets star Kyrie Irving reportedly met with NBA commissioner Adam Silver on Tuesday, according to multiple reports, including one from the Athletic’s Shams Charania, citing unnamed sources. According to Charania, Silver and Irving met and had “a productive and understanding visit,” as Irving and the Nets work toward his return to the court. CNN has reached out to the NBA, the Nets and Irving’s representatives but has not heard back. Before the game, the Nets named assistant coach Jacque Vaughn as their next permanent head coach. Vaughn was the interim head coach after Brooklyn parted ways with former head coach Steve Nash last week after a disappointing 2-5 start.

☆ DC Attorney General sues Washington Commanders, owner Dan Snyder and NFL for deceiving residents
▼ + stars: | 2022-11-10 | by ( Jessica Schneider Eric Levenson David Close Jacob Lev | Jessica Schneider | Eric Levenson | ) edition.cnn.com time to read: +10 min

CNN —DC Attorney General Karl Racine announced a lawsuit against embattled Washington Commanders owner Dan Snyder, the team and the NFL on Thursday, alleging they colluded to deceive DC residents about an NFL investigation into the team’s toxic workplace culture and allegations of sexual assault. The lawsuit cites the District of Columbia’s Consumer Protection Procedures Act, which gives the Attorney General broad authority to hold individuals or a company accountable for misleading customers. At the same time, Snyder and the team tried to interfere with and obstruct the investigation, the lawsuit states. The Attorney General said the penalties could run into the millions of dollars. Robinson’s agent Ryan Williams tweeted his displeasure with the Commanders’ statement on Wednesday night.

The first election to put abortion rights to the test after the Supreme Court overturned Roe v. Wade appears unlikely to reshape the map of abortion access — at least not overnight. States that protect abortion access Mixed results New protections Existing protections Results pending States that restrict abortion access Results pending New restrictions likely Mixed results Existing restrictionsResults pending in races affecting abortion Arizona Montana Nebraska PennsylvaniaMany of the most competitive state-level races with consequences for abortion were too close to call on Wednesday. Gretchen Whitmer and Attorney General Dana Nessel, both Democrats who pledged to protect abortion rights, won re-election. But two candidates for the State Supreme Court who were backed by anti-abortion groups did not win their races. Mr. Cooper, a Democrat, opposes abortion restrictions, and Republicans failed to secure a supermajority in the Legislature that would have allowed them to override his veto.

☆ Turbulent Nets name Vaughn new head coach
▼ + stars: | 2022-11-09 | by ( ) www.reuters.com time to read: +1 min

NEW YORK, Nov 9 (Reuters) - The Brooklyn Nets named longtime assistant Jacque Vaughn their new head coach on Wednesday, amid a turbulent moment in the franchise's history. read moreDays prior, the Nets abruptly parted ways with head coach Steve Nash after an abysmal start to the season, installing Vaughn as interim coach. read moreIf Irving serves a five-game suspension, he would next be available to play Nov. 13 on the road against the Los Angeles Lakers. Vaughn, who won the National Basketball Association (NBA) championship title as a player with the San Antonio Spurs in 2007, joined the Nets as an assistant coach in 2016. He previously served as head coach of the Orlando Magic.

☆ Abortion rights are on the ballot in these states. Here's what you need to know for the midterms
▼ + stars: | 2022-11-07 | by ( Spencer Kimball | ) www.cnbc.com time to read: +7 min

Michigan is poised to become a safe haven of constitutionally protected abortion rights in the Midwest, where access is shrinking. Democrats have made abortion rights central to their campaign to maintain control of Congress and expand their majorities in the midterms. This means reinstating abortion rights at the federal level is unlikely in the near term. Kansas, which is also a very conservative state, resoundingly rejected a ballot measure in August that would have stripped abortion rights from its state constitution. MichiganIn Michigan, voters will decide whether to amend the state constitution to protect not just abortion but reproductive rights broadly.

☆ From Teslas to BMWs, cars are piling up on land and at sea in German port of Bremerhaven
▼ + stars: | 2022-11-07 | by ( Lori Ann Larocco | ) www.cnbc.com time to read: +4 min

Krisztian Bocsi | Bloomberg | Getty ImagesThe Port of Bremerhaven, the main roll on/roll off port in Germany and one of the largest automobile hubs in the world, is experiencing gridlock. He said car imports into Bremerhaven from the U.S. and Mexico are operating on a timeline of months. Bremerhaven is Europe's fourth-largest containership port, with annual capacity over 5 million TEU [twenty-foot equivalent unit] containers. Another UK strike nearsAt the Port of Liverpool in the U.K., a fourth strike is set for November 14-21 if no deal with port management is reached. Braun told CNBC that since these strikes are well organized there is time in advance to plan and circumvent the port, diverting trade elsewhere.

NBA Commissioner Adam Silver blasted Brooklyn Nets guard Kyrie Irving on Thursday, calling out the player's "reckless decision" to post "deeply offensive antisemitic material." “Kyrie Irving made a reckless decision to post a link to a film containing deeply offensive antisemitic material," Silver said in statement. “I think the NBA dropped the ball,” Hall of Fame player and prominent basketball commentator Charles Barkley said on TNT earlier this week. But I have the right to say, 'No, you're not going to take my $40 million and insult my religion.'" "I think the NBA they made a mistake" not taking immediate action against Irving, Barkley said.

Mandatory Credit: Brad PennerNov 3 (Reuters) - The Brooklyn Nets on Thursday suspended star guard Kyrie Irving for at least five games, saying that despite holding a second press conference to address a controversial documentary he had still refused to disavow anti-Semitism. The team said Irving would be suspended until he undergoes a series of unspecified "remedial measures", but no less than five games. Irving issued a joint statement with the Nets and the Anti-Defamation League on Wednesday, saying he opposed all forms of hatred. Irving and the Nets also said they would each donate $500,000 toward organizations that work to eradicate hate. While not specifically mentioning the issues with Irving, the Nets parted ways with head coach Steve Nash on Tuesday after a disappointing start to their season.

☆ Kyrie Irving, Brooklyn Nets each to donate $500,000 to anti-hate organizations; NBA star takes ‘responsibility’ for negative impact of tweets
▼ + stars: | 2022-11-03 | by ( Ben Morse | ) edition.cnn.com time to read: +4 min

CNN —Kyrie Irving and the Brooklyn Nets announced on Wednesday that they will both donate $500,000 towards anti-hate organizations after the point guard tweeted a documentary deemed to be antisemitic last week. “I oppose all forms of hatred and oppression and stand strong with communities that are marginalized and impacted every day,” Irving said. “I am aware of the negative impact of my post towards the Jewish community and I take responsibility. “With this partnership, ADL will work with the Nets and Kyrie to open dialogue and increase understanding. Irving talks with now-former head coach Steve Nash during a game against the San Antonio Spurs on Friday, January 21, 2022.

☆ Steve Nash Is Gone, and the Brooklyn Nets Reboot. Again.
▼ + stars: | 2022-11-02 | by ( Jason Gay | ) www.wsj.com time to read: +1 min

Whatever is wrong with the Brooklyn Nets, and there is plenty— disaster doesn’t feel like an adequate rendering for this chronically chaotic professional basketball outfit, 2-5 entering Tuesday’s play—it is not principally the doing of Steve Nash. But because these are impatient times, and a scapegoat must be offered, and players are expensive and/or immovable, it is Nash on his way out of town after a Tuesday uncoupling charitably rebranded as a parting of the ways. Surely Nash, a former two-time NBA MVP known for his court vision, sensed it was coming. The job he took at the beginning of the 2020-21 season bears no resemblance to the shamble to be inherited by Brooklyn’s next hire, perhaps Ime Udoka—yes, that’s right, the Nets are reportedly interested in the head coach the Boston Celtics suspended in September for an entire season for what was murkily described as “violations of team policies.” Confronting crisis with crisis! You couldn’t make this team up if you tried.

Search resuls for: "Nash"

25 mentions found