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☆ Microsoft and Paige are building the world's largest AI model for detecting cancer
▼ + stars: | 2023-09-07 | by ( Ashley Capoot | ) www.cnbc.com time to read: +6 min

The AI model is training on an unprecedented amount of data that includes billions of images, according to a release . Paige also built an AI model that can help pathologists identify breast cancer, colon cancer and prostate cancer when it appears on the screen. But in order to expand its operations and build an AI tool that can identify more cancer types, Paige turned to Microsoft for help. Over the past year and a half, Paige has been using Microsoft's cloud storage and supercomputing infrastructure to build an advanced new AI model. Paige's original AI model used more than 1 billion images from 500,000 pathology slides, but Fuchs said the model the company has built with Microsoft is "orders of magnitude larger than anything out there."

Persons: Paige, Fuchs, Thomas Fuchs, Andy Moye, ChatGPT, Moye, Desney Tan, Tan Organizations: CNBC, Food and Drug Administration, Memorial Sloan Kettering Cancer Center, Netflix, Microsoft, Microsoft Health Futures, Cornell Locations: New York

☆ When Screening for Prostate Cancer Comes Too Late
▼ + stars: | 2023-09-04 | by ( Brianna Abbott | ) www.wsj.com time to read: 1 min

This copy is for your personal, non-commercial use only. Distribution and use of this material are governed by our Subscriber Agreement and by copyright law. For non-personal use or to order multiple copies, please contact Dow Jones Reprints at 1-800-843-0008 or visit www.djreprints.com. https://www.wsj.com/health/healthcare/when-screening-for-prostate-cancer-comes-too-late-1e364678

Persons: Dow Jones, 1e364678

☆ Tofu is still a popular alternative to meat, but is it actually good for you? Here's what the science says
▼ + stars: | 2023-08-30 | by ( Renée Onque | ) www.cnbc.com time to read: +1 min

Today, it is one of the most popular plant-based foods and an easy substitute for animal products like chicken and eggs. According to the American Heart Association, tofu also contains essential vitamins and minerals like:CalciumManganeseIronVitamin AThe plant-based food also has isoflavones, a type of plant estrogen, says Mok. Soy products and isoflavones aren't looked at favorably in the U.S. due to a complicated history, according to the AHA. This has caused many to raise an eyebrow at tofu as a healthy alternative. Here's what Mok says — and research shows — about whether or not tofu qualifies as a healthy food.

Persons: Jamie Mok, aren't, Mok Organizations: Academy of Nutrition, American Heart Association, AHA Locations: Asia, U.S

But automatically calling something cancer can lead to aggressive treatment, even if the cancer in question is unlikely to cause problems. For prostate cancer, a biopsy showing a grade of Gleason 6 (also known as Grade Group 1) is considered low or very low risk. In breast cancer, diagnosis of ductal carcinoma in situ, or DCIS, is similarly low or very low risk, representing the very earliest, noninvasive stage of the disease. These findings make up about 20 percent to 25 percent of all prostate and breast cancer diagnoses in the United States, involving about 100,000 people annually. Accordingly, many make the understandable choice of aggressive treatment they don’t require.

Persons: Gleason, Esserman Locations: United States

☆ Michael Parkinson, UK's 'king of the chat show', dies aged 88
▼ + stars: | 2023-08-17 | by ( Kylie Maclellan | ) www.reuters.com time to read: +3 min

LONDON, Aug 17 (Reuters) - British broadcaster Michael Parkinson, best known for interviewing some of the world's biggest celebrities on his long-running eponymous chat show, has died aged 88. After moving into current affairs television in the late 1960s, he was given his own prime-time chat show 'Parkinson' by the BBC in 1971. "After a brief illness Sir Michael Parkinson passed away peacefully at home last night in the company of his family," a family statement said. Parkinson later said he regretted getting angry with the actress. While he listed U.S. film director Orson Welles as one of his favourite guests, Parkinson also acknowledged many would simply recall the show where he was attacked by comedian Rod Hull's puppet Emu.

Persons: Michael Parkinson, Parkinson, Muhammad Ali, Elton John, John Lennon, Michael Caine, Madonna, Michael, Tim Davie, Ali, Parkinson sparred, Nick Robinson, Mary, Sir Michael Parkinson, Helen Mirren, Meg Ryan, Mirren, Ryan, Orson Welles, Rod Hull's, Kylie MacLellan, Suban Abdulla, Kate Holton, William James, Michael Holden, Christina Fincher Organizations: BBC, National Service, ITV, U.S, Twitter, Thomson Locations: British, Yorkshire, England

☆ UBS says this stock is the 'best story' among U.S. large caps, sees more than 15% upside ahead
▼ + stars: | 2023-08-14 | by ( Christina Cheddar Berk | ) www.cnbc.com time to read: +3 min

Calling it the "best fundamental story" among U.S. large caps, UBS analyst Colin Bristow on Friday lifted his price target to $612 from $526. The stock has already gained 47% year to date, mostly on the back of lofty expectations for weight loss drug sales. Bristow also expects data for its Crohn's disease treatment by year-end, as well as readouts on Verzenio for prostate cancer. Then by 2024, Lilly is expected to submit data for a cell therapy for type 1 diabetes. And there's potential for even more upside if the drug adds other indications such as renal treatment, he said.

Persons: Eli Lilly, Colin Bristow, Bristow, Lilly, Jaypirca, Novo's, — CNBC's Michael Bloom Organizations: UBS, Food, Drug, European Union, Novo Locations: U.S

☆ These 10 medications are likely targets for Medicare price negotiations this fall
▼ + stars: | 2023-08-10 | by ( Spencer Kimball | ) www.cnbc.com time to read: +3 min

Though it is still unclear which 10 drugs Medicare will select, several pharmaceutical companies have already revealed in court filings that they expect four of their blockbuster medications to be targeted. Bristol-Myers Squibb and Johnson & Johnson , in separate filings, said their blood thinners Eliquis and Xarelto will be subject to the negotiations this year. The list price of Januvia has surged 275% since 2006, according to the AARP. Johnson & Johnson reported $2.47 billion in revenue from Xarelto. "More and more people face cost-sharing that is directly affected by drug price increases," Leigh Purvis, who analyzes health-care costs for AARP, told reporters on a call Thursday.

Persons: Daniel Acker, Merck, Johnson, Abbvie, Imbruvica, Jardiance, Boehringer Ingelheim, Amgen Symbicort, Pfizer Xtandi, Breo, Biden, Januvia, Eliquis, Xarelto, Leigh Purvis Organizations: Merck, Co, Inc, Bloomberg, Getty, Medicare, Services, Myers Squibb, Johnson, Pharmacy, AstraZeneca Ibrance, Pfizer, Astellas Pharma, GSK, AARP, Bristol Myers Squibb, Jama Network, Industry Locations: Bristol, U.S, Januvia, Xarelto

☆ Still Dreaming of Retirement in the Sun Belt?
▼ + stars: | 2023-08-05 | by ( Paula Span | ) www.nytimes.com time to read: +1 min

The number of older Americans like the Coxes who are exposed to extreme heat is increasing, the result of an aging population, continuing migration to heat-prone places and climate change. Phoenix, long a retirement destination, has averaged 108 days a year of 100-plus degree temperatures since 1970. But this year has been brutal: By July 31, Phoenix had already reached 68 days this year with temperatures over 100 degrees. Temperatures hit at least 110 degrees Fahrenheit for 31 straight days, from the last day of June to the end of July, setting a record. Summer in the Phoenix suburbs has been “miserable,” Ms. Cox said, on a midmorning when the temperature in Goodyear had already reached 106.

Persons: Cox, Cox’s, ”, Deborah Carr, Phoenix, Ms, “, haven’t Organizations: Boston University, Goodyear Locations: Goodyear, Phoenix

☆ Chile's Jara leads campaign for prostate testing eight years after "finger of god"
▼ + stars: | 2023-08-05 | by ( ) www.reuters.com time to read: +2 min

REUTERS/Ivan AlvaradoAug 5 (Reuters) - Chilean defender Gonzalo Jara, widely remembered for sticking his finger up Uruguay's Edinson Cavani's backside at the 2015 Copa America, has become the face of a campaign to promote prostate testing for cancer prevention in his country. Jara's gesture, dubbed "the finger of god", earned him a three-match suspension, which ruled him out from the rest of the tournament. "With that in mind, and to take care of an important member of this great football family, we take advantage of this Superclasico to make a call for prevention and self-care of prostate cancer." The 37-year-old Jara has won 115 international caps and is with Coquimbo in Chile's top flight after stints in England, Germany, Argentina and Mexico. Reporting by Janina Nuno Rios in Mexico City, editing by Pritha SarkarOur Standards: The Thomson Reuters Trust Principles.

Persons: Sandro Ricci, Chile's Gonzalo Jara, Ivan Alvarado, Gonzalo Jara, Jara, Francisca Mora, Dr Bruno Nervi, Janina Nuno Rios, Pritha Sarkar Organizations: America, REUTERS, Copa, Argentina, TNT, Universidad de Chile, Colo Colo, Warner Bros, Chile Sin Cancer, Thomson Locations: Santiago , Chile, Chilean, Chile, Uruguay, Jara, Coquimbo, Chile's, England, Germany, Argentina, Mexico, Mexico City

☆ Novartis raises 2023 forecast, maps out Sandoz spin-off
▼ + stars: | 2023-07-18 | by ( Ludwig Burger | ) www.reuters.com time to read: +2 min

Companies Novartis AG FollowSandoz GmbH FollowFRANKFURT, July 18 (Reuters) - Novartis (NOVN.S) on Tuesday raised its full-year earnings forecast on strong drug sales and mapped out the planned spin-off and stock market debut of its generic medicines division Sandoz for early October. The Swiss drugmaker said in a statement it expected group core operating income to grow by a "low double-digit" percentage in 2023, up from high single-digit growth previously projected. Novartis shareholders will vote on the proposed Sandoz spin-off and complete separation at an extraordinary general meeting on Sept. 15. Gains were driven by better-than-expected sales of heart failure drug Entresto, up 37% in local currencies at $1.52 billion. Kesimpta, a new once-a-month injection against multiple sclerosis, also beat expectations with quarterly revenues more than doubling to $489 million.

Persons: Swiss drugmaker, Sandoz, Harry Kirsch ., Kirsch, Ludwig Burger, Rachel More, Sharon Singleton Organizations: Novartis, Sandoz, FRANKFURT, SIX Swiss Exchange, Swiss pharma, Thomson Locations: Swiss, United States, New Jersey

☆ Novartis stock jumps after drugmaker raises full-year guidance, launches $15 billion buyback
▼ + stars: | 2023-07-18 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +2 min

Novartis shares jumped on Tuesday after the Swiss drugmaker raised its full-year guidance on strong drug sales and announced a $15 billion share buyback. Novartis expects sales to rise by a high-single-digit percentage in 2023, an increase from a previous expectation of mid-single-digit growth. Novartis reported total revenue of $13.62 billion for the quarter, up around 7% from $12.78 billion the same period a year ago. The company's innovative medicines business, which develops patented medicines, raked in sales of $11.24 billion for the quarter. The company's generic medicines division, Sandoz, posted sales of $2.38 billion, up 5% from a year ago.

Persons: Sandoz, Roche Organizations: Novartis, Refinitiv, Sandoz Locations: Swiss, U.S

But Mr. Ramaswamy, now 37, made a fortune anyway. The core company Mr. Ramaswamy built has since had a hand in bringing five drugs to market, including treatments for uterine fibroids, prostate cancer and the rare genetic condition he mentioned on the stump in Iowa. Mr. Ramaswamy’s resilience was in part a result of the savvy way he structured his web of biotechnology companies. He’s a sort of a Music Man,” said Kathleen Sebelius, a Democrat and former health secretary during the Obama administration who advised two of Mr. Ramaswamy’s companies. For his part, Mr. Ramaswamy said that criticism that he overpromised was missing the point.

Persons: Ramaswamy, ”, Kathleen Sebelius, Obama, overpromised Organizations: Democrat Locations: Iowa

☆ Japan stocks are on fire this year. Here are 3 reasons why the rally could have 'staying power'
▼ + stars: | 2023-05-27 | by ( Sarah Min | ) www.cnbc.com time to read: +8 min

Since then, Japanese equities have rallied. Even so, Strategas Securities' Chris Verrone has remained optimistic on Japanese equities, saying this week that the rally is not yet overbought. Meanwhile, JPMorgan chief market strategist Marko Kolanovic said in a note, also on Tuesday, that the rally in Japan still has "staying power." For international investors, those remarks signaled that Japanese companies may be more transparent with shareholders in the future. Investors can also take a company-specific approach, according to Diamond Hill's Mohanraj, who favors Japanese companies that boast differentiated products.

☆ Too Many Older Men Are Still Screened for Prostate Cancer
▼ + stars: | 2023-05-08 | by ( Paula Span | ) www.nytimes.com time to read: 1 min

He’d occasionally noticed blood in his urine and wanted to have that checked out. His doctor ordered a prostate-specific antigen, or P.S.A., test to measure a protein in his blood that might indicate prostate cancer — or a number of more benign conditions. “It came back somewhat elevated,” said Mr. Loree, 68, an instructional designer who lives in Berkeley, Calif. A biopsy found a few cancer cells, “a minuscule amount,” he recalled. Mr. Loree was at very low risk, but nobody likes hearing the c-word. But because his brother and a friend had both been diagnosed with prostate cancer and had undergone aggressive treatment that he preferred to avoid, Mr. Loree felt comfortable with a more conservative approach called active surveillance.

Michel Gaubert first crossed paths with Karl Lagerfeld when he worked at a record store on the Champs-Élysée. “All his life Karl was obsessed with music,” he recalled. All his life Karl was obsessed with music. Then one day Eric came and asked if I wanted to work with the Karl Lagerfeld brand. Karl said Diane de Beauvau-Craon [a French princess and a pal of Mr. Lagerfeld’s] would call me.

☆ The 10 Senate seats most likely to flip in 2024
▼ + stars: | 2023-04-30 | by ( Simone Pathe | ) edition.cnn.com time to read: +19 min

The GOP needs a net gain of one or two seats to flip the chamber, depending on which party wins the White House in 2024, and it’s Democrats who are defending the tougher seats. Jim Justice announcing his Senate bid in West Virginia – the seat most likely to flip party control in 2024. In a presidential year, the national environment is likely to loom large, especially with battleground states hosting key Senate races. Two businessmen with the ability to tap into or raise significant resources could be in the mix – Eric Hovde, who lost the GOP Senate nomination in 2012, and Scott Mayer. Still, unseating Cruz in a state Trump won by nearly 6 points in 2020 will be a tall order.

☆ US FDA panel backs restricted use of AstraZeneca's prostrate cancer drug
▼ + stars: | 2023-04-28 | by ( ) www.reuters.com time to read: +2 min

April 28 (Reuters) - A panel of U.S. Food and Drug Administration advisers on Friday voted for the restricted use of British drugmaker AztraZeneca Plc's (AZN.L) experimental treatment, jointly developed with Merck & Co (MRK.N), for a type of prostate cancer. The FDA panel voted 11-1 with one abstention, in favor of Lynparza, in combination with other medications – abiraterone and prednisone or prednisolone – as a first-line treatment for a type of treatment-resistant prostate cancer in adult patients. They were withdrawn last year as second line of treatment for ovarian cancer patients after the FDA limited the use of PARP inhibitors and requested companies to pull the drug. Lynparza is already approved by the FDA to treat a type of breast cancer, ovarian cancer, as well as a different form of prostate cancer. Prostate cancer is the most common form of cancer among men in the United States with about 288,300 new cases in 2023, according to the American Cancer Society's estimates.

☆ Biogen isn't concerned about competing with Eli Lilly in the Alzheimer’s drug space, CEO says
▼ + stars: | 2023-04-25 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +3 min

Biogen isn't worried about competing with Eli Lilly as they both attempt to bring an Alzheimer's drug to the market, Biogen's CEO said Tuesday. Researchers argue that the accumulation of amyloid plaque is a crucial first step toward the cognitive decline observed in Alzheimer's disease. Eli Lilly didn't immediately respond to a request for comment. He said that will likely require Eli Lilly and Biogen to roll out maintenance doses that will keep plaque levels low. Biogen is banking on the success of its drug leqembi after the disastrous approval and rollout of its old Alzheimer's drug aduhelm last year.

☆ 'Dancing with the Stars' and 'Strictly' judge Len Goodman dies aged 78
▼ + stars: | 2023-04-24 | by ( ) www.reuters.com time to read: +2 min

LONDON, April 24 (Reuters) - Len Goodman, the head judge on British television dancing competition "Strictly Come Dancing" and its U.S. version "Dancing with the Stars", has died aged 78, the BBC said on Monday. Goodman was a successful professional ballroom dancer, winning the British championships in his late twenties before retiring from the sport and opening a dance school. Much later in life, he chaired the judging panel on "Strictly" from its launch in 2004 until 2016, and on its U.S. counterpart for most of the period from 2005 until 2022. "Strictly" was one of the BBC's most popular entertainment shows, attracting an average of more than 11 million viewers at its peak in 2010. As many as 27 million viewers watched some episodes of "Dancing with the Stars" in its early seasons.

☆ Daughter of U.S. citizen jailed by Iran says she has lost confidence in US efforts
▼ + stars: | 2023-04-22 | by ( ) www.reuters.com time to read: +2 min

MADRID, April 22 (Reuters) - The daughter of an environmentalist imprisoned by Iran said on Saturday she had lost confidence in U.S. President Joe Biden's efforts to free her father. Morad Tahbaz, an Iranian-American who also holds British citizenship, has served five years of a 10-year sentence after being convicted of spying. In July his lawyer was quoted as saying he had been granted bail, but his daughter said he was now back in jail. The United States has urged Iran to release Tahbaz and two other citizens, Emad Shargi and Siamak Namazi, who are all imprisoned on espionage charges that Washington says are baseless. Namazi, an oil executive, was jailed for 10 years in 2016 on charges of spying and cooperating with the U.S. government.

Companies Johnson & Johnson FollowApril 18 (Reuters) - Johnson & Johnson (JNJ.N) on Tuesday cautioned investors over the lingering impact of inflation-driven costs this year as the healthcare conglomerate issued a conservative full-year profit forecast, and its shares fell more than 2%. J&J also said it expected a steep decline in sales of its blockbuster Crohn's disease drug Stelara once it loses U.S. patent protection in late 2023. J&J, the first large drugmaker and medical device manufacturer to report earnings, raised the midpoint of its full-year profit forecast by 10 cents despite beating first-quarter estimates by 18 cents. A recovery in medical procedures after being weighed down by hospital staffing shortages helped the medical device unit post sales of $7.48 billion, topping analysts' estimates of $7.31 billion. Consumer health sales rose 7.4% to $3.85 billion, surpassing estimates of $3.62 billion, powered by price hikes to offset the impact from inflation.

☆ Ahmad Jamal, Jazz Pianist With a Measured Approach, Dies at 92
▼ + stars: | 2023-04-16 | by ( Eric Grode | ) www.nytimes.com time to read: 1 min

Ahmad Jamal, whose measured, spare piano style was an inspiration to generations of jazz musicians, died on Sunday at his home in Ashley Falls, Mass. The cause was prostate cancer, his daughter, Sumayah Jamal, said. That approach stood in marked contrast to the challengingly complex music known as bebop, which was sweeping the jazz world when Mr. Jamal began his career as a teenager in the mid-1940s. Bebop pianists, following the lead of Bud Powell, became known for their virtuosic flurries of notes. Mr. Jamal chose a different path, which proved equally influential.

☆ Pennsylvania Sen. Bob Casey announces re-election bid for fourth term
▼ + stars: | 2023-04-10 | by ( Summer Concepcion | ) www.cnbc.com time to read: +3 min

Sen. Bob Casey, D-Pa., on Monday announced he will seek a fourth term in the battleground state next year as Democrats fight to keep their Senate majority. "I'm running for re-election because with so much on the line for Pennsylvania's working families, I want to keep delivering results for Pennsylvania," Casey said in a statement announcing his re-election campaign. No other candidates for the 2024 Pennsylvania Senate race have been officially announced. During his time in the Senate, Casey has joined Republicans and other Democrats to negotiate bipartisan bills. Casey, who has long held anti-abortion views, had a complicated stance on the government's role in abortion rights.

☆ Alzheimer’s patients retain the benefits of Leqembi even when they stop the drug, Eisai says
▼ + stars: | 2023-04-06 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +4 min

Alzheimer's patients who take Leqembi retain the benefits of the treatment even when they stop taking it, new research by Eisai shows. The findings also come as Eisai and Biogen try to regain their footing after the polarizing approval and disastrous rollout of its other Alzheimer's disease therapy, aduhelm, last year. In the analysis, Alzheimer's patients stopped taking Leqembi after 18 months in a phase two clinical trial and later resumed the treatment in an extension trial. Amyloid is a protein that builds up on the brain in Alzheimer's patients and disrupts cell function. That means Alzheimer's disease progressed at a slower rate in patients who received Leqembi compared to those who took the placebo during the clinical trial.

☆ Eli Lilly says experimental Alzheimer's drug reduces brain plaque in early study
▼ + stars: | 2023-04-05 | by ( Annika Kim Constantino | ) www.cnbc.com time to read: +4 min

Eli Lilly 's experimental Alzheimer's drug lowered levels of brain plaque in patients who are in the earliest stages of the devastating disease, initial data shows. Researchers have argued that accumulation of amyloid plaque is a crucial first step toward the cognitive decline observed in Alzheimer's disease. The early data comes as Eli Lilly continues its decades-long bid to bring an Alzheimer's drug to the market. Eli Lilly found the drug caused a "rapid and robust" clearance of amyloid plaque, the presentation said. But Tewari said it's unclear if clearing amyloid plaque will lead to clinical benefits like a reduction in cognitive decline.

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