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Young people are at risk of experiencing significant respiratory symptoms, including bronchitis and shortness of breath, after just 30 days of electronic cigarette use, according to a new study released Tuesday. They said the study, partly funded by the National Institutes of Health, contributes to existing evidence that e-cigarette use is associated with an increased risk of respiratory symptoms. Drug regulators should consider the findings and work to minimize the negative health impact of e-cigarette use on young people, the researchers added. E-cigarette usage is now substantially higher among youths and young adults than it is among adults overall in the U.S., according to the Centers for Disease Control and Prevention. She noted that the study examines only teens and young adults, and that in the demographic of all adults, people "often switch from using cigarettes to using e-cigarettes with likely fewer risks."
Persons: Tackett Organizations: Center for Tobacco Research, The Ohio State University Comprehensive Cancer Center, Southern California Keck School of Medicine, National Institutes of Health, Centers for Disease Control, Manufacturers, Brands, Food and Drug Administration Locations: U.S
The national survey and restrictions on foreign access are part of new regulations on China’s genetic resources, which came into effect in July. The national genetic surveyBiobanking in China – meaning the collection of biological samples – is still “very fragmented,” and in an “embryonic stage,” said Zhang. But these concerns aren’t new – and the national genetic survey seems to be geared more toward scientific research than other purposes, several experts agreed. But China has another motive, too: establishing what some experts call “genomic sovereignty,” meaning full control of the genetic material within their country. While many other countries also have laws regulating the use and transfer of their population’s genetic material, few are as strict as China’s.
Persons: Guang Niu, , Joy Y, Zhang, you’re, Wei Liang, ICHPL, Anna Puglisi, Puglisi, States –, Katherine Wang, ” –, Wang, , Sun, Xi Jinping, Jiankui, Anthony Wallace, ” Zhang Organizations: Hong Kong CNN, Central South University, Centre for Global Science, biosciences, Shanxi Province Reproductive Science, Communist Party, Georgetown’s Center for Security, Emerging Technology, Gray, Group, CNN, Ministry of Science, Technology, National Health Service, National Institutes of Health, NIH Locations: Hong Kong, China, Changsha, Shanxi Province, Taiyuan, States, , Wuhan, Xinijang, Xinjiang, Beijing, AFP, Harvard
But take a look at the corporate disclosures of America's largest pharmaceutical companies, and a puzzling hole opens. Large legal loopholesThe offshore migration of these pharmaceutical companies' profits may seem egregious, but the tax gymnastics are generally legal. On paper, America's corporate-tax rate is 21%, but the country's largest and most profitable pharmaceutical companies don't pay anything close to that. What's more, the superlow rate enjoyed by American pharmaceutical companies isn't necessary for these firms to be internationally competitive. A spoonful of medicine to make the taxes go downAmerica's pharmaceutical companies have made great contributions to medicine.
Persons: Democratic Sen, Ron Wyden, AbbVie, it's, Keytruda, Gilead, Eli Lilly, they've, Brad W, Whitney, Tess Turner Organizations: Merck, National Institutes of Health . Pharmaceutical, Democratic, Pfizer, US pharma, US Treasury, Trump, Treasury, US, Denmark's, Nordisk, Novartis, National Institutes of Health, Whitney Shepardson, Council, Foreign Relations Locations: Oregon, America, Caribbean, Europe, Bermuda, Puerto Rico, Germany, Ireland, Singapore, Switzerland, Belgium, Denmark
CNN —Actor Mandy Moore’s son recently woke up to a startling rash covering his body, according to her Instagram posts. Gianotti-Crosti syndrome. What is Gianotti-Crosti syndrome? Experts say they don’t know why some children get Gianotti-Crosti syndrome and others don’t, but it is thought to be a hypersensitive response to an underlying infection, according to the National Institutes of Health. Usually, the Gianotti-Crosti syndrome resolves itself over time — anywhere from a couple weeks to a couple of months, Levoska said.
Persons: Mandy Moore’s, ” Moore, Melissa Levoska, Shari Lipner, Levoska, Epstein, Barr, , ” Levoska, Lipner, Dermatologists, , it’s Organizations: CNN, Icahn School of Medicine, Weill Cornell Graduate School of Medical Sciences, National Institutes of Health, National Hospital Locations: Instagram, Mount Sinai, New York City, United States, Washington ,
The company told Reuters that 49% of Black volunteers did not meet the trial's amyloid threshold requirements compared to 22% for whites and 55% for Hispanics. "Is it because MCI (mild cognitive impairment) or early dementia type-symptoms in Blacks are caused by other reasons more so than Alzheimer's?" In 96 dementia trials from 2000-2017, diverse populations only made up around 11% of enrollment, according to a 2018 study. Among Black people who died of Alzheimer's, their dementia was more likely to result from multiple causes, such as vascular disease. "Is it that it's not Alzheimer's disease?
Persons: Barrington, Vickie Riley, Charlie, Harriet Shaffer, Barrington Riley, , Eli Lilly, Lilly, Crystal Glover, Eisai, Ivan Cheung, Cheung, Shobha, Biogen, Mark Mintun, Alzheimer's, Dr Lisa Barnes, Barnes, Joshua Grill, we're, Reisa Sperling, Brigham, Julie Steenhuysen, Caroline Humer, Suzanne Goldenberg, Daniel Flynn Organizations: Emory University Brain Health, Americans, Reuters, Prospective Black, Rush, Disease Research, and Drug Administration, FDA, Black, MCI, National Institutes of Health, Rush Center, University of California, Women's Hospital, Thomson Locations: Atlanta , Georgia, U.S, Chicago, Tokyo, Irvine, United States
The National Institutes of Health said Monday it launched mid-stage clinical trials to test at least four treatments, including Pfizer 's antiviral Covid-19 pill Paxlovid, as potential therapies for long Covid. But the lack of a specific long Covid treatment pushes some patients to seek unproven – and potentially dangerous – remedies for the condition. "NIH is committed to a highly coordinated and scientifically rigorous approach to find treatments that will provide relief for the millions of people living with long COVID." The NIH will test the safety and effectiveness of the treatments – which include both drugs and medical devices – in groups of 100 to 300 patients with long Covid symptoms. The first part of the phase two trial will test a longer dosing regimen of Paxlovid to see if it improves long Covid symptoms.
Persons: Lawrence Tabak Organizations: National Institutes of Health, Pfizer, Health, NIH
Kava is a beverage common in many Pacific island nations that can help numb and relax you. Several brands of kava beverages have popped up over the last several years, often marketing themselves as alternatives to alcohol. So, I decided to buy some of these canned versions of kava to try them. I picked Leilo and Mitra-9, two of the most widely-distributed kava brands that come in ready-to-drink forms. I also recruited my wife and a couple of friends, all of whom had also grown up in Hawaii and tried kava there, to provide their perspectives.
Persons: it's, It's, Piper methysticum, mainlanders, Leilo, Mitra Organizations: Service, National Institutes of Health Locations: Pacific, Wall, Silicon, Hawaii, Solomon Islands
A false report that the U.S. Navy’s Judge Advocate General (JAG) Office has indicted 19,000 doctors for so-called COVID crimes stems from an article on a self-described satirical website, but social media users responded as though the claim was authentic. A U.S. Navy Judge Advocate General’s Corps spokesperson said in an email that the claims made in the article are false. No credible news reports suggest that thousands of doctors have been indicted by the Navy’s legal branch for COVID-related crimes (tinyurl.com/2tjsv9cn). The U.S. Department of Justice website also makes no mention of the indictment of 19,000 doctors (tinyurl.com/yjsvxc2a). A U.S. Navy JAG spokesperson denied that 19,000 doctors were indicted for COVID-related crimes, and no credible sources support the claim.
Persons: “ Hope, , General’s, Read Organizations: Facebook, Real Raw, U.S . Centers for Disease Control, National Institutes of Health, U.S . Navy, U.S . Department of Justice, U.S . Navy JAG, COVID, Reuters Locations: U.S, COVID
"For decades the defendant has been selling deadly narcotics: heroin and now heroin laced with fentanyl," they wrote in court papers. An autopsy and court records show that Williams, 54, died of a drug overdose and was found in his Brooklyn apartment on Sept. 6, 2021. Fentanyl was associated with 70,600 of the drug overdoses in the U.S. in 2021, according to the National Institutes of Health. Among the real-life struggles he tapped were his bouts with drug addiction, which he brought to his best known role for "The Wire." Williams also won praise for his performance in "Boardwalk Empire," an HBO series set in Atlantic City, New Jersey during the Prohibition era of the 1920s.
Persons: Michael K, Williams, Omar Little, Carlos Macci, Prosecutors, Macci, Rich McKay, Noeleen Walder, Cynthia Osterman Organizations: HBO, National Institutes of Health, Thomson Locations: Brooklyn, U.S, New York, Baltimore, Atlantic City , New Jersey, Atlanta
Emily Wright, 38, a teacher in Toronto, started taking Ozempic in 2018. The diabetes drug Ozempic, and its sister drug for weight loss, Wegovy, utilize the same medication, semaglutide. Gastroparesis can have many causes, including diabetes, which is a reason many people are on these drugs in the first place. In more than half of cases of gastroparesis, doctors are unable to find a cause. Until more is known, George said, people need to be open with all their doctors about taking any drugs.
Persons: Joanie Knight, , I’d, , Knight, ” Brenda Allen, I’m, ” Allen, Emily Wright, she’s, Wright, “ I’ve, ” Wright, Ozempic, Emily Wright Allen doesn’t, they’ve, Gastroparesis, Michael Camilleri, Camilleri, liraglutide, ” Camilleri, ’ Joanie Knight, it’s, , I’ve, let’s, ’ ” Wright, gastroparesis, ” Knight, we’re, there’s, gastroparesis weren’t, “ Gastroparesis, Linda Nguyen, Nguyen, Renuka George, George, ” George, Dr, Michael Champeau, ” Champeau, Sanjay Gupta Organizations: CNN, US Food and Drug Administration, American Society of Anesthesiologists, Novo Nordisk, Mayo Clinic, National Institutes of Health, Diabetes, , FDA, Stanford University, American Gastroenterological Association, Medical University of South, CNN Health, Stanford Locations: Angie , Louisiana, Dallas, Toronto, Medical University of South Carolina, Louisiana
Opinion | The Birds Are Singing, but Not for Me
  + stars: | 2023-07-22 | by ( David George Haskell | ) www.nytimes.com   time to read: +2 min
Graphs from my audiologist show hearing loss across all sound frequencies, but especially for high sounds, so I was expecting this moment. Yet my hearing loss is now worse than most of my cohort of friends in their mid-50s, a quirk of my genes. The hair cells in our ears are descendants of the wiggly cilia hairs that animate single-celled creatures swimming around in ponds and ocean water. Sudden shocks like gun blasts kill inner-ear hair cells. Instead, aging undermines hair cells.
Persons: I’ve, I’m Organizations: National Institutes of Health
Israeli Prime Minister Benjamin Netanyahu said early Sunday he was going to the hospital for an emergency procedure to receive a pacemaker, but vowed to press ahead with his controversial judicial overhaul plan. Netanyahu's office made the announcement as Israel faces widespread street protests over Netanyahu's contentious judicial overhaul plan. Levin is the mastermind of the overhaul plan. The signatories included Ehud Barak, a former Israeli prime minister, and Moshe Yaalon, a former army chief and defense minister. In a speech Thursday, Netanyahu doubled down on the overhaul and dismissed as absurd the accusations that the plan would destroy Israel's democratic foundations.
Persons: Benjamin Netanyahu, Netanyahu, Yariv Levin, Levin, throngs, Monday's, Joe Biden, Ehud Barak, Moshe Yaalon, Israel Katz, Yoav Gallant Organizations: Israeli, National Institutes of Health, Likud, Channel, West Bank Locations: Tel Aviv, Israel, Jerusalem, Israel's, Beersheba, Haifa, Netanya
In addition, they should perform strength training and balance exercises at least twice weekly. Adults age 65 and older should perform strength training and balance exercises at least twice every week. Couple that with the benefits of strength, balance and flexibility work, and you’ve got a great chance at aging well. Strap on a weighted backpack during your walk, and now you’re “rucking,” an exercise based on military training that combines aerobic exercise with strength training. “If you don’t believe strength training, balance and flexibility work will really help, give it a try for a few months and see what a difference it makes,” he said.
Persons: , George Eldayrie, , John Higgins, Eldayrie, you’ve, ” Higgins, ” Eldayrie, Melanie Radzicki McManus Organizations: CNN, National Institutes of Health, Orlando Health Jewett Orthopedic Institute, US Centers for Disease Control, McGovern Medical, University of Texas Health Science Center, Houston, CNN’s Locations: Winter Garden , Florida, CDC
The Biden administration is taking steps to impose a 10-year ban on funding for the Wuhan Institute of Virology, the Chinese research laboratory at the center of a heated debate over the origins of the coronavirus pandemic, according to a memo made public by a House subcommittee on Tuesday evening and an official familiar with the issue. The memo, written by an official in the Department of Health and Human Services, said the institute had failed to comply with repeated requests from the National Institutes of Health for laboratory notebooks and other documents necessary to establish its safety practices. The N.I.H.’s conclusion that the Wuhan institute “likely violated protocols of the N.I.H. regarding biosafety is undisputed,” wrote the official, whose name was redacted. The memo said that suspension of funding was necessary to “mitigate any potential public health risk,” and that there was “adequate evidence” to initiate “debarment proceedings.”The institute, which has not received any federal money since 2020, now has 30 days to respond to the notice.
Persons: Biden, , Organizations: Wuhan Institute of Virology, Department of Health, Human Services, National Institutes of Health Locations: Wuhan,
July 16 (Reuters) - Alzheimer's disease experts are revamping the way doctors diagnose patients with the progressive brain disorder - the most common type of dementia - adopting a seven-point rating scale based on cognitive and biological changes in the patient. "Stage 1a is really the beginning of evidence that someone has the disease," Jack said. The new scale also includes a Stage 0 for people who carry genes that guarantee they will develop Alzheimer's. Noting the new system's similarity to cancer stages, Jack said, "There's no such thing as mild breast cancer. Jack also noted that many other conditions can cause dementia but not all dementia is Alzheimer's disease.
Persons: Clifford Jack, Eli Lilly's, Maria Carrillo, Jack, Julie Steenhuysen, Will Dunham Organizations: Alzheimer's Association, Mayo Clinic, National Institute of Aging, government's National Institutes of Health, Drug Administration, FDA, Down, Thomson Locations: Amsterdam, Rochester , Minnesota, Chicago
Reuters reported last month that the cancer research arm of the World Health Organization (WHO), known as the International Agency for Research on Cancer (IARC), was set to make that declaration on July 14, according to two sources with knowledge of the process. The designation as "possibly carcinogenic to humans" will provide an incentive to fund more rigorous research into the safety question, toxicology and cancer experts say. "We have been pushing for an IARC review for many years now." But no action was taken until 2022, after aspartame was again nominated for review by CSPI and Melnick in 2019. The research body has said "new evidence" prompted its aspartame review, without giving any details.
Persons: Andy Smith, Smith, Coke, Peter Lurie, Lurie, James Huff, Ron Melnick, CSPI, There's, Samuel Cohen, Erik Millstone, Millstone, Jennifer Rigby, Michele Gershberg, Catherine Evans Organizations: Reuters, World Health Organization, WHO, International Agency for Research, Cancer, MRC, Unit, University of Cambridge, Cola's, Regulators, for Science, Joint Food and Agriculture Organization, U.S . National Institutes of Health, University of Nebraska Medical Center, University of Paris, Britain's University of Sussex, Thomson Locations: United States, U.S, France
A selection of injector pens for the Wegovy weight loss drug are shown in this photo illustration in Chicago, Illinois, March 31, 2023. And a group of patients in the analysis who didn't take a weight loss drug saw their health-care costs decrease by 4% on average during the same time period. Weight loss drugs are also known as GLP-1 agonists, which mimic a hormone produced in the gut to suppress a person's appetite. Prime Therapeutics' analysis does not indicate why patients stopped taking weight loss drugs. But experts say the medicines may further perpetuate a dangerous diet culture that idealizes weight loss and thinness.
Persons: Joseph Leach, Eli Lilly, Elon Musk Organizations: Novo Nordisk, CNBC, Prime Therapeutics, Food and Drug Administration, Therapeutics, Reuters, Pfizer, National Institutes of Health Locations: Chicago , Illinois, U.S, Danish
said it planned to do an in-depth analysis of childhood drownings in several states to better understand the contributing factors. (Research shows that drownings rise with every degree on a thermometer.) There are still over 4,000 of them in the United States annually, and about a quarter of the deaths are of children. shows that Black children between ages 5 and 9 are 2.6 times more likely to drown in swimming pools than white children, and those between ages 10 and 14 are 3.6 times more likely to drown. Disparities are also present in most age groups for Asian and Pacific Islander, Hispanic, and Native American and Alaska Native children.
Persons: drownings, Deborah Girasek Organizations: National Institutes of Health, Uniformed Services University of, Health Sciences Locations: Florida, Wisconsin, Yosemite, United States, Pacific, American, Alaska
Stanton, Kentucky CNN —All Heather and Nick Maberry wanted to do was hold their dead baby, but strict Kentucky abortion laws meant they couldn’t. They were “furious” that the laws meant they never got to kiss or cuddle their daughter, Willow Rose, or tell her goodbye, Heather said. The Maberrys wanted to terminate the pregnancy, but a near-complete abortion ban in their state doesn’t have exceptions for birth defects – even severe ones like anencephaly. CNN reached out to three sponsors of Kentucky abortion laws to ask why fatal fetal anomalies aren’t an exception to the current laws. While she was willing to take that risk for a live baby, Willow was not going to live.
Persons: Heather, Nick Maberry, , Willow Rose, “ We’ll, We’ll, “ We’re, we’ve, , Maberrys, , ” Heather, Nick, Heather Maberry, Heather Neace Maberry Heather, , Heather Neace Maberry, gravidarum, “ I’d, Anencephaly, Willow, ‘ We’ll, Dr, Sanjay Gupta, ” “ Organizations: Kentucky CNN, Kentucky Medicaid, CNN, Maberrys, Facebook, University of Kentucky, National Institutes of Health, Heather’s, CNN Health, Family Planning, of Chicago Locations: Stanton, Kentucky, Madison, Aubrie, Stanton , Kentucky, Lexington, Chicago
CNN —Almost half of the tap water in the United States is contaminated with chemicals known as “forever chemicals,” according to a study from the US Geological Survey. Experts say it’s important for people to understand their risk of exposure through tap water. Water filters may help somewhat if tap water is contaminated, and there are moves to regulate some PFAS chemicals in US drinking water. This US Geological Survey map shows the number of PFAS detected in tap water samples from select sites across the nation. In August 2023, the EPA said it is conducting the “most comprehensive monitoring effort for PFAS ever” at large and midsize public water systems and hundreds of small water systems.
Persons: Jamie DeWitt, There’s, , DeWitt, They’re, Graham Peaslee, Dr, Sanjay Gupta, , Peaslee, ” Peaslee Organizations: CNN, Geological Survey, National Institutes of Health, US Environmental Protection Agency, Survey, Eastern Seaboard, Environmental Health Sciences, Oregon State University’s College of Agricultural Sciences, Utilities, EPA, of Physics, University of Notre Dame, CNN Health Locations: United States, Great, Central, Southern California
The first drug fully generated by artificial intelligence entered clinical trials with human patients this week. "It is the first fully generative AI drug to reach human clinical trials, and specifically Phase II trials with patients," Alex Zhavoronkov, founder and CEO of Insilico Medicine, told CNBC. "While there are other AI-designed drugs in trials, ours is the first drug with both a novel AI-discovered target and a novel AI-generated design." One is a Covid-19 drug in phase one clinical trials, and the other is a cancer drug, specifically a "USP1 inhibitor for the treatment of solid tumors," that recently received FDA approval to initiate clinical trials. "I never imagined in those early days that I would be taking my own AI drugs into clinical trials with patients.
Persons: Alex Zhavoronkov, Zhavoronkov, Insilico Organizations: Insilico, National Institutes of Health, CNBC Locations: Hong Kong, U.S, China
Pfizer on Monday said it would stop developing its experimental obesity and diabetes pill, lotiglipron, due to elevated liver enzymes in patients who took the drug once a day in mid-stage clinical studies. New York-based Pfizer said it will instead focus on its other oral obesity drug, danuglipron, which is in a fully enrolled phase two clinical trial. Pfizer CEO Albert Bourla has said that an obesity pill could eventually generate $10 billion each year for the company. The new class of obesity drugs is piquing public interest and causing a weight loss industry gold rush. Analysts believe Eli Lilly’s pill has an edge over Pfizer’s danuglipron.
Persons: William Sessa, Albert Bourla, Eli Lilly, Eli Lilly’s, danuglipron, Wells, Mohit Bansal, orforglipron, Bansal Organizations: Pfizer, Novo Nordisk, National Institutes of Health Locations: New York, danuglipron
Novo Nordisk 's high-dose experimental obesity pill helped overweight or obese adults lose around 15% of their body weight, according to new late-stage clinical trial results. Novo Nordisk told Reuters it plans to file for Food and Drug Administration approval of the drug later this year. But the highest dose of Rybelsus is 14 milligrams, while the company's experimental obesity pill has a far larger dose of 50 milligrams. Other companies are also developing oral weight loss treatments to appeal to those who don't want weekly injections. Pfizer is also developing its own weight loss pill, called danuglipron, which patients take twice a day.
Persons: Eli Lilly, Dr, Filip Knop, Knop, Eli Lilly's, Elon Musk Organizations: Novo Nordisk, Reuters, Food and Drug, Pfizer, University of Copenhagen, Novo, Companies, Novo Nordisk's Ozempic, National Institutes of Health Locations: Danish
Robert F. Kennedy Jr pledged to gut funding for federal health agencies if he's elected president. The long-shot Democratic presidential hopeful told NBC News that he would not make his anti-vaccine stance the focal point of his campaign. In an interview with NBC, Kennedy said that he would not be "leading with" vaccines as a presidential candidate. "Let me address that, because first of all, I'm not anti-vax," Kucinich told NBC. Kennedy told NBC — and has touted for years — of a conspiracy that aspires to defend vaccines and silence people such as himself, even as the studies he points to are corrected or retracted.
Persons: Robert F, Kennedy Jr, Kennedy, , Brandy Zadrozny, Robert Kennedy, John F, Dennis Kucinich, Kucinich, Zadrozny, NBC —, Cheryl Hines Organizations: NBC News, DOJ, Service, Democratic, and Drug Administration, National Institutes of Health, Centers for Disease Control, Justice Department, NBC, Rep, RFK Jr, Facebook
Lobotomies used to be a horrific way that doctors tried to treat patients with mental illness. Different doctors performed lobotomies differently, but one of the primary approaches was to drill a hole in the side of the skull to access the brain. Doctors thought that severing certain connections in the brain could help treat mental illness. By the 1950s, lobotomies were on their way out, but not before doctors performed over 40,000 of them in the US alone. A drill, shown on the right, is cranked by hand to help doctors access the patient's brain.
Persons: Lobotomies, , Howard Dully, Dully, Walter Freeman —, National Library of Medicine Lobotomies, lobotomies, Egas Moniz, Mical Raz, Raz, Freeman Organizations: Service, NPR, National Institutes of Health, National Library of Medicine, Singapore Medical, University of Rochester, Library of Medicine Locations: Portugal, Singapore, Europe, North America, California, Tennessee, Colorado, Delaware
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