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COUNCIL BLUFFS, Iowa (AP) — Ron DeSantis and Nikki Haley pushed across ice-cold Iowa Saturday to find voters open to an alternative to former President Donald Trump with just two days before the state's caucuses open the Republican primary calendar. DeSantis in particular is under great pressure in Iowa given his campaign's heavy bet on a strong finish in the caucuses. Courtney Raines, a special education teacher, came to hear Haley on Saturday morning and said she would try to see DeSantis later in the day. Carroll Hinchion, a 30-year-old independent, is considering caucusing with Republicans as well and came to hear DeSantis in Council Bluffs. “The Republican caucus that’s going to happen on Monday night is going to send a shockwave.

Persons: Ron DeSantis, Nikki Haley, Donald Trump, Trump, ”, DeSantis, Haley, “ You’re, Michael Durham, braved, Durham, Courtney Raines, “, Raines, Koch, Patti Parlee, Parlee, ” Parlee, Julie Slinger, Joe Biden, Slinger, Carroll Hinchion, Hinchion, Biden, ” Trump, Bob Dole, Kari Lake, that’s, Mariannette Miller, Meeks, Ashley Hinson, Miller, Trump’s, Texas Sen, Ted Cruz, ___ Beaumont, Colvin, Barrow, Meg Kinnard, Hannah Fingerhut Organizations: Republican, Trump, South, Prosperity, Koch Brothers, AFP, ” Independents, Democratic, Democrat, Senate, Associated Press Locations: Iowa, Mississippi, Davenport, New Hampshire, ”, Florida, Bluffs , Iowa, DeSantis, Durham, Bluffs, South Carolina, Urbandale, Iowa City, Arizona, , Iowa, Texas, Miller, Iowa City , Iowa, Urbandale , Iowa, Atlanta, Cedar Falls , Iowa, Davenport , Iowa

COLUMBIA, S.C. (AP) — The number of candidates on stage is shrinking, but the fundamentals of Wednesday’s Republican presidential debate may be familiar to anyone who has watched the previous three meetings. Here’s how to watch the debate and what to watch for:What time is the Republican debate? Political Cartoons View All 1277 ImagesWhat channel is the Republican debate on? Where is the Republican debate? Four Republicans will be on the debate stage, the smallest field yet as polling and donor benchmarks for qualification rise.

Persons: Donald Trump, Nikki Haley, Ron DeSantis, Vivek Ramaswamy, Chris Christie, It’s, NewsNation's Elizabeth Vargas, Megyn Kelly, Kelly, Eliana Johnson, NewsNation, —, Jimmy Carter, Ramaswamy, Haley, Christie, Tuscaloosa . South Carolina Sen, Tim Scott, Doug Burgum, Iowa’s Jan, Trump, it’s, DeSantis, Will, ”, ___ Meg Kinnard, ___ Peoples Organizations: COLUMBIA, Former United Nations, Florida Gov, New, New Jersey Gov, The Washington Free Beacon, Republican, CW, Republican National, GOP, Moody Music Hall, University of Alabama, Tuscaloosa ., North Dakota Gov, Trump, Trump voters, Disney, ___ Locations: New Jersey, Tuscaloosa, Tuscaloosa . Alabama, Tuscaloosa . South Carolina, Florida, South, New York

[1/5] Honoree Dionne Warwick and her family attend the 46th Kennedy Center Honors gala at the Kennedy Center in Washington, U.S., December 3, 2023. REUTERS/Julia Nikhinson Acquire Licensing RightsWASHINGTON, Dec 3 (Reuters) - Washington celebrated singer Dionne Warwick, comedian Billy Crystal, Bee Gees member Barry Gibb, rapper and actress Queen Latifah, and opera star Renée Fleming on Sunday at the Kennedy Center Honors, the top U.S. honor for achievements in the arts. "There simply is no song that Dionne Warwick cannot sing," said record producer Clive Davis, adding that she had "inspired musicians all over the world." Crystal, 75, known for roles in films such as "When Harry Met Sally," "City Slickers," and "Analyze This," was next up. Opera singer J'Nai Bridges said ahead of the show that Fleming had helped make opera more mainstream.

Persons: Dionne Warwick, Julia Nikhinson, Billy Crystal, Bee, Barry Gibb, Queen Latifah, Renée Fleming, Joe Biden, Gladys Knight, Elton John, Stevie Wonder, Clive Davis, Singer Cynthia Erivo, Alfie, Harry Met Sally, Meg Ryan, Robert De Niro, De Niro, Biden, Tony, Whoopi Goldberg, Crystal, Oscar, Kerry Washington, Tituss Burgess, Christine Baranski, Susan Graham, Fleming, Sigourney Weaver, Fleming's, J'Nai Bridges, Gibb, Robin, Maurice, Michael Bublé, Ben Platt, Jeff Mason, Jasper Ward, Gerry Doyle Organizations: Kennedy Center, REUTERS, Rights, Washington, Kennedy, White, Broadway, Bee, Big Town, U.S, CBS, Thomson Locations: Washington , U.S, Warwick

COLUMBIA, S.C. (AP) — The field of candidates onstage for the fourth Republican presidential debate will be the smallest yet. To qualify for the fourth debate, candidates needed at least 6% support in two national polls or 6% in one national poll as well as two polls from four of the early-voting states — Iowa, New Hampshire, Nevada and South Carolina. During the last debate, Haley called the entrepreneur “scum” after he invoked Haley’s daughter during a critique of TikTok. Without Trump at the debates, Christie has been left without his intended target but has brought him up nonetheless. Instead of going to Alabama — or holding his own counterprogramming event, as he has done for past debates — Trump is holding a closed-door campaign fundraiser in Florida.

Persons: Donald Trump, DeSantis, That's, Trump, Israel — Haley, Haley, he's, Ramaswamy, Christie, “ Donald Duck, ”, — Trump, Joe Biden, Hutchinson, Sen, Tim Scott of, ‘, Tim, ’ ”, Doug Burgum —, “, Meg Kinnard Organizations: COLUMBIA, Moody Music Hall, University of Alabama, Republican National Committee, RNC, White, PAC, —, GOP, Republican, Trump, ” WHO, WHO, North Dakota Gov Locations: Tuscaloosa, — Iowa, New Hampshire , Nevada, South Carolina, Iowa, Florida, Alabama, Arkansas, Tim Scott of South Carolina

☆ Meg Ryan defends her son Jack Quaid from 'nepo baby' criticism: 'He's more of a natural than I'll ever be'
▼ + stars: | 2023-12-03 | by ( Eve Crosbie | ) www.businessinsider.com time to read: +3 min

Meg Ryan has defended her son Jack Quaid from "nepo baby" criticism. AdvertisementMeg Ryan has defended her son Jack Quaid against claims that he's gotten his Hollywood career thanks to his famous parents. Meg Ryan and her son Jack Quaid photographed together in 2017. He's really good.' Jack Quaid as Hughie on season three, episode eight of "The Boys."

Persons: Meg Ryan, Jack Quaid, Jack, —, he's, Ryan, Dennis Quaid, isn't, James Devaney, Dennis, Hughie Campbell, Oppenheimer, I've, Hughie, Thrillist Organizations: Service, New York Magazine Locations: Hollywood

DES MOINES, Iowa (AP) — Three senior members of a super PAC backing Florida Gov. Ron DeSantis left the group on Saturday, the latest sign of instability within the 2024 hopeful's political operation just six weeks before the Iowa Republican caucuses. Longtime DeSantis ally Scott Wagner, who had been a member of the group's board, was named interim CEO and board chairman. DeSantis' campaign has relied heavily on Never Back Down for basic campaign functions, though the two sides cannot directly coordinate under federal campaign finance rules. Never Back Down has more staff working in Iowa, more than two dozen, than any campaign or super PAC and have been organizing ahead of the precinct-level caucuses since June.

Persons: Ron DeSantis, Kristin Davison, Chris Jankowski, Erin Perrine, Matt Palmisano, Scott Wagner, Donald Trump's, Nikki Haley, DeSantis, Jankowski, Adam Laxalt, DeSantis ’, Jeff Roe, Texas Sen, Ted Cruz, Glenn Youngkin, Perrine, Matt Wolking, Jessica Syzmanski, Roe, David Polyansky, Polyansky, Casey, “ Scott Wagner, Trump, Ron DeSanctimonious, ”, ___ Peoples, Meg Kinnard, Michelle L, Price Organizations: DES, Florida Gov, Iowa Republican, Saturday, Politico, United Nations, Former Nevada, Republican, Texas, Virginia Gov, PAC, Florida, Gov, ___, Associated Press Locations: DES MOINES, Iowa, United States, New York, Columbia , South Carolina, Des Moines , Iowa

NEW YORK (AP) — Americans for Prosperity, the political arm of the powerful Koch network, formally endorsed Nikki Haley's presidential campaign on Tuesday, promising to commit its nationwide army of activists — and virtually unlimited funds — to helping Haley defeat former President Donald Trump in the GOP primary contest. In a statement, DeSantis spokesman Andrew Romeo likened the Koch endorsement to a contribution to the Trump campaign. “Every dollar spent on Nikki Haley’s candidacy should be reported as an in-kind to the Trump campaign. While she has seized some momentum in the polls, he campaign lacked the same level of infrastructure on the ground in key primary states as DeSantis and Trump. “I’m honored to have the support of Americans for Prosperity Action, including its millions of grassroots members all across the country,” Nikki Haley said in a statement.

Persons: Koch, Nikki Haley's, —, Haley, Donald Trump, Nikki Haley, Joe Biden, Emily Seidel, Seidel, Ron DeSantis, DeSantis, Andrew Romeo, Trump, ” Romeo, Nikki Haley’s, “ I’m, ” Nikki Haley, ”, Meg Kinnard Organizations: Prosperity, GOP, America, Republican, AFP, Florida Gov, Trump Locations: AFP, Florida, Columbia , South Carolina

☆ ‘The Crown’: See Prince William’s romance with Kate Middleton unfold in first-look photos
▼ + stars: | 2023-11-28 | by ( Alli Rosenbloom | ) edition.cnn.com time to read: +2 min

CNN —Netflix’s “The Crown” returns in December with the remaining episodes of Season 6, and royal couple Kate Middleton and Prince William’s romance looks like it will be on full display. A grown-up Prince Harry, played by newcomer Luther Ford, is also seen in the new photos, sitting next to Prince William on a couch. (From left) Luther Ford as Prince Harry and Ed McVey as Prince William in 'The Crown.' Netflix previously teased the royal wedding of then-Prince Charles and Camilla would be featured in the sixth and final season of the series. The last six episodes of “The Crown” will be available to stream on Netflix on December 14.

Persons: ”, Kate Middleton, Prince William’s, Ed McVey, Meg Bellamy, Bellamy, Justin Downing, Prince William, Prince, Princess of Wales, McVey, Rufus Kampa, Princess Diana, paramour Dodi Fayed, Prince Harry, Luther Ford, Queen Elizabeth II’s, Imelda Staunton, Charles, Dominic West, Camilla, Olivia Williams, Prince Charles Organizations: CNN, Netflix, Eton Locations: The

Around 2,500 people gathered to hear Haley, the former governor and United Nations ambassador, according to officials at a satellite campus of the University of South Carolina along the state’s southern coast. She often hits on this theme herself, noting her ousting of a 30-year state incumbent in the South Carolina House, then beating three initially better-known candidates to become the first woman to serve as South Carolina governor. Ron DeSantis campaigns across South Carolina on Friday. On Monday, Haley riffed on Trump’s recent appearance in her home state at Saturday’s football rivalry matchup between the University of South Carolina and her alma mater, Clemson University. Henry McMaster, Haley’s successor and an alumnus of South Carolina, which lost to Clemson.

Persons: — Nikki Haley, Donald Trump, Haley, Trump, Vivek Ramaswamy, Ron DeSantis, Vincent Francescangeli, ” Francescangeli, Trump’s, you’ve, ” Haley, “, Haley riffed, Henry McMaster, Haley’s, —, ”, Francescangeli, Meg Kinnard Organizations: United Nations, University of South, South Carolina House, GOP, Florida Gov, Trump, mater, Clemson University, Clemson, Gamecocks, Tigers Locations: BLUFFTON, S.C, South Carolina, University of South Carolina, Charleston, Monday's, South, New Hampshire, Iowa, Florida, China

An incumbent hasn't lost his party's presidential nomination since Democrats passed over Franklin Pierce in 1856. Abraham Lincoln's election in 1860 marked the last time someone from a new party — in his case, the Republican Party — won the White House. But with the United States deeply divided and somewhat anxious about the prospect of another Biden-Trump campaign, third party candidates insist voters are restless enough to defy history. West announced last month that he no longer was running under the Green Party banner, but as an independent. Democrats assume that many of voters supporting a progressive environmental activist would likely have chosen Clinton if forced to choose between the major parties.

Persons: George Washington, hasn't, Franklin Pierce, Abraham Lincoln's, Republican Party —, ” Jill Stein, “, ”, Stein, Cornel, “ it's, Biden, Trump, Justice Department indicting Trump, Hillary Clinton, Clinton, umbrage, Dean Phillips, “ I’m, ” Phillips, ” Robert F, Kennedy Jr, Kennedy, Kennedy's, John F, Sen, Robert F, Joe Manchin, Utah Sen, Mitt Romney, Jennifer Franks, Romney, McKay Coppins, Manchin, invigorate centrists, he's “, Meg Kinnard, Leah Willingham Organizations: Republican Party, White, Biden, Trump, Green Party, West, Associated Press, NORC, for Public Affairs Research, Justice Department, Republicans, wariness, Trump's, Clinton, Democratic, Rep, Minnesota, Democratic Party, Children’s Health Defense, Electoral College, GOP, Manchin Locations: United States, Minnesota, renominating, South Carolina, Manchin, Utah, Arizona, Michigan, West Virginia, Columbia , South Carolina, Charleston , West Virginia

COLUMBIA, S.C. (AP) — The historic South Carolina city of Charleston has elected its first Republican mayor since the Reconstruction Era. William Cogswell, formerly a Republican state lawmaker, defeated incumbent Democratic Mayor John Tecklenburg by about 2 percentage points in Tuesday's runoff, according to the South Carolina Election Commission. Political Cartoons View All 1262 ImagesCharleston last elected a Republican mayor in the 1870s, according to historical records from the city and other municipal areas. “We can confidently say that I’m going to be the next mayor,” Cogswell said Tuesday night, as final results came in. "When Mayor Cogswell succeeds, Charleston succeeds, and that's something we're all in favor of.”The City of Charleston has become the second reliably blue area in South Carolina — where Republicans dominate congressional and statewide politics — to choose a Republican mayor in recent years.

Persons: William Cogswell, John Tecklenburg, Cogswell, Tecklenburg, Joe Biden, Sen Tim Scott, Drew McKissick, Russell Fry, ” Cogswell, Teckleburg, “, ”, —, Daniel Rickenmann, ___ Meg Kinnard Organizations: COLUMBIA, Republican, Democratic, South, GOP, Charleston, U.S . Rep, Republicans Locations: South Carolina, Charleston, Tuesday's, Charleston's, South, City, South Carolina —, South Carolina’s, Columbia

☆ Poll: Biden’s standing hits new lows amid Israel-Hamas war
▼ + stars: | 2023-11-19 | by ( Mark Murray | ) www.cnbc.com time to read: +3 min

"Failed promises, student loans, foreign policy in general," said Democrat Zico Schell, 23, of San Diego, when asked why he disapproves of Biden's job performance. "This poll is a stunner, and it's stunning because of the impact the Israel-Hamas war is having on Biden," he said. According to the poll, 40% of registered voters approve of Biden's job performance, while 57% disapprove, representing Biden's all-time low in approval (and all-time high in disapproval) in the poll since becoming president. It's only a slight overall change from September, when Biden's approval rating was at 41% — which was then tied with his previous low in the poll. Biden's approval rating dropped to 31% among these voters.

Persons: Joe Biden, Xi Jinping, Brendan SMIALOWSKI, BRENDAN SMIALOWSKI, Joe Biden's, What's, Biden, Donald Trump, Israel, Meg Furey, Zico Schell, Jeff Horwitt, Bill McInturff, McInturff, Horwitt, It's Organizations: Economic Cooperation, APEC, Getty Images, —, NBC News, Biden, Democratic, Hart Research Associates, Republican Locations: Asia, Woodside , California, California, AFP, Israel, Gaza, Austin , Texas, San Diego, Biden's

CHICAGO (AP) — Hundreds of Jewish peace activists and their allies converged at a major train station in downtown Chicago during rush hour Monday morning, blocking the entrance to the Israeli consulate and demanding U.S. support for an Israel cease-fire as battles rage in northern Gaza. Midwestern Jews and allies traveled to Chicago from Iowa, Missouri, Minnesota, Michigan, Indiana, Wisconsin and Illinois for the demonstration, organizers said. The Israeli consulate in Chicago is in a building connected to the Ogilvie Transportation Center, a major commuter rail station. The Chicago rally is unique from the previous Jewish Voice demonstrations because in the Midwest, “progressive Jewish communities are far smaller and separated by distance,” according to an emailed press release from organizers. “Trains continued to run throughout.”The Israeli consulate in Chicago did not immediately respond to a request for comment.

Persons: Ben Lorber, “, ”, Clara Belitz, IfNotNow, Meg Reile, ___ Savage Organizations: CHICAGO, Ogilvie Transportation Center, Chicago, Jewish Voice, Peace, Chicago police, Jewish, Grand, Station, New York, Washington , D.C, Hamas, Metra, West Madison, “, Associated Press, America Statehouse News Initiative, America Locations: Chicago, Israel, Gaza, Iowa , Missouri, Minnesota , Michigan , Indiana , Wisconsin, Illinois, Israeli, New York, Washington ,

☆ Four deaf people died in the Lewiston mass shooting. The tragedy highlights their unique vulnerabilities during a crisis
▼ + stars: | 2023-11-12 | by ( Faith Karimi | ) edition.cnn.com time to read: +8 min

Seal was an advocate for the deaf community and a prominent sign-language interpreter at state government briefings during the coronavirus pandemic. People sign "I love you" at a vigil for victims of last month's mass shooting in Lewiston, Maine. Matt Rourke/APAdvocates for the deaf community say the attack resonated in a population that rarely makes headlines, marking a communal loss that reverberated nationwide. He was desperate for news but was left in the dark, said Minch, who is a member of Maine’s deaf community. Police gather at Schemengees Bar, where four members of the deaf community were killed when a gunman opened fire on October 25.

Persons: they’re, Howard Rosenblum, It’s, ” Meg Erasmus, William “ Billy ” Brackett, Bryan MacFarlane, Joshua Seal, Steve Vozzella, Seal, Matt Rourke, Rosenblum, ” Erasmus, “, ” It’s, Erasmus, Tommy Minch, CNN’s Omar Jimenez, Minch, Regan Thibodeau, David Sokol, ” Minch, Joseph Prezioso, it’s, ” Rosenblum, community’s, ” Organizations: CNN, National Association of, National Deaf Therapy, Maine Educational Center, Johns Hopkins Medicine, USA, Deaf, Police, Getty, Lewiston, “ Locations: Lewiston , Maine, Lewiston, Schemengees, Maine, AFP

☆ Trial confirms heart benefits of Wegovy, but is weight loss responsible – or something else?
▼ + stars: | 2023-11-11 | by ( Meg Tirrell | ) edition.cnn.com time to read: +9 min

To cardiologist Dr. Steven Nissen of the Cleveland Clinic, who wasn’t involved in the trial but is leading a similar one of tirzepatide, those effects are all evidence of the benefits of weight loss. Tirzepatide has shown greater levels of weight loss than semaglutide in clinical trials, leading many, including Nissen, to hope it will show even stronger cardiovascular benefits. Importantly, participants didn’t have a history of diabetes; a previous trial had shown that treating people with diabetes with a GLP-1 drug, Ozempic, reduced their cardiovascular risk. The Wegovy trial showed that 569 of 8,803 people taking the drug had a heart attack or stroke or died from heart-related causes, or 6.5%. The amount of weight loss seen in the trial, 9.4%, was less than in other studies of Wegovy, which showed average weight loss closer to 15%.

Persons: Ania Jastreboff, Wegovy, Dr, Amit Khera, National Institutes of Health’s Dr, Tiffany M, Powell, Wiley, Eli Lilly, Steven Nissen, wasn’t, ” Nissen, “, Tirzepatide, Nissen, Michael Lincoff, Lincoff, ”, Jastreboff, Sanjay Gupta, hadn’t, “ semaglutide Organizations: CNN, Nordisk’s Wegovy, American Heart Association, Yale Obesity Research Center, University of Texas Southwestern Medical Center Dallas, National Institutes of Health’s, New England, of Medicine, US Food and Drug, Cleveland Clinic, Novo Nordisk, Cleveland, CNN Health Locations: Philadelphia, Powell

COLUMBIA, S.C. (AP) — The field of candidates onstage for the third Republican presidential debate will be the smallest yet. Five hopefuls will participate in Wednesday night’s debate at the Adrienne Arsht Center for the Performing Arts of Miami-Dade County, according to the Republican National Committee. After the second debate in September, Ramaswamy asked the RNC to change its rules for the third, requesting that participation be limited to four candidates, with a unique donor requirement of 100,000. The former two-term Arkansas governor participated in the first debate but failed to qualify for the second. He said in a statement after missing out on the second debate that his goal was to increase his polling numbers to 4% in an early state before Thanksgiving.

Persons: Adrienne Arsht, Mike Pence, Donald Trump, DeSantis, Kim Reynolds, Haley, Scott, ”, —, — Haley, Ramaswamy, Christie, Trump, Joe Biden, “ Donald Duck, ___ Meg Kinnard Organizations: COLUMBIA, Adrienne, Adrienne Arsht Center, Performing Arts of Miami, Republican National Committee, RNC, White, GOP, Trump, Miami, The Associated Press, Republican, New, ” WHO, WHO Locations: Dade County, — Iowa, New Hampshire , Nevada, South Carolina, Florida, Iowa, Israel, New Jersey, Hampshire, Hialeah , Florida, Arkansas

☆ ‘What Happens Later’ Review: Meg Ryan’s Rom-Com Return
▼ + stars: | 2023-11-03 | by ( Kyle Smith | ) www.wsj.com time to read: 1 min

David Duchovny and Meg Ryan Photo: Bleecker StreetMeg Ryan and David Duchovny haven’t had a lot of hit movies or TV shows lately—Ms. Ryan hasn’t been seen at all since she appeared in her directorial debut, the indie film “Ithaca,” back in 2016—but it only takes a few minutes of their movie “What Happens Later” to make us remember how much we loved these two ’90s icons in their prime. Trying to build a serviceable romcom around actors in their early 60s presents a challenge, but the key is understanding that nobody makes it to that age without handling as much baggage as an airport. That’s what makes Ms. Ryan’s second directorial effort a surprising treat, and for good measure, the entire movie is set at an airport, that liminal space between two destinations that stands for both possibility and frustration.

Persons: David Duchovny, Meg Ryan Photo, Meg Ryan, David Duchovny haven’t, Ryan hasn’t, ”, Ryan’s

COLUMBIA, S.C. (AP) — A fourth Republican presidential debate has been set for next month, with heightened polling requirements that could make the stage less crowded than before. Political Cartoons View All 1234 ImagesThe RNC has increased the necessary markers with each debate, an effort intended to winnow the once sprawling field. Asa Hutchinson, who participated in the debut debate but hasn't met subsequent qualifications. The third GOP debate, taking place Wednesday in Miami, requires campaigns to meet 4% in polls and notch 70,000 unique donors. Although the party won't confirm until Monday who will be on stage for the third event, it's anticipated that Florida Gov.

Persons: —, Ronna McDaniel, Asa Hutchinson, hasn't, Mike Pence, it's, Ron DeSantis, Nikki Haley, Vivek Ramaswamy, Sen, Tim Scott of, Chris Christie, Donald Trump —, Democrat Joe Biden, ___ Meg Kinnard Organizations: COLUMBIA, The Associated Press, Republican, The New York Times, Arkansas Gov, GOP, Florida Gov, South Carolina Gov, New, New Jersey Gov, RNC, Democrat Locations: Tuscaloosa , Alabama, Iowa , New Hampshire , Nevada, South Carolina, Miami, Florida, Tim Scott of South Carolina, New Jersey, Hialeah , Florida

Ryan and Duchovny did not really know each other before “What Happens Later," but you’d never know it to watch them on screen or hear their off-camera rapport. AP: You have such lived-in banter and chemistry, it’s surprising that you two didn’t really know each other before this. DUCHOVNY: I’m thankful to Meg for giving me the opportunity to work in a movie like this. RYAN: That’s exactly what it is. I’m going to google that to make sure I’m right.

Persons: Nora ”, Meg Ryan’s, Nora Ephron, Ephron, Ryan, Harry Met Sally, ”, David Duchovny, hasn't, “, ” Ryan, “ It’s, Duchovny, you’d, DUCHOVNY, I’ve, RYAN, Nora, It’s, Tom Hanks, Billy Crystal, He’s, Hal Liggett, Rosencrantz, Guildenstern, Hal, 5’10, 6’2, It’s Morgan Freeman, it’s Scarlett Johansson, I’m, Meg, Meg’s, there’s, COVID, you’ve, it’s, Matthew Perry’s, Harder, of Rome Organizations: Associated Press, greyhounds Locations: Seattle, RYAN

☆ Murky road ahead for Duchenne gene therapy as confirmatory trial misses main goal
▼ + stars: | 2023-10-31 | by ( Meg Tirrell | ) edition.cnn.com time to read: +4 min

Sarepta gave the one-time drug a price tag of $3.2 million, making it the second most-expensive medicine in the world. DMD affects one in 3,500 to 5,000 newborns, mostly boys because of the way it’s inherited, according to Johns Hopkins Medicine. The primary goal of the confirmatory trial was improvement on a measure known as the North Star Ambulatory Assessment, a scale of how well kids can stand, walk and perform other movements. The difference wasn’t statistically significant, meaning technically the study failed to meet its main goal. The company said no new safety issues emerged in the trial, which it called EMBARK.

Persons: Doug Ingram, ” Ingram, Sarepta, “, Dr, Sanjay Gupta, Ingram, ” Organizations: CNN, US Food and Drug Administration, Sarepta Therapeutics, FDA, Johns Hopkins Medicine, North Star, CNN Health

☆ Meg Ryan returns to romantic comedies as star, writer and director
▼ + stars: | 2023-10-31 | by ( Rollo Ross | ) www.reuters.com time to read: +1 min

Actor Meg Ryan poses at the Academy Museum of Motion Pictures gala in Los Angeles, California, U.S. September 25, 2021. Eight years after her last Hollywood film, Ryan stars in "What Happens Later" as Willa, a woman who reunites with a former partner ("X-Files" star David Duchovny) when they are both snowed in at an airport. Ryan said she spent three years working to bring the project to the screen. "What Happens Later" is among several films from independent production companies to receive waivers from the SAG-AFTRA actors union, meaning the actors were free to speak about the movie despite the ongoing strike. "You never got the sense that she was overwhelmed or feeling the pressure, which I'm sure she was from time to time."

Persons: Meg Ryan, Mario Anzuoni, Harry Met Sally, Ryan, Willa, David Duchovny, Duchovny, Ryan's, Meg, Lisa Richwine, David Gregorio Our Organizations: Academy Museum of Motion Pictures, REUTERS, SAG, Thomson Locations: Los Angeles , California, U.S, Seattle

☆ Arts Calendar: Happenings for the Week of October 29
▼ + stars: | 2023-10-29 | by ( Wsj Arts In Review Staff | ) www.wsj.com time to read: 1 min

An orca hunts down a group of mobula rays in the Gulf of California in ‘Planet Earth III’ Photo: BBC AmericaFilm• “What Happens Later” (Nov. 3): Meg Ryan is in the director’s chair for only the second time in her career, helming this romcom. She also stars alongside David Duchovny as a pair of exes who bump into each other at the airport and reconnect after a flight delay. • “All Dirt Roads Taste of Salt” (Nov. 3): The beauty and hardships of growing up black in rural Mississippi are explored in Raven Jackson’s debut feature, which follows a girl from youth to adulthood.

Persons: Meg Ryan, David Duchovny, Raven Organizations: BBC America Locations: Gulf of California, Mississippi

☆ Meg Ryan Wrestles With the Rom-Com
▼ + stars: | 2023-10-28 | by ( Melena Ryzik | ) www.nytimes.com time to read: +1 min

Meg Ryan was hurting. A two-hander opposite David Duchovny, it distills moviedom conventions and plays with a different emotional palette; Ryan grappling with her own cinematic brand. It is only her second foray behind the camera and the first time she has appeared onscreen in seven years. “I feel like I had the ride, the Hollywood ride,” she said over a restorative soup lunch on a foggy day. So I don’t have giant ambitions to be back in that.”

Persons: Meg Ryan, ”, David Duchovny, hasn’t Locations: Montecito, Calif, Persevering

☆ British health agency warns of fake Ozempic pens linked to hospitalizations
▼ + stars: | 2023-10-26 | by ( Amanda Musa | ) edition.cnn.com time to read: +3 min

CNN —Britain’s health agency is warning the public not to buy pre-filled pens claiming to contain the weight loss drugs Ozempic and Saxenda without a prescription, after a small number of people were hospitalized. Ozempic is used to treat adults with type 2 diabetes, and is used off-label for weight loss. More than 350 potentially fake Ozempic pens have been seized since January of this year, according to the MHRA. The agency has also received reports that patients have obtained fake Saxenda pens in the UK through “through non-legitimate routes.”No fake weight-loss pens were seized before January 2023, the agency says. The maker of both drugs, Novo Nordisk, told CNN Thursday that it is aware that counterfeit pens are being circulated.

Persons: Ozempic, ” Allison Schneider, Dr, Sanjay Gupta, Alison Cave, ” Ozempic, “, Meg Tirrell Organizations: CNN, Medicines, Healthcare, Agency, Novo Nordisk, “, “ Novo Nordisk, General Pharmaceutical Council, Get CNN, CNN Health, European Medicines Agency, European Union Locations: Ozempic, “ Novo, Novo, Germany, Europe

My children are missing. And there is a huge gap right now between what the government can and do to support and what the civilians are doing on support. Using techniques of sound and using techniques of A.I., by identifying the specific fabric of their underwear, we were able to find another video where you don’t see his face. Those are kinds of information that is tragic information, but it’s very important for the families to know that. People are coming day after day, making sure that we find another person, another person.

Persons: “ We’re Organizations: Facebook Locations: Israel, Gaza

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