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Delta-8 THC, or delta-8 tetrahydrocannabinol, is one of more than 100 chemical compounds found in the cannabis sativa plant. That’s at least one or two students in every average-sized high school class who may be using delta-8. Most of the participants were about 17 years old, so the study may not fully represent how many younger teens are using delta-8. There has been a general concern that the number of students using delta-8 has been growing, according to an editorial published Tuesday alongside this study. Calls to America’s Poison Centers about delta-8 products spiked 82% from 2021 to 2022, the group said in a recent report, with 3,358 exposures managed in 2022.
Persons: , Adam Leventhal, “ Dr, Nora Volkow, ” Leventhal, Jennifer Whitehill, Kelly Dunn, Renee Johnson, Harlow et, Scientists don’t, Dr, Sanjay Gupta Organizations: CNN —, USC Institute for Addiction Science, Midwest, National Institute on Drug, University of Massachusetts Amherst, Johns Hopkins University, National Cannabis Industry Association, Scientists, Research, Get CNN, CNN Health, Centers
And prescriptions for ADHD medications surged during the Covid-19 pandemic, especially among young adults and women. Treatment with ADHD medication especially reduced the risk of death from “unnatural” causes, including accidental injury, suicide and accidental poisoning such as drug overdose. While ADHD medications are relatively short-acting, experts say it’s important to consider the broader outcomes along with the immediate benefits. When it comes to “natural” causes of death such as medical conditions, however, the new study found that medication did not significantly affect mortality among ADHD patients. For these reasons, the link identified between treatment with medication and reduced mortality risk cannot be considered a direct cause-and-effect.
Persons: , , John Mitchell, ” Mitchell, Dr, Sanjay Gupta, ” CNN’s Kristen Rogers Organizations: CNN, New, Psychiatric Institute, Columbia University Irving Medical Center, Duke University School of Medicine, CNN Health Locations: Sweden, United States
Sleep is an important lifestyle factor in reducing risk for type 2 diabetes, a new study has found. In terms of risk for type 2 diabetes, there wasn’t a significant difference between those with normal sleep and those who slept six hours. And even for those who ate the healthiest, their diet didn’t offset the effects of insufficient sleep on diabetes risk. The findings are also based on participants’ recollections of their food and sleep habits, according to the study. Confirming a causal relationship “would require randomized trials intervening on sleeping habits to increase sleep time and see if this reduces risk of diabetes in those at risk, e.g.
Persons: CNN —, Dr, Diana Nôga, ” Nôga, , Leana Wen, Wen wasn’t, ” Wen, Naveed Sattar, ” Sattar, Wen Organizations: CNN, JAMA, biosciences, Uppsala University, Lighthouse Films, George Washington University Milken Institute School of Public Health, University of Glasgow Locations: Sweden, United Kingdom, Scotland,
Toddlers who are exposed to more screen time have fewer conversations with their parents or caregivers by an array of measures. They say less, hear less and have fewer back-and-forth exchanges with adults compared with children who spend less time in front of screens. Researchers have long known that growing up in a language-rich environment is vital for early language development. More language exposure early in life is associated with social development, higher I.Q.s and even better brain function. The new study, led by Mary E. Brushe, a researcher at the Telethon Kids Institute at the University of Western Australia, gathered data from 220 families across South Australia, Western Australia and Queensland with children who were born in 2017.
Persons: Mary E Organizations: Telethon, University of Western Locations: Australia, University of Western Australia, South Australia, Western Australia, Queensland
Brit Awards 2024: See who won
  + stars: | 2024-03-01 | by ( Dan Heching | ) edition.cnn.com   time to read: +4 min
English singer-songwriter RAYE leads the contenders and has the most nominations ever at the Brits, with seven. RAYE also already won the songwriter of the year award ahead of the ceremony. In the best new artist category, RAYE is joined by Mahalia, Olivia Dean, PinkPantheress and Yussef Dayes. Frank Hoensch/Redferns/Getty ImagesThe Brit Awards event, taking place at the O2 Arena in London, is being hosted by Maya Jama, Roman Kemp and Clara Amfo. Announced performers set to take the stage include Dua Lipa, Kylie Minogue, RAYE, Tate McRae, Jungle and more.
Persons: RAYE, Blues ”, Arlo Parks, Jessie Ware, Little Simz, Olivia Dean, PinkPantheress, Dayes, Rachel Agatha Keen, Frank Hoensch, Maya Jama, Roman Kemp, Clara Amfo, Kylie Minogue, Tate McRae, Minogue, Calvin Harris, Ellie Goulding, , ” Cassio, Raye, Central, Ed Sheeran, Hus, Drake, Kenya Grace, ” Lewis Capaldi, ” RAYE, Rudimental, Charlotte Plank, Debbie, Ella Henderson, Goddard, Darren ” J Hus, Mahalia Olivia Dean PinkPantheress RAYE, Yussef Dayes, Damien Meyer, J Hus Jessie Ware Little, Olivia Dean RAYE, Helle Arensbak, Ritzau Scanpix, Barry Can’t, Becky Hill Calvin Harris, Fred, Romy R, Cleo Sol Jorja Smith Mahalia RAYE, Calvin Harris Charli, Olivia Dean RAYE Hip, Cee Dave J Hus, Simz Calvin Harris, David Becker, Caroline Polachek CMAT Kylie Minogue Lana Del Rey Miley Cyrus Olivia Rodrigo SZA, Taylor Swift, Billie Eilish, ” David Kushner, ” Meghan Trainor, Miley Cyrus, Noah Kahan, Oliver Tree, Robin Schulz, Olivia Rodrigo, Peggy Gou, Bill ” Tate McCrae, Baser Sekou Organizations: CNN, Blues, Dua, Mahalia, O2, “ Prada, , Getty, Arlo, Cee, Olivia Dean RAYE Group, Young, International Group, Foo, Pop Locations: United Kingdom, London, Dua Lipa, Dua, Kenya, France, Cee Dua, Aarhus, Denmark, AFP
The general population also experienced excess mortality during this time, but the risk started higher for renters and rose exponentially for those threatened with eviction. From January 2020 through August 2021, the risk of death for renters facing eviction was 2.6 times greater than it was in the general population, the study found. During the baseline period of 2010 to 2016, the mortality rate was 1.4 times higher for renters facing eviction than it was for the general population. Another study from December explored the risk between rising rent costs and mortality risk. Eviction filings were down 45% during the first two years of the pandemic, according to the new study.
Persons: , Nick Graetz, it’s, It’s, Jack Tsai, ” Graetz, Katie Derrick, Jesse Tree, Derrick, Tsai, moratoriums –, Jesse, , Dr, Sanjay Gupta, Steven Furr, we’re, Furr, what’s, ” Tsai Organizations: CNN, Census, UTHealth Houston School of Public Health, US Department of Veterans Affairs ’, Homelessness, , CNN Health, American Academy of Family Physicians, Locations: Princeton, United States, Boise , Idaho, Jesse Tree, Idaho, Alabama
The NewsGrowing numbers of children and adolescents are being prescribed multiple psychiatric drugs to take simultaneously, according to a new study in the state of Maryland. In this group, there was a 9.5 percent increase in the prevalence of “polypharmacy,” which the study defined as taking three or more different classes of psychiatric medications, including antidepressants, mood-stabilizing anticonvulsants, sedatives and drugs for A.D.H.D. Mental health experts said that psychotropic medications can prove very helpful and that doctors have discretion to prescribe what they see fit. And it is unclear how the simultaneous use of multiple psychotropic medications affects brain development long-term. The NumbersThe latest study looked at data from 126,972 people over the study period.
Organizations: Medical, Survey Locations: Maryland, United States
A study found people on the Atlantic diet had a lower risk of metabolic syndrome and less belly fat. AdvertisementIf you love carbs and want to eat more healthfully, a close neighbor of the Mediterranean diet may be just the thing. The Atlantic diet diet focuses on plenty of longevity-boosting foods like produce, olive oil, beans, seafood, and even some wine. AdvertisementBut the Atlantic diet features even more carbs, specifically whole grains and starchy foods like bread, pasta, and potatoes. Half the participants were randomly assigned to follow a traditional Atlantic diet, and provided with food, cooking classes, and other resources to do so.
Persons: , trimmer waistlines Organizations: Service, University of Santiago Locations: Spain, Portugal, University of Santiago de Compostela
Read previewA gentle, low-impact form of exercise may help keep your heart healthy and lower your blood pressure even more than hitting the treadmill, new research suggests. Half the group were randomly assigned to do tai chi, while the other group did cardio exercises such as jogging or cycling. AdvertisementWithin six months, participants who did tai chi saw more improvements in their blood pressure than the cardio group. By the end of the year, the tai chi group had even lower blood pressure, and were significantly more likely to have a healthy blood pressure than their cardio-trained peers, according to the researchers. While more research is needed to understand how it works, the latest study suggests tai chi could be a safe, effective strategy for people of all ages to improve their blood pressure toward healthy levels.
Persons: , Tai, Kien Vuu, Vuu Organizations: Service, Business, China Academy of Chinese Medical Sciences Locations: Beijing
What is the Atlantic diet?
  + stars: | 2024-02-13 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +6 min
CNN —The traditional diet of northern Portugal and northwestern Spain, known as the Southern European Traditional Atlantic Diet, or Atlantic diet for short, may hold some clues to better heart health and a lower risk of dying early from cancer, heart disease or any cause, according to studies conducted in Europe. The diet is based on foods grown or found in that part of the Europe, much like its famous cousin the Mediterranean diet. Because it’s plant-based and locally sourced, the Atlantic diet also helps protect the planet by contributing to the United Nations’ Sustainable Development Goals, the study’s authors noted. Like the Mediterranean diet, the Atlantic diet focuses on home-cooked food served family style, with an emphasis on social interactions between friends and family. However, other studies have shown that not all food groups in the traditional Atlantic diet are beneficial.
Persons: , Walter Willett, Harvard T.H, David Katz, Al Bochi Organizations: CNN, Southern, JAMA, Harvard, of Public Health, Harvard Medical School, United Nations, True Health Initiative, Atlanta, Academy of Nutrition, Locations: Portugal, Spain, Europe, Chan, Boston, Czechia, Poland
CNN —Living a healthy lifestyle with a focus on a nutritious diet, regular exercise, minimum alcohol consumption and other healthy habits can help keep your brain sharp into old age, doctors say. But what if your brain already has signs of beta amyloid or tau — two of the hallmark signs of Alzheimer’s and other brain pathologies? Will a healthy lifestyle still protect you from cognitive decline? Not everyone who has signs of Alzheimer’s or vascular dementia goes on to develop cognitive issues, but many do. In fact, “a higher healthy lifestyle score was associated with better cognition even after accounting for the combined burden of brain pathologies,” according to Yaffe and Leng.
Persons: , Dr, Klodian, Richard Isaacson, , Isaacson, wasn’t, , Kobus, Lewy, Yue Leng, Kristine Yaffe, Yaffe, San Francisco Weill Institute for Neurosciences . Leng, Leng, it’s Organizations: CNN, Rush Institute, Healthy Aging, Rush University, , University of California, San Francisco Weill Institute for Neurosciences . Locations: Chicago, Florida, San
Popham’s wife, Mel, would have a conversation with her husband and an hour later he would have “no recollection,” he tells CNN Sport. Richard Boardman, the lawyer representing the claimants, told CNN Sport that this is causing an “existential threat” to the game. “As far as the brain is concerned, it doesn’t matter what sport is played,” Michael Grey, a neuroscientist at the University of East Anglia, told CNN Sport. Nowinski, a WWE wrestler turned neuroscientist, told CNN Sport that head injury protocols need to go beyond treating concussion. The paper, which looked at 412 Scottish former international male rugby players aged 30 and above and 1,236 members of the public who had been matched for age, sex and socioeconomic status, found that the rugby players’ risk of a dementia diagnosis over time was just over twice as high.
Persons: Alix Popham, Mel, , Popham, ” Popham, I’ve, Alix Popham of Wales, Pat Riordan of, Stu Forster, Lenny Woodard, Woodard, , “ I’d, I’d, ” Woodard, Brook Joyner, Richard Boardman, ” Michael Grey, Chris Nowinski, Scott McIntyre, Nowinski, ” Ann McKee, ” Boardman, Roger Goodell, University of East Anglia Boardman, Grey, , ” Steve Borthwick of, Alun Wyn Jones, Paul Harding, ” Grey, McKee, it’s, aren’t, we’re, shouldn’t, weren’t, ” Alix Popham Organizations: CNN, CNN Sport, rugby, Rugby, Alix Popham of Wales offloads, Pat Riordan of Canada, Wales, Getty, World Rugby, Rugby Football Union, RFU, Welsh Rugby Union, WRU, Springer, University of East, National Football League Players, Wrestling Entertainment, WWE, Washington Post, Boston University CTE Center, British Medical, Exercise, NFL, NFL.com, University of East Anglia, RBS, Nations, University of Glasgow, Boston University, University of Sydney, Scottish, , “ Rugby, England Rugby, Boston University’s CTE, CTE Locations: France, Wales, England, Canada, Nantes, Europe, University of East Anglia, American, Woodward, Boston
The effect of police violence on Black Americans is tracked in two new studies, with one tying police-involved deaths to sleep disturbances and the other finding a racial gap in injuries involving police use of Tasers. The health effects of police violence on Black people “need to be documented as a critical first step to reduce these harms,” three editors of JAMA Internal Medicine wrote in an editorial published Monday with the studies. For the sleep study, researchers looked at responses from more than 2 million people from 2013 through 2019 in two large government surveys. They focused on people's reports of sleep in the months following police-involved killings of unarmed Black people. ___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group.
Persons: Eric Garner, Tamir Rice, , Atheendar, Tasers, , Kevin Griffith Organizations: Mapping, Justice Department, University of Pennsylvania, Vanderbilt University, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP Locations: U.S
TOKYO (AP) — Data from a Japanese auto industry association show that China overtook Japan as the world’s largest vehicle exporter last year. The Japan Automobile Manufacturers Association reported Japan exported 4.42 million vehicles in 2023, up 16% from a year earlier, while domestic auto sales totaled nearly 4.78 million vehicles. According to figures released earlier by the China Association of Automobile Manufacturers, China exported 4.91 million vehicles last year. Japan’s car exports totaled 4.2 million in 2022. Overall, auto sales in Japan have been mostly on the decline since 2000.
Organizations: TOKYO, Japan Automobile Manufacturers Association, China Association of Automobile Manufacturers, Toyota Locations: China, Japan
People who experience food insecurity are at greater risk of dying prematurely and living a shorter life after age 50, researchers say, underscoring how a fairly prevalent problem can impact individual health. Researchers also found estimated life expectancy at age 50 was 32.5 years among individuals with full food security, compared with 29.9 years among adults with marginal food security, 30 years among those with low food security and 28 years among individuals with very low food security. By gender, the new study found women with very low food security lived an average of 5.8 years less at age 50 compared with women with full food security. Men with very low food security, meanwhile, had a life expectancy three years shorter than men with full food security at that age threshold. For example, whites with very low food security lived 6.2 fewer years on average at age 50 than whites with full food security.
Persons: , Organizations: Medicine, Centers for Disease Control Locations: U.S
The NewsTeenagers who use cannabis, alcohol and nicotine are more likely to have underlying psychiatric symptoms, and worse symptoms, than their peers who are not regularly using substances, new research has found. The research, published Monday in JAMA Pediatrics, found that such substances are linked to an array of symptoms and conditions, including anxiety, depression, hyperactivity and suicidal ideation. These findings suggest that asking adolescents about substance use may provide a powerful screening tool when looking for underlying mental health issues, researchers said. “Universally screening for psychiatric symptoms in the context of all types of substance use is what we think might be most important,” said Brenden Tervo-Clemmens, assistant professor of psychiatry at the University of Minnesota and lead author of the paper. “All the symptoms of mental health we examined, be it depression, suicidal thoughts, ADHD, were elevated no matter what the substance was,” he added.
Persons: , Brenden Organizations: Pediatrics, University of Minnesota
Teen suicide: Study identifies behavioral risk factor
  + stars: | 2024-01-25 | by ( Kristen Rogers | ) edition.cnn.com   time to read: +7 min
But you should pay more attention since social withdrawal could signal something deeper is going on, a new study has found. Across the globe, 10% to 20% of adolescents experience suicidal thoughts, and suicide is one of the leading causes of death among them, highlighting the need for strengthened prevention efforts. But the current study examined the associations between the long-term trajectory of multiple categories of psychological and behavioral symptoms and suicidal thoughts. But the link between social withdrawal and suicidal thoughts could be explained by the “loss of protective social connections,” according to the study. “If you hear a lot of complaints about aches and pains, it doesn’t (automatically) mean your child is suicidal,” Willard said.
Persons: , Shuntaro Ando, John Duffy, wasn’t, I’ve, ideation, Duffy, , Christopher Willard, ” Willard wasn’t, ” Willard, Willard, , ” Ando, that’s Organizations: Lifeline, CNN, JAMA, US Centers for Disease Control, University of Tokyo, Harvard Medical School Locations: United States, neuropsychiatry, Tokyo, Chicago, Boston
Read previewA study published on Wednesday in JAMA Internal Medicine estimated that over 64,000 pregnancies were caused by rape in the 14 states with abortion bans since July 2022. Samuel Dickman, Planned Parenthood Montana's medical director, along with his team, attempted to quantify the number of rape-related pregnancies in states with abortion bans triggered by the overturning of Roe v. Wade. As it stands, 14 states have implemented total abortion bans following the Dobbs decision. AdvertisementThe study found that in these 14 states, an estimated 64,565 pregnancies were linked to rape. AdvertisementThe researchers then apportioned the nationwide data among states, multiplying the state-level estimates by the fraction likely to result in pregnancy.
Persons: , Samuel Dickman, Roe, Wade, Dobbs, Dickman, Rachel Perry, Perry Organizations: Service, Medicine, Business, Texas —, US Centers for Disease Control, Prevention, of Justice Statistics, City University of New, NPR, OB, University of California Locations: Texas, City University of New York, Irvine
People who predominantly sit at work have a 16% higher risk of mortality from all causes, and a 34% higher risk of mortality from cardiovascular disease. As I sit here typing, I’m wondering what I should make of these study results. CNN: Are you surprised by the findings in this study — a 16% higher mortality from all causes and a 34% higher mortality from cardiovascular disease for people who predominantly sit at work? Studies have also shown that even light activity to break up the periods of prolonged sitting can reduce that risk. People would do a lot to change that habit, as they should when they sit for prolonged periods at work.
Persons: Leana Wen, I’m, Dana Santas, can’t, crunched, Wen Organizations: CNN’s, CNN, JAMA, George Washington University, Columbia University, BMI, US Centers for Disease Control, Dana Santas CNN Locations:
CNN —Treating loneliness and social isolation may put people classified as obese at a lower risk for health complications, according to a new study. Social isolation was found to be a greater risk factor for all causes of mortality, including cancer and cardiovascular disease, than depression, anxiety and lifestyle risk factors — which included alcohol, exercise and diet, according to the study. But the findings do point to improving “social isolation as a potential remedy for the reduction of mortality,” he said. “Think of maintaining a social network like any other health-promoting activity: exercising regularly, eating well, looking after yourself,” Canli said. And fatphobia can lead communities to make it harder for people with obesity to feel understood and accepted, she said.
Persons: , , Lu Qi, Qi, ” Qi, Philipp Scherer, Gifford O, Touchstone Jr, Randolph G, Dallas . Scherer wasn’t, Turhan Canli, Canli, ” Canli, Rachael Benjamin, Benjamin, Benjamin said, ” Benjamin Organizations: CNN, Tulane University School of Public Health, Tropical Medicine, University of Texas Southwestern Medical School, Diabetes Research, Touchstone Diabetes, Stony Brook University Locations: New Orleans, Dallas, New York City
Alzheimer’s disease, a brain disorder that affects memory and thinking skills, is the most common type of dementia, according to the National Institutes of Health. “A blood test being negative speeds up the investigation for other causes of the symptoms and this is just as important,” Ashton said. Isaacson, who has researched blood biomarkers in people with no or minimal cognitive complaints, likened testing blood samples for signs of Alzheimer’s disease to how people undergo routine blood tests for high cholesterol. It is possible that currently available treatments for Alzheimer’s disease would work better in those diagnosed early in this way,” he said. The combination of a simple screening test with an effective treatment for Alzheimer’s disease would have a dramatic impact for individuals and for society.”
Persons: ” Nicholas Ashton, Ashton, , Kaj Blennow, Henrik Zetterberg, antiamyloid, immunoassay, ” Ashton, Richard Isaacson, ” Isaacson, Isaacson, , , Dr, Sanjay Gupta, David Curtis, ” Curtis Organizations: CNN, University of Gothenburg, National Institutes of Health, Quest Diagnostics, Alzheimer’s, Alzheimer’s Association, Get CNN, CNN Health, University College London, Science Media Locations: Sweden, United States, Wisconsin, Pau, Florida
For some, the seasonal shift can lead to a clinically depressive state aptly called seasonal affective disorder, or SAD. Even better, it takes less effort than you might think to realize the mental benefits. Below, I’ve outlined four science-backed ways you can become more active to boost your mental health and ease the winter blues. Meeting the World Health Organization’s guidelines of 2.5 hours of moderate exercise weekly provides maximum overall physical and mental health benefits, but studies have shown that even relatively small doses of activity offer significant mental health benefits. Whatever form of exercise you choose, adding just a little more physical activity into your life will provide noticeable mood-boosting benefits to help you get past the seasonal slump.
Persons: Dana Santas, I’ve, Julia Amaral, What’s Organizations: Pain, CNN, American Psychological Association, Getty, Facebook, Massachusetts General Hospital, CNN’s Locations: playtime
The Heart Surgery That Isn’t as Safe for Older Women
  + stars: | 2024-01-20 | by ( Paula Span | ) www.nytimes.com   time to read: +1 min
Last Thanksgiving, Cynthia Mosson had been on her feet all day in her kitchen in Frankfort, Ind., preparing dinner for nine. She was nearly finished — the ham in the oven, the dressing made — when she suddenly felt the need to sit down. “I started hurting in my left shoulder,” said Ms. Mosson, 61. They said testing revealed serious blockages in all her coronary arteries and told her, “You’re going to need open-heart surgery,” Ms. Mosson recalled. When such patients head into an operating room, what happens next has a lot to do with their sex, a recent study in JAMA Surgery reported.
Persons: Cynthia Mosson, , , Mosson, “ You’re, ” Ms Locations: Frankfort , Ind
Cancer Deaths Are Falling, but There May Be an Asterisk
  + stars: | 2024-01-17 | by ( Gina Kolata | ) www.nytimes.com   time to read: +1 min
The cancer society highlighted three chief factors in reduced cancer deaths: declines in smoking, early detection and greatly improved treatments. Breast cancer mortality is one area where treatment had a significant impact. That includes metastatic cancer, which counted for nearly 30 percent of the reduction in the breast cancer death rate. Breast cancer treatment has improved so much that it has become a bigger factor than screening in saving lives, said Ruth Etzioni, a biostatistician at the Fred Hutchinson Cancer Center. “The biggest untold story in breast cancer is how much treatment has improved,” said Dr. H. Gilbert Welch, a cancer epidemiologist at Brigham and Women’s Hospital.
Persons: , , Donald Berry, Sylvia K, Plevritis, Ruth Etzioni, Mette Kalager, H, Gilbert Welch Organizations: University of Texas, Anderson Cancer Center, Stanford University, Fred Hutchinson Cancer Center, University of Oslo, Oslo University Hospital, Brigham, Women’s
CNN —Drinking a glass or more of 100% fruit juice each day was linked to a small increase in weight in children and adults, according to a new analysis of prior studies. In such a context, fruit juice is a much better choice than soda, for many reasons,” said Katz in an email. How juice impacts the bodyFor some, the concern over 100% fruit juice may be baffling — fruit is healthy, right? Eating a whole apple, for example, doesn’t spike blood sugar levels because fructose, the sugar found naturally in fruits and some vegetables, is released slowly into the blood. In children, each additional serving per day of 100% fruit juice was associated with a 0.03 higher body mass index, or BMI, change, according to the study.
Persons: , Walter Willett, Harvard T.H, ” Willett, Tamara Hannon, “ There’s, Hannon, David Katz, “ It’s, Katz, Britt Erlanson, ” Hannon, ” That’s, Vasanti Malik, ” Malik, Malik, Organizations: CNN, Harvard, of Public Health, Harvard Medical School, American Academy of Pediatrics, AAP, Riley Hospital for Children, Indiana University School of Medicine, True Health, True Health Initiative, Bank, Getty, BMI, CDC Locations: Chan, Boston, Indianapolis
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