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More than 40% of Americans are obese, according to the U.S. Centers for Disease Control and Prevention, and demand is strong for treatments to reduce body weight as well as maintain weight loss. The company said it would continue to develop its twice-daily weight loss drug candidate. Structure Therapeutics (GPCR.O) is developing oral obesity drugs that it says are simpler to manufacture than the current injectables. "We define weight loss quality as the percentage of weight loss attributed to fat loss," said Versanis Chief Scientific Officer Lloyd Klickstein. "With diets, bariatric surgery, incretin drugs or other weight loss drugs, two-thirds to three-quarters of the weight loss is fat, but one-quarter to one-third is lean."
Persons: Robert Gabbay, Eli Lilly, Lilly's, Wegovy, Mico Guevarra, Lilly, Jeff Emmick, Ray Stevens, Boehringer Ingelheim, Versanis, Lloyd Klickstein, Chaguturu, Deena Beasley, Michele Gershberg, Jamie Freed Organizations: DIEGO, Novo Nordisk's, American Diabetes Association, Novo, U.S . Centers for Disease Control, ADA, Pfizer, Therapeutics, Zealand Pharma, Novartis, CVS Health, Aetna, Thomson Locations: San Diego, GLP
Novo plans to seek U.S. Food and Drug Administration approval of the high-dose pill later this year, but timing of a market launch is "to be determined," according to Mico Guevarra, medical director at Novo Nordisk. Novo Nordisk already markets an oral semaglutide, under the brand name Rybelsus, for treatment of type 2 diabetes, but its highest dose is 14mg. Oral semaglutide, according to the FDA label, needs to be taken in the morning on an empty stomach, 30 minutes before eating, drinking, or using any other oral medication - you are allowed only 4 ounces of plain water. If you eat too soon, the pill is less effective, but if you wait longer than 30 minutes its absorption may be enhanced. read moreNovo Nordisk said most patients in its obesity trial reported gastrointestinal side effects from oral semaglutide, including mostly mild-to-moderate nausea, constipation, diarrhea and vomiting.
Persons: semaglutide, Mico, Guevarra, Eli Lilly, LLY.N, Deena Beasley, Diane Craft Organizations: DIEGO, Nordisk, Food, Drug, Novo Nordisk, American Diabetes Association, FDA, Thomson Locations: Danish
London CNN —When The National Portrait Gallery opened its doors to the public in London on Thursday, it was the first time in three years it has done so. The National Portrait Gallery was officially opened by Catherine, Princess of Wales, seen standing in front of Joshua Reynolds’ Portrait of Mai (Omai). Why would the National Portrait Gallery commit to taking this work they wouldn’t see until it’s finished, 90% of which is created by non-artists? What did she do?” Haworth told the National Portrait Gallery about the figure. Some art critics have been scathing of the gallery’s rework, with Jonathan Jones at the Guardian dubbing it “the same old cocktail party.” His review begins: “The National Portrait Gallery has been closed for three years.
Persons: Princess Catherine of Wales, , Jamie Fobert, Purcell, The Mary Weston, David Parry, Tracey Emin, Sam Taylor Johnson’s, David Beckham, Zadie Smith, Toyin Ojih Odutola, Sir Michael Eavis, Peter Blake, Ada Lovelace, Margaret Sarah Carpenter, Catherine , Princess of, Joshua Reynolds ’, Mai, Paul Grover, Jann Haworth, Liberty Blake, Boudicca, Elizabeth I, Mary Beard, Beatrix Potter, Agatha Christie, Nicola Adams, Pepper’s, Haworth, ” Blake, , ” Jann Haworth, Toby Hancock, Blake, “ It’s, ’ It’s, it’s, ” Haworth, Oliver Hess, Jonathan Jones, Nicholas Cullinan, You’ll Organizations: London CNN, Jamie Fobert Architects, Getty, Chanel Culture Fund, Olympic, Beatles, Art, CNN, Guardian Locations: London, United Kingdom, Britain, The, Nigerian American, Glastonbury, British, Catherine , Princess of Wales, AFP, Salt Lake City
BARCELONA, June 17 (Reuters) - Spain's Socialist Prime Minister Pedro Sanchez was given a last-minute consolation on Saturday when Barcelona's city council appointed a new Socialist mayor after a deal involving two rival parties. Despite pro-independence parties appearing certain to run Spain's second city, Jaume Collboni, the Socialist candidate, became mayor after the far-left Barcelona en Comu of the outgoing mayor Ada Colau gave him its support in a move supported by the conservative People's Party. The decision was a boost for the Socialist Party, which leads the national government, after mostly poor results in local elections around the country on May 28. Xavier Trias, 76, who represents the pro-business, pro independence party Junts per Catalunya, had been favourite to become mayor until the 11th-hour deal favouring Collboni. The political shift in Barcelona is a further setback for Catalonia's pro-independence movement, which has faltered in recent years.
Persons: Pedro Sanchez, Jaume Collboni, Ada Colau, Sanchez, Xavier Trias, Graham Keeley, Joan Faus, David Holmes Organizations: Socialist, People's Party, Socialist Party, Thomson Locations: BARCELONA, Barcelona's, Barcelona, Catalunya, Comu
An American Airlines flight attendant said she was accused of fraud after taking medical leave. Jeannine Schumacher said she took medical leave for reconstructive surgery after a mastectomy. An American Airlines flight attendant said she was accused of taking fraudulent medical leave linked to a cancer diagnosis. Following successful treatment, Schumacher said she requested medical leave for reconstructive surgery, which her attendance manager appeared to informally approve over the phone for four consecutive months. Up to half of breast-cancer survivors in the US undergo reconstructive surgery after a mastectomy, according to the National Library of Medicine.
Persons: Jeannine Schumacher, Schumacher, who's, she'd, There's Organizations: American Airlines, Association of Professional, American Cancer Society, National Library of Medicine, Department of Labor, Airlines Locations: Phoenix
The Association of Concert Venues of Catalonia, a trade body, estimates that in the past 20 years, 220 nightlife venues have closed in Barcelona and the surrounding metropolitan area. In a city of 1.6 million people, the total estimated capacity of its 198 music venues is less than 50,000, the venues association says. The number of visitors to Barcelona soared in the past two decades, resulting in complaints about noise and overcrowding from residents. Under the left-wing mayor Ada Colau, the city has prioritized locals’ quality of life, limiting the number of tourist-related businesses, including nightlife venues, that can open in many parts of town. “Barcelona has four music schools, and lots of musicians graduate every year, so we need small and medium-sized venues to absorb this whole scene.”Thanks to its weather and beaches, the city has become a popular location for music festivals.
Persons: Ada Colau, , Carmen Zapata Organizations: , City Hall Locations: Catalonia, Barcelona, , “ Barcelona
The Binance website on a laptop arranged in the Brooklyn borough of New York, US, on Wednesday, June 7, 2023. The list of digital tokens deemed as unregistered securities by the Securities and Exchange Commission now spans over $120 billion of crypto after the US agencys lawsuits against Binance Holdings Ltd. and Coinbase Global Inc. The SEC sued Coinbase and Binance last week, accusing both of selling unregistered securities, among other charges. On Tuesday, the U.S. regulator alleged that Coinbase was operating as an unregistered exchange and broker, and that 13 assets listed on its platform were considered crypto asset securities. On Monday, it also accused Binance of inflating trading volumes, diverting customer funds and misleading customers about its controls, among others.
Persons: Gabby Jones, Coinbase, Ripple's XRP, Binance's, Binance Organizations: Securities and Exchange Commission, Binance Holdings, Coinbase Global Inc, Bloomberg, Getty, U.S . Securities, Exchange Commission, SEC, Polygon's Locations: Brooklyn, New York, U.S
Eli Lilly also is expected to present data on another weight-loss drug called orforglipron, which patients take orally instead of through an injection. Retatrutide, Mounjaro and weight-loss drug Wegovy, produced by rival Novo Nordisk (NVO), are all injectable. But if the data were to fall short of expectations, the analysts don't foresee much downside to J & J shares. However, with JNJ-2113, Morgan Stanley noted that J & J management has touted its efficacy profile "without the baggage of a JAK label." J & J has consistently denied those accusations.
Persons: Eli Lilly, Johnson, Morgan Stanley —, Eli Lilly Eli Lilly, Morgan Stanley, Eli Lilly's Mounjaro, Mounjaro, Lilly's, retatrutide, hasn't, haven't, Jim Cramer's, Jim Cramer, Jim, AJ Mast Organizations: American Diabetes Association, Novo Nordisk, U.S . Food, Drug Administration, Pfizer, Novo Nordisk's, Johnson, American Academy of Dermatology, topline, J's, LTL Management, CNBC, Bloomberg, Getty, & ' $ Locations: U.S, Novo, Indianapolis , Indiana
SEC Chair Gary Gensler stepped up his attack on the crypto industry this week, suing Coinbase and Binance for securities violations and casting doubt on the future of token trading. They include Solana's SOL token, Cardano's ADA token, Polygon's MATIC coin and Protocol Labs' Filecoin token (FIL). "No other coins are affected and your crypto is still safe on Robinhood," the company said in a post. Binance's BNB token, ranked fourth, fell 16%. "The investing public has the benefit of U.S. securities laws," Gensler said in an interview with CNBC's "Squawk on the Street" on Tuesday.
Persons: Gary Gensler, Coinbase, Crypto.com, Binance's, Biden, Sam Bankman, Gensler, CNBC's Organizations: U.S . Securities, Exchange Commission, Banking, Housing, Urban Affairs, SEC, CNBC, ADA, Labs, Polygon, Solana Locations: Cardano, Solana
SEC Chair Gary Gensler stepped up his attack on the crypto industry this week, suing Coinbase and Binance for securities violations and casting doubt on the future of token trading. In alleging that Coinbase was acting as an unregistered broker and exchange, the Securities and Exchange Commission said at least 13 crypto assets available to the company's customers were considered "crypto asset securities." They include Solana's SOL token, Cardano's ADA token, Polygon's MATIC coin and Protocol Labs' Filecoin token (FIL). Binance's BNB token, ranked fourth, fell 16%. "The investing public has the benefit of U.S. securities laws," Gensler said in an interview with CNBC's "Squawk on the Street" on Tuesday.
Persons: Gary Gensler, Coinbase, Crypto.com, Binance's, Joe Biden, Sam Bankman, Gensler, CNBC's Organizations: U.S . Securities, Exchange Commission, Banking, Housing, Urban Affairs, SEC, CNBC, Securities and Exchange Commission, ADA, Labs, Polygon, Solana Locations: Cardano, Solana
Fires are burning across the breadth of Canada, blanketing parts of the eastern United States with choking, orange-gray smoke. So much wildfire smoke pushed through the border that in Buffalo, schools canceled outdoor activities. The average global temperatures today are more than 1.1 degrees Celsius (2 degrees Fahrenheit) higher than in the preindustrial era. The trees and grasses of eastern Canada turned to tinder. “We should expect a stunning year of global extremes,” he wrote.
Persons: It’s, El Niño, Justin Trudeau, , Alexandra Paige Fischer, Park Williams, Wiliams, Brendan Rogers, haven’t, La, Jeff Berardelli, El, Ada Monzón Organizations: Northern, University of Michigan, Stanford, University of California, Climate Research, El, Twitter Locations: Canada, United States, Puerto Rico, North America, El, Buffalo, Detroit, Los Angeles, Alberta, Vietnam, China, Siberia, WFLA, Tampa Bay, Fla, WAPA
Three Books That Make Tess Gunty Angry
  + stars: | 2023-06-08 | by ( ) www.nytimes.com   time to read: +4 min
I can’t believe I get to share a time period with all of these people. In this poem, the speaker is thunderstruck by a newfound “plague of gratitude.” The speaker says: “Not long ago I was hard to even/hug ... The poem plunged me into that first miraculous flash of hope you enjoy after a long storm of bad brain chemistry. They are facilitated by an absence of legal restrictions and the primeval excuse that if We don’t do it first, They will. My family is always shocked by how many books on neuroscience and quantum physics I’ve amassed.
Persons: Claudia Rankine, Anne Carson, Maggie Nelson, Yuri Herrera, Zadie Smith, Diane Williams, Valeria Luiselli, Olga Tokarczuk, Rachel Kushner, Elena Ferrante, Ben Lerner, Carmen Maria Machado, Joy Williams, Hanif Abdurraqib, Nuar Alsadir, Robin Coste Lewis, Natalie Diaz, Ocean Vuong, Sharon Olds, Morgan Parker, Tommy Pico, Terrance Hayes, Ada Limón, Tracy K, Smith, Annie Baker, Amy Herzog, Paula Vogel, Svetlana Alexievich, Rachel Aviv, Ed Yong, Matthew Desmond, Alexandra Kleeman, Susan Choi, Chris Ware, Tommy Orange, Javier Zamora, Jenny Offill, Annie Ernaux, Anne Enright, Lydia Davis, Raven Leilani, Mark Z, Jennifer Egan, George Saunders, Wolf, Kaveh Akbar, ” Akbar alchemizes, , I’m, Patrick Radden Keefe, Sackler, , Brian Christian, I’ve, Iain McGilchrist, Alex Locations: Ocean, America, , postindustrial Indiana
About two dozen bronze statues from the third century BC to the first century AD, extracted from the ruins of an ancient spa, will go on display in Rome's Quirinale Palace from June 22, after months of restoration. When the discovery was announced in November, experts called it the biggest collection of ancient bronze statues ever found in Italy and hailed it as a breakthrough that would "rewrite history". The statues were found in 2021 and 2022 in the hilltop village of San Casciano dei Bagni, still home to popular thermal baths, where archaeologists had long suspected ancient ruins could be discovered. Digging started in 2019 on a small plot of land next to the village's Renaissance-era public baths, but weeks of excavations revealed "only traces of some walls", San Casciano Mayor Agnese Carletti said. Then former bin man and amateur local historian Stefano Petrini had "a flash" of intuition, remembering that years earlier he had seen bits of ancient Roman columns on a wall on the other side of the public baths.
Persons: dei, Casciano Mayor Agnese Carletti, Stefano Petrini, San, Petrini, Emanuele Mariotti, Maria Giuseppina Valeri, Laura Rivaroli, Roman, San Casciano dei, Ada Salvi, Salvi, Mariotti, Marcius Grabillo, Janet Lawrence Organizations: Casciano Mayor, Culture Ministry, Grosseto, Arezzo, Thomson Locations: Rome, Italy, Tuscany, Quirinale, San, Casciano, San Casciano's, San Casciano, Tuscan, Siena
Spain's ruling Socialists suffered heavy losses to opposition conservatives in Sunday's local election, with around 95% of the votes counted, showing their electoral vulnerability ahead of an end-of-year general election. Only three of the 12 regions holding elections will retain Socialist dominance by very narrow margins, with the rest likely go to the conservative People's Party, albeit with coalitions or informal support agreements with the far-right Vox party. The gains for the People's Party (PP) indicate the conservatives could unseat the current left-wing coalition led by the Partido Socialista Obrero Español (PSOE) if they replicate the performance in national elections by December. The numbers showed few clear majorities, except in the Madrid region where regional president Isabel Diaz Ayuso of the PP looked set to win re-election with an absolute majority. Campaigning had been marked by several controversies, from allegations of voter fraud in small towns to an unprecedented case of kidnapping.
Here's what to do if you run into a bear, a shark, an orca, or other potentially dangerous mammals. Here's what you should do if you encounter any of these apex predators and how you can avoid an attack. REUTERS/Jim UrquhartThere are two kinds of bears you're likely to run into while outdoors in North America, depending on where you are: grizzly bears and black bears. The park service says you should try to find a safe place like a car or building. Bison have injured more people in Yellowstone, one of the country's most visited national parks, than any other animal, according to the National Park Service.
Quantum computers are wondrous because they operate on quantum mechanics. Quantum computers are wondrous because they operate on quantum mechanics: the tiniest parts of the universe where the rules of physics as we think we know them don't always apply. I visited as part of an invitational media-and-analysts' day held a few days before Quantinuum officially launched H2, its 32-qubit, second-generation quantum computer on Tuesday. Companies like Nvidia and Microsoft, which is building its own quantum computer, are partners to Quantinuum. A schematic drawing of the Quantinuum H2 computer.
A whale expert told Khaleej Times you should "never enter the water" if you see a killer whale. There was even one incident where killer whales sank a sailboat. Nigel Killeen / Contributor / Getty ImagesLuckily, there have never been any recorded fatal orca attacks on humans in the wild, Natoli told Khaleej Times. "Try not to approach them from the back or from the front, stay on their side instead," Natoli told Khaleej Times. By contrast, in the United Arab Emirates, Natoli told Khaleej Times that sightings are rare in the region, with only about one every year and a half.
(Reuters) - A group of at least eight partners has left law firm Lewis Brisbois Bisgaard & Smith, including national labor and employment chair John Barber, to start a new firm. Barber and seven other labor and employment lawyers based in California have left Lewis Brisbois, a firm spokesperson confirmed Monday. Lewis Brisbois co-chairman Bob Smith said in the Sunday statement the firm thanks the lawyers and wishes them well. Lewis Brisbois in February hired a new cybersecurity group, poaching six attorneys from Wilson Elser Moskowitz Edelman & Dicker including co-chair Robert Walker. Read more:44-member Lewis Brisbois cybersecurity team jumps to Constangy firmLaw firm Lewis Brisbois hires cybersecurity co-chair after group departureOur Standards: The Thomson Reuters Trust Principles.
The Sulacks weighed their options: Have a transplant with a match that was less than ideal – far less – or wait for gene therapy to become available. The news release didn’t say anything else about the SCID gene therapy. Or was the company abandoning its plans for SCID gene therapy altogether? In February, 2021, the parents of more than 20 children who were waiting for the gene therapy treatment, including the Sulacks, wrote a letter to Gaspar. Insurance companies have sometimes balked at paying for gene therapy, which is typically given in one treatment.
REUTERS/Dado Ruvic/File PhotoApril 11 (Reuters) - Investors are finally set to gain access to more than $33 billion of ether this week under a planned revamp of the blockchain. A new software upgrade to the Ethereum blockchain, dubbed Shapella, will let market players redeem their "staked ether" - coins they have deposited and locked up on the network over the past three years in return for interest. About 15% of all ether is staked, totaling $33.73 billion in market value, according to data from Dune Analytics. "It seems unlikely, therefore, that much of the staked ether will be sold," Rangar added. Following the upgrade, staked ether will no longer be locked up on the blockchain, so investors may be more willing to stake coins.
The lawsuits say Walmart didn't accommodate the former employees, one who has Crohn's disease, and other, epilepsy. Crohn's disease is a chronic condition that causes inflammation in individuals' digestive tract. In early November 2016, Tucker went to the emergency room due to a "medical episode" and had to miss work, according to the lawsuit. Per the lawsuit, Walmart ignored those requests as well as subsequent ones, and did not excuse absences for further medical episodes. Per the non-profit Crohn's & Colitis Foundation, Crohn's disease does count as a disability under the ADA.
Supreme Court Rules for Deaf Student
  + stars: | 2023-03-21 | by ( Jess Bravin | ) www.wsj.com   time to read: 1 min
The Supreme Court’s decision on a case involving Miguel Luna Perez, seen in a 2016 school photo, could give educational officials greater incentive to respond to disabled students’ needs. WASHINGTON—A unanimous Supreme Court opened a new door for disabled students who think their public school isn’t meeting their needs, allowing them to pursue damages under the Americans with Disabilities Act in addition to seeking educational accommodations from local districts. The justices found no conflict between the ADA and a separate statute, the Individuals with Disabilities Education Act, which requires school districts to provide a free and appropriate education to disabled students
WASHINGTON, March 21 (Reuters) - The U.S. Supreme Court on Tuesday allowed a deaf student in Michigan to sue his public school district for allegedly failing to provide him adequate classroom instruction, a ruling that bolsters the ability of students with disabilities to remedy shortcomings in their education. The 9-0 ruling authored by conservative Justice Neil Gorsuch revived student Miguel Luna Perez's lawsuit seeking monetary damages from the school system in Sturgis, Michigan, as the justices overturned a lower court's decision to dismiss the case. Perez has said the school district assigned him an unqualified classroom aide who did not know sign language, and then misled his parents as to how much progress he was making. After settling an administrative complaint under IDEA with the district promising additional schooling at the Michigan School for the Deaf, Perez filed his lawsuit in federal court under the ADA, seeking compensatory damages. Circuit Court of Appeals in 2021 dismissed the case, agreeing with the school district that Perez could not bring his lawsuit before first exhausting the administrative procedures under IDEA.
New mandate requires most office workers to come into the office at least 3 times a week starting in May. About 3 weeks since the announcement of the new policy, more than 29,200 Amazon employees have signed an internal petition opposing the mandate. Roughly 30,000 Amazon employees have joined that Slack channel, which was created shortly after the RTO announcement. In the petition, Amazon employees added internal data supporting continued remote work and dozens of comments explaining why they oppose the change. A 2013 Stanford University study of Chinese workers found that remote workers are 13% more productive than their in-office counterparts.
In late 2018, the companies behind the most widely traded cryptocurrency were struggling to maintain their access to the global banking system. Some of their backers turned to shadowy intermediaries, falsified documents and shell companies to get back in, documents show. One of those intermediaries, a major tether trader in China, was trying to “circumvent the banking system by providing fake sales invoices and contracts for each deposit and withdrawal,” Stephen Moore , one of the owners of Tether Holdings Ltd., said in an email viewed by The Wall Street Journal.
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