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Eisai and Biogen are scheduled to present full data from their lecanemab study on Tuesday at the Clinical Trials on Alzheimer's Disease conference in San Francisco. Lecanemab’s success rests on years of research into the causes of Alzheimer’s as well as advances in measuring amyloid deposits through brain scans and spinal fluids. At least 16 treatments are being tested in clinical trials, with results expected over the next three years, according to a Reuters review of the clinicaltrials.gov registry. The drugmaker has been largely absent from the Alzheimer's space after the high-profile failure of its drug verubecestat five years ago. But several antibody therapies from Lilly, Biogen and AbbVie(ABBV.N) that were designed to slow the rate of tau accumulations failed outright last year.
CNN —Eating more flavonols, antioxidants found in many vegetables, fruits, tea and wine, may slow your rate of memory loss, a new study finds. The cognitive score of people in the study who ate the most flavonols declined 0.4 units per decade more slowly than those who ate the fewest flavonols. One of the most common flavonols, quercetin, has shown promise in reducing the onset of colorectal cancer and other cancers, according to studies. (For comparison, the average flavonol intake in US adults is about 16 to 20 milligrams per day, according to the study.) The study looked at the impact of the four major flavonols — kaempferol, quercetin, myricetin and isorhamnetin — on the rate of cognitive decline over the seven years.
Siegler is a cognitive “SuperAger,” possessing a brain as sharp as people 20 to 30 years younger. She is part of an elite group enrolled in the Northwestern SuperAging Research Program, which has been studying the elderly with superior memories for 14 years. Once accepted, colorful 3D scans are taken of the brain and cognitive testing and brain scans are repeated every year or so. A SuperAger’s brain, usually donated to the research program by participants after death, also has bigger, healthier cells in the entorhinal cortex. SuperAger brains had three times fewer tau tangles, or abnormal formations of protein within nerve cells, than the brains of cognitively healthy controls, the study also found.
In 2021, Arizona changed its rules to let non-lawyers co-own law firms, many of which are highly profitable: They collectively made an estimated $320 billion in the US last year. Today, 47 states — all but Arizona, Utah, and Washington — ban anyone but lawyers from owning law firms. Some of the firms Arizona has approved have said they plan to advertise nationwide, and refer cases to other law firms that will actually do the work. Pre-settlement funding, which is one of the riskier kinds of loan for plaintiffs' law firms, often has interest rates of 12 to 20 percent, Ziser said. The UK has allowed outside investment in law firms since 2007 without major scandal, he said, but it also takes a loser-pays approach to lawsuits that can cut down on frivolous claims.
LIV CEO and commissioner Greg Norman watches play on the third hole during the final round of the LIV Golf Invitational Series Chicago at Rich Harvest Farms in Sugar Grove, Illinois. LIV Golf CEO Greg Norman will be visiting Capitol Hill this week to meet with members of Congress, as the Saudi-backed league tangles with the PGA Tour. The LIV Golf league was founded as a competitor to the PGA Tour and is financed by Saudi Arabia's Public Investment Fund. LIV has already poached major golfers such as Phil Mickelson from the PGA Tour, and Norman himself is a former tour star. The LIV Saudi Golf League is not that.
It was 1988, and he'd approached President Ronald Reagan in the Cabinet room at the White House. People scoffed at the glowing hourlong media conference that President Donald Trump's White House doctor gave about his health. Reagan publicly announced he had Alzheimer's disease five years after he left the White House. Francis Shen, who teaches psychiatry at Harvard Medical School's Center for Bioethics, would like to see information about political leaders' cognitive health made public. Cognitive health should be no different, he said, because it also might affect the way presidents and members of Congress make important decisions.
Southern California’s Notorious Container Ship Backup Ends
  + stars: | 2021-04-07 | by ( Paul Berger | ) www.wsj.com   time to read: +5 min
The backup of container ships off Southern California’s coast that was at the heart of U.S. supply chain congestion during the Covid-19 pandemic has effectively disappeared. But the biggest gain likely has come from fewer boxes reaching the busiest U.S. seaport complex for container imports. By January 2022, only 31% of container ships arrived at ports on time, down from about 70% before the pandemic, according to Sea-Intelligence. By September 2021, the average cost for shipping a container from Asia to the U.S. West Coast exceeded $20,000, a sixfold increase from a year earlier, according to the Freightos Baltic Index. Last week, the average cost to ship a container from Asia to the U.S. West Coast had declined 84% from a year earlier to $2,720.
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