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Moderna and Merck released more positive three-year data Monday on their experimental vaccine, given to patients with the most deadly form of skin cancer in combination with the therapy Keytruda. The vaccine together with Merck's Keytruda improved survival and showed long-lasting efficacy in a midstage study in patients with a deadly form of skin cancer. Melanoma is responsible for the large majority of skin cancer deaths, according to the American Cancer Society. Moderna is also conducting another phase three trial of the vaccine in patients with a type of lung cancer. This year, Merck and Moderna started a two-part mid- to late-stage trial on the vaccine and Keytruda in patients at an advanced stage of a common skin cancer.
Persons: Merck's, Kyle Holen, Keytruda, Stephane Bancel, Bancel Organizations: Moderna, Merck, American Society of Clinical Oncology, CNBC, U.S . Food, Drug Administration, FDA, American Cancer Society Locations: Chicago, U.S, Moderna
Advertisement"The clerk of the court will give you instructions on how to go about scheduling that probation interview and getting that probation report," the judge said. But Trump won't do a penitent probation interview — or any at all, Kuby predicted. Advertisement"If he wants to show remorse, then certainly the probation report is a good place to start doing that," he added. During the first part of the interview, Trump would be asked for standard, so-called "pedigree" information — name, aliases, address, profession, marital status, that kind of thing. During the rest of the interview, Trump would be offered the chance to speak about his conviction and make a plea for leniency.
Persons: , Donald Trump, Juan Merchan, Blanche, Trump, Todd Blanche, Susan Necheles, Emil Bove, Diana Florence, I've, Ron Kuby, Kuby, Merchan, Angel Rodriguez, Rodriguez, Christine Cornell, , Arnold Levine, He'd, Levine, Florence Organizations: Service, New York City Department, Investigation, Business, Unit, Trump, Attorney's, BI, Avenues, Justice, Legal Aid Society, New, Defense Task Force Locations: New, Merchan's, Manhattan, Florence
CHICAGO — Pfizer on Friday said its drug for an advanced form of lung cancer showed promising long-term results in a late-stage trial, which may help establish it as the new standard treatment for the condition. The drug, called Lorbrena, also cut the risk of the cancer progressing in patients' brains. Only about 5% of all non-small cell lung cancer patients have the mutation, which causes cancer cells to grow and spread abnormally. But Pfizer's drug isn't currently considered the standard – or the most appropriate and widely used – treatment for the condition. Nearly 300 people in the trial either received Lorbrena or Pfizer's older lung cancer drug Xalkori.
Persons: isn't, Chris Boshoff, Lorbrena, David Spigel, Sarah Cannon, Spigel, Andrew Berens, Pfizer's Boshoff Organizations: CHICAGO, Pfizer, CNBC, Lorbrena's, American Society of Clinical Oncology, Clinical Oncology, Sarah, Sarah Cannon Research Institute, Lorbrena, Leerink Locations: U.S, Chicago
That femur led to a stegosaurus fossil, among the largest and most complete ever found, which has subsequently been nicknamed “Apex.” In July the Sotheby’s auction house will sell Apex at auction at an estimated value of $4 million to $6 million, making the skeleton the latest flashpoint in a long-running debate about the private fossil trade. Dinosaur fossils have fetched escalating prices at auction houses since 1997, when Sotheby’s sold “Sue” the Tyrannosaurus rex to the Field Museum in Chicago for $8.36 million. In 2020, “Stan,” another largely complete T. rex skeleton, sold at Christie’s for $31.8 million. Such pricing has raised serious concerns among academic paleontologists, said Stuart Sumida, vice president of the Society of Vertebrate Paleontology. Many of them have watched fossils that may unlock scientific mysteries get steered into the hands of wealthy private collectors rather than toward research institutions in recent decades.
Persons: Jason Cooper, Sotheby’s, Sue ”, “ Stan, , Stuart Sumida Organizations: Apex, Field Museum, Vertebrate Locations: Colorado, Dinosaur, , Chicago
The 10 books the rich will be reading this summer
  + stars: | 2024-05-26 | by ( Robert Frank | ) www.cnbc.com   time to read: +11 min
That's why J.P. Morgan Private Bank, every May, releases its summer reading list, often serving as a book club for billionaires. This year marks the 25th anniversary of the list, now called the J.P. Morgan Summer Reading List. The 10 books are carefully curated to match the tastes and preoccupations of J.P. Morgan's wealthy clients. It also helps with client events, since authors on the list often agree to do special dinners or speaking events for J.P. Morgan clients. Authors love being on the list as well since J.P. Morgan buys thousands of books to hand out and since clients often refer the books to others.
Persons: Robert Frank, Today's, Alicia Keys, Swizz Beatz, J.P, Morgan, Darin Oduyoye, Oduyoye, Gary White, Matt Damon, Charles Duhigg, Jonathan Haidt, Haidt, Kasseem Dean, , Gordon Parks, Michel Basquiat, Lorna Simpson, Odili Donald Odita, Kennedy Yanko, Kimberli Gant, Salman Khan Salman Khan, Jack Daniel, Fawn Weaver, Daniel's, Daniels, Weaver, Joshua Robinson, Jonathan Clegg, Robinson, Clegg, Melinda Stevens, Issy von Simson, Tabitha Joyce, Fortunato, Adam Pearson, Fortunato Chocolate, Laura Mae Martin, Laura Mae Martin —, Martin, Jake Gyllenhaal, Greta Caruso, Tony, Damon Organizations: Morgan Private Bank, Morgan, Reading, Wealth Management, J.P, Giants, Art, Phaidon, Brooklyn Museum, Education, Khan Academy, Wall, Mercedes, Nacional, Google, Solutions, JPMorgan, Manhattan Company Locations: Water, Lynchburg , Tennessee, America, United States, Croatian
CNN —Facing a crowd of journalists, inventor Thomas Midgley Jr. poured a lead additive over his hands and then proceeded to inhale its fumes for about a minute. Unfazed, he said, “I could do this every day without getting any health problems whatsoever.”Soon afterward, Midgley needed medical treatment. The task of addressing the issue of engine knocking fell to Midgley while he was working at General Motors in 1916. An estimated 1 million people a year still die from lead poisoning, according to the World Health Organization. The toxicity of lead was already well-known when Midgley added it to gas, but that didn’t stop Ethyl from becoming a commercial success.
Persons: Thomas Midgley Jr, , , Midgley, , Ford, Gerald Markowitz, Colin Creitz, Charles Kettering, ” Markowitz, ” Midgley, Bill Kovarik, Midgley —, Kettering —, Freon, Joe Sohm, CFCs, Perkin, Priestley, Kettering, Willard Gibbs, Carl E, ” Kovarik, Markowitz, I’m Organizations: CNN, General Motors, City University of New, GM, Standard Oil, DuPont, Network, UNICEF, World Health Organization, Radford University, America, Montreal Protocol, International Association for Suicide Prevention, Befrienders, Society of Chemical Industry, American Chemical Society, National Academy of Sciences, TNT, Linde Locations: Beaver Falls , Pennsylvania, United States, City University of New York, Algeria, American, Dayton , Ohio, Virginia, Montreal, Chicago
Diabetes is a key risk factor for kidney disease, which is one of the leading causes of death in the United States and worldwide; about 1 in 3 people with diabetes also has chronic kidney disease, according to the US Centers for Disease Control and Prevention. But new research shows that weekly injections of semaglutide cut the risk of severe outcomes from diabetic kidney disease by about 24%. The new study found even broader related benefits of semaglutide treatment among people with diabetic kidney disease. “Kidney disease attributed to diabetes, or diabetic kidney disease, is one of the most common and deadly complications of diabetes. Yet, unfortunately, there’s very low awareness around it,” said Dr. Katherine Tuttle, chair of the Diabetic Kidney Disease Collaborative for the American Society of Nephrology.
Persons: , Vlado Perkovic, “ Semaglutide, Martin Holst Lange, Katherine Tuttle, ” It’s, Tuttle, semaglutide, It’s, Dr, Sanjay Gupta, White, ” Tuttle Organizations: CNN, Diabetes, US Centers for Disease Control, New England, of Medicine, European Renal Association Congress, University of New, University of New South Wales Sydney, Novo Nordisk, American Society of Nephrology, Providence Inland Northwest Health, Health Sciences, University of Washington, CNN Health Locations: United States, University of New South, Danish, American
CNN —Greater spotted eagles are already a species under threat. Listed as “vulnerable” by the International Union for Conservation of Nature, greater spotted eagles have been largely eradicated from western and central Europe, according to the study. On March 1, 2022, a week after Russia invaded Ukraine, the first of 21 tagged greater spotted eagles crossed into Ukraine on its usual migration, according to researchers from the UK and Estonia. The researchers observed no difference in migration performance and deviation patterns outside of Ukraine, according to the study. Russell said the war in Ukraine is “really raising the profile of some of the environmental issues caused by conflict.
Persons: , Charlie Russell, Russell, ” Russell, , Nathalie Pettorelli, Pettorelli, ” Pettorelli, “ ecocide ” Organizations: CNN, Eagles, International Union for Conservation of Nature, , UK’s University of East, Zoological Society of London Locations: Ukraine, Europe, Poland, Belarus, Russia, Estonia, UK’s University of East Anglia,
Injected medications called GLP-1 agonists are in high demand because they have proved to be so effective for weight loss. The difference, which was statistically significant, amounted to a 52% increased risk of being diagnosed with stomach paralysis while on a GLP-1 medication. Compared with those who were not taking a GLP-1 medication, those who did were about 66% more likely to be diagnosed with gastroparesis. This study found that 0.53% of patients on GLP-1 medications were diagnosed with stomach paralysis, or about 1 case of gastroparesis for every 200 people taking the drugs. People taking GLP-1 medications were also more likely to have nausea and vomiting or gastroesophageal reflux disease (GERD) and to be prescribed a proton pump inhibitor.
Persons: gastroparesis, GERD, , Prateek Sharma, Sharma, ” Sharma, Michael Camilleri, , Camilleri, It’s, who’d, Dr, Sanjay Gupta, it’s Organizations: CNN, Drugmaker, Nordisk, University Hospitals, Diabetes, University of Kansas, University of Kansas School of Medicine, American Society, Mayo Clinic, CNN Health Locations: Washington, Cleveland, GLP, Mayo
The artist Hank Willis Thomas is pointing to one of the images: of two well-dressed, neatly coiffed men standing atop a cliff. "She's Somewhat of a Drag," a 1959 advertisement Thomas repurposed in his series "Unbranded: A Century of White Women." Across his work, Thomas reframes iconic and mundane imagery to connect viewers to historical moments of resistance and reshape our understanding of who counts in society. Here, a pro-football player appears to face off with an enslaved cotton picker, in Thomas' work "From Cain't See in the Mornin' Til Cain't See at Night." His body of work work reflects the observation — and, perhaps, a warning — that we have moved toward “existing in a society of branded consciousness."
Persons: Hank Willis Thomas, Thomas, Aaron Wessling, Jordan, , Thomas ’, Drummond, , ” Thomas, mascara, Jordan Schnitzer, ” Schnitzer, ” Thomas ’, Thomas reframes, Barack Obama, , “ I’ve, doesn’t Organizations: CNN, Art, White, White Women, Family, Cotton, Corporate America, Civil Rights, American Express Locations: , Oregon, United States, Gorée
Bennett, who's three years older than me and was a bit further along in the balding process, had been my hair loss mentor. But now, he was one of the growing number of men who traveled 5,000 miles to Istanbul, the global capital for hair transplant surgery. According to the Turkish Health Tourism Association, about one million people traveled to Turkey for a hair transplant in 2022, spending about $2 billion. Bennett/Spencer Macnaughton Show less Bennett lounging poolside in December 2022 , 11 months after his hair transplant. Spencer Macnaughton during his hair transplant in Istanbul Turkey Kenny Wassus/Business InsiderWhen they finally announced I was finished, it was around 10 p.m.
Persons: Bennett, Turkey —, who's, It's, poolside, what's, I'd, , Aygin . Bennett, Spencer Macnaughton, Serkan Aygin, he'd, Kenny Wassus, Aygin, He's, they'd, Choi, you've, Istanbul Turkey Kenny Wassus, Kenny, I've, I'm Organizations: Mercedes Club, Business, Turkish Health Tourism Association, FDA, International Society of Dermatology, Turkish Airlines, Istanbul Airport Locations: midtown Manhattan, Turkey, Istanbul, Manhattan, New Jersey, Turkish, United States, New York, Istanbul Turkey, Detroit
Could Trump's next courtroom outburst or gag-violating Truth Social post really be the final straw that gets him locked up on contempt of court? "You get more due process" when you commit an act of contempt outside the courtroom, Levine said. "It's when the judge calls the court officers and tells them to surround the defendant so that he doesn't try to walk out of the courtroom." AdvertisementBut Trump already has at least two court officers standing behind him at all times in Merchan's courtroom, for his own protection. Reality will instead set in when the judge gives what's usually the final instruction to the court officers, "Take charge," Galluzzo said.
Persons: Trump, , audibly, Stormy Daniels, Donald Trump, misbehaving, Trump's, Juan Merchan, Arthur Aidala, Harvey Weinstein, Weinstein, Aidala, Arnold Levine, Levine, heckles Daniels, Matthew Galluzzo, Galluzzo, Daniel Scott, who's, Scott, Joe Schmoe, Daniels Organizations: Service, , New, Trump, Legal Aid Society of New York, Defense Task Force, Secret Service Locations: ,, Manhattan, Merchan's, Merchan, Trump
Chattanooga's utility built a $280 million smart grid, creating $2.7 billion in economic value. The local utility, called EPB of Chattanooga, spent $280 million to refurbish its power system with smart technologies to make a "smart grid." The traditional power grid carries electricity from a power plant to homes and commercial buildings. Smart grids can bring huge economic benefitsEven Congress knows the nation needs a smart grid. Though a smart grid requires a big up-front investment, it can save a lot of money down the line.
Persons: , That's, Tiago Majuelos, Monika Skolimowska, Kevin Schneider, Schneider, Joshua Rhodes, David Wade, EPB, Wade, Taylor, David Swanson, We're Organizations: Infrastructure, Service, Chattanooga Smart, US Department of Energy, Wall Street, Getty, Pacific Northwest National Laboratory, American Society of Civil Engineers, University of Texas, Department of Energy, C Electric Company, BI, Reuters, Nationwide Locations: Chattanooga , Tennessee, Chattanooga, Tennessee, EPB, California, Austin, Hamilton County, Palm Springs , California, Columbia, Southern California
Opinion: Why memes about Mommy and wine are no joke
  + stars: | 2024-04-24 | by ( Kara Alaimo | ) edition.cnn.com   time to read: +6 min
Editor’s note: Kara Alaimo, an associate professor of communication at Fairleigh Dickinson University, writes about issues affecting women and social media. At work, women on average earn just 84 cents for every dollar earned by men and are up against endless stereotypes about why they’re not leadership material. “Anyone who’s been on social media in the last ten years has seen the memes: ‘Mommy needs wine.’ ‘I wine because my kids whine.’ You can buy infant onesies that say ‘I’m the reason mommy drinks’ on Amazon,” Yvonne points out. It requires social structures such as an adequate childcare system and resources for women who need to leave abusive homes. We all also need to stop sharing jokes and memes that suggest it’s humorous for people of any gender to deal with the stresses they’re up against by imbibing carcinogens.
Persons: Kara Alaimo, Kara, Celeste Yvonne, it’s, Yvonne, they’re, who’s, ” Yvonne, , I’ve, Holly Whitaker, Carol Lee Flinders, ” Whitaker Organizations: Fairleigh Dickinson University, Women, Press, Facebook, CNN, JAMA, Pew Research Center, US Centers for Disease Control Locations: United States
So, whether you want help recognizing the toxic employees around you — or you'd like to avoid becoming one yourself — watch out for these three red flags, CEOs say. The entitled employeeDon't ever act like you're owed a promotion or raise, says Tom Gimbel, CEO of staffing and recruiting firm LaSalle Network. "[People who say] 'I'm only going to do what's in my job description, I'm not going the extra mile, I'm not going to commit time to this' and expect to be rewarded" aren't desirable employees, Gimbel tells CNBC Make It. Sometimes, employees are caught off-guard when colleagues with less tenure get promoted first, but time alone doesn't entitle anyone to a promotion. When the employee turned in the work, it contained a noticeable error — and they blamed Fox, saying her instructions were unclear.
Persons: Tom Gimbel, I'm, Gimbel, Talia Fox, Fox Organizations: Society of Human Resource Management, LaSalle Network, CNBC, KUSI
The union says it is trying to appeal a decision not to change the performance evaluation of one of the workers. Boeing says the investigation was part of a confidential process and that the report could only be shared with the FAA. The complaint filed on behalf of the two engineers involves a different issue— the onboard computer networks on the planes. The union says Boeing managers “strongly objected” to rerunning calculations regarding the systems based on new assumptions, citing cost and production delays, but that Boeing ultimately agreed. Boeing re-did the required analysis,” the press release says.
Persons: , SPEEA, , Sam Salehpour, Rich Plunkett Organizations: CNN, Boeing, Federal Aviation Administration, Society of Professional Engineering Employees, Aerospace, National Labor Relations, Boeing’s, FAA, ” Boeing, Strategic
Generative A.I. technologies can write poetry and computer programs or create images of teddy bears and videos of cartoon characters that look like something from a Hollywood movie. Now, new A.I. The company is expected to present the paper next month at the annual meeting of the American Society of Gene and Cell Therapy. Much as ChatGPT learns to generate language by analyzing Wikipedia articles, books and chat logs, Profluent’s technology creates new gene editors after analyzing enormous amounts of biological data, including microscopic mechanisms that scientists already use to edit human DNA.
Persons: ChatGPT Organizations: American Society of Gene, Cell Locations: Berkeley, Calif
The Mother of Invention
  + stars: | 2024-04-19 | by ( Julia Boorstin | ) www.cnbc.com   time to read: 1 min
Share Share Article via Facebook Share Article via Twitter Share Article via LinkedIn Share Article via EmailThe Mother of InventionSociety often comes up short when it comes to working mothers. Inspired by their personal and professional experiences, Upwards Co-Founder & CEO Jessica Chang, and Bobbie Co-Founder & CEO Laura Modi, set out to address shortcomings in the market and founded businesses to help other families. They discuss leadership as working moms, navigating entrepreneurship and the true power that comes from defying expectations and beating the odds.
Persons: Jessica Chang, Bobbie Co, Laura Modi Organizations: Invention Society
Using two tactics to retrain his brain, Karp gained confidence and pursued a career in academia. The MIT and Harvard professor shares the benefits of working in a flow state in his new book. Though I still struggle every day in various ways, I'm grateful to be able to say that these LIT tools enabled me to meet and far exceed those dismal early expectations. AdvertisementYou're never too old to charge your brain this way, and most definitely no one is ever too young. In fact, LIT tools can be lifesavers for kids, as they were for me.
Persons: Jeffery Karp, Karp, , Eric Kandel, you've, we're, I've, they've, Jeff Karp, William Morrow, Jeffrey Michael Karp Organizations: MIT, Harvard, Service, Harvard Medical School, National Academy of Inventors, Royal Society of Chemistry, American Institute for Medical, Biological Engineering's College of Fellows, Biomedical Engineering Society, Canadian Academy of Engineering, Karp Lab, Center, Medical Locations: Canada, playbook, LIT
CNN —The US Food and Drug Administration is warning that dangerous counterfeit versions of Botox have been identified in multiple states, putting the safety of consumers at risk. The incidents of counterfeit Botox being administered to consumers appear to be connected to products that have been purchased from unlicensed sources and then administered by either unlicensed or licensed providers. The counterfeit Botox products may be identified by the lot number C3709C3 found on the outer carton and vial, the FDA said. Counterfeit botox has been found in several states. Most often, when counterfeit Botox is sold, “the injector knows they’re purchasing something counterfeit,” Sung said.
Persons: Washington –, Botox, Lavanya Krishnan, Arya Derm, ” Krishnan, Krishnan, Allergan, , , Jimmy Sung, you’re, can’t, ” Sung, Michael Cameron, Cameron, ” Cameron, Sung, “ I’m, I’ve, Steven Williams, ” Williams, Dr, Sanjay Gupta, Cynthia Elliott, ” Elliott Organizations: CNN, Food and Drug Administration, FDA, US Centers for Disease Control, CDC, American Board of Cosmetic, Revance Therapeutics, Merz Aesthetics, Tribeca Aesthetics, Cameron Dermatology, Mount Sinai Health, American Society of Plastic Surgeons, , CNN Health Locations: – Colorado, Florida , Illinois , Kentucky , Nebraska , New Jersey , New York , Tennessee, San Francisco, United States, New York City, New York, Florida
Not even a six-figure fine can get Mark Cuban to change his leadership tactics. A year later, he was fined $100,000 by the league for his unconventional methods of team leadership, he tells CNBC Make It. At the time, Cuban was 41 and full of energy after buying his way into his dream job. He still leans on his interpersonal leadership approach today, often providing advice, building connections and offering mentorship to contestants on ABC's "Shark Tank." If you're struggling with your own leadership style, Cuban recommends figuring out what being a leader actually means to you.
Persons: Mark Cuban, he'd, Draymond, Cuban, David Stern, Stern Organizations: Cuban, Yahoo, NBA's Dallas Mavericks, CNBC, NBA, Mavericks, National Society of Leadership
On Wednesday, the Association for Computing Machinery, the world’s largest society of computing professionals, announced that this year’s Turing Award will go to Avi Wigderson, an Israeli-born mathematician and theoretical computer scientist who specializes in randomness. Often called the Nobel Prize of computing, the Turing Award comes with a $1 million prize. The award is named for Alan Turing, the British mathematician who helped create the foundations for modern computing in the mid-20th century. Other recent winners include Ed Catmull and Pat Hanrahan, who helped create the computer-generated imagery, or C.G.I., that drives modern movies and television, and the A.I. researchers Geoffrey Hinton, Yann LeCun and Yoshua Bengio, who nurtured the techniques that gave rise to chatbots like ChatGPT.
Persons: Turing, Avi Wigderson, Alan Turing, Ed Catmull, Pat Hanrahan, Geoffrey Hinton, Yann LeCun, Yoshua Bengio Organizations: Association for Computing Machinery Locations: Israeli, British
"That whole process flow is designed to help radiologists get through their task with assistance more quickly," Kurian said in an interview. Google Cloud and Bayer are not the only companies exploring AI applications for medical imaging. Google Cloud has been working with Bayer on the radiology platform for around five years. The foundation was built using existing Google Cloud solutions like Vertex AI, Healthcare API and BigQuery, and Kurian said the platform's data is encrypted. Google Cloud and Bayer are exploring a number of different pricing models for the platform, he said.
Persons: Thomas Kurian, radiologists, Kurian, Keith Kirkpatrick, there's, Kirkpatrick, Bayer, Guido Mathews, Mathews Organizations: Google, Bayer, Tuesday, CNBC, Radiological Society of North, American College of Radiology's, Google Cloud, Philips, Amazon Web Services, GE HealthCare Locations: U.S, Radiological Society of North America, Netherlands
CNN —Colombian superstar Shakira has said her two sons “absolutely hated” the movie “Barbie” because it was “emasculating,” adding that she partially agreed. “I think that men have a purpose in society and women have another purpose as well. (“Barbie” was produced by Warner Bros. Pictures, which shares the same parent company as CNN.) Margot Robbie as Barbie in Warner Bros. Pictures' "Barbie". Courtesy of Warner Bros. PicturesWhile the core of its female empowerment message was largely praised, some pointed out the dangers of portraying misogyny as deriving from incompetence rather than malice.
Persons: Shakira, , , Sasha, Gerard Piqué, ” “ Barbie ”, Barbie ”, Greta Gerwig’s, Barbie, Ken, Margot Robbie, Ryan Gosling, “ Barbie ”, ” Gerwig Organizations: CNN, Warner Bros . Pictures, Warner Bros ., New York Times Locations: Milan, Spanish
A container ship colliding into the Francis Scott Key Bridge in Baltimore is drawing attention to potential vulnerabilities among some of America’s more than 600,000 bridges. The Key Bridge stood for 47 years, and in that time it never received the sort of jolt that anyone could have thought would bring it down. Extreme weather events, increasingly heavy trucks and collisions from larger container ships pose significant risks to US bridges, engineers and other infrastructure experts say. The Key Bridge was “fracture critical,” the National Transportation Safety Board said Wednesday. To minimize the potential of ships bringing down bridges, bridges need to be built with what are known as redundancies— protections around bridges’ danger points.
Persons: Francis Scott Key, Dali, Ananth Prasad, Prasad, , Jessie Yeung, Curt Devine, Casey Tolan, Isabelle Chapman Organizations: American Society of Civil Engineers, Congressional Research Service, National Transportation Safety, World Association, Transport Infrastructure, Florida Transportation Builders ’ Association, CNN Locations: Baltimore, America, United States, China, Argentina, Florida
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