NDTV's chief strategy officer, Arijit Chatterjee, and chief technology and product officer, Kawaljit Singh Bedi, also quit, resignations that come after founders Prannoy Roy and Radhika Roy left the company's board in December.
NDTV made several failed attempts to block the takeover, citing regulatory restrictions on moving shares.
The ports-to-energy conglomerate's takeover had stoked fears over the freedom of the press among some journalists and led to Ravish Kumar, a senior executive editor at NDTV, resigning soon after Adani acquired its stake.
While announcing the latest set of resignations, NDTV, in a regulatory filing, said, "The company is in the process of putting up a new leadership team which will set a fresh strategic direction and goals for the company."
(This story has been refiled to correct the typographical error in the fourth paragraph)Reporting by Chris Thomas in Bengaluru; Editing by Savio D'SouzaOur Standards: The Thomson Reuters Trust Principles.