Liverpool's second successive defeat against a team in the bottom three, following last week's reverse at Nottingham Forest, left them in ninth place, eight points off the top four.
Chelsea also lost ground as Graham Potter's return to Brighton & Hove Albion ended in a 4-1 hammering.
Manchester City have 29 points from 12 games, one point more than Arsenal who host bottom club Nottingham Forest on Sunday.
Spurs moved to 26 points from 13 games with Newcastle, who have lost only once all season, on 24.
Fulham could have moved level on points with Chelsea but were held to a 0-0 draw at home to Everton.