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A 58-year-old man with heart failure who received a new heart from a genetically modified pig died on Monday, nearly six weeks after receiving the pig organ, University of Maryland Medical Center officials announced on Tuesday. The first patient, 57-year-old David Bennett, died last year, two months after his transplant. He had developed multiple complications, and traces of a virus that infects pigs were found in his new heart. Both of the patients had terminal heart disease when they received the transplanted organs, and neither managed to recover sufficiently to leave the hospital. But while doctors said that Mr. Bennett did not show any signs of acute rejection of the new heart, which is the most significant risk in organ transplants, they said that Mr. Faucette’s transplanted heart had started to display some initial signs of rejection.
Persons: Lawrence Faucette, David Bennett, Mr, Bennett, Faucette’s Organizations: University of Maryland Medical Center Locations: Frederick, Md
About 2 percent of births in the United States involve infertility treatment of some kind, according to the paper. Background: The largest study yetPrevious studies of stroke after infertility treatments have yielded mixed results. What’s Next: A warning for womenIn an interview, Dr. Ananth outlined three possible explanations for a link between stroke and infertility treatment. “We know that women who receive infertility treatment have certain vascular complications, typically an increased risk of pre-eclampsia and placental abruption,” he said. Third, he added, “is that people who receive the treatment receive it for a reason.
Persons: , Cande, Ananth, Robert Wood, Organizations: JAMA, Robert Wood Johnson Medical School Locations: United States, New Jersey
Almost half of the women surveyed said they had held back in talking with a maternity care provider about their questions or concerns, a particularly disturbing finding. Background: Maternal mortality rates have soared in the U.S.Maternal mortality rates in the United States are among the highest in the industrialized world. Maternal mortality rates are two to three times higher among these women than among white and Hispanic women. Nevertheless, the findings suggest serious flaws in the care provided to pregnant women and women giving birth. Birthing women deserve respectful health care, which is strongly linked to positive outcomes, C.D.C.
Persons: they’d, Porter Novelli, you’re, , Wanda Barfield Locations: U.S, United States
From there it spreads, becoming a so-called flesh-eating infection that extends quickly beyond the wound into healthy tissue. The bacterium also spreads when people who are immunocompromised or have liver disease eat raw oysters that are contaminated. Physicians warn patients with these conditions against eating raw oysters, which become infected by seawater they filter for food. An open wound means any cut, scrape or other abrasion that might allow the bacterium into your body. If you develop a skin infection, let your health provider know quickly — this is an infection that can spread rapidly.
Persons: beachgoers, It’s, ” Dr, Schaffner, “ Don’t Locations: Connecticut
A number of studies last year demonstrated that pig kidneys that had been transplanted into brain-dead individuals made urine, an essential function, for short periods of time. “The really new finding here is that these pig kidneys can clear enough creatinine to support an adult human,” Dr. Locke said. “If you want to have life-sustaining kidney function, the kidneys have to do more than just make urine,” Dr. Locke said. A few months later, researchers at the University of Maryland transplanted a heart from a genetically modified pig into a 57-year-old patient with heart failure. So far, transplants of genetically modified pig kidneys have been made only to brain-dead patients.
Persons: , Jayme Locke, Dr, Locke Organizations: Transplant Institute, NYU Langone Health, University of Maryland, Revivicor, United Therapeutics Corporation, Langone Health, Food and Drug Administration Locations: Alabama, New York
The trains from Tel Aviv were packed one evening last month when Inbal Boxerman, a 40-year-old mother of two, was blocked by a wall of men as she tried to board. One of them told her that women were not allowed on — the car was for men only. It was a public train operated by Israel Railways, and segregated seating is illegal in the country. The men stopping her appeared to be protesters going home from a rally supporting the governing coalition, which includes extremist religious and far-right parties pushing for more sex segregation and a return to more traditional gender roles. “I said, ‘For real?’” said Ms. Boxerman, who works in marketing.
Persons: Inbal Boxerman, Boxerman, , ’ ” Organizations: Israel Railways Locations: Tel Aviv, Israel
To what extent the test will improve outcomes and save lives is not clear, however, as there is no effective treatment for pre-eclampsia, which usually eases after birth. “We don’t have a therapy that reverses or cures pre-eclampsia other than delivery of the baby, which is more like a last resort,” Dr. Woelkers said. The new blood test, made by Thermo Fisher Scientific, has been available in Europe for several years. It is intended for pregnant women who are hospitalized for a blood pressure disorder in the 23rd to 35th weeks of gestation. “A lot of women will have edema and headaches.” (Edema means swelling.)
Persons: , Woelkers, , Sarosh Rana Organizations: Fisher, University of Chicago Locations: Europe
Why Some Americans Buy Guns
  + stars: | 2023-06-23 | by ( Roni Caryn Rabin | ) www.nytimes.com   time to read: 1 min
In 2020, while many communities were under Covid lockdowns, protesters were flooding the streets and economic uncertainty and social isolation were deepening, Americans went on a shopping spree. Some 22 million guns were sold that year, 64 percent more than in 2019. The death count from guns, including suicides, rose to 45,222 in 2020 from 39,702 in 2019. The number of lives lost to guns rose again in 2021, to 48,830. After quashing research into gun violence for 25 years, Congress began funneling millions of dollars to federal agencies in 2021 to gather data.
Persons: Covid lockdowns Organizations: Shooting Sports Foundation
After a woman gives birth, the baby’s well-being usually becomes the focus of family attention, and the mother’s health often recedes as a priority. But new research has highlighted the frequency with which serious pregnancy-related medical complications emerge after childbirth — often well after the mother is discharged from the hospital. When are postpartum complications most likely to occur? The first six weeks after delivery are the most dangerous; women and their partners or support teams should be particularly vigilant during the first week. But complications related to pregnancy can emerge up to a year after childbearing.
Sherri Willis-Prater’s baby boy was 2 months old, and she was about to return to her job at a school cafeteria in Chicago. But as she walked up the short flight of stairs to her kitchen one evening, she nearly collapsed, gasping for breath. At the hospital, Ms. Willis-Prater, who was 42 at the time, was connected to a ventilator that pumped air into her lungs. After giving birth, Ms. Willis-Prater thought “I made it across the finish line,” she recalled in an interview. “I don’t have to worry about anything anymore.”Most people think of labor and birth as the most dangerous part of pregnancy.
New Mammogram Advice: What to Know
  + stars: | 2023-05-09 | by ( Roni Caryn Rabin | ) www.nytimes.com   time to read: +1 min
The U.S. Preventive Services Task Force, a panel of experts that issues guidelines about preventive care, has recommended all women start routine breast cancer screening at 40, instead of at 50, the previous recommendation. The panel continues to advise spacing the screenings at two-year intervals, although some other medical organizations endorse annual mammograms. The advice applies to all “cisgender women and other people assigned female at birth” who are at average risk for breast cancer and do not have any troubling symptoms that might indicate breast cancer. This group includes women with dense breast tissue and a family history of breast cancer. The recommendation does not apply to anyone who has already had breast cancer, has genetic mutations that increase breast cancer risk, has received high-dose radiation to the chest, or has had breast lesions identified in previous biopsies.
But there have been troubling trends in breast cancer in recent years. They include an apparent increase in the number of cancers diagnosed in women under 50 and a failure to narrow the survival gap for younger Black women, who die of breast cancer at twice the rate of white women of the same age. The panel has said there is insufficient evidence to make recommendations one way or the other for women who were 75 and older. had for the first time commissioned studies of breast cancer specifically among Black women, as well as for all women, and needed more research into the factors driving the racial disparity. The task force also is calling for a clinical trial to compare the effectiveness of annual and biennial screening among Black women.
But the report’s authors noted that even now, Covid is killing Americans in large numbers. By contrast, Asian Americans and children ages 5 to 14 had the lowest death rates. Black Americans and Native American or Alaska Native people had the highest age-adjusted death rates from all causes. Death rates were lowest for multiracial and Asian individuals. Compared with the early days of the pandemic, Covid was less likely to be lethal last year.
Now, a woman’s risk of developing breast cancer could “be updated every time she gets a new mammogram.”Background: Breast Density MattersBreast density is now an acknowledged risk factor for breast cancer, albeit one of many. Dozens of states have started requiring mammography centers to notify women if they have dense breast tissue. In March, the Food and Drug Administration recommended that providers tell women about their breast density. But this is the first study to measure changes in density over time and to report a link to breast cancer. One next step may to be examine breast density over time in women taking medication to prevent breast cancer to see if the density decreases, Dr. Knudsen suggested.
An old tuberculosis vaccine known to bolster the immune system did not prevent Covid infections among health care workers, scientists reported on Thursday. But the trial was shorter and smaller than originally designed, and the investigators said that the results did not rule out other potential benefits associated with the vaccine, known as B.C.G. The study, published in The New England Journal of Medicine, was the largest clinical trial of the vaccine’s potential to protect against Covid infections. The trial of health care workers began in March 2020, during the early days of the pandemic, when no effective treatments for Covid were available and a new vaccine against the highly infectious disease seemed to be a remote fantasy. The hope was that the old vaccine might be repurposed to save lives.
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