A blast of Arctic air will also plunge much of the country into bitter and, in some cases, dangerous cold, forecasters say.
In some parts of this area, the wind chill could reach as low as minus 70 degrees, according to the Weather Service.
Brief bursts of moderate to heavy snow lasting an hour or two are likely to occur immediately behind the Arctic front.
Strong southerly winds, combined with the new moon-tide cycle, could also bring coastal flooding from northern New Jersey to northeast Massachusetts, the Weather Service said.
Meteorologists warned local residents that this is not a normal lake effect event with a narrow band of heavy snow.