The A's were down 10-8 when Seth Brown followed a walk to Aledmys Diaz with a two-run homer off Guardians closer Emmanuel Clase in the last of the ninth.
Angels 7, Mariners 3Shohei Ohtani and Taylor Ward hit two-run homers as Los Angeles defeated host Seattle.
Yankees 8, Phillies 1Anthony Rizzo ignited a five-run fifth inning with a two-run homer, and host New York cruised to victory over Philadelphia.
His counterpart, Jose Berrios (0-1), allowed eight runs, nine hits and two walks while striking out seven in 5 2/3 innings.
Ozzie Albies hit a two-run homer and Austin Riley had a solo shot for the Braves, who have won three of four games to start the season.