Hired in 2015, partly to help restore sluggish sales in its Eastern Europe division, including Russia, Hart has successfully overseen Carlsberg's SAIL'22 strategy, which focused on cutting costs and improve sales of more premium beer brands.
Carlsberg said in a statement that Hart planned to leave by the end of the third quarter.
"Cees 't Hart has delivered remarkable results during his time at Carlsberg," Supervisory Board Chair Henrik Poulsen said.
"He has really been a significant person in the transformation that has taken place, it's been very impressive to witness," Laustsen added.
It is seeking an option with the buyer to buy back the Russian business in future.