Pennsylvania Lieutenant Governor and U.S. Senate candidate John Fetterman speaks during a rally in Philadelphia, Pennsylvania, U.S., September 24, 2022.
The chamber is currently split 50-50 between Republicans and Democrats, who are able to control the agenda thanks to Vice President Kamala Harris' tie-breaking vote.
The state is a former Republican stronghold where Democrats have made surprise gains in recent elections - Biden won the state by 0.3% in 2020.
Masters' struggles have led Republicans to pull funding and analysts have shifted their predictions for the race in Kelly's favor.
National groups have been pouring in money, and the topic of abortion is front and center since the state's Republican legislature banned all abortions after six weeks.