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Whooping cough cases climbing for decadesAs with many infectious diseases, cases of whooping cough dropped to unusually low levels during the pandemic as people limited social interactions and took other precautions to defend against Covid-19. In 2020, the US had about 6,000 cases of pertussis, and that number dropped even further in 2021 to roughly 2,000 cases. Whooping cough starts with symptoms that look a lot like a regular cold: a runny nose, sneezing, a low-grade fever and a tickly cough. That’s led to a hunt for better, more durable immunizations against whooping cough that also don’t cause as many side effects. In some ways, whooping cough is an ideal infection to test in human challenge models.
Persons: , Susan Hariri, Archana Chatterjee, Chatterjee, they’re, it’s, pertussis –, Hariri, Tod Merkel, Merkel, It’s, That’s, Dr, Sanjay Gupta, Melinda Wharton Organizations: CNN, US Centers for Disease Control, CDC’s National Center, Food and Drug Administration, Chicago Medical School, Products Advisory, Covid, FDA’s, Vaccines Research, Regulators, CNN Health, FDA, National Center Locations: United States, Canada
Centessa Pharmaceuticals could be at the forefront of a leading narcolepsy treatment that can send its shares soaring, according to Morgan Stanley. One of the company's drugs is ORX750 for the treatment of sleep-wake disorders, including narcolepsy type 1 and 2, or NT1 and NT2. Additionally, Centessa is developing ORX142 for the treatment of excessive daytime sleepiness, or EDS, in certain neurological, neurodegenerative and psychiatric disorders. The drug is designed to increase wakefulness, reduce cataplexy and potentially be a novel treatment for narcolepsy type 1. Given the firm's view of ORX750 as a now de-risked mechanism for treating narcolepsy, Hung modeled a higher peak market share for the treatment in NT1 by 2036.
Persons: Morgan Stanley, Jeffrey Hung, narcolepsy, Hung Organizations: Pharmaceuticals, IH, EDS Locations: NT1, NT2
Coronary calcium buildup causes atherosclerosis, a chronic and inflammatory cardiovascular disease marked by narrowed arterial walls and thus reduced blood flow. Environmental contaminants have been increasingly recognized as risk factors for cardiovascular disease, but the association of metals with coronary artery calcification has been “largely unknown,” the study authors said. They hypothesized that higher urinary levels of nonessential metals — cadmium, tungsten and uranium — and essential metals — cobalt, copper and zinc — that have previously been associated with cardiovascular disease may be linked with calcification. The participants didn’t already have clinical cardiovascular disease and were recruited from Baltimore; Chicago; Los Angeles; New York City; St. Paul, Minnesota; and Winston Salem, North Carolina. The trouble with measuring urinary metal levelsThe study has a few other limitations.
Persons: Drs, Sadeer, Khurram Nasir, Sanjay Rajagopalan, weren’t, , Katlyn, McGraw, Winston, cardiologists, Andrew Freeman, wasn’t, they’re, ” Freeman, “ It’s, , Kindi, Nasir, Rajagopalan, ” McGraw, , Freeman Organizations: CNN, American College of Cardiology, Houston Methodist, University Hospitals Harrington, & Vascular Institute, Columbia University’s Mailman, of Public Health, Jewish Health Locations: Cleveland, Baltimore, Chicago, Los Angeles ; New York City, St, Paul , Minnesota, Winston Salem , North Carolina, Denver, Columbia
Packaged foods, soda, chips, hot dogs, chicken nuggets and ice cream all fall under the category of ultraprocessed foods, which can include dozens of synthetic additives such as preservatives, emulsifiers and artificial dyes. For every 10% increase in the amount of a person’s diet made up of ultraprocessed foods, the team found that there was a 17% increased risk for developing type 2 diabetes, the data showed. The scientists also found that reducing the amount of ultraprocessed food you are consuming can lower the risk, according to the study. “Ultra-processed foods are everywhere,” Dicken said via email. “We also know that increased body fat (from excess calories) increases the risk of type 2 diabetes.
Persons: Nerys Astbury, Astbury, Samuel Dicken, ” Dicken, , , Sarah Gallo, Dicken, It’s, Hilda Mulrooney, Mulrooney, ” Mulrooney Organizations: CNN, Nuffield Department, Primary Health Care Sciences, University of Oxford, University College London, Consumer Brands Association, London Metropolitan University Locations: Europe, US
Those with "addictive personalities" were assumed to be people who heavily relied on drugs or alcohol. In the TikTok-era, having an addictive personality has taken on a new meaning. But, psychologists believe that when a person's repeated behaviors interrupt their daily functions, it is worth examining how to curb those impulses. Someone with an addictive personality "requires immediate gratification," says Detroit-based psychologist Michele Leno. Here are three key indicators that you or someone you know might have an addictive personality.
Persons: addictivepersonality, Michele Leno, aren't Locations: Detroit
“Given that sleep is highly visible as a risk factor, non-stigmatizing, and highly treatable … we suggest study of sleep as a risk factor and critical intervention target for youth suicide,” said senior study author Dr. Rebecca Bernert, a suicidologist and founder of the Stanford Suicide Prevention Research Laboratory in California, via email. Suicide is a leading cause of death among children ages 10 to 14, a group that also has high rates of sleep disturbance, according to the study. And sleep disturbances “have emerged as an evidence-based risk factor for suicidal behaviors” among adults, regardless of whether a person has depressive symptoms, the authors said. At that time, guardians answered questionnaires about their child’s sleep health, which included factors such as problems with falling or staying asleep, waking up, excessive sleepiness, sleep-disorder breathing, excessive sweating during sleep, and behaviors that occur when someone partially awakes from deep sleep. Supporting your child’s healthAt all ages, your kids need good nighttime habits that support healthy sleep, Willard said.
Persons: ideation, , Rebecca Bernert, Christopher Willard, wasn’t, ” Willard, Rebecca Berry, University’s, Berry wasn’t, Bernert, ” Bernert, Berry, Sleep, Willard, ” Berry, Organizations: Lifeline, CNN, JAMA, Stanford, Prevention Research, Harvard Medical School, University’s Grossman School of Medicine, Stanford University School of Medicine Locations: California, United States, Massachusetts, Boston, New
Read previewDomantas Katelė, an official in Lithuania's Ministry of Social Security and Labour, is widely known as his country's "Gen Z" minister. AdvertisementThe World Happiness Report backs up his claim, ranking Lithuania as the happiest place in the world for those under 30 earlier this year. AdvertisementIt seems paradoxical: How can a country be great for young people while also being Europe's suicide capital? Užupis, a small district alongside the Vilnia River, is popular with Vilnius' young, bohemian crowd. AdvertisementDomantas Katelė is often referred to as the "Gen Z" minister.
Persons: , Z, it's, Joshua Nelken, Zers, Adriana Doroškevičiūtė, Richard Bogu, It's, Bogu, Antanas Grižas Organizations: Service, Lithuania's Ministry of Social Security, Labour, Business, Union, Lithuania, European Union, Data, BI, Soviet Bloc Locations: Lithuania, Vilnius, Soviet Union, Europe, Old, Užupis, Soviet
CNN —Following the MIND diet for 10 years produced a small but significant decrease in the risk of developing thinking, concentration and memory problems, a new study found. The MIND diet was specifically designed to combat cognitive decline, said lead study author Dr. Russell Sawyer, an assistant professor of clinical neurology and rehabilitation medicine at the University of Cincinnati Gardner Neuroscience Institute. People who followed the MIND diet more closely were 4% less likely to develop memory and thinking problems than those who did not adhere to the diet, the study found. “The benefits of the MIND diet may have a differential impact in women and Blacks and this is an area for future research.”Leafy green vegetables, berries, whole grains, seeds, and a bit of fish and poultry are staples of the MIND diet. jenifoto/iStockphoto/Getty ImagesMore research neededA 2023 randomized controlled clinical trial found the MIND diet no better than the control diet in reducing signs of cognitive decline in the brain.
Persons: Russell Sawyer, ” Sawyer, Sawyer, , David Katz, ” Katz Organizations: CNN, University of Cincinnati Gardner Neuroscience Institute, , True Health Initiative, American Academy of Neurology, National Institutes of Health, Southern, Blacks
Biotechnology stocks offer an under-the-radar and unappreciated way to profit from the central bank's looming campaign to start cutting the cost of borrowing, according to Goldman Sachs. Investors may have already begun to anticipate the effect of lower rates on some biotech companies. IBB .SPX mountain 2024-06-30 The iShares Biotechnology ETF has risen more than twice as much as the S & P 500 this quarter. The iShares Biotech ETF is up 7.7% this quarter while the Nasdaq Biotech Index has advanced 7.4%, more than double the 3.2% gain in the S & P 500 since June 30. Year-to-date, Regeneron is up 30.6% and Vertex by 18.3%, both outperforming the 18.1% rise in the S & P 500.
Persons: Goldman Sachs, John Flood, Goldman, Flood, Regeneron Organizations: Biotechnology, Federal Reserve, Gilead Sciences, Nasdaq Biotechnology, IQVIA Holdings, Regeneron Pharmaceuticals, Amgen, Vertex Pharmaceuticals, iShares Biotech, Nasdaq Biotech Locations: Gilead
Black women are more likely than white women to die from even the most treatable types of breast cancer, a study published Tuesday in the Journal of Clinical Oncology found. While Black women and white women are diagnosed with breast cancer at similar rates, Black women are 40% more likely to die from the disease. For those with HR-positive, HER2-positive tumors, Black women were 34% more likely to die than white women. Black women were 17% more likely to die from triple-negative breast cancer than white women, a finding that surprised Warner. “If you look at breast cancer data from 40 years ago, there really weren’t differences in mortality for breast cancer between Black and white women.
Persons: Erica Warner, Warner, , ” Warner, Eric Winer, ” Winer, Wendy Wilcox, , ” Wilcox, Marissa Howard, McNatt, Howard, Black, we’ve Organizations: Clinical Oncology, Massachusetts General Hospital, Yale Cancer Center, , for Disease Control, New York, New York City Health, Breast Care, Atrium, Wake Forest Baptist Locations: Massachusetts, New York City, North Carolina
The Food and Drug Administration expanded the approval of Kisqali, a drug for metastatic breast cancer, to also treat patients with earlier stages of the disease, drugmaker Novartis said Tuesday. The approval means that tens of thousands of women diagnosed with early-stage breast cancer will have access to a medication that can help prevent their cancer from coming back. The expanded approval is for patients with HR-positive, HER2-negative breast cancer, the most common form of the disease. It comes as rates of breast cancer are increasing in younger women: From 2000 to 2019, rates of breast cancer in women ages 20 to 49 increased by 15.6% according to a study published earlier this year in JAMA Network Open. “You’re always going to be faced with the fact every single day that you have had breast cancer,” she said.
Persons: , Eleonora Teplinsky, it’s, Kisqali, Vandana Abramson, Teplinksy, Nikki Odum, ‘ I’m, ’ ”, Odum, Justin, Denise Yardley, ” Odum, Yardley, Sarah Cannon, Komal, Abramson, ” Teplinsky, that’s, “ You’re, Organizations: Drug Administration, Novartis, Health, European Society for Medical Oncology, Breast Cancer Research, Vanderbilt, Ingram Cancer Center, Kisqali, Sarah, Sarah Cannon Research Institute, Memorial Sloan Kettering Cancer Center Locations: New Jersey, Barcelona, , Nashville , Tennessee, , Smyrna , Tennessee, Nashville, New York
This is one of them: Drinking several cups of caffeinated coffee or tea a day may protect against Type 2 diabetes, coronary heart disease and stroke. They also looked at responses from about 172,000 people who specified that they drank caffeinated coffee or tea. None of them had a history of cardiometabolic disease — defined by a diagnosis of at least two of the three conditions: Type 2 diabetes, coronary heart disease or stroke — when the study began. And among those who did eventually develop cardiometabolic disease, drinking moderate amounts of coffee every day was still associated with lower risk of developing another cardiometabolic disease. Studies have also shown a link between high caffeine intake and a greater risk of dementia and stroke.
Persons: , Chaofu Ke, ” Ke, Luke Laffin, , Laffin, , ” Laffin, Stephen Kopecky, ” Kopecky, It’s, Kopecky Organizations: Soochow University, Center, Cleveland Clinic, Mayo Clinic Locations: China, Sweden, Rochester , Minnesota
Are trampolines safe for kids? A doctor explains
  + stars: | 2024-09-17 | by ( Katia Hetter | ) edition.cnn.com   time to read: +8 min
The American Academy of Pediatrics issued a statement in 2012 to strongly recommend against the use of recreational trampolines in kids. Jumpers on the same apparatus increases injury risk, especially for the smallest individuals, according to the AAP. The report also found that injuries from full-size trampolines had a six times higher risk of requiring surgery compared with injuries from mini-size trampolines. Stay close to your child and instruct them not to try dangerous maneuvers like flips. If our kids do go to a home that has trampolines, we try to steer them away from the trampoline.
Persons: pediatricians, Leana Wen, Wen Organizations: CNN, American Academy of Pediatrics, George Washington University, Care, AAP
“Coffee and caffeine consumption may play an important protective role in almost all phases of CM development,” Ke said. What researchers don’t knowThe methodology is strong and the results line up with existing data about caffeine and heart health, but there are still questions about the extent of the connection between caffeine and heart health, Marcus said. Because the study is observational, it can only show a connection between caffeine and heart health, he said. Other factors may actually be the cause of the improved heart health, he added. And contrary to popular wisdom, drinking caffeine in coffee is associated with experiencing a lower risk of abnormal heart rhythms, he added, pointing to his and others’ research.
Persons: Chaofu Ke, Cardiometabolic, ” Ke, Ke, Gregory Marcus, ” Marcus, Marcus, Organizations: CNN, Soochow University, Metabolism, University of California Locations: Suzhou, China, San Francisco
CNN —Jared Holz thought about taking one of the new GLP-1 drugs for weight loss for months before he actually filled the prescription. At least a dozen similar experimental weight-loss drugs designed to be taken as pills are working their way through clinical trials, with the most advanced now in the third and final stage of testing. Dushay cited hopes that pill versions of GLP-1 drugs could ease shortages, come at lower cost and enhance convenience. The oral GLP-1 raceRight on the heels of oral semaglutide is a group of drugs led by Eli Lilly’s orforglipron, an oral medication that also targets GLP-1, which is a hormone implicated in insulin regulation, appetite and digestion. Drugmakers including Pfizer and Roche, as well as smaller companies like Structure Therapeutics, Terns Pharmaceuticals and Viking Therapeutics, also have oral weight-loss drugs in earlier stages of development, BMO research shows.
Persons: Jared Holz, ” Holz, , Jody Dushay, Dushay, ” Dushay, it’s, Rybelsus, Jorge Moreno, , ” Moreno, Eli Lilly’s orforglipron, Lilly, Evan Seigerman, amycretin, who’ve, Dr, Sanjay Gupta, Holz, he’s, he’d Organizations: CNN, Harvard Medical School, Beth Israel Deaconess Medical, Novo Nordisk, US Food and Drug Administration, Yale School of Medicine, BMO Capital Markets, Pfizer, Roche, Therapeutics, Terns Pharmaceuticals, Viking Therapeutics, BMO, Nordisk, European Association for, Diabetes, Inversago Pharma, CNN Health Locations: Danish, Novo
Read previewAround 200,000 Haitians living in the US are on Temporary Protected Status, including many of those living in Springfield, Ohio, who have been targeted by former President Donald Trump and others with baseless claims about eating pets. Trump has already called for mass deportations from the town, saying last week: "We're going to start with Springfield and Aurora." "Once a country is designated, each individual covered by the designation must apply separately for TPS status," she said, noting that existing TPS holders must also renew their paperwork with each redesignation. However, if Trump wins, Leblang told BI this is far less likely. Indeed, it already was once before when Trump sought to end TPS for certain countries during his last administration.
Persons: , Donald Trump, Trump, Nancy Morawetz, Alejandro Mayorkas, Tom K, Wong, Harris, David Leblang, Leblang, Justin Sullivan, Lori A, Nessel, Biden, Julia Gelatt, Gelatt Organizations: Service, Trump, TPS, Haiti, Business, Biden, NYU, BI, Homeland, US Immigration Policy Center, University of Virginia, Seton Hall University School of Law, Department of Homeland Security, US Locations: Springfield , Ohio, Haitian, Springfield, Aurora, Haiti, Honduras, Nicaragua, El Salvador, Sudan, Canada
Read previewA busy office worker said he transformed his physique in four months thanks to an efficient workout plan. AdvertisementIn theory, researchers and trainers say, the combos allow one muscle group to rest while you're working a different muscle group with another exercise, tapping into the benefits of rest without added time. A superset involves performing exercises back-to-back without a break, and can save time by allowing one muscle group to rest while another is working. Using supersets, you can create a full-body plan, and work out harder, because you're not exhausting any one muscle group. Doing a few sets per muscle group more frequently allowed him to make each set count by adding more weight and pushing himself harder, he said.
Persons: , Andre Frade, Adam Enaz, Enaz, bro, that's, Frade Organizations: Service, Business Locations: London
X owner Elon Musk, who has endorsed Trump, replied, "And no one is even trying to assassinate Biden/Kamala." Related stories"I don't think this is much more than just confirmation that X is not a place for brands. This year, advertisers slashed their X marketing budgets ahead of major events like the Super Bowl. Musk is still the richest person in the world, with a net worth of about $250 billion, per Bloomberg. AdvertisementSo X may suffer, but Musk will probably come out alright.
Persons: , Donald Trump, Elon Musk, Trump, Biden, Kamala, Tucker Carlson, Brian Morrissey, Digiday, Brendan Gahan, Musk, Musk's, Gahan, bode, Morrissey, he's, haven't, outrageousness, Eric Dezenhall Organizations: Service, Business, LinkedIn, Authority, Disney, Apple, Walmart, Cannes, Street Journal, Twitter, Bloomberg, Dezenhall Resources Locations: South Africa
AdvertisementIt's a story all too familiar for some older Americans: An unexpected health crisis derails their retirement planning. With insufficient help from health insurance or Social Security, medical bills eat up any savings or income they have. Jones, who gets $2,200 a month in Social Security, has had to take on part-time work, which made her ineligible for some federal assistance. She paid for chemo out of pocket, spending her way through her retirement savings and maxing out her credit cards. Amend said it's crucial for older Americans to believe everything will be OK, noting "your mindset perpetuates what your outcome will be."
Persons: , Kimberly Mullen, Mullen, She's, she'll, Nancy Altman, Saul Martinez, Karen Knudsen, they've, Uber, Wendy Jones, it's, she's, Jones, Teresa Ghilarducci, , Ghilarducci, Rebecca Buffum, Buffum, I'm, Andrew Whitaker, Marion, Robert Papalia, Papalia, Leonard Bianconi, Bianconi, Gallup, Monique Morrissey, haven't, Harris, Morrissey, Frank, Weeks, he's Organizations: Service, Business, Social Security, American Cancer Society, Social, Walmart, Medicare, New School for Social Research, Schwartz, for Economic, Kaiser Family Foundation, BI, Institute, Biden, American Heart Association Locations: Kentucky, North Carolina
When I saw my son experience withdrawals and lying to get more screen time, I realized tech really could be addictive. I believed my son had a screen addiction (although he's never been officially diagnosed by a different provider). AdvertisementWe minimized the use of screens for schoolworkAt first, we wanted my son to have as little screen time as possible. Two years later, we're just starting to consider letting my son get a phone because he has been doing so well following our family media plan. I recognize that, eventually, my son will need more unrestricted access to screens so that he's prepared as an adult.
Persons: , Scott Kollins, he's, we've, I'm, We've, hadn't, we're, She's, didn't Organizations: Service, Business, YouTube, Duke University School of Medicine
If you want your degree to help you land a fulfilling job, consider studying music therapy. The medical and therapeutic fields are among the college majors helping graduates get jobs that make the world a better place, according to graduates surveyed in a recent Payscale report. Music therapy programs cover coursework in music, music therapy, science and psychology, according to the American Music Therapy Association. "Knowledge and skills are developed through coursework and clinical training, which cover the theory and practical application of music therapy treatment procedures and techniques," the organization states on its website. Here are the nine majors and degrees that alumni are most likely to say led to meaningful careers, according to Payscale.
Persons: Payscale Organizations: American Music Therapy Association
The hotly anticipated results are in from a landmark pair of major clinical trials of a long-acting, injectable HIV-prevention drug that only requires dosing every six months. The pharma giant has already secured approval for the injectable drug in treating highly drug-resistant HIV. Given the clear statistical superiority of lenacapavir over Truvada, the trial’s blinded phase will now be ended several months early. When taken as prescribed, Truvada is over 99% effective at preventing HIV; Descovy is comparably effective. This chorus is sure to get louder now that lenacapavir is officially highly effective at protecting gay and bisexual men and trans people as well.
Persons: lenacapavir, , Jared Baeten, , ” Jen Kates, ” Gilead, Gilead, Truvada, ViiV Healthcare’s, Amy Killelea, Jirair Ratevosian, Hansel Tookes, ” Tookes, Dr, Boghuma, “ lenacapavir, Tim Horn Organizations: Gilead Sciences, pharma, NBC, Food and Drug Administration, Disease Control, PrEP, Yale School of Nursing, University of Miami Miller School of Medicine, NBC News, Southern, Affordable, CDC, Emory University Locations: Gilead, United States, , U.S, Australia, United Kingdom, Arlington , Virginia, America, South Africa, Thailand, Truvada, Atlanta, Saharan Africa
Taking a high dose of ADHD drugs is linked to more than five times greater risk of developing psychosis or mania, according to a new study published Thursday in the American Journal of Psychiatry. The research is among the first to find a relationship between escalating doses of the drugs — amphetamines, in particular — and a greater likelihood of psychotic symptoms. The drugs include Adderall, Vyvanse and generic amphetamines, such as dextroamphetamine. The medium dosage — 20 mg to 40 mg of Adderall, 50 mg to 100 mg of Vyvanse or 15 mg to 30 mg of dextroamphetamine — was linked to a 3.5 times higher risk. There was no increased risk of psychosis with another ADHD drug, Ritalin, which isn’t an amphetamine.
Persons: it’s, , Jacob Ballon, hadn’t, Will Cronenwett, ” Cronenwett, Vyvanse, Takeda, Lauren Moran, Brigham, , ” Moran, Moran, Cronenwett, ” Ballon, they’re Organizations: American, of Psychiatry, Stanford Medicine, Northwestern Medicine, Psychiatry, NBC News, Takeda Pharmaceuticals, . Food, Drug Administration, FDA, Pharmaceuticals, McLean Hospital, Mass Locations: United States, U.S, Boston
The latest weapon in the battle against cancer is showing promising results — and it's a growing opportunity for investors, according to Redburn Atlantic. To treat cancer, targeted radiopharmaceutical therapy directly goes after tumors with radiation by binding a radioactive particle to a targeting molecule. Delving into diagnostics There are also opportunities in the radiopharma diagnostics space, according to Redburn Atlantic. It has a "strong pipeline of radionuclides for both diagnosis and therapy," he said. "Lantheus benefits from its focus on this rapidly expanding market, with 78% of revenues from radiopharmaceuticals and related products," Ridley-Day added.
Persons: Ed Ridley, Eli Lilly, Myers, Ridley, Astra's, Lantheus Organizations: Big pharma, Novartis, Mariana Oncology, Biopharma, Myers Squibb, RayzeBio, AstraZeneca, Fusion Pharmaceuticals, GE Healthcare Technologies, Lantheus Holdings, GE Healthcare, GE Locations: Bristol, radiopharmaceuticals
CNN —A drug currently used to treat HIV has also been found to dramatically reduce the risk of infection, significantly more than the primary option available for pre-exposure prophylaxis or PrEP. In a Phase 3 clinical trial, 99.9% of participants who took a twice-a-year injection of lenacapavir for HIV prevention did not acquire an infection, according to data from drugmaker Gilead Sciences. There were only two cases among 2,180 patients – effectively reducing the risk of HIV infection by 96% and proving 89% more effective than Truvada, a pill taken once a day. It’s a “significant breakthrough in HIV prevention,” according to a news release from the World Health Organization in July. Gilead said it will use these trial data to start the drug approval process in multiple countries by the end of the year.
Persons: lenacapavir, , Onyema Ogbuagu, Dr, Sanjay Gupta, It’s, Gilead Organizations: CNN, Gilead Sciences, Yale, Research, CNN Health, World Health Organization Locations: Gilead, Argentina, Brazil, Mexico, Peru, South Africa, Thailand, United States, Africa
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