Zverev, 26, recorded 10 aces to dispatch Safiullin and win the match in two hours, 56 minutes.
Safiullin, 26, collected 33 winners but was undone, in part, by 15 unforced errors and four double faults.
1 seed Karen Khachanov captured his fifth tour-level title and first since 2018 with a 7-6 (2), 6-1 win over eighth-seeded Yoshihito Nishioka of Japan in Zhuhai, China.
Khachanov, 27, recorded 34 winners and nine aces to win the match in one hour, 43 minutes.
Nishioka, 27, was bidding for his third tour-level title and first since Seoul last year.
Persons:
Safiullin, Italy's Jannik, Hannah Mckay, Alexander Zverev, Zverev, Karen Khachanov, Nishioka
Organizations:
Lawn Tennis, Croquet Club, Thomson
Locations:
London, Britain, Germany, Russian, Chengdu, China, Safiullin, Japan, Zhuhai, Seoul