Traders work on the trading floor at the New York Stock Exchange (NYSE) in Manhattan, New York City, U.S., September 13, 2022.
read more"The key to tomorrow is going to be indications by the Fed chief as to what's the next possible move.
The benchmark U.S. 10-year Treasury yield hit 3.54%, its highest level since April 2011, in anticipation of the rate hike, while the closely watched yield curve between two-year and 10-year notes inverted further.
ET, Dow e-minis were down 153 points, or 0.49%, S&P 500 e-minis were down 22.25 points, or 0.57%, and Nasdaq 100 e-minis were down 78.75 points, or 0.65%.
read morePayPal Holdings Inc (PYPL.O) fell 2.6% after Susquehanna Financial Group downgraded the fintech company's stock to "neutral" from "buy".